RU2004133322A - Способ модулирования фототоксичности - Google Patents
Способ модулирования фототоксичности Download PDFInfo
- Publication number
- RU2004133322A RU2004133322A RU2004133322/14A RU2004133322A RU2004133322A RU 2004133322 A RU2004133322 A RU 2004133322A RU 2004133322/14 A RU2004133322/14 A RU 2004133322/14A RU 2004133322 A RU2004133322 A RU 2004133322A RU 2004133322 A RU2004133322 A RU 2004133322A
- Authority
- RU
- Russia
- Prior art keywords
- modulator
- alkyl
- carbon atoms
- proline
- compound
- Prior art date
Links
- 206010034972 Photosensitivity reaction Diseases 0.000 title 1
- 208000007578 phototoxic dermatitis Diseases 0.000 title 1
- 231100000018 phototoxicity Toxicity 0.000 title 1
- 230000008832 photodamage Effects 0.000 claims abstract 6
- 102000008186 Collagen Human genes 0.000 claims abstract 2
- 108010035532 Collagen Proteins 0.000 claims abstract 2
- 229920001436 collagen Polymers 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- GRFNBEZIAWKNCO-UHFFFAOYSA-N 3-pyridinol Chemical compound OC1=CC=CN=C1 GRFNBEZIAWKNCO-UHFFFAOYSA-N 0.000 claims 4
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 3
- 229960002429 proline Drugs 0.000 claims 3
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims 2
- 229960002591 hydroxyproline Drugs 0.000 claims 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- LCYXYLLJXMAEMT-SAXRGWBVSA-N Pyridinoline Chemical compound OC(=O)[C@@H](N)CCC1=C[N+](C[C@H](O)CC[C@H](N)C([O-])=O)=CC(O)=C1C[C@H](N)C(O)=O LCYXYLLJXMAEMT-SAXRGWBVSA-N 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 150000005215 alkyl ethers Chemical class 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- ZORHSASAYVIBLY-AKGZTFGVSA-N methyl (2s)-4-hydroxypyrrolidine-2-carboxylate Chemical compound COC(=O)[C@@H]1CC(O)CN1 ZORHSASAYVIBLY-AKGZTFGVSA-N 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims 1
- 239000002453 shampoo Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 239000011726 vitamin B6 Substances 0.000 claims 1
- 235000019158 vitamin B6 Nutrition 0.000 claims 1
- 229940011671 vitamin b6 Drugs 0.000 claims 1
- 230000006378 damage Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Birds (AREA)
- Ophthalmology & Optometry (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Cosmetics (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
- Medicines Containing Plant Substances (AREA)
- Radiation-Therapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Photovoltaic Devices (AREA)
- Pyridine Compounds (AREA)
Claims (20)
1. Способ модулирования фотопоражения у нуждающегося в этом субъекта, заключающийся в нанесении на кожу указанного субъекта модулятора фотопоражения, достаточное для модуляции фотопоражения, вызванного ультрафиолетовым светом.
2. Способ по п.1, отличающийся тем, что указанный модулятор усиливает фотопоражение.
3. Способ по п.2, отличающийся тем, что указанный модулятор образуется из коллагена.
4. Способ по п.2, отличающийся тем, что указанный модулятор имеет структуру, состоящую из 3-гидроксипиридинового фармакофора.
5. Способ по п.4, отличающийся тем, что указанный модулятор представляет собой N-алкил-3-гидроксипиридин или его соль.
6. Способ по п.5, отличающийся тем, что N-алкил-3-гидроксипиридин или его соль содержат алкильный фрагмент, имеющий 2-20 углеродных атомов.
7. Способ по п.6, отличающийся тем, что алкильный фрагмент представляет собой этильную группу.
8. Способ по п.2, отличающийся тем, что указанный модулятор связан с молекулой носителя.
9. Способ по п.2, отличающийся тем, что указанный модулятор представляет собой витамин В6, пиридинолин или 3-гидроксипиридин.
10. Способ по п.1, отличающийся тем, что указанный модулятор ингибирует фотопоражение.
11. Способ по п.10, отличающийся тем, что указанный модулятор представляет собой пролин, 4-гидроксипролин или его алкиловый эфир.
12. Способ по п.11, отличающийся тем, что алкиловый эфир пролина содержит алкильный фрагмент, включающий 1-24 углеродных атома.
13. Способ по п.12, отличающийся тем, что алкиловый эфир пролина представляет собой L-пролин-ОСН3 или 4-ОН-L-ОСН3.
