RU2007117497A - Трициклические гетероциклы - Google Patents
Трициклические гетероциклы Download PDFInfo
- Publication number
- RU2007117497A RU2007117497A RU2007117497/04A RU2007117497A RU2007117497A RU 2007117497 A RU2007117497 A RU 2007117497A RU 2007117497/04 A RU2007117497/04 A RU 2007117497/04A RU 2007117497 A RU2007117497 A RU 2007117497A RU 2007117497 A RU2007117497 A RU 2007117497A
- Authority
- RU
- Russia
- Prior art keywords
- chlorinating agent
- organic solvent
- compound
- reacting
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (15)
1. Одностадийный способ получения соединения формулы
из соединения формулы
2. Способ получения соединения формулы
из соединения формулы
при этом не требуется использование защитных групп.
3. Способ по п.1, в котором не требуется использование защитных групп.
4. Способ по любому из пп.1-3, включающий взаимодействие соединения формулы ASC с соответствующим хлорирующим агентом в органическом растворителе, необязательно в присутствии основания, и выделение полученного соединения формулы I из реакционной смеси.
5. Способ по п.4, в котором хлорирующим агентом является дихлортрифенилфосфоран.
6. Способ по любому из пп.1-3 и 5, включающий взаимодействие соединения FR520 в органическом растворителе с хлорирующим агентом в присутствии основания, причем хлорирующий агент получают при взаимодействии трифенилфосфина и N-хлорсукцинимида в органическом растворителе.
7. Способ по п.4, включающий взаимодействие соединения FR520 в органическом растворителе с хлорирующим агентом в присутствии основания, причем хлорирующий агент получают при взаимодействии трифенилфосфина и N-хлорсукцинимида в органическом растворителе.
8. Способ по п.6, в котором органический растворитель выбирают из группы, включающей ароматические углеводороды, простые эфиры и нитрилы.
9. Способ по п.7, в котором органический растворитель выбирают из группы, включающей ароматические углеводороды, простые эфиры и нитрилы.
10. Способ по п.6, в котором основанием является пиридин.
11.Способ по п.6, в котором основанием является пиридин.
12. Способ по любому из пп.1-3 и 5, включающий взаимодействие соединения формулы ASC с хлорирующим агентом в органическом растворителе, причем хлорирующий агент получают при взаимодействии трифенилфосфина с хлорзамещенным алканом.
13. Способ по п 4, включающий взаимодействие соединения формулы ASC с хлорирующим агентом в органическом растворителе, причем хлорирующий агент получают при взаимодействии трифенилфосфина с хлорзамещенным алканом.
14. Способ по п.12, в котором хлорзамещенным алканом является CCl4.
15. Способ по п.12, в котором хлорзамещенным алканом является CCl4
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0422643.7 | 2004-10-12 | ||
| GB0422643A GB0422643D0 (en) | 2004-10-12 | 2004-10-12 | Organic compounds |
| GB0427599.6 | 2004-12-16 | ||
| GB0427599A GB0427599D0 (en) | 2004-12-16 | 2004-12-16 | Organic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2007117497A true RU2007117497A (ru) | 2008-11-20 |
| RU2394037C2 RU2394037C2 (ru) | 2010-07-10 |
Family
ID=36084355
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007117497/04A RU2394037C2 (ru) | 2004-10-12 | 2005-10-10 | Одностадийный способ получения 33-эпихлор-33-дезоксиаскомицина |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US7514554B2 (ru) |
| EP (1) | EP1802635B8 (ru) |
| JP (1) | JP5032326B2 (ru) |
| KR (1) | KR101228188B1 (ru) |
| CN (1) | CN101031573B (ru) |
| AR (1) | AR051386A1 (ru) |
| AU (1) | AU2005293799B2 (ru) |
| BR (1) | BRPI0516873A (ru) |
| CA (1) | CA2581046C (ru) |
| DK (1) | DK1802635T3 (ru) |
| EC (1) | ECSP077384A (ru) |
| ES (1) | ES2389206T3 (ru) |
| GT (1) | GT200500282A (ru) |
| HK (1) | HK1105634A1 (ru) |
| IL (1) | IL182307A (ru) |
| JO (1) | JO2727B1 (ru) |
| MA (1) | MA28932B1 (ru) |
| MX (1) | MX2007004258A (ru) |
| MY (1) | MY140880A (ru) |
| NO (1) | NO338603B1 (ru) |
| NZ (1) | NZ554010A (ru) |
