RU2005106346A - METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE ENTEROBACTERIACEAE FAMILY IN WHICH THE LEUO GENE IS INACTIVATED - Google Patents

METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE ENTEROBACTERIACEAE FAMILY IN WHICH THE LEUO GENE IS INACTIVATED Download PDF

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Publication number
RU2005106346A
RU2005106346A RU2005106346/13A RU2005106346A RU2005106346A RU 2005106346 A RU2005106346 A RU 2005106346A RU 2005106346/13 A RU2005106346/13 A RU 2005106346/13A RU 2005106346 A RU2005106346 A RU 2005106346A RU 2005106346 A RU2005106346 A RU 2005106346A
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RU
Russia
Prior art keywords
amino acid
aromatic
bacterium
producing
group
Prior art date
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RU2005106346/13A
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Russian (ru)
Inventor
Константин В чеславович Рыбак (RU)
Константин Вячеславович Рыбак
Эльвира Борисовна Ворошилова (RU)
Эльвира Борисовна Ворошилова
Тать на Викторовна Леонова (RU)
Татьяна Викторовна Леонова
Юрий Иванович Козлов (RU)
Юрий Иванович Козлов
Original Assignee
Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU)
Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ)
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Application filed by Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU), Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) filed Critical Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU)
Priority to RU2005106346/13A priority Critical patent/RU2005106346A/en
Priority to DE602006013796T priority patent/DE602006013796D1/en
Priority to EP06715685A priority patent/EP1856243B1/en
Priority to PCT/JP2006/305194 priority patent/WO2006103936A2/en
Priority to AT06715685T priority patent/ATE465270T1/en
Publication of RU2005106346A publication Critical patent/RU2005106346A/en
Priority to US11/849,403 priority patent/US20090215129A1/en

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Claims (11)