14. Способ по п.1, заключающийся в нанесении указанного модулятора в виде крема, лосьона, шампуня, спрея или пластыря.
15. Соединение алкиловый эфир 4-гидрокси-L-пролина, имеющий алкильную цепь, состоящую из 1-24 углеродных атомов.
16. Соединение по п.15, величина log P которого составляет, примерно, от -1.00 до +8.00.
17. Соединение по п.15, отличающееся тем, что алкильная цепь содержит 1-10 углеродных атомов.
18. Соединение по п.15, отличающееся тем, что алкильная цепь содержит 16-22 углеродных атома.
19. Соединение по п.15, отличающееся тем, что алкильная цепь содержит 11-24 углеродных атома.
20. Соединение по п.15, представляющее метиловый эфир 4-гидрокси-L-пролина.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37403302P | 2002-04-19 | 2002-04-19 | |
| US60/374,033 | 2002-04-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2004133322A true RU2004133322A (ru) | 2005-08-10 |
| RU2301800C2 RU2301800C2 (ru) | 2007-06-27 |
Family
ID=29251125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004133322/04A RU2301800C2 (ru) | 2002-04-19 | 2003-04-17 | Способ модулирования фототоксичности |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US6992071B2 (ru) |
| EP (1) | EP1496891B1 (ru) |
| JP (2) | JP4527405B2 (ru) |
| CN (1) | CN1298321C (ru) |
| AT (1) | ATE516802T1 (ru) |
| AU (1) | AU2003234119B2 (ru) |
| CA (2) | CA2482320C (ru) |
| CY (1) | CY1112194T1 (ru) |
| DK (1) | DK1496891T3 (ru) |
| ES (1) | ES2367258T3 (ru) |
| HK (1) | HK1077761B (ru) |
| IL (2) | IL164560A0 (ru) |
| MX (1) | MXPA04010228A (ru) |
| NZ (1) | NZ535982A (ru) |
| PT (1) | PT1496891E (ru) |
| RU (1) | RU2301800C2 (ru) |
| WO (1) | WO2003088909A2 (ru) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA04010228A (es) * | 2002-04-19 | 2005-06-08 | Univ Arizona | Metodos para modular la fotoxicidad. |
| WO2009112360A1 (en) * | 2008-03-10 | 2009-09-17 | Basf Se | Encapsulated phase change materials in seed coatings |
| CN102365086A (zh) * | 2009-03-30 | 2012-02-29 | 株式会社资生堂 | 紫外线损伤减轻用组合物 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4310461A (en) * | 1980-06-23 | 1982-01-12 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
| US4902684A (en) * | 1988-06-20 | 1990-02-20 | E. R. Squibb & Sons, Inc. | Benzazepine and benzothiazepine derivatives |
| US6309440B1 (en) * | 1998-08-25 | 2001-10-30 | Thomas T. Yamashita | Method and composition for promoting and controlling growth of plants |
| US5208249A (en) * | 1992-08-20 | 1993-05-04 | Clintec Nutrition Co. | Method for stimulating intracellular synthesis of glutathione using esters of L-2-oxothiazolidine-4-carboxylate |
| JPH0797322A (ja) * | 1993-09-29 | 1995-04-11 | Shiseido Co Ltd | 一重項酸素消去剤 |
| US5681554A (en) * | 1995-06-28 | 1997-10-28 | Cosmair, Inc. | Composition for treating hair and method for using the same |
| US6013250A (en) * | 1995-06-28 | 2000-01-11 | L'oreal S. A. | Composition for treating hair against chemical and photo damage |
| JP2961074B2 (ja) * | 1995-09-06 | 1999-10-12 | 明治製菓株式会社 | 光化学療法用の新生血管閉塞剤 |
| JPH09249567A (ja) * | 1996-01-12 | 1997-09-22 | Otsuka Pharmaceut Co Ltd | 医薬組成物 |
| DE69726144T9 (de) * | 1996-05-07 | 2004-09-09 | Bernstein, Eric F. | Topische verwendung von tempol zur vorbeugung der lichtalterung |
| US20010056085A1 (en) * | 1996-07-09 | 2001-12-27 | Avner Ramu | Methods of using vesicant drug formulations |
| US6274564B1 (en) * | 1996-09-18 | 2001-08-14 | William J. Sarill | Compositions of cobalamin and related corrinoids, and uses thereof |
