RU2006129637A - Вагинальные композиции для лечения инфекций - Google Patents
Вагинальные композиции для лечения инфекций Download PDFInfo
- Publication number
- RU2006129637A RU2006129637A RU2006129637/14A RU2006129637A RU2006129637A RU 2006129637 A RU2006129637 A RU 2006129637A RU 2006129637/14 A RU2006129637/14 A RU 2006129637/14A RU 2006129637 A RU2006129637 A RU 2006129637A RU 2006129637 A RU2006129637 A RU 2006129637A
- Authority
- RU
- Russia
- Prior art keywords
- applying
- composition
- cooling
- specified
- perineum
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims 9
- 208000015181 infectious disease Diseases 0.000 title claims 2
- 238000000034 method Methods 0.000 claims 22
- -1 ravukonazole Chemical compound 0.000 claims 7
- 230000000843 anti-fungal effect Effects 0.000 claims 6
- 229940121375 antifungal agent Drugs 0.000 claims 6
- 238000001816 cooling Methods 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- MCCACAIVAXEFAL-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole;nitric acid Chemical compound O[N+]([O-])=O.ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 MCCACAIVAXEFAL-UHFFFAOYSA-N 0.000 claims 4
- 239000004615 ingredient Substances 0.000 claims 4
- 229960005040 miconazole nitrate Drugs 0.000 claims 4
- 210000002640 perineum Anatomy 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 3
- OZUGVJIHUINCMG-UHFFFAOYSA-N Purpuromycin Natural products COC(=O)C1=Cc2cc3C(O)CC4(Cc5c(O)c6C(=O)C=CC(=O)c6c(O)c5O4)Oc3c(O)c2C(=O)O1 OZUGVJIHUINCMG-UHFFFAOYSA-N 0.000 claims 2
- 125000005233 alkylalcohol group Chemical group 0.000 claims 2
- 230000000840 anti-viral effect Effects 0.000 claims 2
- 230000003115 biocidal effect Effects 0.000 claims 2
- 229960005074 butoconazole Drugs 0.000 claims 2
- SWLMUYACZKCSHZ-UHFFFAOYSA-N butoconazole Chemical compound C1=CC(Cl)=CC=C1CCC(SC=1C(=CC=CC=1Cl)Cl)CN1C=NC=C1 SWLMUYACZKCSHZ-UHFFFAOYSA-N 0.000 claims 2
- JTEGQNOMFQHVDC-NKWVEPMBSA-N lamivudine Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)SC1 JTEGQNOMFQHVDC-NKWVEPMBSA-N 0.000 claims 2
- VGXVKHPGBHVPMW-UHFFFAOYSA-N methyl 4,4',9',10-tetrahydroxy-7'-methoxy-5',8',9-trioxospiro[3,4-dihydropyrano[4,3-g]chromene-2,2'-3h-benzo[f][1]benzofuran]-7-carboxylate Chemical compound OC1=C2C(=O)C(OC)=CC(=O)C2=C(O)C(C2)=C1OC12CC(O)C(C=C2C=C(OC(=O)C2=C2O)C(=O)OC)=C2O1 VGXVKHPGBHVPMW-UHFFFAOYSA-N 0.000 claims 2
- 239000008247 solid mixture Substances 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims 1
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims 1
- BLSQLHNBWJLIBQ-OZXSUGGESA-N (2R,4S)-terconazole Chemical compound C1CN(C(C)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2N=CN=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 BLSQLHNBWJLIBQ-OZXSUGGESA-N 0.000 claims 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims 1
- MPIPASJGOJYODL-SFHVURJKSA-N (R)-isoconazole Chemical compound ClC1=CC(Cl)=CC=C1[C@@H](OCC=1C(=CC=CC=1Cl)Cl)CN1C=NC=C1 MPIPASJGOJYODL-SFHVURJKSA-N 0.000 claims 1
- KPQZUUQMTUIKBP-UHFFFAOYSA-N 1-(2-methyl-5-nitro-1-imidazolyl)-2-propanol Chemical compound CC(O)CN1C(C)=NC=C1[N+]([O-])=O KPQZUUQMTUIKBP-UHFFFAOYSA-N 0.000 claims 1
- AFNXATANNDIXLG-SFHVURJKSA-N 1-[(2r)-2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole Chemical compound C1=CC(Cl)=CC=C1CS[C@H](C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 AFNXATANNDIXLG-SFHVURJKSA-N 0.000 claims 1
