RU2013145162A - Анализ экспрессии биомаркеров в клетках с помощью кластеров - Google Patents

Анализ экспрессии биомаркеров в клетках с помощью кластеров Download PDF

Info

Publication number
RU2013145162A
RU2013145162A RU2013145162/15A RU2013145162A RU2013145162A RU 2013145162 A RU2013145162 A RU 2013145162A RU 2013145162/15 A RU2013145162/15 A RU 2013145162/15A RU 2013145162 A RU2013145162 A RU 2013145162A RU 2013145162 A RU2013145162 A RU 2013145162A
Authority
RU
Russia
Prior art keywords
cell
clusters
cluster
cells
sets
Prior art date
Application number
RU2013145162/15A
Other languages
English (en)
Russian (ru)
Inventor
Колин Крэйг МАККАЛЛОК
Original Assignee
Дженерал Электрик Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дженерал Электрик Компани filed Critical Дженерал Электрик Компани
Publication of RU2013145162A publication Critical patent/RU2013145162A/ru

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57555Immunoassay; Biospecific binding assay; Materials therefor for cancer of the prostate
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00Pattern recognition
    • G06F18/20Analysing
    • G06F18/21Design or setup of recognition systems or techniques; Extraction of features in feature space; Blind source separation
    • G06F18/211Selection of the most significant subset of features
    • G06F18/2115Selection of the most significant subset of features by evaluating different subsets according to an optimisation criterion, e.g. class separability, forward selection or backward elimination
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00Arrangements for image or video recognition or understanding
    • G06V10/70Arrangements for image or video recognition or understanding using pattern recognition or machine learning
    • G06V10/77Processing image or video features in feature spaces; using data integration or data reduction, e.g. principal component analysis [PCA] or independent component analysis [ICA] or self-organising maps [SOM]; Blind source separation
    • G06V10/771Feature selection, e.g. selecting representative features from a multi-dimensional feature space
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00Scenes; Scene-specific elements
    • G06V20/60Type of objects
    • G06V20/69Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/698Matching; Classification
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/56Staging of a disease; Further complications associated with the disease
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/60Complex ways of combining multiple protein biomarkers for diagnosis

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Multimedia (AREA)
  • Artificial Intelligence (AREA)
  • Data Mining & Analysis (AREA)
  • Evolutionary Computation (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Software Systems (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Databases & Information Systems (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Computing Systems (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Image Processing (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
RU2013145162/15A 2011-04-22 2012-04-23 Анализ экспрессии биомаркеров в клетках с помощью кластеров RU2013145162A (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161478224P 2011-04-22 2011-04-22
US61/478,224 2011-04-22
US13/252,069 US20120270752A1 (en) 2011-04-22 2011-10-03 Analyzing the expression of biomarkers in cells with moments
US13/252,072 US20120269418A1 (en) 2011-04-22 2011-10-03 Analyzing the expression of biomarkers in cells with clusters
US13/252,072 2011-10-03
US13/252,069 2011-10-03
PCT/EP2012/057395 WO2012143562A2 (en) 2011-04-22 2012-04-23 Analyzing the expression of biomarkers in cells with clusters

Publications (1)

Publication Number Publication Date
RU2013145162A true RU2013145162A (ru) 2015-05-27

Family

ID=47021377

Family Applications (3)

Application Number Title Priority Date Filing Date
RU2013145162/15A RU2013145162A (ru) 2011-04-22 2012-04-23 Анализ экспрессии биомаркеров в клетках с помощью кластеров
RU2013145151/15A RU2013145151A (ru) 2011-04-22 2012-04-23 Анализ экспрессии биомаркеров в клетках с помощью моментов распределения
RU2013145154/15A RU2013145154A (ru) 2011-04-22 2012-04-23 Анализ экспрессии биомаркеров в клетках с помощью кластеров

Family Applications After (2)

Application Number Title Priority Date Filing Date
RU2013145151/15A RU2013145151A (ru) 2011-04-22 2012-04-23 Анализ экспрессии биомаркеров в клетках с помощью моментов распределения
RU2013145154/15A RU2013145154A (ru) 2011-04-22 2012-04-23 Анализ экспрессии биомаркеров в клетках с помощью кластеров

Country Status (8)

