RU2006141418A - Иммуномодулирующее средство, противораковое средство и здоровая пища, содержащая производные моноацетилдиацилглицерина - Google Patents
Иммуномодулирующее средство, противораковое средство и здоровая пища, содержащая производные моноацетилдиацилглицерина Download PDFInfo
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- RU2006141418A RU2006141418A RU2006141418/15A RU2006141418A RU2006141418A RU 2006141418 A RU2006141418 A RU 2006141418A RU 2006141418/15 A RU2006141418/15 A RU 2006141418/15A RU 2006141418 A RU2006141418 A RU 2006141418A RU 2006141418 A RU2006141418 A RU 2006141418A
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- Prior art keywords
- monoacetyldiacylglycerol
- derivatives
- formula
- cancer
- represented
- Prior art date
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- 239000002955 immunomodulating agent Substances 0.000 title claims 6
- 235000001497 healthy food Nutrition 0.000 title claims 3
- 230000001093 anti-cancer Effects 0.000 title 1
- -1 9-octadecenoyl (oleoyl) Chemical group 0.000 claims 7
- 239000004480 active ingredient Substances 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 3
- 230000002519 immonomodulatory effect Effects 0.000 claims 3
- 102000004388 Interleukin-4 Human genes 0.000 claims 2
- 108090000978 Interleukin-4 Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 229940124321 AIDS medicine Drugs 0.000 claims 1
- 210000004366 CD4-positive T-lymphocyte Anatomy 0.000 claims 1
- 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 108010002616 Interleukin-5 Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 125000002714 alpha-linolenoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])/C([H])=C([H])\C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 125000002886 arachidonoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])/C([H])=C([H])\C([H])([H])/C([H])=C([H])\C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 208000026900 bile duct neoplasm Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000005779 cell damage Effects 0.000 claims 1
- 208000037887 cell injury Diseases 0.000 claims 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 125000002669 linoleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 125000002811 oleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
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Claims (13)
1. Иммуномолулирующее средство, содержащее в качестве эффективного ингредиента производные моноацетилдиацилглицерина, представленные формулой 1, приведенной ниже:
где R1/R2 является 9-октадеценоил(олеоил)/(гексадеканоил(пальмитоил), гексадеканоил(пальмитоил)/(9-октадеценоил(олеоил), гексадеканоил(пальмитоил)/9,12-октадекадиеноил(линолеоил), гексадеканоил(пальмитоил)/9,12,15-октадекатриеноил(линоленоил) или гексадеканоил(пальмитоил)/5,8,11,14-эйкозатетраеноил(арахидоноил).
2. Иммуномолулирующее средство по п.1, в котором производные моноацетилдиацилглицерина, представленные формулой 1, являются моноацетилдиацилглицерином, представленным формулой 2, приведенной ниже:
3. Иммуномодулирующее средство по п.1, в котором производные моноацетилдиацилглицерина стимулируют в Т-клетках секрецию цитокинов, выбранных из группы, включающей IL-2, IL-4 и IL-5.
4. Иммуномодулирующее средство по п.1, в котором производные моноацетилдиацилглицерина подавляют повреждение клеток, возникающее в результате аутоиммунной реакции.
5. Иммуномодулирующее средство по п.1, в котором производные моноацетилдиацилглицерина стимулируют секрецию IL-4 и пролиферацию и активацию как Т4-, так и Т8-клеток.
6. Иммуномодулирующее средство по п.1, в котором производные моноацетилдиацилглицерина составляют от 20 до 100 вес.% от общего веса иммуномодулирующего средства.
7. Лекарственное средство от СПИДа, содержащее в качестве эффективного активного ингредиента производные моноацетилдиацилглицерина, представленные формулой 1, приведенной выше.
8. Лекарственное средство от сепсиса, содержащее в качестве эффективного активного ингредиента производные моноацетилдиацилглицерина, представленные формулой 1, приведенной выше.
9. Противораковое средство, содержащее в качестве эффективного активного ингредиента производные моноацетилдиацилглицерина, представленные формулой 1, приведенной выше.
10. Противораковое средство по п.9, которое применяют для лечения рака желчных протоков, рака почек или злокачественной меланомы.
11. Противораковое средство по п.9, которое активирует дендритные клетки, которые дают возможность Т-клеткам узнавать антиген раковых клеток.
12. Здоровая пища для иммуномодуляции или предупреждения рака, содержащая в качестве эффективного активного ингредиента производные моноацетилдиацилглицерина, представленные формулой 1, приведенной выше.
