RU2010154623A - Производные 1-аминоалкилциклогексана для лечения расстройств сна - Google Patents
Производные 1-аминоалкилциклогексана для лечения расстройств сна Download PDFInfo
- Publication number
- RU2010154623A RU2010154623A RU2010154623/15A RU2010154623A RU2010154623A RU 2010154623 A RU2010154623 A RU 2010154623A RU 2010154623/15 A RU2010154623/15 A RU 2010154623/15A RU 2010154623 A RU2010154623 A RU 2010154623A RU 2010154623 A RU2010154623 A RU 2010154623A
- Authority
- RU
- Russia
- Prior art keywords
- neramexane
- administered
- pharmaceutically acceptable
- acceptable salt
- use according
- Prior art date
Links
- 208000019116 sleep disease Diseases 0.000 title claims abstract 6
- 150000003839 salts Chemical class 0.000 claims abstract 14
- OGZQTTHDGQBLBT-UHFFFAOYSA-N neramexane Chemical group CC1(C)CC(C)(C)CC(C)(N)C1 OGZQTTHDGQBLBT-UHFFFAOYSA-N 0.000 claims abstract 13
- 229950004543 neramexane Drugs 0.000 claims abstract 13
- CLUKHUGGXSIGRX-UHFFFAOYSA-N methanesulfonic acid;1,3,3,5,5-pentamethylcyclohexan-1-amine Chemical group CS(O)(=O)=O.CC1(C)CC(C)(C)CC(C)(N)C1 CLUKHUGGXSIGRX-UHFFFAOYSA-N 0.000 claims abstract 12
- 239000008177 pharmaceutical agent Substances 0.000 claims abstract 6
- 238000009472 formulation Methods 0.000 claims abstract 3
- 239000000203 mixture Substances 0.000 claims abstract 3
- 208000012902 Nervous system disease Diseases 0.000 claims abstract 2
- 208000025966 Neurological disease Diseases 0.000 claims abstract 2
- 208000009205 Tinnitus Diseases 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims abstract 2
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims abstract 2
- 238000004519 manufacturing process Methods 0.000 claims abstract 2
- 230000002265 prevention Effects 0.000 claims abstract 2
- 231100000886 tinnitus Toxicity 0.000 claims abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 claims 1
- 102000001419 Melatonin receptor Human genes 0.000 claims 1
- 108050009605 Melatonin receptor Proteins 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 claims 1
- 229960003987 melatonin Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000004448 titration Methods 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13178908P | 2008-06-12 | 2008-06-12 | |
| EP08010749.3 | 2008-06-12 | ||
| US61/131,789 | 2008-06-12 | ||
| EP08010749 | 2008-06-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2010154623A true RU2010154623A (ru) | 2012-08-10 |
Family
ID=39721946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010154623/15A RU2010154623A (ru) | 2008-06-12 | 2009-06-10 | Производные 1-аминоалкилциклогексана для лечения расстройств сна |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20110207793A1 (enExample) |
| EP (1) | EP2315586A1 (enExample) |
| JP (1) | JP5923305B2 (enExample) |
| KR (1) | KR20110005909A (enExample) |
| CN (1) | CN102026633A (enExample) |
| AR (1) | AR074246A1 (enExample) |
| AU (1) | AU2009256905A1 (enExample) |
| BR (1) | BRPI0911920A2 (enExample) |
| CA (1) | CA2722763A1 (enExample) |
| IL (1) | IL209417A0 (enExample) |
| MX (1) | MX2010013450A (enExample) |
| RU (1) | RU2010154623A (enExample) |
| TW (1) | TW201010691A (enExample) |
| WO (1) | WO2009149920A1 (enExample) |