Country Link
US (5) US20120269419A1 (https=)
EP (4) EP2700042B1 (https=)
JP (4) JP6143743B2 (https=)
BR (4) BR112013027122A2 (https=)
CA (4) CA2833804A1 (https=)
RU (3) RU2013145162A (https=)
SG (4) SG194588A1 (https=)
WO (4) WO2012143558A2 (https=)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201111594D0 (en) * 2011-07-06 2011-08-24 Equateq Ltd New improved process
EP2929420B1 (en) * 2012-12-06 2022-03-02 Leica Microsystems CMS GmbH Systems and methods for split screen display of a biological specimen and for capturing records thereof
US9488639B2 (en) * 2013-02-25 2016-11-08 Flagship Biosciences, Inc. Cell-based tissue analysis
US8995740B2 (en) * 2013-04-17 2015-03-31 General Electric Company System and method for multiplexed biomarker quantitation using single cell segmentation on sequentially stained tissue
CA2916520A1 (en) * 2013-07-03 2015-01-08 Coyne Ip Holdings, Llc Methods for predicting responses to chemical or biologic substances
US9322051B2 (en) 2013-10-07 2016-04-26 General Electric Company Probing of biological samples
US9298968B1 (en) * 2014-09-12 2016-03-29 Flagship Biosciences, Inc. Digital image analysis of inflammatory cells and mediators of inflammation
JP6791598B2 (ja) 2015-01-22 2020-11-25 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 異なる細胞サブセットの比率の決定方法およびシステム
US9953133B2 (en) 2015-06-03 2018-04-24 General Electric Company Biological data annotation and visualization
US10672505B2 (en) 2015-06-03 2020-06-02 General Electric Company Biological data annotation and visualization
WO2017109860A1 (ja) * 2015-12-22 2017-06-29 株式会社ニコン 画像処理装置
US20180032681A1 (en) * 2016-07-29 2018-02-01 General Electric Company Biological feature analysis technique
CN110192140A (zh) * 2016-11-16 2019-08-30 华盛顿大学 用于循环荧光成像的系统和方法
US11042551B2 (en) * 2016-12-02 2021-06-22 Fair Isaac Corporation Fast automatic explanation of scored observations
US11436719B2 (en) 2017-02-16 2022-09-06 Kyoto University Cell evaluation method, cell evaluation device, and recording medium storing cell evaluation program
US10242473B2 (en) * 2017-03-22 2019-03-26 Sas Institute Inc. Computer system to generate scalable plots using clustering
US10535434B2 (en) 2017-04-28 2020-01-14 4D Path Inc. Apparatus, systems, and methods for rapid cancer detection
KR101990430B1 (ko) * 2017-06-22 2019-06-18 한국과학기술원 암의 재발 예후 예측을 위한 바이오마커 발굴 시스템 및 방법
US12249401B2 (en) 2017-07-21 2025-03-11 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for analyzing mixed cell populations
US10706328B2 (en) 2018-05-07 2020-07-07 Google Llc Focus-weighted, machine learning disease classifier error prediction for microscope slide images
US10971255B2 (en) * 2018-09-14 2021-04-06 Zasti Inc. Multimodal learning framework for analysis of clinical trials
US11101043B2 (en) 2018-09-24 2021-08-24 Zasti Inc. Hybrid analysis framework for prediction of outcomes in clinical trials
US20220015714A1 (en) * 2018-11-29 2022-01-20 Somalogic, Inc. Methods For Determining Disease Risk Combining Downsampling of Class-Imbalanced Sets With Survival Analysis
US11128667B2 (en) * 2018-11-29 2021-09-21 Rapid7, Inc. Cluster detection and elimination in security environments
CN113158982A (zh) * 2021-05-17 2021-07-23 广东中卡云计算有限公司 一种半介入式的目标关键点标注方法
WO2023033056A1 (ja) * 2021-09-01 2023-03-09 イミュニティリサーチ株式会社 細胞集団同定システム、方法、およびプログラム
IT202200001817A1 (it) 2022-02-02 2023-08-02 Aizoon S R L Procedimento per la prognosi di una malattia in seguito ad un trattamento terapeutico, relativo sistema e prodotto informatico
IT202200005861A1 (it) 2022-03-24 2023-09-24 Aizoon S R L Procedimento per stimare una variabile di interesse associata ad una data malattia in funzione di una pluralità di diversi dati omici, relativo dispositivo e prodotto informatico
CA3207405A1 (en) 2022-07-25 2024-01-25 Aizoon S.r.l. Method for providing a clinical decision support, corresponding system for providing a clinical decision support, and computer program product
WO2025258375A1 (ja) * 2024-06-12 2025-12-18 ソニーグループ株式会社 情報処理方法及び情報処理システム