- ZCJYUTQZBAIHBS-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)benzyl]oxy}ethyl]imidazole Chemical compound ClC1=CC(Cl)=CC=C1C(OCC=1C=CC(SC=2C=CC=CC=2)=CC=1)CN1C=NC=C1 ZCJYUTQZBAIHBS-UHFFFAOYSA-N 0.000 claims 1
- OCAPBUJLXMYKEJ-UHFFFAOYSA-N 1-[biphenyl-4-yl(phenyl)methyl]imidazole Chemical compound C1=NC=CN1C(C=1C=CC(=CC=1)C=1C=CC=CC=1)C1=CC=CC=C1 OCAPBUJLXMYKEJ-UHFFFAOYSA-N 0.000 claims 1
- LEZWWPYKPKIXLL-UHFFFAOYSA-N 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound C1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 LEZWWPYKPKIXLL-UHFFFAOYSA-N 0.000 claims 1
- JLGKQTAYUIMGRK-UHFFFAOYSA-N 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound ClC1=CC(Cl)=CC=C1C(OCC=1C2=CC=CC(Cl)=C2SC=1)CN1C=NC=C1 JLGKQTAYUIMGRK-UHFFFAOYSA-N 0.000 claims 1
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 claims 1
- HUADITLKOCMHSB-AVQIMAJZSA-N 2-butan-2-yl-4-[4-[4-[4-[[(2s,4r)-2-(2,4-difluorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N(C(C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3O[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 HUADITLKOCMHSB-AVQIMAJZSA-N 0.000 claims 1
- UDYUIWXQUBNDHC-UHFFFAOYSA-N 6-[[4-(4-chlorophenoxy)phenoxy]methyl]-1-hydroxy-4-methylpyridin-2-one Chemical compound ON1C(=O)C=C(C)C=C1COC(C=C1)=CC=C1OC1=CC=C(Cl)C=C1 UDYUIWXQUBNDHC-UHFFFAOYSA-N 0.000 claims 1
- 241000723346 Cinnamomum camphora Species 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims 1
- XQSPYNMVSIKCOC-NTSWFWBYSA-N Emtricitabine Chemical compound C1=C(F)C(N)=NC(=O)N1[C@H]1O[C@@H](CO)SC1 XQSPYNMVSIKCOC-NTSWFWBYSA-N 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- CTETYYAZBPJBHE-UHFFFAOYSA-N Haloprogin Chemical compound ClC1=CC(Cl)=C(OCC#CI)C=C1Cl CTETYYAZBPJBHE-UHFFFAOYSA-N 0.000 claims 1
- VSNHCAURESNICA-UHFFFAOYSA-N Hydroxyurea Chemical compound NC(=O)NO VSNHCAURESNICA-UHFFFAOYSA-N 0.000 claims 1
- 208000005615 Interstitial Cystitis Diseases 0.000 claims 1
- IPWKIXLWTCNBKN-UHFFFAOYSA-N Madelen Chemical compound CC1=NC=C([N+]([O-])=O)N1CC(O)CCl IPWKIXLWTCNBKN-UHFFFAOYSA-N 0.000 claims 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 1
- HJLSLZFTEKNLFI-UHFFFAOYSA-N Tinidazole Chemical compound CCS(=O)(=O)CCN1C(C)=NC=C1[N+]([O-])=O HJLSLZFTEKNLFI-UHFFFAOYSA-N 0.000 claims 1
- 206010046914 Vaginal infection Diseases 0.000 claims 1
- 208000003728 Vulvodynia Diseases 0.000 claims 1
- 206010069055 Vulvovaginal pain Diseases 0.000 claims 1
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims 1
- 229960004150 aciclovir Drugs 0.000 claims 1
- 229960001997 adefovir Drugs 0.000 claims 1
- WOZSCQDILHKSGG-UHFFFAOYSA-N adefovir depivoxil Chemical compound N1=CN=C2N(CCOCP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)C=NC2=C1N WOZSCQDILHKSGG-UHFFFAOYSA-N 0.000 claims 1
- 229950006816 albaconazole Drugs 0.000 claims 1
- UHIXWHUVLCAJQL-MPBGBICISA-N albaconazole Chemical compound C([C@@](O)([C@H](N1C(C2=CC=C(Cl)C=C2N=C1)=O)C)C=1C(=CC(F)=CC=1)F)N1C=NC=N1 UHIXWHUVLCAJQL-MPBGBICISA-N 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- XZKWIPVTHGWDCF-KUZYQSSXSA-N amorolfine hydrochloride Chemical compound Cl.C1=CC(C(C)(C)CC)=CC=C1CC(C)CN1C[C@@H](C)O[C@@H](C)C1 XZKWIPVTHGWDCF-KUZYQSSXSA-N 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229960002206 bifonazole Drugs 0.000 claims 1
