RU2006101787A - METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE ENTEROBACTERIACEAE FAMILY IN WHICH THE YRBG GENE IS INACTIVATED - Google Patents

METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE ENTEROBACTERIACEAE FAMILY IN WHICH THE YRBG GENE IS INACTIVATED Download PDF

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Publication number
RU2006101787A
RU2006101787A RU2006101787/13A RU2006101787A RU2006101787A RU 2006101787 A RU2006101787 A RU 2006101787A RU 2006101787/13 A RU2006101787/13 A RU 2006101787/13A RU 2006101787 A RU2006101787 A RU 2006101787A RU 2006101787 A RU2006101787 A RU 2006101787A
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Russia
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amino acid
aromatic
producing
group
bacterium
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RU2006101787/13A
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Russian (ru)
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RU2330881C2 (en
Inventor
Дмитрий Владимирович Филиппов (RU)
Дмитрий Владимирович Филиппов
Эльвира Борисовна Ворошилова (RU)
Эльвира Борисовна Ворошилова
тинер Михаил Маркович Гус (RU)
Михаил Маркович Гусятинер
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Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU)
Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ)
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Application filed by Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU), Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) filed Critical Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU)
Priority to RU2006101787/13A priority Critical patent/RU2330881C2/en
Priority to PCT/JP2007/051342 priority patent/WO2007086547A1/en
Publication of RU2006101787A publication Critical patent/RU2006101787A/en
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Publication of RU2330881C2 publication Critical patent/RU2330881C2/en

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Claims (11)

1. Бактерия-продуцент L-аминокислоты, принадлежащая к семейству Enterobacteriaceae, модифицированная таким образом, что экспрессия гена yrbG в указанной бактерии ослаблена.1. Bacteria producing L-amino acids belonging to the family Enterobacteriaceae, modified so that the expression of the yrbG gene in the specified bacteria is weakened. 2. Бактерия по п.1, отличающаяся тем, что экспрессия указанного гена yrbG ослаблена за счет инактивации указанного гена yrbG.2. The bacterium according to claim 1, characterized in that the expression of the specified yrbG gene is weakened due to the inactivation of the specified yrbG gene. 3. Бактерия по п.1, отличающаяся тем, что указанная бактерия принадлежит к роду Escherichia.3. The bacterium according to claim 1, characterized in that said bacterium belongs to the genus Escherichia. 4. Бактерия по п.1, отличающаяся тем, что указанная бактерия принадлежит к роду Pantoea.4. The bacterium according to claim 1, characterized in that said bacterium belongs to the genus Pantoea. 5. Бактерия-продуцент L-аминокислоты по любому из пп.1-4, отличающаяся тем, что указанная L-аминокислота выбрана из группы, состоящей из ароматической L-аминокислоты и неароматической L-аминокислоты.5. The bacterium producing L-amino acids according to any one of claims 1 to 4, characterized in that said L-amino acid is selected from the group consisting of aromatic L-amino acids and non-aromatic L-amino acids. 6. Бактерия-продуцент L-аминокислоты по п.5, отличающаяся тем, что указанная ароматическая L-аминокислота выбрана из группы, состоящей из L-фенилаланина, L-тирозина и L-триптофана.6. The L-amino acid producing bacterium according to claim 5, characterized in that said aromatic L-amino acid is selected from the group consisting of L-phenylalanine, L-tyrosine and L-tryptophan. 7. Бактерия-продуцент L-аминокислоты по п.5, отличающаяся тем, что указанная неароматическая L-аминокислота выбрана из группы, состоящей из L-треонина, L-лизина, L-цистеина, L-метионина, L-лейцина, L-изолейцина, L-валина, L-гистидина, L-глицина, L-серина, L-аланина, L-аспарагина, L-аспартата, L-глутамина, L-глутаминовой кислоты, L-пролина и L-аргинина.7. The L-amino acid producing bacterium according to claim 5, characterized in that said non-aromatic L-amino acid is selected from the group consisting of L-threonine, L-lysine, L-cysteine, L-methionine, L-leucine, L- isoleucine, L-valine, L-histidine, L-glycine, L-serine, L-alanine, L-asparagine, L-aspartate, L-glutamine, L-glutamic acid, L-proline and L-arginine. 8. Способ получения L-аминокислоты, включающий выращивание бактерии по любому из пп.1-7 в питательной среде, вызывающее продукцию и накопление указанной L-аминокислоты в культуральной жидкости, и выделение указанной L-аминокислоты из культуральной жидкости.8. A method for producing an L-amino acid, comprising growing a bacterium according to any one of claims 1 to 7 in a nutrient medium, causing production and accumulation of said L-amino acid in the culture fluid, and isolation of said L-amino acid from the culture fluid. 9. Способ по п.8, отличающийся тем, что указанная L-аминокислота выбрана из группы, состоящей из ароматической L-аминокислоты и неароматической L-аминокислоты.9. The method of claim 8, wherein said L-amino acid is selected from the group consisting of an aromatic L-amino acid and a non-aromatic L-amino acid. 10. Способ по п.9, отличающийся тем, что указанная ароматическая L-аминокислота выбрана из группы, состоящей из L-фенилаланина, L-тирозина и L-триптофана.10. The method according to claim 9, characterized in that said aromatic L-amino acid is selected from the group consisting of L-phenylalanine, L-tyrosine and L-tryptophan. 11. Способ по п.9, отличающийся тем, что указанная неароматическая L-аминокислота выбрана из группы, состоящей из L-треонина, L-лизина, L-цистеина, L-метионина, L-лейцина, L-изолейцина, L-валина, L-гистидина, L-глицина, L-серина, L-аланина, L-аспарагина, L-аспартата, L-глутамина, L-глутаминовой кислоты, L-пролина и L-аргинина.11. The method according to claim 9, characterized in that said non-aromatic L-amino acid is selected from the group consisting of L-threonine, L-lysine, L-cysteine, L-methionine, L-leucine, L-isoleucine, L-valine , L-histidine, L-glycine, L-serine, L-alanine, L-asparagine, L-aspartate, L-glutamine, L-glutamic acid, L-proline and L-arginine.
RU2006101787/13A 2006-01-24 2006-01-24 L-THREONINE TECHNIQUE USING BACTERIUM OF Escherichia GENUS WITH INACTIVATED yrbG GENE RU2330881C2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
RU2006101787/13A RU2330881C2 (en) 2006-01-24 2006-01-24 L-THREONINE TECHNIQUE USING BACTERIUM OF Escherichia GENUS WITH INACTIVATED yrbG GENE
PCT/JP2007/051342 WO2007086547A1 (en) 2006-01-24 2007-01-23 A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF THE yrbG GENE

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Application Number Priority Date Filing Date Title
RU2006101787/13A RU2330881C2 (en) 2006-01-24 2006-01-24 L-THREONINE TECHNIQUE USING BACTERIUM OF Escherichia GENUS WITH INACTIVATED yrbG GENE

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RU2006101787A true RU2006101787A (en) 2007-07-27
RU2330881C2 RU2330881C2 (en) 2008-08-10

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