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6463438B1 (en) * 1994-06-03 2002-10-08 Urocor, Inc. Neural network for cell image analysis for identification of abnormal cells
US5740269A (en) * 1994-09-20 1998-04-14 Neopath, Inc. Method and apparatus for robust biological specimen classification
US6996549B2 (en) * 1998-05-01 2006-02-07 Health Discovery Corporation Computer-aided image analysis
US6282305B1 (en) * 1998-06-05 2001-08-28 Arch Development Corporation Method and system for the computerized assessment of breast cancer risk
US6337472B1 (en) * 1998-10-19 2002-01-08 The University Of Texas System Board Of Regents Light imaging microscope having spatially resolved images
JP2005503760A (ja) * 2001-01-24 2005-02-10 プロテイン デザイン ラブス, インコーポレイテッド 乳癌の診断方法、組成物および乳癌のモジュレーターのスクリーニング方法
WO2004013658A2 (en) * 2002-07-30 2004-02-12 Deutsches Krebsforschungszentrum Method and apparatus for multiple labeling detection and evaluation of a plurality of particles
US20040121413A1 (en) * 2002-12-20 2004-06-24 Aebersold Rudolf H. Androgen-regulated genes and uses for diagnosis, prognosis and treatment of prostate neoplastic conditions
US20050265588A1 (en) * 2004-02-03 2005-12-01 Bioimagene, Inc. Method and system for digital image based flourescent in situ hybridization (FISH) analysis
WO2006113747A2 (en) * 2005-04-19 2006-10-26 Prediction Sciences Llc Diagnostic markers of breast cancer treatment and progression and methods of use thereof
US8041090B2 (en) * 2005-09-10 2011-10-18 Ge Healthcare Uk Limited Method of, and apparatus and computer software for, performing image processing
US7933435B2 (en) * 2005-11-21 2011-04-26 Vala Sciences, Inc. System, method, and kit for processing a magnified image of biological material to identify components of a biological object
CN101484806A (zh) * 2006-05-17 2009-07-15 协乐民公司 一种对组织进行自动分析的方法
US7741045B2 (en) * 2006-11-16 2010-06-22 General Electric Company Sequential analysis of biological samples
US8019134B2 (en) * 2006-11-16 2011-09-13 Definiens Ag Automatic image analysis and quantification for fluorescence in situ hybridization
EP2132327A2 (en) * 2007-03-27 2009-12-16 Rosetta Genomics Ltd Gene expression signature for classification of cancers
CA2683134A1 (en) * 2007-05-07 2008-11-13 Ge Healthcare Bio-Sciences Corp. System and method for the automated analysis of cellular assays and tissues
WO2008143849A2 (en) * 2007-05-14 2008-11-27 Historx, Inc. Compartment segregation by pixel characterization using image data clustering
EP2195467B1 (en) * 2007-09-06 2016-12-14 bioTheranostics, Inc. Tumor grading and cancer prognosis in breast cancer
US9858389B2 (en) * 2008-07-25 2018-01-02 Fundação D. Anna De Sommer Champalimaud E Dr. Carlos Montez Champalimaud Method and system for determining the risk of occurrence of prostate cancer
US9779213B2 (en) * 2008-07-25 2017-10-03 Fundacao D. Anna Sommer Champalimaud E Dr. Carlos Montez Champalimaud System for evaluating a pathological stage of prostate cancer
US8320655B2 (en) * 2009-10-16 2012-11-27 General Electric Company Process and system for analyzing the expression of biomarkers in cells
US20110091081A1 (en) * 2009-10-16 2011-04-21 General Electric Company Method and system for analyzing the expression of biomarkers in cells in situ in their tissue of origin
WO2011087778A1 (en) * 2009-12-22 2011-07-21 The Children's Hospital Of Philadelphia Automated quantitative multidimensional volumetric analysis and visualization