- 229960002962 butenafine Drugs 0.000 claims 1
- ABJKWBDEJIDSJZ-UHFFFAOYSA-N butenafine Chemical compound C=1C=CC2=CC=CC=C2C=1CN(C)CC1=CC=C(C(C)(C)C)C=C1 ABJKWBDEJIDSJZ-UHFFFAOYSA-N 0.000 claims 1
- 229960000846 camphor Drugs 0.000 claims 1
- 229930008380 camphor Natural products 0.000 claims 1
- KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 claims 1
- SCKYRAXSEDYPSA-UHFFFAOYSA-N ciclopirox Chemical compound ON1C(=O)C=C(C)C=C1C1CCCCC1 SCKYRAXSEDYPSA-UHFFFAOYSA-N 0.000 claims 1
- 229960002227 clindamycin Drugs 0.000 claims 1
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims 1
- 229960004022 clotrimazole Drugs 0.000 claims 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 claims 1
- 239000002826 coolant Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 150000002016 disaccharides Chemical class 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 229960003913 econazole Drugs 0.000 claims 1
- 229960000366 emtricitabine Drugs 0.000 claims 1
- 229940072253 epivir Drugs 0.000 claims 1
- VEVFSWCSRVJBSM-HOFKKMOUSA-N ethyl 4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 VEVFSWCSRVJBSM-HOFKKMOUSA-N 0.000 claims 1
- 229960001274 fenticonazole Drugs 0.000 claims 1
- 229960004884 fluconazole Drugs 0.000 claims 1
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 claims 1
- 229960000690 flutrimazole Drugs 0.000 claims 1
- QHMWCHQXCUNUAK-UHFFFAOYSA-N flutrimazole Chemical compound C1=CC(F)=CC=C1C(N1C=NC=C1)(C=1C(=CC=CC=1)F)C1=CC=CC=C1 QHMWCHQXCUNUAK-UHFFFAOYSA-N 0.000 claims 1
- MLBVMOWEQCZNCC-OEMFJLHTSA-N fosamprenavir Chemical compound C([C@@H]([C@H](OP(O)(O)=O)CN(CC(C)C)S(=O)(=O)C=1C=CC(N)=CC=1)NC(=O)O[C@@H]1COCC1)C1=CC=CC=C1 MLBVMOWEQCZNCC-OEMFJLHTSA-N 0.000 claims 1
- 229960003142 fosamprenavir Drugs 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 229960001906 haloprogin Drugs 0.000 claims 1
- 229960001330 hydroxycarbamide Drugs 0.000 claims 1
- 229960001936 indinavir Drugs 0.000 claims 1
- CBVCZFGXHXORBI-PXQQMZJSSA-N indinavir Chemical compound C([C@H](N(CC1)C[C@@H](O)C[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H]2C3=CC=CC=C3C[C@H]2O)C(=O)NC(C)(C)C)N1CC1=CC=CN=C1 CBVCZFGXHXORBI-PXQQMZJSSA-N 0.000 claims 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 1
- 229960004849 isoconazole Drugs 0.000 claims 1
- 229960004125 ketoconazole Drugs 0.000 claims 1
- 229960001627 lamivudine Drugs 0.000 claims 1
- 229940041616 menthol Drugs 0.000 claims 1
- 229960000282 metronidazole Drugs 0.000 claims 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims 1
- 150000002772 monosaccharides Chemical group 0.000 claims 1
- 229960000988 nystatin Drugs 0.000 claims 1
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 claims 1
- 229920001542 oligosaccharide Polymers 0.000 claims 1
- 150000002482 oligosaccharides Chemical class 0.000 claims 1
- 229960002313 ornidazole Drugs 0.000 claims 1
- 229960003483 oxiconazole Drugs 0.000 claims 1
- QRJJEGAJXVEBNE-MOHJPFBDSA-N oxiconazole Chemical compound ClC1=CC(Cl)=CC=C1CO\N=C(C=1C(=CC(Cl)=CC=1)Cl)\CN1C=NC=C1 QRJJEGAJXVEBNE-MOHJPFBDSA-N 0.000 claims 1
- 229920005862 polyol Polymers 0.000 claims 1
- 150000003077 polyols Chemical class 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229960001589 posaconazole Drugs 0.000 claims 1
