RU2012113844A - Пероральные суспензионные лекарственные формы ацетата эсликарбазепина - Google Patents
Пероральные суспензионные лекарственные формы ацетата эсликарбазепина Download PDFInfo
- Publication number
- RU2012113844A RU2012113844A RU2012113844/15A RU2012113844A RU2012113844A RU 2012113844 A RU2012113844 A RU 2012113844A RU 2012113844/15 A RU2012113844/15 A RU 2012113844/15A RU 2012113844 A RU2012113844 A RU 2012113844A RU 2012113844 A RU2012113844 A RU 2012113844A
- Authority
- RU
- Russia
- Prior art keywords
- dosage form
- amount
- agent
- form according
- sorbitol
- Prior art date
Links
- 229940100692 oral suspension Drugs 0.000 title claims abstract 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 title 1
- 239000002552 dosage form Substances 0.000 claims abstract 54
- 239000004599 antimicrobial Substances 0.000 claims abstract 11
- 239000000080 wetting agent Substances 0.000 claims abstract 11
- 239000007788 liquid Substances 0.000 claims abstract 9
- 239000000375 suspending agent Substances 0.000 claims abstract 9
- QIALRBLEEWJACW-INIZCTEOSA-N eslicarbazepine acetate Chemical compound CC(=O)O[C@H]1CC2=CC=CC=C2N(C(N)=O)C2=CC=CC=C12 QIALRBLEEWJACW-INIZCTEOSA-N 0.000 claims abstract 6
- 229960003233 eslicarbazepine acetate Drugs 0.000 claims abstract 6
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims abstract 6
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims abstract 6
- 239000000230 xanthan gum Substances 0.000 claims abstract 6
- 229920001285 xanthan gum Polymers 0.000 claims abstract 6
- 229940082509 xanthan gum Drugs 0.000 claims abstract 6
- 235000010493 xanthan gum Nutrition 0.000 claims abstract 6
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims abstract 3
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims abstract 3
- 229960002216 methylparaben Drugs 0.000 claims abstract 3
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims abstract 3
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims abstract 3
- 229960003415 propylparaben Drugs 0.000 claims abstract 3
- -1 polyoxyethylene stearate Polymers 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims 13
- 239000007853 buffer solution Substances 0.000 claims 10
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 9
- 239000000600 sorbitol Substances 0.000 claims 9
- 239000007864 aqueous solution Substances 0.000 claims 5
- 239000000243 solution Substances 0.000 claims 3
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000019634 flavors Nutrition 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000006186 oral dosage form Substances 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Dispersion Chemistry (AREA)
- Psychiatry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24119509P | 2009-09-10 | 2009-09-10 | |
| US61/241,195 | 2009-09-10 | ||
| PCT/PT2010/000038 WO2011031176A1 (en) | 2009-09-10 | 2010-09-10 | Oral suspension formulations of esclicarbazepine acetate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012113844A true RU2012113844A (ru) | 2013-10-20 |
Family
ID=43037794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012113844/15A RU2012113844A (ru) | 2009-09-10 | 2010-09-10 | Пероральные суспензионные лекарственные формы ацетата эсликарбазепина |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20130040939A1 (enExample) |
| EP (1) | EP2475357A1 (enExample) |
| JP (1) | JP2013504569A (enExample) |
| KR (1) | KR20120094473A (enExample) |
| CN (1) | CN102612359A (enExample) |
| AR (1) | AR078283A1 (enExample) |
| AU (1) | AU2010293105A1 (enExample) |
| BR (1) | BR112012005254A2 (enExample) |
| CA (1) | CA2773249A1 (enExample) |
| IN (1) | IN2012DN02379A (enExample) |
| MX (1) | MX2012002831A (enExample) |
| RU (1) | RU2012113844A (enExample) |
| WO (1) | WO2011031176A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0700773D0 (en) | 2007-01-15 | 2007-02-21 | Portela & Ca Sa | Drug therapies |
| CA2769181C (en) | 2009-07-27 | 2017-11-28 | Bial-Portela & Ca., S.A. | Use of 5h-dibenz / b, f/ azepine-5-carboxamide derivatives for treating fibromyalgia |
| EP2747770A1 (en) | 2011-08-26 | 2014-07-02 | BIAL - Portela & Cª S.A. | Treatments involving eslicarbazepine acetate or eslicarbazepine |
| GB201306095D0 (en) * | 2013-04-04 | 2013-05-22 | Bial Portela & Ca Sa | New treatments |
| JP6122815B2 (ja) * | 2014-02-20 | 2017-04-26 | ライオン株式会社 | 経口製剤及びその製造方法 |