Also Published As

Publication number Publication date
WO2012143558A3 (en) 2012-12-20
JP6163152B2 (ja) 2017-07-12
SG194588A1 (en) 2013-12-30
EP2700037A2 (en) 2014-02-26
EP2700038B1 (en) 2021-04-21
RU2013145154A (ru) 2015-05-27
JP2014516413A (ja) 2014-07-10
JP2014517954A (ja) 2014-07-24
WO2012143556A2 (en) 2012-10-26
WO2012143558A2 (en) 2012-10-26
US20140185905A1 (en) 2014-07-03
EP2700042A2 (en) 2014-02-26
WO2012143561A2 (en) 2012-10-26
BR112013027123A2 (pt) 2017-01-10
JP6063447B2 (ja) 2017-01-18
EP2700038A2 (en) 2014-02-26
BR112013027122A2 (pt) 2017-01-10
EP2700036A2 (en) 2014-02-26
US20120270752A1 (en) 2012-10-25
WO2012143561A3 (en) 2013-05-23
CA2833295A1 (en) 2012-10-26
JP2014521926A (ja) 2014-08-28
CA2833428A1 (en) 2012-10-26
WO2012143562A3 (en) 2013-02-28
BR112013027125A2 (pt) 2017-01-10
EP2700042B1 (en) 2021-03-17
US20120269419A1 (en) 2012-10-25
JP2014521925A (ja) 2014-08-28
US20120269418A1 (en) 2012-10-25
CA2833497A1 (en) 2012-10-26
SG194592A1 (en) 2013-12-30
BR112013027124A2 (pt) 2017-01-10
SG194594A1 (en) 2013-12-30
US20120271553A1 (en) 2012-10-25
WO2012143556A3 (en) 2013-05-30
CA2833804A1 (en) 2012-10-26
JP6063446B2 (ja) 2017-01-18
JP6143743B2 (ja) 2017-06-07
RU2013145151A (ru) 2015-05-27
WO2012143562A2 (en) 2012-10-26
SG194590A1 (en) 2013-12-30

Similar Documents

Publication Publication Date Title
RU2013145162A (ru) Анализ экспрессии биомаркеров в клетках с помощью кластеров
JP2014516413A5 (https=)
CN107679052B (zh) 大数据分析方法以及利用了该分析方法的质谱分析系统
Gill et al. Validity of the mental health component scale of the 12-item Short-Form Health Survey (MCS-12) as measure of common mental disorders in the general population
US10049447B2 (en) Pathology case review, analysis and prediction
JP2014517954A5 (https=)
Filipovych et al. Semi-supervised cluster analysis of imaging data
Zhu et al. Predicting visual function from the measurements of retinal nerve fiber layer structure
Prakash et al. 4x-expert systems for early prediction of osteoporosis using multi-model algorithms
JP2014521926A5 (https=)
Wazaefi et al. Evidence of a limited intra-individual diversity of nevi: intuitive perception of dominant clusters is a crucial step in the analysis of nevi by dermatologists
Hund et al. Analysis of patient groups and immunization results based on subspace clustering
Colbaugh et al. Ensemble transfer learning for Alzheimer's disease diagnosis
Soladoye et al. Enhancing Alzheimer's disease prediction using random forest: A novel framework combining backward feature elimination and ant colony optimization
Oi et al. The roles of non-heterosexuality outside of identity and gender non-conformity in Allostatic Load among young adults
MA Basher et al. Heterogeneity-preserving discriminative feature selection for disease-specific subtype discovery
Ejigu et al. Geostatistical methods for modelling non-stationary patterns in disease risk
CN114493018A (zh) 一种基于脂代谢基因的肺腺癌预后预测方法和装置
Kalogiannis et al. Geriatric group analysis by clustering non-linearly embedded multi-sensor data
CN119446260A (zh) 一种基于dna甲基化的人体生物学年龄检测方法
Nagesh et al. A spatiotemporal approach to predicting glaucoma progression using a ct-hmm
Kobelyatskaya et al. exBAClock: a comprehensive database of published clocks for age quantification and age-related diseases
Indah et al. Clustering Analysis for Regional Variations in Beef Production: A Comparative Study of Hierarchical and Non-Hierarchical
Long et al. Graph based MRI brain scan classification and correlation discovery
CN110019826A (zh) 医疗知识图谱的构建方法、构建装置、设备和存储介质

Legal Events

Date Code Title Description
FA92 Acknowledgement of application withdrawn (lack of supplementary materials submitted)

Effective date: 20160816