- RAGOYPUPXAKGKH-XAKZXMRKSA-N posaconazole Chemical compound O=C1N([C@H]([C@H](C)O)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3C[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 RAGOYPUPXAKGKH-XAKZXMRKSA-N 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 229940064914 retrovir Drugs 0.000 claims 1
- 229960000329 ribavirin Drugs 0.000 claims 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 1
- 229960003040 rifaximin Drugs 0.000 claims 1
- NZCRJKRKKOLAOJ-XRCRFVBUSA-N rifaximin Chemical compound OC1=C(C(O)=C2C)C3=C4N=C5C=C(C)C=CN5C4=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O NZCRJKRKKOLAOJ-XRCRFVBUSA-N 0.000 claims 1
- 229950006862 rilopirox Drugs 0.000 claims 1
- 229950005137 saperconazole Drugs 0.000 claims 1
- 229960001852 saquinavir Drugs 0.000 claims 1
- QWAXKHKRTORLEM-UGJKXSETSA-N saquinavir Chemical compound C([C@@H]([C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)C=1N=C2C=CC=CC2=CC=1)C1=CC=CC=C1 QWAXKHKRTORLEM-UGJKXSETSA-N 0.000 claims 1
- 229960004076 secnidazole Drugs 0.000 claims 1
- 229960005429 sertaconazole Drugs 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 229960002607 sulconazole Drugs 0.000 claims 1
- 229960004556 tenofovir Drugs 0.000 claims 1
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 claims 1
- 229960000580 terconazole Drugs 0.000 claims 1
- 229960005053 tinidazole Drugs 0.000 claims 1
- 229950000976 trospectomycin Drugs 0.000 claims 1
- KHAUBYTYGDOYRU-IRXASZMISA-N trospectomycin Chemical compound CN[C@H]([C@H]1O2)[C@@H](O)[C@@H](NC)[C@H](O)[C@H]1O[C@H]1[C@]2(O)C(=O)C[C@@H](CCCC)O1 KHAUBYTYGDOYRU-IRXASZMISA-N 0.000 claims 1
- 229960002703 undecylenic acid Drugs 0.000 claims 1
- 210000001215 vagina Anatomy 0.000 claims 1
- 229960004740 voriconazole Drugs 0.000 claims 1
- BCEHBSKCWLPMDN-MGPLVRAMSA-N voriconazole Chemical compound C1([C@H](C)[C@](O)(CN2N=CN=C2)C=2C(=CC(F)=CC=2)F)=NC=NC=C1F BCEHBSKCWLPMDN-MGPLVRAMSA-N 0.000 claims 1
- 208000010484 vulvovaginitis Diseases 0.000 claims 1
- HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0261—Compresses or poultices for effecting heating or cooling medicated
-
- A—HUMAN NECESSITIES
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- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/10—Cooling bags, e.g. ice-bags
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (21)
1. Способ лечения вагинальной инфекции, включающий очищение промежности женщины, охлаждение промежности и нанесение на инфицированную поверхность активного соединения для лечения инфекции.
2. Способ по п.1, в котором указанная стадия охлаждения включает нанесение влажного субстрата на инфицированную поверхность.
3. Способ по п.1, в котором указанная стадия охлаждения включает нанесение на пораженную поверхность композиции, содержащей от приблизительно 5 до приблизительно 20% мас./мас. низшего алкилового спирта.
4. Способ по п.3, в котором указанная стадия охлаждения включает нанесение на пораженную поверхность композиции, содержащей от приблизительно 5 до приблизительно 10% мас./мас. низшего алкилового спирта.
5. Способ по п.4, в котором указанная стадия охлаждения включает нанесение на пораженную поверхность композиции, которая может содержать от приблизительно 5 до приблизительно 35% мас./мас. полиола.
6. Способ по п.3, в котором указанная композиция дополнительно содержит противогрибковое соединение.
