RU2010112472A - Композиции циклоспорина - Google Patents
Композиции циклоспорина Download PDFInfo
- Publication number
- RU2010112472A RU2010112472A RU2010112472/15A RU2010112472A RU2010112472A RU 2010112472 A RU2010112472 A RU 2010112472A RU 2010112472/15 A RU2010112472/15 A RU 2010112472/15A RU 2010112472 A RU2010112472 A RU 2010112472A RU 2010112472 A RU2010112472 A RU 2010112472A
- Authority
- RU
- Russia
- Prior art keywords
- cornea
- sensitivity
- loss
- caused
- cyclosporin
- Prior art date
Links
- 229930105110 Cyclosporin A Natural products 0.000 title claims abstract 13
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title claims abstract 13
- 108010036949 Cyclosporine Proteins 0.000 title claims abstract 13
- 229960001265 ciclosporin Drugs 0.000 title claims abstract 13
- 239000000203 mixture Substances 0.000 title claims abstract 13
- 229930182912 cyclosporin Natural products 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract 33
- 210000004087 cornea Anatomy 0.000 claims abstract 21
- 230000035945 sensitivity Effects 0.000 claims abstract 20
- 208000036142 Viral infection Diseases 0.000 claims abstract 8
- 230000009385 viral infection Effects 0.000 claims abstract 8
- 238000001356 surgical procedure Methods 0.000 claims abstract 4
- 238000011065 in-situ storage Methods 0.000 claims abstract 2
- 230000000860 keratorefractive effect Effects 0.000 claims abstract 2
- 230000000149 penetrating effect Effects 0.000 claims abstract 2
- 239000003755 preservative agent Substances 0.000 claims abstract 2
- 230000002335 preservative effect Effects 0.000 claims abstract 2
- 241000700588 Human alphaherpesvirus 1 Species 0.000 claims 1
- 241000701074 Human alphaherpesvirus 2 Species 0.000 claims 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Inorganic Chemistry (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/858,200 | 2007-09-20 | ||
| US11/858,200 US20080146497A1 (en) | 2006-07-25 | 2007-09-20 | Cyclosporin Compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2010112472A true RU2010112472A (ru) | 2011-10-27 |
Family
ID=39528114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010112472/15A RU2010112472A (ru) | 2007-09-20 | 2008-09-18 | Композиции циклоспорина |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20080146497A1 (enExample) |
| EP (1) | EP2190407B1 (enExample) |
| JP (1) | JP2010540446A (enExample) |
| KR (1) | KR20100091946A (enExample) |
| CN (1) | CN101835463A (enExample) |
| AU (1) | AU2008349774A1 (enExample) |
| BR (1) | BRPI0816995A2 (enExample) |
| CA (1) | CA2700182A1 (enExample) |
| IL (1) | IL204614A0 (enExample) |
| MX (1) | MX2010003045A (enExample) |
| RU (1) | RU2010112472A (enExample) |
| WO (1) | WO2009099467A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050059583A1 (en) | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
| MX2010003364A (es) | 2007-10-08 | 2010-07-06 | Lux Biosciences Inc | Composiciones oftalmicas que comprenden inhibidores de calcineurina o inhibidores de mtor. |
| WO2010127301A1 (en) * | 2009-05-01 | 2010-11-04 | Allergan, Inc. | Method of treating allergic conjunctivitis with cyclosporin compositions |
| US9017725B2 (en) * | 2009-06-09 | 2015-04-28 | Aurinia Pharmaceuticals Inc. | Topical drug delivery systems for ophthalmic use |
| RU2014129268A (ru) * | 2011-12-16 | 2016-02-10 | Аллерган, Инк. | Офтальмологические составы, которые содержат привитые сополимеры поливинилкапролактам-поливинилацетат-полиэтиленгликоля |
