RU2009113812A - Композиции и способы для профилактики рака с помощью купредоксинов - Google Patents
Композиции и способы для профилактики рака с помощью купредоксинов Download PDFInfo
- Publication number
- RU2009113812A RU2009113812A RU2009113812/10A RU2009113812A RU2009113812A RU 2009113812 A RU2009113812 A RU 2009113812A RU 2009113812/10 A RU2009113812/10 A RU 2009113812/10A RU 2009113812 A RU2009113812 A RU 2009113812A RU 2009113812 A RU2009113812 A RU 2009113812A
- Authority
- RU
- Russia
- Prior art keywords
- azurin
- patient
- pharmaceutical composition
- peptide according
- cancer
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 21
- 206010028980 Neoplasm Diseases 0.000 title claims abstract 9
- 201000011510 cancer Diseases 0.000 title claims abstract 9
- 239000000203 mixture Substances 0.000 title claims abstract 4
- 230000002265 prevention Effects 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 22
- 108010007337 Azurin Proteins 0.000 claims abstract 16
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 11
- 241000588653 Neisseria Species 0.000 claims abstract 5
- 230000003902 lesion Effects 0.000 claims abstract 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims abstract 2
- 241001673062 Achromobacter xylosoxidans Species 0.000 claims abstract 2
- 241000588813 Alcaligenes faecalis Species 0.000 claims abstract 2
- 241000588779 Bordetella bronchiseptica Species 0.000 claims abstract 2
- 208000026310 Breast neoplasm Diseases 0.000 claims abstract 2
- 241000589342 Methylomonas sp. Species 0.000 claims abstract 2
- 241000588650 Neisseria meningitidis Species 0.000 claims abstract 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims abstract 2
- 101900113211 Pseudomonas aeruginosa Azurin Proteins 0.000 claims abstract 2
- 241000607272 Vibrio parahaemolyticus Species 0.000 claims abstract 2
- 229940005347 alcaligenes faecalis Drugs 0.000 claims abstract 2
- 239000003937 drug carrier Substances 0.000 claims abstract 2
- 208000005017 glioblastoma Diseases 0.000 claims abstract 2
- 238000001990 intravenous administration Methods 0.000 claims abstract 2
- 201000001441 melanoma Diseases 0.000 claims abstract 2
- 210000000496 pancreas Anatomy 0.000 claims abstract 2
- 210000004027 cell Anatomy 0.000 claims 5
- 230000003632 chemoprophylactic effect Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 238000010253 intravenous injection Methods 0.000 claims 2
- 206010003571 Astrocytoma Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 210000003679 cervix uteri Anatomy 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 210000003128 head Anatomy 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000010255 intramuscular injection Methods 0.000 claims 1
- 239000007927 intramuscular injection Substances 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 210000003739 neck Anatomy 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 210000000664 rectum Anatomy 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 238000010254 subcutaneous injection Methods 0.000 claims 1
- 239000007929 subcutaneous injection Substances 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
- 210000004127 vitreous body Anatomy 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 210000001130 astrocyte Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/104—Pseudomonadales, e.g. Pseudomonas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84435806P | 2006-09-14 | 2006-09-14 | |
| US60/844,358 | 2006-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2009113812A true RU2009113812A (ru) | 2010-10-20 |
Family
ID=39184582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009113812/10A RU2009113812A (ru) | 2006-09-14 | 2007-09-13 | Композиции и способы для профилактики рака с помощью купредоксинов |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP2061498A4 (https=) |
| JP (2) | JP2010503409A (https=) |
| KR (1) | KR20090059152A (https=) |
| CN (1) | CN101595124A (https=) |
| AU (1) | AU2007296429A1 (https=) |
| BR (1) | BRPI0714987A2 (https=) |
| CA (1) | CA2663498A1 (https=) |
| IL (1) | IL197602A0 (https=) |
| MX (1) | MX2009002787A (https=) |
| NO (1) | NO20091267L (https=) |
| RU (1) | RU2009113812A (https=) |
| SG (1) | SG174784A1 (https=) |
