RU2005114511A - Трансплантируемая клетка - Google Patents
Трансплантируемая клетка Download PDFInfo
- Publication number
- RU2005114511A RU2005114511A RU2005114511/13A RU2005114511A RU2005114511A RU 2005114511 A RU2005114511 A RU 2005114511A RU 2005114511/13 A RU2005114511/13 A RU 2005114511/13A RU 2005114511 A RU2005114511 A RU 2005114511A RU 2005114511 A RU2005114511 A RU 2005114511A
- Authority
- RU
- Russia
- Prior art keywords
- cell
- cells
- inhibition
- nucleic acid
- human
- Prior art date
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- 210000004027 cell Anatomy 0.000 claims 33
- 210000001744 T-lymphocyte Anatomy 0.000 claims 10
- 108020004707 nucleic acids Proteins 0.000 claims 10
- 102000039446 nucleic acids Human genes 0.000 claims 10
- 150000007523 nucleic acids Chemical group 0.000 claims 10
- 230000005764 inhibitory process Effects 0.000 claims 9
- 239000002955 immunomodulating agent Substances 0.000 claims 8
- 229940121354 immunomodulator Drugs 0.000 claims 8
- 230000002584 immunomodulator Effects 0.000 claims 8
- 230000014509 gene expression Effects 0.000 claims 7
- 241001465754 Metazoa Species 0.000 claims 6
- 230000002401 inhibitory effect Effects 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 102000005962 receptors Human genes 0.000 claims 5
- 108020003175 receptors Proteins 0.000 claims 5
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims 4
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 210000003719 b-lymphocyte Anatomy 0.000 claims 4
- 210000004443 dendritic cell Anatomy 0.000 claims 4
- 210000002540 macrophage Anatomy 0.000 claims 4
- 210000001616 monocyte Anatomy 0.000 claims 4
- 210000000822 natural killer cell Anatomy 0.000 claims 4
- 210000000056 organ Anatomy 0.000 claims 4
- 230000004913 activation Effects 0.000 claims 3
- 239000013543 active substance Substances 0.000 claims 3
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 3
- 230000004069 differentiation Effects 0.000 claims 3
- 210000003714 granulocyte Anatomy 0.000 claims 3
- 230000028993 immune response Effects 0.000 claims 3
- 239000003550 marker Substances 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 230000003448 neutrophilic effect Effects 0.000 claims 3
- 210000000130 stem cell Anatomy 0.000 claims 3
- 102000008949 Histocompatibility Antigens Class I Human genes 0.000 claims 2
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 claims 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000012636 effector Substances 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 210000004698 lymphocyte Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- 230000035899 viability Effects 0.000 claims 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
- 102000006306 Antigen Receptors Human genes 0.000 claims 1
- 108010083359 Antigen Receptors Proteins 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 241000975394 Evechinus chloroticus Species 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 102000043129 MHC class I family Human genes 0.000 claims 1
- 108091054437 MHC class I family Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 239000004098 Tetracycline Substances 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 230000033228 biological regulation Effects 0.000 claims 1
- 230000008614 cellular interaction Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000004154 complement system Effects 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000010348 incorporation Methods 0.000 claims 1
- 230000005012 migration Effects 0.000 claims 1
- 238000013508 migration Methods 0.000 claims 1
- 230000031990 negative regulation of inflammatory response Effects 0.000 claims 1
- 210000000440 neutrophil Anatomy 0.000 claims 1
- 230000000242 pagocytic effect Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 229960003387 progesterone Drugs 0.000 claims 1
- 239000000186 progesterone Substances 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 1
- 229960002930 sirolimus Drugs 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 229930101283 tetracycline Natural products 0.000 claims 1
- 229960002180 tetracycline Drugs 0.000 claims 1
- 235000019364 tetracycline Nutrition 0.000 claims 1
