RU2008135764A - PHARMACEUTICAL COMPOSITION FOR TREATMENT OF CERVICAL DYSPLASTIC PROCESSES - Google Patents
PHARMACEUTICAL COMPOSITION FOR TREATMENT OF CERVICAL DYSPLASTIC PROCESSES Download PDFInfo
- Publication number
- RU2008135764A RU2008135764A RU2008135764/15A RU2008135764A RU2008135764A RU 2008135764 A RU2008135764 A RU 2008135764A RU 2008135764/15 A RU2008135764/15 A RU 2008135764/15A RU 2008135764 A RU2008135764 A RU 2008135764A RU 2008135764 A RU2008135764 A RU 2008135764A
- Authority
- RU
- Russia
- Prior art keywords
- suppository
- epigallocatechin
- gallate
- drug according
- treatment
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Virology (AREA)
- Gynecology & Obstetrics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
1. Лекарственное средство для лечения диспластических процессов шейки матки и слизистой прямой кишки в форме суппозитория, характеризующееся тем, что содержит 3,3'-дииндолилметан, эпигаллокатехин-3-галлат, а также катализатор ингибирующей активности эпигаллокатехин-3-галлата в отношении ДНК-метилтрансфераз, представляющий собой катионы Mg2+ в виде фармацевтически приемлемой соли магния, липофильную основу, содержащую твердый жир, поливинилпирролидон и бутилгидроксианизол и/или бутилгидрокситолуол при следующем содержании, мас.%: ! 3,3'-Дииндолилметан1,0-10,0Эпигаллокатехин-3-галлат1,0-8,0Поливинилпирролидон0,5-1,2Бутилгидроксианизол0,3-0,5Соль магния0,1-2,0Липофильная основаОстальное ! 2. Лекарственное средство по п.1, характеризующееся тем, что указанный суппозиторий представляет собой вагинальный суппозиторий. ! 3. Лекарственное средство по п.1, характеризующееся тем, что указанный суппозиторий представляет собой ректальный суппозиторий. ! 4. Лекарственное средство по любому из пп.1-3, характеризующееся тем, что катализатор ингибирующей активности эпигаллокатехин-3-галлата в отношении ДНК-метилтрансфераз представляет собой магний хлористый.1. A drug for the treatment of dysplastic processes of the cervix and rectal mucosa in the form of a suppository, characterized in that it contains 3,3'-diindolylmethane, epigallocatechin-3-gallate, as well as a catalyst for the inhibitory activity of epigallocatechin-3-gallate in relation to DNA- methyltransferase, which is a Mg2 + cation in the form of a pharmaceutically acceptable magnesium salt, a lipophilic base containing solid fat, polyvinylpyrrolidone and butylhydroxyanisole and / or butylhydroxytoluene with the following content, wt.%:! 3.3'-Diindolylmethane 1.0-10.0 Epigallocatechin-3-gallate 1.0-8.0 Polyvinylpyrrolidone 0.5-1.2 Butyl hydroxyanisole 0.3-0.5 Magnesium salt 0.1-2.0 Lipophilic base 2. The drug according to claim 1, characterized in that the suppository is a vaginal suppository. ! 3. The drug according to claim 1, characterized in that the suppository is a rectal suppository. ! 4. The drug according to any one of claims 1 to 3, characterized in that the catalyst for the inhibitory activity of epigallocatechin-3-gallate in relation to DNA methyltransferases is magnesium chloride.
