RU2012106426A - 1н-хиназолин-2,4-дионы, предназначенные для лечения нейронного восковидного липофусциноза - Google Patents
1н-хиназолин-2,4-дионы, предназначенные для лечения нейронного восковидного липофусциноза Download PDFInfo
- Publication number
- RU2012106426A RU2012106426A RU2012106426/04A RU2012106426A RU2012106426A RU 2012106426 A RU2012106426 A RU 2012106426A RU 2012106426/04 A RU2012106426/04 A RU 2012106426/04A RU 2012106426 A RU2012106426 A RU 2012106426A RU 2012106426 A RU2012106426 A RU 2012106426A
- Authority
- RU
- Russia
- Prior art keywords
- dioxo
- dihydro
- quinazolin
- methanesulfonamide
- trifluoromethyl
- Prior art date
Links
- 230000001537 neural effect Effects 0.000 title claims abstract 20
- 150000001875 compounds Chemical class 0.000 claims abstract 23
- 150000003839 salts Chemical class 0.000 claims abstract 20
- 229940002612 prodrug Drugs 0.000 claims abstract 19
- 239000000651 prodrug Substances 0.000 claims abstract 19
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 8
- LCFHHNPWFZWYFJ-UHFFFAOYSA-N n-[6-(1-methoxyethyl)-2,4-dioxo-7-(trifluoromethyl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound N1C(=O)N(NS(C)(=O)=O)C(=O)C2=C1C=C(C(F)(F)F)C(C(C)OC)=C2 LCFHHNPWFZWYFJ-UHFFFAOYSA-N 0.000 claims abstract 6
- 230000002265 prevention Effects 0.000 claims abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 4
- 239000001257 hydrogen Substances 0.000 claims abstract 4
- IOMNVPHVACWAQD-UHFFFAOYSA-N n-[6-(1-hydroxyethyl)-2,4-dioxo-7-(trifluoromethyl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound N1C(=O)N(NS(C)(=O)=O)C(=O)C2=C1C=C(C(F)(F)F)C(C(O)C)=C2 IOMNVPHVACWAQD-UHFFFAOYSA-N 0.000 claims abstract 4
- 125000001424 substituent group Chemical group 0.000 claims abstract 4
- -1 1-Hydroxypropyl Chemical group 0.000 claims abstract 3
- LSKJPQVORRUXOV-UHFFFAOYSA-N n-[6-(1-ethoxyethyl)-2,4-dioxo-7-(trifluoromethyl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound N1C(=O)N(NS(C)(=O)=O)C(=O)C2=C1C=C(C(F)(F)F)C(C(C)OCC)=C2 LSKJPQVORRUXOV-UHFFFAOYSA-N 0.000 claims 5
- MCECSFFXUPEPDB-UHFFFAOYSA-N n-[6-(2-methylpyrazol-3-yl)-2,4-dioxo-7-propan-2-yl-1h-quinazolin-3-yl]methanesulfonamide Chemical compound CC(C)C1=CC=2NC(=O)N(NS(C)(=O)=O)C(=O)C=2C=C1C1=CC=NN1C MCECSFFXUPEPDB-UHFFFAOYSA-N 0.000 claims 5
- OEKIBARTEOJEKR-UHFFFAOYSA-N n-[7-ethyl-6-(2-methylpyrazol-3-yl)-2,4-dioxo-1h-quinazolin-3-yl]methanesulfonamide Chemical compound CCC1=CC=2NC(=O)N(NS(C)(=O)=O)C(=O)C=2C=C1C1=CC=NN1C OEKIBARTEOJEKR-UHFFFAOYSA-N 0.000 claims 5
- HBYOBTHYFIRAOW-UHFFFAOYSA-N n-[2,4-dioxo-6-(oxolan-2-yl)-7-(trifluoromethyl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound C1=C2C(=O)N(NS(=O)(=O)C)C(=O)NC2=CC(C(F)(F)F)=C1C1CCCO1 HBYOBTHYFIRAOW-UHFFFAOYSA-N 0.000 claims 4
- YMFABCOTRXIHFU-UHFFFAOYSA-N n-[7-(difluoromethyl)-6-(2-methylpyrazol-3-yl)-2,4-dioxo-1h-quinazolin-3-yl]methanesulfonamide Chemical compound CN1N=CC=C1C1=CC(C(N(NS(C)(=O)=O)C(=O)N2)=O)=C2C=C1C(F)F YMFABCOTRXIHFU-UHFFFAOYSA-N 0.000 claims 4