- 150000003522 tetracyclines Chemical class 0.000 claims 1
- 238000001890 transfection Methods 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
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- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- A01K2207/15—Humanized animals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
- A01K2267/025—Animal producing cells or organs for transplantation
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C12N2510/00—Genetically modified cells
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- C12N2517/00—Cells related to new breeds of animals
- C12N2517/02—Cells from transgenic animals
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- C12N2830/00—Vector systems having a special element relevant for transcription
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
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- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Environmental Sciences (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
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- Dermatology (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02022868.0 | 2002-10-14 | ||
| EP02022868 | 2002-10-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2005114511A true RU2005114511A (ru) | 2005-11-20 |
Family
ID=32103881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005114511/13A RU2005114511A (ru) | 2002-10-14 | 2003-10-13 | Трансплантируемая клетка |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1556487A2 (fr) |
| JP (1) | JP2006502716A (fr) |
| KR (1) | KR20050071579A (fr) |
| CN (1) | CN1705744A (fr) |
| AU (1) | AU2003266903A1 (fr) |
| BR (1) | BR0315286A (fr) |
| CA (1) | CA2502312A1 (fr) |
| MX (1) | MXPA05003912A (fr) |
| PL (1) | PL376397A1 (fr) |
| RU (1) | RU2005114511A (fr) |
| WO (1) | WO2004035787A2 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010042189A2 (fr) | 2008-10-08 | 2010-04-15 | Intrexon Corporation | Cellules modifiées exprimant des immuno-modulateurs multiples et leurs utilisations |
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| US5912411A (en) * | 1993-06-14 | 1999-06-15 | University Of Heidelberg | Mice transgenic for a tetracycline-inducible transcriptional activator |
| US5602301A (en) * | 1993-11-16 | 1997-02-11 | Indiana University Foundation | Non-human mammal having a graft and methods of delivering protein to myocardial tissue |
| FR2782732A1 (fr) * | 1998-08-28 | 2000-03-03 | Transgene Sa | Systeme d'expression inductible |
| EP1234047A1 (fr) * | 1999-12-01 | 2002-08-28 | Centre for Translational Research in Cancer | Systeme inductible par medicament inductible et utilisation associee |
| DE10014690A1 (de) * | 2000-03-24 | 2001-10-18 | Franz Wolfgang M | Verfahren zur Isolierung in vito differenzierter Körperzellen |
| AU2001261585B2 (en) * | 2000-05-12 | 2006-08-31 | Beth Israel Deaconess Medical Center, Inc. | Compositions and methods for achieving immune suppression |
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- 2003-10-13 JP JP2004543888A patent/JP2006502716A/ja not_active Withdrawn
- 2003-10-13 AU AU2003266903A patent/AU2003266903A1/en not_active Withdrawn
- 2003-10-13 BR BR0315286-3A patent/BR0315286A/pt active Pending
- 2003-10-13 CN CNA2003801014139A patent/CN1705744A/zh not_active Withdrawn
- 2003-10-13 MX MXPA05003912A patent/MXPA05003912A/es not_active Application Discontinuation
- 2003-10-13 WO PCT/CH2003/000665 patent/WO2004035787A2/fr not_active Application Discontinuation
- 2003-10-13 RU RU2005114511/13A patent/RU2005114511A/ru not_active Application Discontinuation
- 2003-10-13 CA CA002502312A patent/CA2502312A1/fr not_active Withdrawn
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|---|---|
| KR20050071579A (ko) | 2005-07-07 |
| WO2004035787A2 (fr) | 2004-04-29 |
| MXPA05003912A (es) | 2005-09-30 |
| AU2003266903A1 (en) | 2004-05-04 |
| BR0315286A (pt) | 2005-08-30 |
| JP2006502716A (ja) | 2006-01-26 |
| CN1705744A (zh) | 2005-12-07 |
| WO2004035787A3 (fr) | 2004-08-26 |
| CA2502312A1 (fr) | 2004-04-29 |
| PL376397A1 (en) | 2005-12-27 |
| EP1556487A2 (fr) | 2005-07-27 |
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