| PE (1) | PE20060581A1 (ru) |
| PL (1) | PL1802635T3 (ru) |
| PT (1) | PT1802635E (ru) |
| RU (1) | RU2394037C2 (ru) |
| TN (1) | TNSN07133A1 (ru) |
| TW (1) | TWI361192B (ru) |
| WO (1) | WO2006040111A2 (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1817315A1 (en) * | 2004-12-01 | 2007-08-15 | Teva Gyógyszergyár Zártköruen Muködo Részvenytarsaság | Processes for producing crystalline macrolides |
| IT1394309B1 (it) | 2009-05-22 | 2012-06-06 | Poli Ind Chimica Spa | Nuovo approccio chimico-enzimatico alla sintesi del pimecrolimus |
| CN106854228B (zh) * | 2015-12-08 | 2020-05-29 | 博瑞生物医药（苏州）股份有限公司 | 一种吡美莫司的制备方法 |
| EP3178824A1 (en) | 2015-12-08 | 2017-06-14 | Medichem, S.A. | Process for preparing pimecrolimus |
| PL3619215T3 (pl) | 2017-05-01 | 2022-03-21 | Meda Pharma Gmbh & Co. Kg | Sposób przekształcania surowej askomycyny w oczyszczony pimecrolimus |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4464366A (en) | 1979-12-19 | 1984-08-07 | Ciba Geigy Corporation | Cephem compounds having a terminal aminocarboxylic acid grouping and containing an azacyclyl(thio)ureido group |
| US4894366A (en) * | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
| US5352671A (en) * | 1989-11-09 | 1994-10-04 | Sandoz Ltd. | Heteroatoms-containing tricyclic compounds |
| EP0427680B1 (en) * | 1989-11-09 | 1995-08-23 | Sandoz Ltd. | Heteroatoms-containing tricyclic compounds |
| EP0480623A1 (en) | 1990-10-11 | 1992-04-15 | Merck & Co. Inc. | New halomacrolides and derivatives having immunosuppressive activity |
| MY110603A (en) | 1993-05-27 | 1998-08-29 | Novartis Ag | Tetrahydropyran derivatives |
| US6160117A (en) | 1997-11-06 | 2000-12-12 | Zeneca Limited | Chemical process |
| GB0012383D0 (en) | 2000-05-22 | 2000-07-12 | Novartis Ag | Organic compounds |
| US6667312B2 (en) | 2000-12-08 | 2003-12-23 | 3M Innovative Properties Company | Thioether substituted imidazoquinolines |
-
2005
- 2005-10-07 GT GT200500282A patent/GT200500282A/es unknown
- 2005-10-09 JO JO2005138A patent/JO2727B1/en active
- 2005-10-10 AU AU2005293799A patent/AU2005293799B2/en active Active
- 2005-10-10 US US11/575,757 patent/US7514554B2/en active Active
- 2005-10-10 PT PT05793907T patent/PT1802635E/pt unknown
- 2005-10-10 MX MX2007004258A patent/MX2007004258A/es active IP Right Grant
- 2005-10-10 ES ES05793907T patent/ES2389206T3/es active Active
- 2005-10-10 CN CN2005800333070A patent/CN101031573B/zh active Active
- 2005-10-10 DK DK05793907.6T patent/DK1802635T3/da active
- 2005-10-10 WO PCT/EP2005/010889 patent/WO2006040111A2/en active Application Filing
- 2005-10-10 RU RU2007117497/04A patent/RU2394037C2/ru active
- 2005-10-10 NZ NZ554010A patent/NZ554010A/en unknown
- 2005-10-10 CA CA2581046A patent/CA2581046C/en active Active
- 2005-10-10 PL PL05793907T patent/PL1802635T3/pl unknown
- 2005-10-10 BR BRPI0516873-2A patent/BRPI0516873A/pt not_active Application Discontinuation
- 2005-10-10 KR KR1020077008216A patent/KR101228188B1/ko active IP Right Grant
- 2005-10-10 EP EP05793907.6A patent/EP1802635B8/en active Active
- 2005-10-10 JP JP2007536064A patent/JP5032326B2/ja active Active
- 2005-10-11 PE PE2005001202A patent/PE20060581A1/es not_active Application Discontinuation
- 2005-10-11 TW TW094135403A patent/TWI361192B/zh active
- 2005-10-11 AR ARP050104257A patent/AR051386A1/es not_active Application Discontinuation
- 2005-10-11 MY MYPI20054764A patent/MY140880A/en unknown
-
2007
- 2007-03-29 IL IL182307A patent/IL182307A/en active IP Right Grant
- 2007-04-11 EC EC2007007384A patent/ECSP077384A/es unknown
- 2007-04-11 TN TNP2007000133A patent/TNSN07133A1/fr unknown
- 2007-04-12 MA MA29826A patent/MA28932B1/fr unknown
- 2007-04-24 NO NO20072127A patent/NO338603B1/no unknown
- 2007-10-05 HK HK07110850.1A patent/HK1105634A1/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC41 | Official registration of the transfer of exclusive right |
Effective date: 20131029 |