| CA2285343A1 (en) * | 1997-03-31 | 1998-10-08 | Wakamoto Pharmaceutical Co., Ltd. | Biphenyl derivatives and medicinal compositions |
| US6103487A (en) * | 1997-08-27 | 2000-08-15 | Merck & Co., Inc. | Method of treating cancer |
| FR2775595B1 (fr) * | 1998-03-09 | 2000-05-05 | Seppic Sa | Composition synergique comprenant un compose a structure lipoaminoacide et un extrait de menuphar |
| JPH11255715A (ja) * | 1998-03-13 | 1999-09-21 | Kao Corp | Ｎ，ｎ−ジ置換アニリン誘導体 |
| US20020006418A1 (en) * | 1998-10-13 | 2002-01-17 | John Kung | Composition to enhance permeation of topical skin agents |
| FR2792650B1 (fr) * | 1999-04-20 | 2003-02-28 | Oreal | Equivalent de peau agee, son procede de preparation et son utilisation |
| WO2000066599A1 (en) * | 1999-04-30 | 2000-11-09 | Oberthuer Walter | Antioxidative vitamin b6 analogs |
| JP2002543129A (ja) * | 1999-05-05 | 2002-12-17 | メルク エンド カムパニー インコーポレーテッド | 抗微生物剤としての新規なプロリン類 |
| US20020006394A1 (en) * | 2000-02-11 | 2002-01-17 | Redmond Robert W. | Photochemical tissue bonding |
| US6464992B2 (en) * | 2000-04-14 | 2002-10-15 | University Of Kentucky Research Foundation | Topical micronutrient delivery system and uses thereof |
| US20030185864A1 (en) * | 2000-07-19 | 2003-10-02 | Asako Kobayashi | Preventives or remedies for atopic dermatitis |
| JP2002128651A (ja) * | 2000-10-25 | 2002-05-09 | Kose Corp | 光老化抑制剤およびそれを含有することを特徴とする皮膚外用剤 |
| CA2436300A1 (en) * | 2001-02-05 | 2002-08-15 | L. Stephen Buchanan | Multi-tapered dental files |
| MXPA04010228A (es) * | 2002-04-19 | 2005-06-08 | Univ Arizona | Metodos para modular la fotoxicidad. |
| DE102005000868A1 (de) * | 2004-10-15 | 2006-04-20 | Henkel Kgaa | Zusammensetzungen mit Inhibitoren der Prostaglandin- und/oder Leukotrien-Synthese in Kombination mit Stimulatoren der Freisetzung kutaner Neuromediatoren |
-
2003
- 2003-04-17 MX MXPA04010228A patent/MXPA04010228A/es active IP Right Grant
- 2003-04-17 ES ES03728425T patent/ES2367258T3/es not_active Expired - Lifetime
- 2003-04-17 NZ NZ535982A patent/NZ535982A/en not_active IP Right Cessation
- 2003-04-17 CN CNB038087766A patent/CN1298321C/zh not_active Expired - Fee Related
- 2003-04-17 PT PT03728425T patent/PT1496891E/pt unknown
- 2003-04-17 WO PCT/US2003/011842 patent/WO2003088909A2/en active Application Filing
- 2003-04-17 US US10/418,629 patent/US6992071B2/en not_active Expired - Lifetime
- 2003-04-17 RU RU2004133322/04A patent/RU2301800C2/ru not_active IP Right Cessation
- 2003-04-17 AU AU2003234119A patent/AU2003234119B2/en not_active Ceased
- 2003-04-17 CA CA2482320A patent/CA2482320C/en not_active Expired - Fee Related
- 2003-04-17 CA CA2668311A patent/CA2668311C/en not_active Expired - Fee Related
- 2003-04-17 DK DK03728425.4T patent/DK1496891T3/da active
- 2003-04-17 EP EP03728425A patent/EP1496891B1/en not_active Expired - Lifetime
- 2003-04-17 AT AT03728425T patent/ATE516802T1/de active
- 2003-04-17 JP JP2003585662A patent/JP4527405B2/ja not_active Expired - Fee Related
-
2004
- 2004-09-09 US US10/937,537 patent/US20050042188A1/en not_active Abandoned
- 2004-10-13 IL IL16456004A patent/IL164560A0/xx unknown
-
2005
- 2005-09-13 US US11/226,615 patent/US7226937B2/en not_active Expired - Lifetime
-
2006
- 2006-01-05 HK HK06100235.9A patent/HK1077761B/zh not_active IP Right Cessation
-
2010
- 2010-02-15 IL IL203968A patent/IL203968A/en active IP Right Grant
- 2010-04-28 JP JP2010103731A patent/JP5244150B2/ja not_active Expired - Lifetime
-
2011
- 2011-10-14 CY CY20111100977T patent/CY1112194T1/el unknown
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