| WO (1) | WO2008033987A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9096663B2 (en) | 2001-02-15 | 2015-08-04 | The Board Of Trustees Of The University Of Illinois | Compositions and methods for treating conditions related to ephrin signaling with cupredoxins and mutants thereof |
| US7556810B2 (en) | 2005-07-19 | 2009-07-07 | The Board Of Trustees Of The University Of Ilinois | Compositions and methods to control angiogenesis with cupredoxins |
| US7381701B2 (en) | 2001-02-15 | 2008-06-03 | The Borad Of Trustees Of The University Of Illinois | Compositions and methods for treating conditions related to ephrin signaling with cupredoxins |
| EA200700813A1 (ru) | 2004-10-07 | 2008-10-30 | Ананда Чакрабарти | Транспортирующие вещества, производные купредоксина и способы их применения |
| US9434770B2 (en) | 2004-10-07 | 2016-09-06 | Tapas K Das Gupta | Modified cupredoxin derived peptides |
| US9968685B2 (en) | 2004-10-07 | 2018-05-15 | Brad N. Taylor | Methods to treat cancer with cupredoxins |
| US9598470B2 (en) * | 2004-10-07 | 2017-03-21 | Craig W. Beattie | Compositions and methods to prevent cancer by stabilizing P53 through non MDM2-mediated pathways |
| US10675326B2 (en) | 2004-10-07 | 2020-06-09 | The Board Of Trustees Of The University Of Illinois | Compositions comprising cupredoxins for treating cancer |
| CA2615617A1 (en) | 2005-07-19 | 2007-01-25 | The Board Of Trustees Of The University Of Illinois | Transport agents for crossing the blood-brain barrier and into brain cancer cells, and methods of use thereof |
| JP2010511408A (ja) * | 2006-12-04 | 2010-04-15 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ | 癌をＣｐＧリッチＤＮＡおよびキュプレドキシンで治療するための組成物および方法 |
| JP2010518123A (ja) * | 2007-02-08 | 2010-05-27 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ | 癌をキュプレドキシンで予防するための組成物および方法 |
| KR102718038B1 (ko) | 2017-09-29 | 2024-10-16 | 온크그노스틱스 게엠베하 | 신생물증 및 암에 대한 위험 결정 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7491394B2 (en) * | 2001-02-15 | 2009-02-17 | The Board Of Trustees Of The University Of Illinois | Cytotoxic factors for modulating cell death |
| CN1506375A (zh) * | 2002-12-12 | 2004-06-23 | 浙江养生堂天然药物研究所有限公司 | 具有广谱抗肿瘤作用的细菌蛋白天青蛋白及其用途和含有其的药物组合物 |
| EA200700813A1 (ru) * | 2004-10-07 | 2008-10-30 | Ананда Чакрабарти | Транспортирующие вещества, производные купредоксина и способы их применения |
| AU2006277009A1 (en) * | 2005-05-20 | 2007-02-15 | The Board Of Trustees Of The University Of Illinois | Compositions and methods for treating conditions related to ephrin signaling with cupredoxins |
| WO2007024368A2 (en) * | 2005-07-19 | 2007-03-01 | The Board Of Trustees Of The University Of Illinois | Compositions and methods to control angiogenesis with cupredoxins |
-
2007
- 2007-09-13 EP EP07842403A patent/EP2061498A4/en not_active Withdrawn
- 2007-09-13 KR KR1020097007352A patent/KR20090059152A/ko not_active Withdrawn
- 2007-09-13 BR BRPI0714987-5A patent/BRPI0714987A2/pt not_active Application Discontinuation
- 2007-09-13 WO PCT/US2007/078371 patent/WO2008033987A2/en not_active Ceased
- 2007-09-13 CN CNA2007800417624A patent/CN101595124A/zh active Pending
- 2007-09-13 JP JP2009528468A patent/JP2010503409A/ja not_active Withdrawn
- 2007-09-13 CA CA002663498A patent/CA2663498A1/en not_active Abandoned
- 2007-09-13 SG SG2011064334A patent/SG174784A1/en unknown
- 2007-09-13 AU AU2007296429A patent/AU2007296429A1/en not_active Abandoned
- 2007-09-13 RU RU2009113812/10A patent/RU2009113812A/ru unknown
- 2007-09-13 MX MX2009002787A patent/MX2009002787A/es not_active Application Discontinuation
-
2009
- 2009-03-15 IL IL197602A patent/IL197602A0/en unknown
- 2009-03-26 NO NO20091267A patent/NO20091267L/no not_active Application Discontinuation
-
2013
- 2013-10-04 JP JP2013209725A patent/JP2014050390A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NO20091267L (no) | 2009-06-04 |
| JP2014050390A (ja) | 2014-03-20 |
| KR20090059152A (ko) | 2009-06-10 |
| AU2007296429A1 (en) | 2008-03-20 |
| EP2061498A2 (en) | 2009-05-27 |
| EP2061498A4 (en) | 2009-11-04 |
| SG174784A1 (en) | 2011-10-28 |
| IL197602A0 (en) | 2011-08-01 |
| JP2010503409A (ja) | 2010-02-04 |
| BRPI0714987A2 (pt) | 2013-07-30 |
| CA2663498A1 (en) | 2008-03-20 |
| WO2008033987A3 (en) | 2009-04-30 |
| CN101595124A (zh) | 2009-12-02 |
| MX2009002787A (es) | 2009-08-27 |
| WO2008033987A2 (en) | 2008-03-20 |
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