- DSELHYJGEKXXRP-UHFFFAOYSA-N n-[2,4-dioxo-6-(1-propan-2-yloxyethyl)-7-(trifluoromethyl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound N1C(=O)N(NS(C)(=O)=O)C(=O)C2=C1C=C(C(F)(F)F)C(C(C)OC(C)C)=C2 DSELHYJGEKXXRP-UHFFFAOYSA-N 0.000 claims 3
- FCGZKGLYOHESAU-UHFFFAOYSA-N n-[2,4-dioxo-6-(1-propan-2-yloxypropyl)-7-(trifluoromethyl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound N1C(=O)N(NS(C)(=O)=O)C(=O)C2=C1C=C(C(F)(F)F)C(C(OC(C)C)CC)=C2 FCGZKGLYOHESAU-UHFFFAOYSA-N 0.000 claims 3
- WUTUFPNWYUNDFI-UHFFFAOYSA-N n-[2,4-dioxo-6-(2-propan-2-ylpyrazol-3-yl)-7-(trifluoromethyl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound CC(C)N1N=CC=C1C1=CC(C(N(NS(C)(=O)=O)C(=O)N2)=O)=C2C=C1C(F)(F)F WUTUFPNWYUNDFI-UHFFFAOYSA-N 0.000 claims 3
- KBYZURXFFPMEEI-UHFFFAOYSA-N n-[2,4-dioxo-6-(oxolan-3-yl)-7-(trifluoromethyl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound C1=C2C(=O)N(NS(=O)(=O)C)C(=O)NC2=CC(C(F)(F)F)=C1C1CCOC1 KBYZURXFFPMEEI-UHFFFAOYSA-N 0.000 claims 3
- WMLSFJLHWQYACM-UHFFFAOYSA-N n-[2,4-dioxo-7-propan-2-yl-6-(2-propan-2-ylpyrazol-3-yl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound CC(C)C1=CC=2NC(=O)N(NS(C)(=O)=O)C(=O)C=2C=C1C1=CC=NN1C(C)C WMLSFJLHWQYACM-UHFFFAOYSA-N 0.000 claims 3
- UQTXIYMVGFQNKE-UHFFFAOYSA-N n-[6-(1-hydroxybutyl)-2,4-dioxo-7-(trifluoromethyl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound N1C(=O)N(NS(C)(=O)=O)C(=O)C2=C1C=C(C(F)(F)F)C(C(O)CCC)=C2 UQTXIYMVGFQNKE-UHFFFAOYSA-N 0.000 claims 3
- MIGNZRPDULLXTQ-UHFFFAOYSA-N n-[6-(1-hydroxypropyl)-2,4-dioxo-7-(trifluoromethyl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound N1C(=O)N(NS(C)(=O)=O)C(=O)C2=C1C=C(C(F)(F)F)C(C(O)CC)=C2 MIGNZRPDULLXTQ-UHFFFAOYSA-N 0.000 claims 3
- QLUSFZJXGQYNMK-UHFFFAOYSA-N n-[6-(2-methylpyrazol-3-yl)-2,4-dioxo-7-(trifluoromethyl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound CN1N=CC=C1C1=CC(C(N(NS(C)(=O)=O)C(=O)N2)=O)=C2C=C1C(F)(F)F QLUSFZJXGQYNMK-UHFFFAOYSA-N 0.000 claims 3
- JVZQDMCKWPOOIY-UHFFFAOYSA-N n-[6-[2-(2-methoxyethyl)pyrazol-3-yl]-2,4-dioxo-7-propan-2-yl-1h-quinazolin-3-yl]methanesulfonamide Chemical compound COCCN1N=CC=C1C1=CC(C(N(NS(C)(=O)=O)C(=O)N2)=O)=C2C=C1C(C)C JVZQDMCKWPOOIY-UHFFFAOYSA-N 0.000 claims 3
- ZWDLCWUDNRHDGU-UHFFFAOYSA-N n-[7-(1,1-difluoroethyl)-6-(2-methylpyrazol-3-yl)-2,4-dioxo-1h-quinazolin-3-yl]methanesulfonamide Chemical compound CN1N=CC=C1C1=CC(C(N(NS(C)(=O)=O)C(=O)N2)=O)=C2C=C1C(C)(F)F ZWDLCWUDNRHDGU-UHFFFAOYSA-N 0.000 claims 3
- JVPVBPHLIBMROY-UHFFFAOYSA-N n-[7-(difluoromethyl)-2,4-dioxo-6-(2-propan-2-ylpyrazol-3-yl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound CC(C)N1N=CC=C1C1=CC(C(N(NS(C)(=O)=O)C(=O)N2)=O)=C2C=C1C(F)F JVPVBPHLIBMROY-UHFFFAOYSA-N 0.000 claims 3
- HSGNDJYOXXCRGB-UHFFFAOYSA-N n-[7-(fluoromethyl)-2,4-dioxo-6-(2-propan-2-ylpyrazol-3-yl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound CC(C)N1N=CC=C1C1=CC(C(N(NS(C)(=O)=O)C(=O)N2)=O)=C2C=C1CF HSGNDJYOXXCRGB-UHFFFAOYSA-N 0.000 claims 3
