RU2012117418A - Фотоинициированные наночастицы для нацеливания на клетку и ткань - Google Patents
Фотоинициированные наночастицы для нацеливания на клетку и ткань Download PDFInfo
- Publication number
- RU2012117418A RU2012117418A RU2012117418/15A RU2012117418A RU2012117418A RU 2012117418 A RU2012117418 A RU 2012117418A RU 2012117418/15 A RU2012117418/15 A RU 2012117418/15A RU 2012117418 A RU2012117418 A RU 2012117418A RU 2012117418 A RU2012117418 A RU 2012117418A
- Authority
- RU
- Russia
- Prior art keywords
- ligand
- composition
- photodetectable
- particles
- individual
- Prior art date
Links
- 230000008685 targeting Effects 0.000 title claims abstract 20
- 239000002105 nanoparticle Substances 0.000 title 1
- 239000003446 ligand Substances 0.000 claims abstract 38
- 125000006239 protecting group Chemical group 0.000 claims abstract 22
- 239000002245 particle Substances 0.000 claims abstract 21
- 210000004027 cell Anatomy 0.000 claims abstract 17
- 238000000034 method Methods 0.000 claims abstract 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 12
- 239000000126 substance Substances 0.000 claims abstract 11
- -1 antibodies Proteins 0.000 claims abstract 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract 9
- MWOGMBZGFFZBMK-LJZWMIMPSA-N (2s)-2-[[(2s)-2-[[2-[[(2s,3s)-2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound NC(N)=NCCC[C@@H](C(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 MWOGMBZGFFZBMK-LJZWMIMPSA-N 0.000 claims abstract 5
- ISAOCJYIOMOJEB-UHFFFAOYSA-N desyl alcohol Natural products C=1C=CC=CC=1C(O)C(=O)C1=CC=CC=C1 ISAOCJYIOMOJEB-UHFFFAOYSA-N 0.000 claims abstract 5
- 108010052768 tyrosyl-isoleucyl-glycyl-seryl-arginine Proteins 0.000 claims abstract 5
- YWSPWKXREVSQCA-UHFFFAOYSA-N 4,5-dimethoxy-2-nitrobenzaldehyde Chemical compound COC1=CC(C=O)=C([N+]([O-])=O)C=C1OC YWSPWKXREVSQCA-UHFFFAOYSA-N 0.000 claims abstract 4
- 108091023037 Aptamer Proteins 0.000 claims abstract 4
- 244000028419 Styrax benzoin Species 0.000 claims abstract 4
- 235000000126 Styrax benzoin Nutrition 0.000 claims abstract 4
- 235000008411 Sumatra benzointree Nutrition 0.000 claims abstract 4
- 229960002130 benzoin Drugs 0.000 claims abstract 4
- 210000004271 bone marrow stromal cell Anatomy 0.000 claims abstract 4
- 210000004413 cardiac myocyte Anatomy 0.000 claims abstract 4
- 210000001671 embryonic stem cell Anatomy 0.000 claims abstract 4
- 210000002950 fibroblast Anatomy 0.000 claims abstract 4
- 235000019382 gum benzoic Nutrition 0.000 claims abstract 4
- 230000001678 irradiating effect Effects 0.000 claims abstract 3
- 150000002170 ethers Chemical class 0.000 claims 1
- 102000006495 integrins Human genes 0.000 claims 1
- 108010044426 integrins Proteins 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0042—Photocleavage of drugs in vivo, e.g. cleavage of photolabile linkers in vivo by UV radiation for releasing the pharmacologically-active agent from the administered agent; photothrombosis or photoocclusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
- A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
- A61K47/6935—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24753509P | 2009-09-30 | 2009-09-30 | |
| US61/247,535 | 2009-09-30 | ||
| PCT/US2010/050846 WO2011041496A1 (en) | 2009-09-30 | 2010-09-30 | Phototriggered nanoparticles for cell and tissue targeting |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012117418A true RU2012117418A (ru) | 2013-11-10 |
Family
ID=43826645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012117418/15A RU2012117418A (ru) | 2009-09-30 | 2010-09-30 | Фотоинициированные наночастицы для нацеливания на клетку и ткань |