1. Бактерия-продуцент L-аминокислоты, принадлежащая к семейству Enterobacteriaceae, модифицированная таким образом, что экспрессия гена leuO в указанной бактерии ослаблена.1. The bacterium producing L-amino acids belonging to the family Enterobacteriaceae, modified so that the expression of the leuO gene in the specified bacteria is weakened. 2. Бактерия по п.1, отличающаяся тем, что экспрессия указанного гена leuO ослаблена за счет инактивации указанного гена leuO.2. The bacterium according to claim 1, characterized in that the expression of the specified leuO gene is weakened due to the inactivation of the specified leuO gene. 3. Бактерия по п.1, отличающаяся тем, что указанная бактерия принадлежит к роду Escherichia.3. The bacterium according to claim 1, characterized in that said bacterium belongs to the genus Escherichia. 4. Бактерия по п.1, отличающаяся тем, что указанная бактерия принадлежит к роду Pantoea.4. The bacterium according to claim 1, characterized in that said bacterium belongs to the genus Pantoea. 5. Бактерия-продуцент L-аминокислоты по любому из пп.1-4, отличающаяся тем, что указанная L-аминокислота выбрана из группы, состоящей из ароматической L-аминокислоты и неароматической L-аминокислоты.5. The bacterium producing L-amino acids according to any one of claims 1 to 4, characterized in that said L-amino acid is selected from the group consisting of aromatic L-amino acids and non-aromatic L-amino acids. 6. Бактерия-продуцент L-аминокислоты по п.5, отличающаяся тем, что указанная ароматическая L-аминокислота выбрана из группы, состоящей из L-фенилаланина, L-тирозина и L-триптофана.6. The L-amino acid producing bacterium according to claim 5, characterized in that said aromatic L-amino acid is selected from the group consisting of L-phenylalanine, L-tyrosine and L-tryptophan. 7. Бактерия-продуцент L-аминокислоты по п.5, отличающаяся тем, что указанная неароматическая L-аминокислота выбрана из группы, состоящей из L-треонина, L-лизина, L-цистеина, L-метионина, L-лейцина, L-изолейцина, L-валина, L-гистидина, L-глицина, L-серина, L-аланина, L-аспарагина, L-аспартата, L-глутамина, L-глутаминовой кислоты, L-пролина и L-аргинина.7. The L-amino acid producing bacterium according to claim 5, characterized in that said non-aromatic L-amino acid is selected from the group consisting of L-threonine, L-lysine, L-cysteine, L-methionine, L-leucine, L- isoleucine, L-valine, L-histidine, L-glycine, L-serine, L-alanine, L-asparagine, L-aspartate, L-glutamine, L-glutamic acid, L-proline and L-arginine. 8. Способ получения L-аминокислоты, включающий выращивание бактерии по любому из пп.1-7 в питательной среде, вызывающее продукцию и накопление указанной L-аминокислоты в культуральной жидкости; и выделение указанной L-аминокислоты из культуральной жидкости.8. A method for producing an L-amino acid, comprising growing a bacterium according to any one of claims 1 to 7 in a nutrient medium, causing production and accumulation of said L-amino acid in the culture fluid; and isolating said L-amino acid from the culture fluid. 9. Способ по п.8, отличающийся тем, что указанная L-аминокислота выбрана из группы, состоящей из ароматической L-аминокислоты и неароматической L-аминокислоты.9. The method of claim 8, wherein said L-amino acid is selected from the group consisting of an aromatic L-amino acid and a non-aromatic L-amino acid. 10. Способ по п.9, отличающийся тем, что указанная ароматическая L-аминокислота выбрана из группы, состоящей из L-фенилаланина, L-тирозина и L-триптофана.10. The method according to claim 9, characterized in that said aromatic L-amino acid is selected from the group consisting of L-phenylalanine, L-tyrosine and L-tryptophan. 11. Способ по п.9, отличающийся тем, что указанная неароматическая L-аминокислота выбрана из группы, состоящей из L-треонина, L-лизина, L-цистеина, L-метионина, L-лейцина, L-изолейцина, L-валина, L-гистидина, L-глицина, L-серина, L-аланина, L-аспарагина, L-аспартата, L-глутамина, L-глутаминовой кислоты, L-пролина и L-аргинина.11. The method according to claim 9, characterized in that said non-aromatic L-amino acid is selected from the group consisting of L-threonine, L-lysine, L-cysteine, L-methionine, L-leucine, L-isoleucine, L-valine , L-histidine, L-glycine, L-serine, L-alanine, L-asparagine, L-aspartate, L-glutamine, L-glutamic acid, L-proline and L-arginine.
RU2005106346/13A 2005-03-10 2005-03-10 METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE ENTEROBACTERIACEAE FAMILY IN WHICH THE LEUO GENE IS INACTIVATED RU2005106346A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
RU2005106346/13A RU2005106346A (en) 2005-03-10 2005-03-10 METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE ENTEROBACTERIACEAE FAMILY IN WHICH THE LEUO GENE IS INACTIVATED
DE602006013796T DE602006013796D1 (en) 2005-03-10 2006-03-09 PROCESS FOR THE PREPARATION OF A L-AMINOIC ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH LOW-LEUO EXPRESSION
EP06715685A EP1856243B1 (en) 2005-03-10 2006-03-09 Process for producing an l-amino acid employing a bacterium of the enterobacteriaceae family with attenuated leuo expression
PCT/JP2006/305194 WO2006103936A2 (en) 2005-03-10 2006-03-09 Method for producing an l-amino acid using a bacterium of the enterobacteriaceae family with attenuated leuo expression
AT06715685T ATE465270T1 (en) 2005-03-10 2006-03-09 METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIA OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED LEUO EXPRESSION
US11/849,403 US20090215129A1 (en) 2005-03-10 2007-09-04 Method for Producing an L-Amino Acid Using a Bacterium of the Enterobacteriaceae Family Having Expression of the leuO Gene Attenuated

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2005106346/13A RU2005106346A (en) 2005-03-10 2005-03-10 METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE ENTEROBACTERIACEAE FAMILY IN WHICH THE LEUO GENE IS INACTIVATED

Related Child Applications (1)

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RU2006104651/13A Substitution RU2312894C1 (en) 2006-02-16 2006-02-16 METHOD FOR PREPARING L-AMINO ACIDS USING MICROORGANISM BELONGING TO GENUS Escherichia WHEREIN leuO GENE IS INACTIVATED

Publications (1)

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RU2005106346A true RU2005106346A (en) 2006-08-20

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RU2005106346/13A RU2005106346A (en) 2005-03-10 2005-03-10 METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE ENTEROBACTERIACEAE FAMILY IN WHICH THE LEUO GENE IS INACTIVATED

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Effective date: 20070409