- KEEFXFPTFSCWQH-UHFFFAOYSA-N n-[7-ethyl-2,4-dioxo-6-(2-propan-2-ylpyrazol-3-yl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound CCC1=CC=2NC(=O)N(NS(C)(=O)=O)C(=O)C=2C=C1C1=CC=NN1C(C)C KEEFXFPTFSCWQH-UHFFFAOYSA-N 0.000 claims 3
- KPWVCITWUDVCGS-UHFFFAOYSA-N n-[7-ethyl-6-(2-ethylpyrazol-3-yl)-2,4-dioxo-1h-quinazolin-3-yl]methanesulfonamide Chemical compound CCC1=CC=2NC(=O)N(NS(C)(=O)=O)C(=O)C=2C=C1C1=CC=NN1CC KPWVCITWUDVCGS-UHFFFAOYSA-N 0.000 claims 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 claims 2
- NZWSWGBRWWTWJP-UHFFFAOYSA-N n-[2,4-dioxo-6-(1-propoxypropyl)-7-(trifluoromethyl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound N1C(=O)N(NS(C)(=O)=O)C(=O)C2=C1C=C(C(F)(F)F)C(C(CC)OCCC)=C2 NZWSWGBRWWTWJP-UHFFFAOYSA-N 0.000 claims 2
- RVFCUKBZUNLKHH-UHFFFAOYSA-N n-[6-(1-cyclopentyloxyethyl)-2,4-dioxo-7-(trifluoromethyl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound C=1C(C(N(NS(C)(=O)=O)C(=O)N2)=O)=C2C=C(C(F)(F)F)C=1C(C)OC1CCCC1 RVFCUKBZUNLKHH-UHFFFAOYSA-N 0.000 claims 2
- QDIISXGZVBGRKE-UHFFFAOYSA-N n-[6-(1-hydroxy-3-methoxypropyl)-2,4-dioxo-7-(trifluoromethyl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound N1C(=O)N(NS(C)(=O)=O)C(=O)C2=C1C=C(C(F)(F)F)C(C(O)CCOC)=C2 QDIISXGZVBGRKE-UHFFFAOYSA-N 0.000 claims 2
- AZAOVWWNNFAHAG-UHFFFAOYSA-N n-[6-[2-(2-methoxyethyl)pyrazol-3-yl]-2,4-dioxo-7-(trifluoromethyl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound COCCN1N=CC=C1C1=CC(C(N(NS(C)(=O)=O)C(=O)N2)=O)=C2C=C1C(F)(F)F AZAOVWWNNFAHAG-UHFFFAOYSA-N 0.000 claims 2
- OPYMZVLVOCASOX-UHFFFAOYSA-N n-[7-(1,1-difluoroethyl)-2,4-dioxo-6-(2-propan-2-ylpyrazol-3-yl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound CC(C)N1N=CC=C1C1=CC(C(N(NS(C)(=O)=O)C(=O)N2)=O)=C2C=C1C(C)(F)F OPYMZVLVOCASOX-UHFFFAOYSA-N 0.000 claims 2
- FDHRJKWFUHLAFO-UHFFFAOYSA-N n-[7-(1-fluoroethyl)-2,4-dioxo-6-(2-propan-2-ylpyrazol-3-yl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound CC(C)N1N=CC=C1C1=CC(C(N(NS(C)(=O)=O)C(=O)N2)=O)=C2C=C1C(C)F FDHRJKWFUHLAFO-UHFFFAOYSA-N 0.000 claims 2
- 125000004776 1-fluoroethyl group Chemical group [H]C([H])([H])C([H])(F)* 0.000 claims 1
- 208000036626 Mental retardation Diseases 0.000 claims 1
- 208000017478 adult neuronal ceroid lipofuscinosis Diseases 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 208000017482 infantile neuronal ceroid lipofuscinosis Diseases 0.000 claims 1
- 230000000366 juvenile effect Effects 0.000 claims 1
- 208000025014 late infantile neuronal ceroid lipofuscinosis Diseases 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- NXSCFPKPPNHCCN-UHFFFAOYSA-N n-[2,4-dioxo-6-(1-propoxyethyl)-7-(trifluoromethyl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound N1C(=O)N(NS(C)(=O)=O)C(=O)C2=C1C=C(C(F)(F)F)C(C(C)OCCC)=C2 NXSCFPKPPNHCCN-UHFFFAOYSA-N 0.000 claims 1