| JP6786240B2 (ja) * | 2016-03-31 | 2020-11-18 | 小林製薬株式会社 | 粘性経口組成物 |
| WO2019058353A1 (en) * | 2017-09-25 | 2019-03-28 | Jubilant Generics Limited | MODIFIED RELEASE SUSPENSION OF ESLICARBAZEPINE |
| US11318145B2 (en) * | 2018-09-25 | 2022-05-03 | Jubilant Generics Limited | Eslicarbazepine suspension |
| WO2019058354A1 (en) * | 2017-09-25 | 2019-03-28 | Jubilant Generics Limited | SUSPENSION OF ESLICARBAZÉPINE |
| US20220265552A1 (en) * | 2017-09-25 | 2022-08-25 | Jubilant Generics Limited | Eslicarbazepine suspension |
| CN116440075B (zh) * | 2023-06-01 | 2025-05-06 | 苏州中化药品工业有限公司 | 一种干混悬剂及其制备方法 |
| US20260199235A1 (en) | 2025-01-14 | 2026-07-16 | Saptalis Pharmaceuticals, LLC | Immediate-release, liquid oral pharmaceutical suspension dosage form of eslicarbazepine acetate |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8618847D0 (en) * | 1986-08-01 | 1986-09-10 | Smith Kline French Lab | Pharmaceutical formulations |
| PL177323B1 (pl) * | 1993-10-01 | 1999-10-29 | Syntex Inc | Kompozycja farmaceutyczna zawierająca mykofenolan mofetylu lub kwas mykofenolowy i sposób wytwarzania kompozycji farmaceutycznej zawierającej mykofenolan mofetylu lub kwas mykofenolowy |
| US6184220B1 (en) * | 1998-03-27 | 2001-02-06 | Boehringer Ingelheim Pharma Kg | Oral suspension of pharmaceutical substance |
| GB9930058D0 (en) * | 1999-12-20 | 2000-02-09 | Novartis Ag | Organic compounds |
| US20020028794A1 (en) * | 2000-07-21 | 2002-03-07 | Brubaker Greg Allen | Megestrol acetate suspension |
| US6510799B2 (en) * | 2001-07-02 | 2003-01-28 | Magna Force, Inc. | Apparatus, systems and methods for levitating and moving objects |
| US7300670B2 (en) * | 2002-04-03 | 2007-11-27 | Unilab Pharmatech, Ltd. | Oral suspension formulation |
| ATE541562T1 (de) * | 2002-06-17 | 2012-02-15 | Taro Pharmaceuticals Usa Inc | Ibuprofen-suspension |
| NZ527142A (en) * | 2003-07-23 | 2006-03-31 | Douglas Pharmaceuticals Ltd | A stable suspension formulation |
| US7118508B2 (en) * | 2004-07-28 | 2006-10-10 | General Motors Corporation | Planetary transmissions having three interconnected gear members and clutched input members |
| WO2006018814A2 (en) * | 2004-08-16 | 2006-02-23 | Ranbaxy Laboratories Limited | Oral liquid suspensions of metaxalone |
| US20060252745A1 (en) * | 2005-05-06 | 2006-11-09 | Almeida Jose L D | Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use |
| EP2380573B1 (en) | 2005-05-06 | 2015-02-25 | Bial-Portela & CA, S.A. | Eslicarbazepine acetate and methods of use |
| WO2007007182A2 (en) * | 2005-07-08 | 2007-01-18 | Aurobindo Pharma Limited | Solid and liquid dosage forms of an antiepileptic agent |
-
2010
- 2010-09-10 CN CN2010800402118A patent/CN102612359A/zh active Pending
- 2010-09-10 AR ARP100103320A patent/AR078283A1/es unknown
- 2010-09-10 EP EP10757859A patent/EP2475357A1/en not_active Withdrawn
- 2010-09-10 MX MX2012002831A patent/MX2012002831A/es not_active Application Discontinuation
- 2010-09-10 WO PCT/PT2010/000038 patent/WO2011031176A1/en not_active Ceased
- 2010-09-10 US US13/394,414 patent/US20130040939A1/en not_active Abandoned
- 2010-09-10 CA CA2773249A patent/CA2773249A1/en not_active Abandoned
- 2010-09-10 RU RU2012113844/15A patent/RU2012113844A/ru not_active Application Discontinuation
- 2010-09-10 IN IN2379DEN2012 patent/IN2012DN02379A/en unknown
- 2010-09-10 JP JP2012528773A patent/JP2013504569A/ja active Pending
- 2010-09-10 KR KR1020127008885A patent/KR20120094473A/ko not_active Withdrawn
- 2010-09-10 AU AU2010293105A patent/AU2010293105A1/en not_active Abandoned
- 2010-09-10 BR BR112012005254A patent/BR112012005254A2/pt not_active Application Discontinuation
-
2017
- 2017-10-17 US US15/785,890 patent/US20180256594A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013504569A (ja) | 2013-02-07 |
| AR078283A1 (es) | 2011-10-26 |
| CN102612359A (zh) | 2012-07-25 |
| BR112012005254A2 (pt) | 2016-03-15 |
| US20180256594A1 (en) | 2018-09-13 |
| KR20120094473A (ko) | 2012-08-24 |
| US20130040939A1 (en) | 2013-02-14 |
| AU2010293105A1 (en) | 2012-04-05 |
| EP2475357A1 (en) | 2012-07-18 |
| CA2773249A1 (en) | 2011-03-17 |
| IN2012DN02379A (enExample) | 2015-08-21 |
| AU2010293105A8 (en) | 2012-07-19 |
| MX2012002831A (es) | 2012-05-08 |
| WO2011031176A1 (en) | 2011-03-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20150327 |