7. Способ по п.6, в котором указанное противогрибковое соединение выбирают из группы, состоящей из миконазола нитрата, клотримазола, эконазола, албаконазола, равуконазола, саперконазола, терконазола, кетоконазола, бутаконазола, бутаконазола, тиоконазола, флуконазола, секнидазола, метронидазола, вориконазола, фентиконазола, сертаконазола, позаконазола, бифоназола, оксиконазола, сулконазола, элубиола, вориконазола, изоконазола, флутримазола и их фармацевтически приемлемых солей, тернафина, нафтифина, аморолфина, бутенафина, циклопирокса, гризеофульвина, ундециленовой кислоты, галопрогина, тронафтата, нистатина, иода, рилопирокса, BAY 108888, пурпуромицина и их фармацевтически приемлемых солей.
8. Способ по п.3, в котором указанная композиция дополнительно содержит антибиотик.
9. Способ по п.8, в котором указанный антибиотик выбирают из группы, состоящей из метронидазола, клиндамицина, тинидазола, орнидазола, секнидазола, рефаксимина, троспектомицина, пурпуромицина и их фармацевтически приемлемых солей.
10. Способ по п.3, в котором указанная композиция дополнительно содержит антивирусное соединение.
11. Способ по п.10, в котором указанное антивирусное соединение представляет собой ацикловир, эмтрицитабин, рибавирин, адефовир, дипивиоксил, тенефовир, ретровир, эпивир, индинавир, ламивудин, эметрицитабин, секвинавир, гидроксимочевину и фосампренавир.
12. Способ по п.3, в котором указанная композиция содержит низшие спирты, ментол, камфору и сахара.
13. Способ по п.12, в котором указанный сахар выбирают из группы, состоящей из моносахаридов, дисахаридов, олигосахаридов или полисахаридов.
14. Способ по п.12, в котором указанный сахар является сорбитом.
15. Способ по п.1, в котором указанные стадии очищения и охлаждения включают нанесение влажного субстрата на промежность, и указанная стадия лечения включает введение активного противогрибкового ингредиента во влагалище.
16. Способ по п.15, где указанный способ дополнительно включает стадию нанесения на промежность полутвердой композиции, содержащей активный противогрибковый ингредиент.
17. Способ по п.16, в котором указанная полутвердая композиция представляет собой крем.
18. Способ по п.15, в котором указанный активный противогрибковый ингредиент представляет собой миконазола нитрат.
19. Способ по п.16, в котором указанный активный противогрибковый ингредиент представляет собой миконазола нитрат.
20. Способ по п.19, в котором указанный миконазола нитрат помещен в мягкую желатиновую дозированную форму.
21. Способ лечения вульвовестибулита, интерстициального цистита, вульвовагинита или вульводинии, включающий нанесение на промежность женщины композиции, содержащей охлаждающий агент.
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| US11/034,289 | 2005-01-12 |
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| CN103933063A (zh) | 2007-11-30 | 2014-07-23 | 托尔特克制药有限责任公司 | 用于治疗阴道感染和致病性阴道生物被膜的组合物和方法 |
| US10869777B2 (en) * | 2010-03-28 | 2020-12-22 | Kimberly Cull | Treating medical conditions in body cavities |
| CN103415286A (zh) * | 2010-11-11 | 2013-11-27 | 阿克伦分子有限公司 | 用于治疗疼痛的化合物和方法 |
| RU2485955C2 (ru) * | 2010-11-17 | 2013-06-27 | Леонид Леонидович Клопотенко | Фармацевтическая композиция, содержащая флуконазол, и/или кетоконазол, и/или тербинафин и липосомы для местного применения |
| RU2486912C1 (ru) * | 2012-06-25 | 2013-07-10 | Антон Евгеньевич Супрун | Средство для спринцевания влагалища в первую фазу лечения кандидозного кольпита (молочницы) |
| US9029342B2 (en) | 2012-09-17 | 2015-05-12 | Board Of Regents Of The University Of Texas System | Compositions of matter that reduce pain, shock, and inflammation by blocking linoleic acid metabolites and uses thereof |