- OFJHQRJECRDHRW-UHFFFAOYSA-N n-[6-(1-butoxyethyl)-2,4-dioxo-7-(trifluoromethyl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound N1C(=O)N(NS(C)(=O)=O)C(=O)C2=C1C=C(C(F)(F)F)C(C(C)OCCCC)=C2 OFJHQRJECRDHRW-UHFFFAOYSA-N 0.000 claims 1
- MMTLKGVPYZLJTG-UHFFFAOYSA-N n-[6-(1-ethoxypropyl)-2,4-dioxo-7-(trifluoromethyl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound N1C(=O)N(NS(C)(=O)=O)C(=O)C2=C1C=C(C(F)(F)F)C(C(CC)OCC)=C2 MMTLKGVPYZLJTG-UHFFFAOYSA-N 0.000 claims 1
- MWEPLWMITBXDHS-UHFFFAOYSA-N n-[6-(1-hydroxy-2-methylpropyl)-2,4-dioxo-7-(trifluoromethyl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound N1C(=O)N(NS(C)(=O)=O)C(=O)C2=C1C=C(C(F)(F)F)C(C(O)C(C)C)=C2 MWEPLWMITBXDHS-UHFFFAOYSA-N 0.000 claims 1
- QNOGGNMZYXNFMK-UHFFFAOYSA-N n-[6-(1-methoxy-2-methylpropyl)-2,4-dioxo-7-(trifluoromethyl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound N1C(=O)N(NS(C)(=O)=O)C(=O)C2=C1C=C(C(F)(F)F)C(C(C(C)C)OC)=C2 QNOGGNMZYXNFMK-UHFFFAOYSA-N 0.000 claims 1
- QDNJESWDNWORKP-UHFFFAOYSA-N n-[6-(1-methoxybutyl)-2,4-dioxo-7-(trifluoromethyl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound N1C(=O)N(NS(C)(=O)=O)C(=O)C2=C1C=C(C(F)(F)F)C(C(OC)CCC)=C2 QDNJESWDNWORKP-UHFFFAOYSA-N 0.000 claims 1
- DKMLPACXXYKYSU-UHFFFAOYSA-N n-[6-(2-hydroxypyrazol-3-yl)-2,4-dioxo-7-(trifluoromethyl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound C1=C2C(=O)N(NS(=O)(=O)C)C(=O)NC2=CC(C(F)(F)F)=C1C1=CC=NN1O DKMLPACXXYKYSU-UHFFFAOYSA-N 0.000 claims 1
- CZVNRIDLEZRQFH-UHFFFAOYSA-N n-[6-(3-hydroxypropyl)-2,4-dioxo-7-(trifluoromethyl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound FC(F)(F)C1=C(CCCO)C=C2C(=O)N(NS(=O)(=O)C)C(=O)NC2=C1 CZVNRIDLEZRQFH-UHFFFAOYSA-N 0.000 claims 1
- NMIQVXYXYPUJHC-UHFFFAOYSA-N n-[6-(oxan-2-yl)-2,4-dioxo-7-(trifluoromethyl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound C1=C2C(=O)N(NS(=O)(=O)C)C(=O)NC2=CC(C(F)(F)F)=C1C1CCCCO1 NMIQVXYXYPUJHC-UHFFFAOYSA-N 0.000 claims 1
- USURBQLTQADVAD-UHFFFAOYSA-N n-[6-[1-(2-methylpropoxy)ethyl]-2,4-dioxo-7-(trifluoromethyl)-1h-quinazolin-3-yl]methanesulfonamide Chemical compound N1C(=O)N(NS(C)(=O)=O)C(=O)C2=C1C=C(C(F)(F)F)C(C(C)OCC(C)C)=C2 USURBQLTQADVAD-UHFFFAOYSA-N 0.000 claims 1
- MMKXICJSNZKSDT-UHFFFAOYSA-N n-[7-(1-fluoroethyl)-6-(2-methylpyrazol-3-yl)-2,4-dioxo-1h-quinazolin-3-yl]methanesulfonamide Chemical compound CC(F)C1=CC=2NC(=O)N(NS(C)(=O)=O)C(=O)C=2C=C1C1=CC=NN1C MMKXICJSNZKSDT-UHFFFAOYSA-N 0.000 claims 1
- ISBCBAUWMPBZMW-UHFFFAOYSA-N n-[7-(difluoromethyl)-6-(1-ethoxyethyl)-2,4-dioxo-1h-quinazolin-3-yl]methanesulfonamide Chemical compound N1C(=O)N(NS(C)(=O)=O)C(=O)C2=C1C=C(C(F)F)C(C(C)OCC)=C2 ISBCBAUWMPBZMW-UHFFFAOYSA-N 0.000 claims 1
- XWWOWSFUSLLOTP-UHFFFAOYSA-N n-[7-(fluoromethyl)-6-(2-methylpyrazol-3-yl)-2,4-dioxo-1h-quinazolin-3-yl]methanesulfonamide Chemical compound CN1N=CC=C1C1=CC(C(N(NS(C)(=O)=O)C(=O)N2)=O)=C2C=C1CF XWWOWSFUSLLOTP-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000000750 progressive effect Effects 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22794009P | 2009-07-23 | 2009-07-23 | |