Claims (4)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2008135764/15A RU2395281C2 (en) | 2008-09-04 | 2008-09-04 | Pharmaceutical composition for treatment of dysplastic processes of cervix |
EA201100417A EA018383B1 (en) | 2008-09-04 | 2009-08-18 | Composition for treating dysplastic changes in the uterine cervix |
PCT/RU2009/000412 WO2010027294A1 (en) | 2008-09-04 | 2009-08-18 | Composition for treating dysplastic changes in the uterine cervix |
UAA201011132A UA95583C2 (en) | 2008-09-04 | 2009-08-18 | Composition for treatment of displastic processes of uterine cervix |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2008135764/15A RU2395281C2 (en) | 2008-09-04 | 2008-09-04 | Pharmaceutical composition for treatment of dysplastic processes of cervix |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2008135764A true RU2008135764A (en) | 2010-03-10 |
RU2395281C2 RU2395281C2 (en) | 2010-07-27 |
Family
ID=41797309
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2008135764/15A RU2395281C2 (en) | 2008-09-04 | 2008-09-04 | Pharmaceutical composition for treatment of dysplastic processes of cervix |
Country Status (4)
Country | Link |
---|---|
EA (1) | EA018383B1 (en) |
RU (1) | RU2395281C2 (en) |
UA (1) | UA95583C2 (en) |
WO (1) | WO2010027294A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2456987C1 (en) * | 2011-03-21 | 2012-07-27 | Сергей Владимирович Енгашев | Method for producing gelatine capsules of 3,31-diindolylmethane |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2454232C2 (en) * | 2010-09-16 | 2012-06-27 | Федеральное государственное бюджетное учреждение "Российский онкологический научный центр имени Н.Н. Блохина" Российской академии медицинских наук (ФГБУ "РОНЦ им. Н.Н. Блохина" РАМН) | Application of triindolyl methane derivatives as anticancer drugs |
GB2533381A (en) * | 2014-12-18 | 2016-06-22 | Nordic Labs Ltd | Novel treatment of STIs |
RU2601621C2 (en) * | 2015-03-18 | 2016-11-10 | Общество с ограниченной ответственностью "Фармацевтический завод иммунных лекарственных средств" | Sodium deoxyribonucleate suppositories, rectal and vaginal |
GB2542106A (en) * | 2015-04-01 | 2017-03-15 | Nordic Labs Ltd | Novel treatment of STIs |
RU2601893C1 (en) * | 2015-11-30 | 2016-11-10 | Всеволод Иванович Киселев | Drug preparation based on indole-3-carbinol with increased epigenetic activity |
US20200179337A1 (en) * | 2016-05-16 | 2020-06-11 | Aktsionernoe Obschestvo "Veles Farma" | Means for treating sexually transmitted infections |
CN108969602A (en) * | 2018-09-29 | 2018-12-11 | 南京依美生物科技有限公司 | It is a kind of to treat the Chinese medicine composition and preparation method that human papilloma virus sun is turned out cloudy |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1275905B1 (en) * | 1995-03-14 | 1997-10-24 | Indena Spa | POLYPHENOLIC FRACTIONS OF TEA, THEIR USE AND FORMULATIONS THAT CONTAIN THEM |
RU2196568C1 (en) * | 2001-08-08 | 2003-01-20 | Киселев Всеволод Иванович | Pharmaceutical composition for prophylaxis and treatment of uterus cervix dysplasia and cancer and larynx papillomatosis and method of prophylaxis and treatment of said sicknesses based on thereof |
CA2471932A1 (en) * | 2002-01-11 | 2003-07-17 | Matthias Rath | A nutrient pharmaceutical formulation comprising polyphenols and use in treatment of cancer |
RU2318510C1 (en) * | 2006-04-19 | 2008-03-10 | Всеволод Иванович Киселев | 3,3'-diindolylmethane (metindol)-base vaginal suppository |
RU2315594C1 (en) * | 2006-09-01 | 2008-01-27 | Всеволод Иванович Киселев | Anti-estrogenic and anti-proliferative agent for treatment and prophylaxis of female reproductive system diseases |
-
2008
- 2008-09-04 RU RU2008135764/15A patent/RU2395281C2/en active
-
2009
- 2009-08-18 EA EA201100417A patent/EA018383B1/en not_active IP Right Cessation
- 2009-08-18 WO PCT/RU2009/000412 patent/WO2010027294A1/en active Application Filing
- 2009-08-18 UA UAA201011132A patent/UA95583C2/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2456987C1 (en) * | 2011-03-21 | 2012-07-27 | Сергей Владимирович Енгашев | Method for producing gelatine capsules of 3,31-diindolylmethane |
Also Published As
Publication number | Publication date |
---|---|
WO2010027294A1 (en) | 2010-03-11 |
RU2395281C2 (en) | 2010-07-27 |
UA95583C2 (en) | 2011-08-10 |
EA201100417A1 (en) | 2011-10-31 |
EA018383B1 (en) | 2013-07-30 |
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Date | Code | Title | Description |
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PC41 | Official registration of the transfer of exclusive right |
Effective date: 20180907 |