RU2008111173A - METHOD FOR OBTAINING DIALDEHYDE DEXTRAN - Google Patents
METHOD FOR OBTAINING DIALDEHYDE DEXTRAN Download PDFInfo
- Publication number
- RU2008111173A RU2008111173A RU2008111173/04A RU2008111173A RU2008111173A RU 2008111173 A RU2008111173 A RU 2008111173A RU 2008111173/04 A RU2008111173/04 A RU 2008111173/04A RU 2008111173 A RU2008111173 A RU 2008111173A RU 2008111173 A RU2008111173 A RU 2008111173A
- Authority
- RU
- Russia
- Prior art keywords
- dextran
- dialdehydedextran
- oxidation
- solution
- carried out
- Prior art date
Links
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
1. Способ получения диальдегиддекстрана, включающий окисление декстрана, удаление примесей, осаждение диальдегиддекстрана этанолом, промывание и высушивание диальдегиддекстрана, отличающийся тем, что реакцию окисления декстрана проводят перманганатом калия при нагревании в присутствии органической кислоты, надосадочную жидкость, содержащую диальдегиддекстран, фильтруют от выпавшей в осадок двуокиси марганца, осаждение диальдегиддекстрана этанолом осуществляют при температуре 60-80°С. ! 2. Способ по п.1, отличающийся тем, что в качестве исходного продукта используют декстран с молекулярной массой 20-75 кДа в виде 10%-ного водного или водно-солевого раствора. ! 3. Способ по п.1, отличающийся тем, что для окисления декстрана используют 2%-ный раствор перманганата калия в количестве от 1 до 6% от объема раствора декстрана. ! 4. Способ по п.1, отличающийся тем, что окисление декстрана проводят при температуре 80-100°С. ! 5. Способ по п.1, отличающийся тем, что в качестве органической кислоты используют уксусную или муравьиную кислоту в концентрации 5-35% и в количестве 0,5-2,0% от исходного объема раствора декстрана.1. The method of obtaining dialdehydedextran, including the oxidation of dextran, removal of impurities, the precipitation of dialdehydedextran with ethanol, washing and drying dialdehydedextran, characterized in that the oxidation reaction of dextran is carried out with potassium permanganate when heated in the presence of organic acid, the supernatant containing the dialdehydedextran is filtered off, manganese dioxide, the precipitation of dialdehydedextran with ethanol is carried out at a temperature of 60-80 ° C. ! 2. The method according to claim 1, characterized in that dextran with a molecular weight of 20-75 kDa is used as a starting product in the form of a 10% aqueous or water-salt solution. ! 3. The method according to claim 1, characterized in that for the oxidation of dextran using a 2% solution of potassium permanganate in an amount of from 1 to 6% of the volume of a solution of dextran. ! 4. The method according to claim 1, characterized in that the oxidation of dextran is carried out at a temperature of 80-100 ° C. ! 5. The method according to claim 1, characterized in that the organic acid is used acetic or formic acid in a concentration of 5-35% and in an amount of 0.5-2.0% of the initial volume of a solution of dextran.
Claims (5)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2008111173/04A RU2008111173A (en) | 2008-03-21 | 2008-03-21 | METHOD FOR OBTAINING DIALDEHYDE DEXTRAN |
EA200801377A EA011718B1 (en) | 2008-03-21 | 2008-05-15 | Method for producing dialdehydedextran |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2008111173/04A RU2008111173A (en) | 2008-03-21 | 2008-03-21 | METHOD FOR OBTAINING DIALDEHYDE DEXTRAN |
Publications (1)
Publication Number | Publication Date |
---|---|
RU2008111173A true RU2008111173A (en) | 2009-09-27 |
Family
ID=40852075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2008111173/04A RU2008111173A (en) | 2008-03-21 | 2008-03-21 | METHOD FOR OBTAINING DIALDEHYDE DEXTRAN |
Country Status (2)
Country | Link |
---|---|
EA (1) | EA011718B1 (en) |
RU (1) | RU2008111173A (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2542534C1 (en) * | 2013-08-27 | 2015-02-20 | Открытое акционерное общество "Федеральный научно-производственный центр "Алтай" | Method of producing dialdehyde dextran |
RU2618341C1 (en) * | 2016-02-09 | 2017-05-03 | Общество с ограниченной ответственностью "Генерис Фарм" | Method for oxidized dextran obtaining |
RU2646451C1 (en) * | 2017-05-11 | 2018-03-05 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт экспериментальной и клинической медицины" (НИИЭКМ) | Method of quantitative identification of aldehyde groups in oxidized dextran |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1173448B (en) * | 1960-07-25 | 1964-07-09 | Miles Lab | Process for the production of dialdehyde polysaccharides with improved dispersibility and stability |
SU1530630A1 (en) * | 1986-12-30 | 1989-12-23 | Научно-производственное объединение "Биолар" | Method of producing dialdehyde dextrane |
RU2125451C1 (en) * | 1994-11-09 | 1999-01-27 | Новосибирский медицинский институт | Method of preparing a conjugate isoniazid-dextran |
RU2143900C1 (en) * | 1999-03-31 | 2000-01-10 | Институт цитологии и генетики СО РАН | Method of preparing isoniazid with prolonged effect |
RU2163120C1 (en) * | 1999-10-12 | 2001-02-20 | Новосибирский медицинский институт | Isoniazid-dextran conjugate and application thereof |
-
2008
- 2008-03-21 RU RU2008111173/04A patent/RU2008111173A/en not_active Application Discontinuation
- 2008-05-15 EA EA200801377A patent/EA011718B1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EA200801377A1 (en) | 2009-04-28 |
EA011718B1 (en) | 2009-04-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20110322 |