| US61/227,940 | 2009-07-23 | ||
| PCT/EP2010/060733 WO2011009951A1 (en) | 2009-07-23 | 2010-07-23 | 1h-quinazoline-2, 4 -diones for use in the treatment of neuronal ceroid lipofuscinosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012106426A true RU2012106426A (ru) | 2013-08-27 |
Family
ID=42671655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012106426/04A RU2012106426A (ru) | 2009-07-23 | 2010-07-23 | 1н-хиназолин-2,4-дионы, предназначенные для лечения нейронного восковидного липофусциноза |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20120122903A1 (enExample) |
| EP (1) | EP2456442A1 (enExample) |
| JP (1) | JP2012533605A (enExample) |
| KR (1) | KR20120052341A (enExample) |
| CN (1) | CN102470137A (enExample) |
| AU (1) | AU2010274921B2 (enExample) |
| BR (1) | BR112012001258A2 (enExample) |
| CA (1) | CA2768333A1 (enExample) |
| IN (1) | IN2012DN00235A (enExample) |
| MX (1) | MX2012000956A (enExample) |
| RU (1) | RU2012106426A (enExample) |
| WO (1) | WO2011009951A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9527807B2 (en) | 2011-04-05 | 2016-12-27 | Takeda Pharmaceutical Company Limited | Sulfonamide derivative and use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9400680D0 (en) * | 1994-01-14 | 1994-03-09 | Sandoz Ltd | Improvements in or relating to organic compounds |
| GB0416730D0 (en) * | 2004-07-27 | 2004-09-01 | Novartis Ag | Organic compounds |
| GB0507298D0 (en) * | 2005-04-11 | 2005-05-18 | Novartis Ag | Organic compounds |
-
2010
- 2010-07-23 CN CN2010800334750A patent/CN102470137A/zh active Pending
- 2010-07-23 BR BR112012001258A patent/BR112012001258A2/pt not_active IP Right Cessation
- 2010-07-23 MX MX2012000956A patent/MX2012000956A/es not_active Application Discontinuation
- 2010-07-23 RU RU2012106426/04A patent/RU2012106426A/ru not_active Application Discontinuation
- 2010-07-23 EP EP10734746A patent/EP2456442A1/en not_active Withdrawn
- 2010-07-23 JP JP2012521055A patent/JP2012533605A/ja active Pending
- 2010-07-23 WO PCT/EP2010/060733 patent/WO2011009951A1/en not_active Ceased
- 2010-07-23 KR KR1020127004575A patent/KR20120052341A/ko not_active Withdrawn
- 2010-07-23 CA CA2768333A patent/CA2768333A1/en not_active Abandoned
- 2010-07-23 US US13/384,280 patent/US20120122903A1/en not_active Abandoned
- 2010-07-23 IN IN235DEN2012 patent/IN2012DN00235A/en unknown
- 2010-07-23 AU AU2010274921A patent/AU2010274921B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BR112012001258A2 (pt) | 2016-02-10 |
| JP2012533605A (ja) | 2012-12-27 |
| IN2012DN00235A (enExample) | 2015-05-01 |
| EP2456442A1 (en) | 2012-05-30 |
| KR20120052341A (ko) | 2012-05-23 |
| AU2010274921B2 (en) | 2014-08-14 |
| MX2012000956A (es) | 2012-02-28 |
| CA2768333A1 (en) | 2011-01-27 |
| CN102470137A (zh) | 2012-05-23 |
| AU2010274921A1 (en) | 2012-02-02 |
| US20120122903A1 (en) | 2012-05-17 |
| WO2011009951A1 (en) | 2011-01-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20141209 |