| ZA (1) | ZA201007763B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101801366A (zh) * | 2007-09-12 | 2010-08-11 | 莫茨药物股份两合公司 | 用于neramexane的逐步增量包装和其在治疗内耳病中的用途 |
| US20110294890A1 (en) * | 2010-05-28 | 2011-12-01 | Merz Pharma Gmbh & Co. Kgaa | Neramexane for the treatment or prevention of inner ear disorders |
| SG11201608630SA (en) * | 2014-04-28 | 2016-11-29 | Kyorin Seiyaku Kk | Drug for treatment of tinnitus patients |
| CN113274365B (zh) * | 2021-07-22 | 2021-10-22 | 广东科泰鼎润药业科技有限公司 | 雷美替胺速释缓释双释放制剂及其制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19528388A1 (de) * | 1995-08-02 | 1997-02-06 | Hans Peter Prof Dr Med Zenner | Verwendung von Adamantan-Derivaten zur Behandlung von Erkrankungen des Innenohrs |
| UA61962C2 (uk) * | 1997-06-30 | 2003-12-15 | Мерц Фарма Гмбх Унд Ко. Кгаа | Сполука 1-аміноалкілциклогексану, фармацевтична композиція на її основі та спосіб лікування |
| US6071966A (en) * | 1997-06-30 | 2000-06-06 | Merz + Co. Gmbh & Co. | 1-amino-alkylcyclohexane NMDA receptor antagonists |
| CN100339070C (zh) * | 2002-10-24 | 2007-09-26 | 莫茨药物股份两合公司 | 包含1－氨基环己烷衍生物类和乙酰胆碱酯酶抑制剂类的药物组合物 |
| US20070141148A1 (en) * | 2005-11-30 | 2007-06-21 | Merz Pharma Gmbh & Co. Kgaa | Neramexane MR matrix tablet |
| JP2007246507A (ja) * | 2006-02-15 | 2007-09-27 | Kracie Seiyaku Kk | 疲労の予防・治療組成物及び予防・治療方法 |
| DE102006011922A1 (de) * | 2006-03-15 | 2007-09-20 | Uwe Stoldt | Mittel zur Behandlung von Tinnitus |
-
2009
- 2009-06-09 TW TW098119212A patent/TW201010691A/zh unknown
- 2009-06-10 AU AU2009256905A patent/AU2009256905A1/en not_active Abandoned
- 2009-06-10 CA CA2722763A patent/CA2722763A1/en not_active Abandoned
- 2009-06-10 US US12/737,092 patent/US20110207793A1/en not_active Abandoned
- 2009-06-10 WO PCT/EP2009/004184 patent/WO2009149920A1/en not_active Ceased
- 2009-06-10 RU RU2010154623/15A patent/RU2010154623A/ru not_active Application Discontinuation
- 2009-06-10 KR KR1020107027774A patent/KR20110005909A/ko not_active Ceased
- 2009-06-10 JP JP2011512891A patent/JP5923305B2/ja not_active Expired - Fee Related
- 2009-06-10 EP EP09761483A patent/EP2315586A1/en not_active Withdrawn
- 2009-06-10 MX MX2010013450A patent/MX2010013450A/es unknown
- 2009-06-10 BR BRPI0911920A patent/BRPI0911920A2/pt not_active IP Right Cessation
- 2009-06-10 CN CN2009801170115A patent/CN102026633A/zh active Pending
- 2009-06-12 AR ARP090102149A patent/AR074246A1/es not_active Application Discontinuation
-
2010
- 2010-10-29 ZA ZA2010/07763A patent/ZA201007763B/en unknown
- 2010-11-18 IL IL209417A patent/IL209417A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011522850A (ja) | 2011-08-04 |
| CA2722763A1 (en) | 2009-12-17 |
| IL209417A0 (en) | 2011-01-31 |
| JP5923305B2 (ja) | 2016-05-24 |
| ZA201007763B (en) | 2011-07-27 |
| BRPI0911920A2 (pt) | 2015-10-06 |
| KR20110005909A (ko) | 2011-01-19 |
| AR074246A1 (es) | 2011-01-05 |
| CN102026633A (zh) | 2011-04-20 |
| TW201010691A (en) | 2010-03-16 |
| EP2315586A1 (en) | 2011-05-04 |
| MX2010013450A (es) | 2011-02-23 |
| US20110207793A1 (en) | 2011-08-25 |
| WO2009149920A1 (en) | 2009-12-17 |
| AU2009256905A1 (en) | 2009-12-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20130121 |