13. Здоровая пища по п.12, в которой производные моноацетилдиацилглицерина составляют от 0,02 до 100 вес.% от общего веса этой пищи.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20040028514 | 2004-04-24 | ||
| KR10-2004-0028514 | 2004-04-24 | ||
| KR1020040070650A KR20050118057A (ko) | 2004-04-24 | 2004-09-04 | 아세틸디아실글리세롤류의 화합물을 유효성분으로함유하는 항암제 및 건강식품 |
| KR10-2004-0070650 | 2004-09-04 | ||
| KR10-2004-0109805 | 2004-12-21 |
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| RU2006141418A true RU2006141418A (ru) | 2008-05-27 |
| RU2341257C2 RU2341257C2 (ru) | 2008-12-20 |
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| JP (1) | JP4892473B2 (ru) |
| KR (1) | KR20050118057A (ru) |
| CN (1) | CN1946392B (ru) |
| RU (1) | RU2341257C2 (ru) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2010006261A1 (en) * | 2008-07-10 | 2010-01-14 | Hong John J | Methods for inducing stem cell migration and specialization with ec-18 |
| US20100227021A1 (en) * | 2009-03-06 | 2010-09-09 | Woodland Outdoor Group, Llc | Deer food formulations and related methods |
| MD3972C2 (ru) * | 2009-03-11 | 2010-07-31 | Ион МЕРЕУЦЭ | Средство и метод лечения предраковых состояний |
| KR101278874B1 (ko) * | 2011-09-23 | 2013-06-26 | 주식회사 엔지켐생명과학 | 1-팔미토일-3-아세틸글리세롤의 제조방법 및 이를 이용한 1-팔미토일-2-리놀레오일-3-아세틸글리세롤의 제조방법 |
| RU2496871C1 (ru) * | 2012-08-09 | 2013-10-27 | Сергей Владимирович Осутин | Способ выделения стволовых клеток из костного мозга для внутрисосудистого введения |
| JP6201054B2 (ja) | 2013-08-19 | 2017-09-20 | エンジーケム ライフサイエンシーズ コーポレーションＥｎｚｙｃｈｅｍ Ｌｉｆｅｓｃｉｅｎｃｅｓ Ｃｏｒｐｏｒａｔｉｏｎ | モノアセチルジアシルグリセロール化合物を有効成分として含有する血液癌または癌転移抑制用組成物 |
| RU2642631C2 (ru) * | 2013-08-19 | 2018-01-25 | Энзикем Лайфсайенсиз Корпорейшн | Композиция для предотвращения или лечения хронических обструктивных заболеваний легких, содержащая моноацетилдиглицерольные соединения в качестве активного ингредиента |
| JP6081025B2 (ja) * | 2013-08-19 | 2017-02-15 | エンジーケム ライフサイエンシーズ コーポレーションＥｎｚｙｃｈｅｍ Ｌｉｆｅｓｃｉｅｎｃｅｓ Ｃｏｒｐｏｒａｔｉｏｎ | モノアセチルジアシルグリセロール化合物を有効成分として含有する喘息の予防または治療用組成物 |
| CA2921845C (en) * | 2013-08-19 | 2018-07-10 | Korea Research Institute Of Bioscience And Biotechnology | Compositions containing monoacetyldiacylglycerol compound as an active indredient for preventing or treating rheumatoid arthritis |
| JP6129423B2 (ja) * | 2013-09-03 | 2017-05-17 | エンジーケム ライフサイエンシーズ コーポレーションＥｎｚｙｃｈｅｍ Ｌｉｆｅｓｃｉｅｎｃｅｓ Ｃｏｒｐｏｒａｔｉｏｎ | モノアセチルジアシルグリセロール化合物を有効成分に含有するアトピー皮膚炎の予防または治療用組成物 |
| RU2016114826A (ru) * | 2013-09-17 | 2017-10-23 | Энзикем Лайфсайенсиз Корпорейшн | Композиция, стимулирующая дифференциацию или пролиферацию клеток эритроцитов, содержащая моноацетилдиацилглицериновое соединение в качестве действующего вещества |
| EP3142657B1 (en) | 2014-05-15 | 2019-09-11 | Enzychem Lifesciences Corporation | Methods for treating neutropenia |
| HUE046710T2 (hu) * | 2014-10-09 | 2020-03-30 | Univ Yamaguchi | CAR expressziós vektor és CAR-t expresszáló T-sejtek |
| JP6113133B2 (ja) * | 2014-11-06 | 2017-04-12 | 日本メナード化粧品株式会社 | 幹細胞の未分化状態維持剤及び増殖促進剤 |
| US9808438B2 (en) | 2015-11-09 | 2017-11-07 | Enzychem Lifesciences Corporation | Method for treating mucositis |
| KR101817552B1 (ko) * | 2016-10-13 | 2018-01-11 | 주식회사 엔지켐생명과학 | 모노아세틸디아실글리세롤 화합물을 함유하는 간염의 예방 또는 치료용 조성물 |