| US8778365B1 (en) | 2013-01-31 | 2014-07-15 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| US9446131B2 (en) | 2013-01-31 | 2016-09-20 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| US9433680B2 (en) | 2013-01-31 | 2016-09-06 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| US9452173B2 (en) | 2013-01-31 | 2016-09-27 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| RU2544163C1 (ru) * | 2013-11-29 | 2015-03-10 | Закрытое акционерное общество "ФИРН М" (ЗАО "ФИРН М") | Лекарственное средство в форме геля для лечения проявлений герпетической инфекции у больных с ожогами и отморожениями. |
| CN104055837A (zh) * | 2014-06-04 | 2014-09-24 | 冯伟 | 一种强力治疗霉菌性阴道炎的药物 |
| KR20190026962A (ko) | 2014-09-05 | 2019-03-13 | 심바이오믹스 세러퓨틱스 엘엘씨 | 세균질증 치료에 사용하기 위한 세크니다졸 |
| CA2988082C (en) | 2015-06-01 | 2020-09-29 | Symbiomix Therapeutics, Llc | Novel nitroimidazole formulations and uses thereof |
| CN105106487A (zh) * | 2015-09-24 | 2015-12-02 | 青岛海之源智能技术有限公司 | 甲硝唑硝酸咪康唑复方软膏及制备方法 |
| WO2018144841A1 (en) * | 2017-02-03 | 2018-08-09 | Board Of Regents, The University Of Texas System | Topical voriconazole for the treatment of pain |
| WO2018199303A1 (ja) * | 2017-04-28 | 2018-11-01 | 持田製薬株式会社 | ミコナゾール及び／又は硝酸ミコナゾールを含むシート製剤 |
| BR112020012195A2 (pt) * | 2017-12-18 | 2020-11-24 | Ansella Therapeutics, Inc. | composições e métodos para prevenir e tratar condições |
| US20210251975A1 (en) * | 2018-08-23 | 2021-08-19 | Gwangju Institute Of Science And Technology | Use of ciclopirox for inhibiting hbv core assembly |
| CN113226206A (zh) * | 2018-10-17 | 2021-08-06 | 佛罗里达大学研究基金会 | 在心脏消融期间控制食道温度 |
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| US2666013A (en) * | 1950-08-25 | 1954-01-12 | Jr Edgar A Ferguson | Pruritus therapy |
| US4636520A (en) * | 1984-07-16 | 1987-01-13 | Fujisawa Pharmaceutical Co., Ltd. | Antifungal composition employing pyrrolnitrin in combination with an imidazole compound |
| US6017521A (en) * | 1989-10-31 | 2000-01-25 | Columbia Laboratories, Inc. | Use of polycarboxylic acid polymers to treat vaginal infections |
| US5270032A (en) * | 1990-10-04 | 1993-12-14 | The Research Foundation Of State University Of New York | Composition and method for the prevention and treatment of candidiasis |
| US5174475A (en) * | 1991-03-26 | 1992-12-29 | Glaxo Inc. | Sequential dosing of antifungal and antiinflammatory compositions |
| US6200557B1 (en) * | 1993-07-06 | 2001-03-13 | Perry A. Ratcliff | Method of treating HIV by a topical composition |
| US5514698A (en) * | 1994-03-21 | 1996-05-07 | Ortho Pharmaceutical Corporation | Antifungal vaginal cream composition |
| US5935595A (en) * | 1996-05-10 | 1999-08-10 | Steen; Mary | Device and method for reducing wound trauma |
| US20030091540A1 (en) * | 2001-10-16 | 2003-05-15 | Nawaz Ahmad | Compositions and methods for delivering antibacterial, antifungal and antiviral ointments to the oral, nasal or vaginal cavity |
| US20040033968A1 (en) * | 2002-08-16 | 2004-02-19 | Lin Shun Y. | Optimal volume of intra-vaginal semisolid dosage forms for treating vaginal infections |
| AU2003279493B2 (en) * | 2002-10-25 | 2009-08-20 | Foamix Pharmaceuticals Ltd. | Cosmetic and pharmaceutical foam |
| US6955662B2 (en) * | 2002-10-28 | 2005-10-18 | Scott Andrew Moser | Disposable perineum cleaning device |
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- 2005-01-13 CN CNA2005800025309A patent/CN1913922A/zh active Pending
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Also Published As
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| RU2385720C2 (ru) | 2010-04-10 |
| JP2007534661A (ja) | 2007-11-29 |
| CA2553390A1 (en) | 2005-08-11 |
| EP1703919A1 (en) | 2006-09-27 |
| MXPA06008155A (es) | 2007-10-18 |
| WO2005072774A1 (en) | 2005-08-11 |
| KR20070034984A (ko) | 2007-03-29 |
| US20050222169A1 (en) | 2005-10-06 |
| CN1913922A (zh) | 2007-02-14 |
| AU2005209175A1 (en) | 2005-08-11 |
| BRPI0506898A (pt) | 2007-06-12 |
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