Country Status (12)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004262853B2 (en) | 2003-07-17 | 2008-06-05 | Upfield Europe B.V. | Process for the preparation of an edible dispersion comprising oil and structuring agent |
| CA2598401C (en) | 2005-02-17 | 2013-10-29 | Unilever Plc | Process for the preparation of a spreadable dispersion |
| WO2010033200A2 (en) | 2008-09-19 | 2010-03-25 | President And Fellows Of Harvard College | Creation of libraries of droplets and related species |
| AU2009328392B2 (en) | 2008-12-19 | 2013-08-22 | Upfield Europe B.V. | Edible fat powders |
| EA024216B1 (ru) | 2010-06-22 | 2016-08-31 | Юнилевер Н.В. | Порошкообразные пищевые жиры |
| CA2820354C (en) | 2010-12-17 | 2019-06-11 | Unilever Plc | Process of compacting a microporous fat powder and compacted fat powder so obtained |
| CA2820360C (en) | 2010-12-17 | 2018-10-30 | Unilever Plc | Edible water in oil emulsion |
| US20160279068A1 (en) | 2013-11-08 | 2016-09-29 | President And Fellows Of Harvard College | Microparticles, methods for their preparation and use |
| CN103623417B (zh) * | 2013-12-18 | 2016-01-20 | 东华大学 | 一种功能化聚酰胺-胺树状大分子的纳米复合物的应用 |
| JP2018537414A (ja) | 2015-10-13 | 2018-12-20 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ゲルマイクロスフェアの作製及び使用のためのシステム及び方法 |
| WO2021002131A1 (ja) * | 2019-07-01 | 2021-01-07 | 富士フイルム株式会社 | 半導体膜、光電変換素子、イメージセンサおよび半導体膜の製造方法 |
| KR20210149956A (ko) * | 2020-06-02 | 2021-12-10 | 삼성디스플레이 주식회사 | 양자점 조성물, 발광 소자 및 이의 제조 방법 |
| CN114574187B (zh) * | 2020-11-30 | 2024-03-05 | 北京京东方技术开发有限公司 | 纳米粒子、纳米粒子层图案化的方法及相关应用 |
| US20240032412A1 (en) * | 2020-12-25 | 2024-01-25 | Boe Technology Group Co., Ltd. | Quantum dot material, light-emitting device and manufacturing method therefor, and display apparatus |
| US12187935B1 (en) * | 2023-12-12 | 2025-01-07 | Applied Materials, Inc. | Liquid dispersion of quantum dots in an acrylic monomer medium |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5998580A (en) * | 1995-10-13 | 1999-12-07 | Fay; Frederick F. | Photosensitive caged macromolecules |
| US20070041934A1 (en) * | 2005-08-12 | 2007-02-22 | Regents Of The University Of Michigan | Dendrimer based compositions and methods of using the same |
| US20080318246A1 (en) * | 2007-03-07 | 2008-12-25 | The Albert Einstein College Of Medicine Of Yeshiva University | Deeply quenched enzyme sensors |
-
2010
- 2010-09-30 BR BR112012009182A patent/BR112012009182A2/pt not_active IP Right Cessation
- 2010-09-30 AU AU2010300629A patent/AU2010300629A1/en not_active Abandoned
- 2010-09-30 RU RU2012117418/15A patent/RU2012117418A/ru not_active Application Discontinuation
- 2010-09-30 EP EP10821224A patent/EP2482922A1/en not_active Withdrawn
- 2010-09-30 CA CA2780137A patent/CA2780137C/en not_active Expired - Fee Related
- 2010-09-30 IN IN3178DEN2012 patent/IN2012DN03178A/en unknown
- 2010-09-30 WO PCT/US2010/050846 patent/WO2011041496A1/en active Application Filing
- 2010-09-30 CN CN2010800538264A patent/CN102883773A/zh active Pending
- 2010-09-30 KR KR1020127010831A patent/KR20120080615A/ko not_active Withdrawn
- 2010-09-30 US US13/499,543 patent/US20130004522A1/en not_active Abandoned
- 2010-09-30 MX MX2012003990A patent/MX2012003990A/es not_active Application Discontinuation
-
2012
- 2012-04-01 IL IL218964A patent/IL218964A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2780137A1 (en) | 2011-04-07 |
| CA2780137C (en) | 2014-07-22 |
| CN102883773A (zh) | 2013-01-16 |
| IL218964A0 (en) | 2012-06-28 |
| EP2482922A1 (en) | 2012-08-08 |
| BR112012009182A2 (pt) | 2018-03-20 |
| AU2010300629A1 (en) | 2012-06-21 |
| IN2012DN03178A (enrdf_load_stackoverflow) | 2015-09-25 |
| KR20120080615A (ko) | 2012-07-17 |
| MX2012003990A (es) | 2012-06-27 |
| US20130004522A1 (en) | 2013-01-03 |
| WO2011041496A1 (en) | 2011-04-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20131001 |