| KR101836822B1 (ko) * | 2016-10-17 | 2018-03-09 | 주식회사 엔지켐생명과학 | 모노아세틸디아실글리세롤 화합물을 함유하는 건선의 예방 또는 치료용 조성물 |
| RU2020121489A (ru) | 2017-11-30 | 2021-12-30 | Энзикем Лайфсайенсиз Корпорейшн | Композиции для профилактики или лечения острой лучевой болезни |
| KR20190063536A (ko) * | 2017-11-30 | 2019-06-10 | 주식회사 엔지켐생명과학 | 1-팔미토일-2-리놀레오일-3-아세틸글리세롤을 포함하는 급성 방사선 증후군의 예방 또는 치료용 조성물 |
| KR102176809B1 (ko) * | 2018-10-11 | 2020-11-10 | 몸엔용바이오 농업회사법인 주식회사 | 녹용 및 가시오가피로 구성된 복합생약 추출물을 함유한 면역증강용 약학조성물 및 건강기능식품 |
| CA3126887A1 (en) * | 2019-01-16 | 2020-07-23 | Enzychem Lifesciences Corporation | Methods and compositions for treatment of cancer |
| KR102218540B1 (ko) * | 2019-04-16 | 2021-02-22 | 주식회사 엔지켐생명과학 | 모노아세틸디아실글리세롤 화합물을 함유하는 당뇨병 치료용 조성물 및 당뇨병의 치료 방법 |
| US20220062218A1 (en) * | 2019-04-16 | 2022-03-03 | Enzychem Lifesciences | Compositions and methods for treating diabetes |
| US20220370397A1 (en) * | 2019-10-28 | 2022-11-24 | Enzychem Lifesciences Corporation | Methods and compositions for treatment of cancer |
| KR20240089762A (ko) * | 2021-10-18 | 2024-06-20 | 주식회사 엔지켐생명과학 | 점막염 치료용 조성물 및 방법 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPS6212716A (ja) * | 1985-07-11 | 1987-01-21 | Nippon Oil & Fats Co Ltd | 制がん剤 |
| GB9116054D0 (en) * | 1991-07-24 | 1991-09-11 | Efamol Holdings | Preparation of fatty acid medicaments |
| SG48993A1 (en) * | 1992-10-01 | 1998-05-18 | Wellcome Found | Immunopotentiatory agent and physiologically acceptable salts thereof |
| DE4330664A1 (de) * | 1993-09-10 | 1995-03-16 | Beiersdorf Ag | Verwendungen von Pflanzenölen |
| JPH0827010A (ja) * | 1994-07-19 | 1996-01-30 | Nichinichi Seiyaku Kk | 制癌免疫療法剤 |
| DE69833333T2 (de) * | 1997-11-20 | 2006-10-19 | Jhon, Gil Ja | Pharmazeutische zusammensetzung enthaltend geweihextrakte von cervus nippon mit wachstumsstimulierender aktivität auf hematopoietische stammzellen und megakaryozyten |
| US6307024B1 (en) * | 1999-03-09 | 2001-10-23 | Zymogenetics, Inc. | Cytokine zalpha11 Ligand |
| US20020188024A1 (en) * | 2000-08-23 | 2002-12-12 | Chilton Floyd H. | Fatty acid-containing emulsion with increased bioavailability |
| US20030032674A1 (en) * | 2001-08-13 | 2003-02-13 | Hwang Daniel H. | Use of unsaturated fatty acids to treat severe inflammatory diseases |
| WO2004037341A2 (en) * | 2002-05-07 | 2004-05-06 | Schroeppel Edward A | Method and device for treating concer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy |
| KR20050103259A (ko) | 2004-04-24 | 2005-10-27 | 김상희 | 인터루킨-2 및 모노아세틸디글리세라이드-３을유효성분으로 함유하는 항암제 |
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2005
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- 2005-04-22 US US11/587,377 patent/US7662853B2/en active Active
- 2005-04-22 JP JP2007509400A patent/JP4892473B2/ja active Active
- 2005-04-22 CN CN2005800129149A patent/CN1946392B/zh active Active
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2009
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2007534681A (ja) | 2007-11-29 |
| CN1946392B (zh) | 2010-12-29 |
| US20100137435A1 (en) | 2010-06-03 |
| JP4892473B2 (ja) | 2012-03-07 |
| US7662853B2 (en) | 2010-02-16 |
| RU2341257C2 (ru) | 2008-12-20 |
| US20080200543A1 (en) | 2008-08-21 |
| CN1946392A (zh) | 2007-04-11 |
| KR20050118057A (ko) | 2005-12-15 |
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