| FR2988297B1 (fr) * | 2012-03-22 | 2014-03-28 | Thea Lab | Solution ophtalmique aqueuse a base de ciclosporine a sans conservateur |
| AU2013267435B2 (en) | 2012-06-01 | 2017-11-09 | Allergan, Inc. | Cyclosporin A analogs |
| EP3169308B1 (en) * | 2014-07-18 | 2021-01-27 | Allergan, Inc. | Suspension compositions of cyclosporin a for subconjunctival and periocular injection |
| KR101587412B1 (ko) * | 2014-10-17 | 2016-01-21 | 주식회사 휴온스 | 사이클로스포린 및 트레할로스를 포함하는 안과용 조성물 |
| WO2016112321A1 (en) | 2015-01-08 | 2016-07-14 | Allergan, Inc. | Cyclosporin derivatives wherein the mebmt sidechain has been cyclized |
| US20190224275A1 (en) | 2017-05-12 | 2019-07-25 | Aurinia Pharmaceuticals Inc. | Protocol for treatment of lupus nephritis |
| RU2762767C1 (ru) * | 2020-09-15 | 2021-12-22 | Федеральное государственное автономное учреждение "Национальный медицинский исследовательский центр "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова Министерства здравоохранения Российской Федерации | Способ определения тактильной чувствительности роговицы |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2577049B2 (ja) * | 1987-06-04 | 1997-01-29 | 三共株式会社 | シクロスポリン製剤 |
| ATE109970T1 (de) * | 1987-09-03 | 1994-09-15 | Univ Georgia Res Found | Cyclosporin-augenmittel. |
| SG45449A1 (en) * | 1992-05-13 | 1998-01-16 | Sandoz Ltd | Ophthalmic compositions |
| EP1301210A2 (en) * | 2000-07-14 | 2003-04-16 | Allergan, Inc. | Compositions containing therapeutically active components having enhanced solubility |
| PL1904056T3 (pl) * | 2005-07-18 | 2009-09-30 | Minu Llc | Zastosowanie makrolidu do przywracania czucia rogówkowego |
| US7501393B2 (en) * | 2005-07-27 | 2009-03-10 | Allergan, Inc. | Pharmaceutical compositions comprising cyclosporins |
| TWI435729B (zh) * | 2005-11-09 | 2014-05-01 | Combinatorx Inc | 治療病症之方法，組合物及套組 |
-
2007
- 2007-09-20 US US11/858,200 patent/US20080146497A1/en not_active Abandoned
-
2008
- 2008-09-18 CA CA2700182A patent/CA2700182A1/en not_active Abandoned
- 2008-09-18 WO PCT/US2008/076756 patent/WO2009099467A2/en not_active Ceased
- 2008-09-18 JP JP2010525937A patent/JP2010540446A/ja active Pending
- 2008-09-18 MX MX2010003045A patent/MX2010003045A/es not_active Application Discontinuation
- 2008-09-18 RU RU2010112472/15A patent/RU2010112472A/ru not_active Application Discontinuation
- 2008-09-18 EP EP08872212.9A patent/EP2190407B1/en not_active Not-in-force
- 2008-09-18 CN CN200880113223A patent/CN101835463A/zh active Pending
- 2008-09-18 KR KR1020107008509A patent/KR20100091946A/ko not_active Withdrawn
- 2008-09-18 BR BRPI0816995 patent/BRPI0816995A2/pt not_active IP Right Cessation
- 2008-09-18 AU AU2008349774A patent/AU2008349774A1/en not_active Abandoned
-
2010
- 2010-03-18 IL IL204614A patent/IL204614A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101835463A (zh) | 2010-09-15 |
| EP2190407B1 (en) | 2016-12-07 |
| EP2190407A2 (en) | 2010-06-02 |
| WO2009099467A3 (en) | 2009-10-22 |
| IL204614A0 (en) | 2010-11-30 |
| CA2700182A1 (en) | 2009-08-13 |
| KR20100091946A (ko) | 2010-08-19 |
| MX2010003045A (es) | 2010-04-29 |
| BRPI0816995A2 (pt) | 2015-03-24 |
| JP2010540446A (ja) | 2010-12-24 |
| AU2008349774A1 (en) | 2009-08-13 |
| US20080146497A1 (en) | 2008-06-19 |
| WO2009099467A2 (en) | 2009-08-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20130226 |