RU2003131696A - TRANSGENIC PLANTS EXPRESSING THERAPEUTICALLY ACTIVE PROTEINS - Google Patents

TRANSGENIC PLANTS EXPRESSING THERAPEUTICALLY ACTIVE PROTEINS Download PDF

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RU2003131696A
RU2003131696A RU2003131696/13A RU2003131696A RU2003131696A RU 2003131696 A RU2003131696 A RU 2003131696A RU 2003131696/13 A RU2003131696/13 A RU 2003131696/13A RU 2003131696 A RU2003131696 A RU 2003131696A RU 2003131696 A RU2003131696 A RU 2003131696A
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plant
protein
plant according
antigen
allergen
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RU2003131696/13A
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Russian (ru)
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Бернард ХЕЙФЕТЦ Питер (US)
Бернард ХЕЙФЕТЦ Питер
Артур ГОФФ Стивен (US)
Артур ГОФФ Стивен
Блум ТАТТЛ Анимари (US)
Блум ТАТТЛ Анимари
Эльзе ГРИОТ-ВЕНК Моника (CH)
Эльзе ГРИОТ-ВЕНК Моника
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Зингента Партисипейшнс Аг (Ch)
Зингента Партисипейшнс Аг
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Publication of RU2003131696A publication Critical patent/RU2003131696A/en

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H5/00—Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8214—Plastid transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Claims (42)

1. Растение, в пластидный геном которого включена молекула ДНК, кодирующая протеин, который является терапевтически активным при введении хозяину, нуждающемуся в этом, в терапевтически эффективном количестве, где растение обладает способностью экспрессировать указанный протеин.1. A plant in the plastid genome of which is included a DNA molecule encoding a protein that is therapeutically active when administered to a host in need thereof, in a therapeutically effective amount, where the plant has the ability to express said protein. 2. Растение по п.1, где протеин вводят хозяину перорально.2. The plant according to claim 1, where the protein is administered to the host orally. 3. Растение по п.1, где протеин представляет собой антиген.3. The plant according to claim 1, where the protein is an antigen. 4. Растение по п.3, где антиген обладает способностью подавлять или снижать иммунный ответ или воспалительное состояние у указанного хозяина, вызванные антигеном.4. The plant according to claim 3, where the antigen has the ability to suppress or reduce the immune response or inflammatory condition in the specified host, caused by the antigen. 5. Растение по п.4, где антиген представляет собой аллерген.5. The plant according to claim 4, where the antigen is an allergen. 6. Растение по п.5, где аллерген представляет собой ингаляционный аллерген.6. The plant according to claim 5, where the allergen is an inhaled allergen. 7. Растение по п.5, где аллерген представляет собой аллерген пыльцы.7. The plant according to claim 5, where the allergen is a pollen allergen. 8. Растение по п.7, где аллерген пыльцы выбирают из группы, включающей аллергены амброзии Amb a I, Amb a I.1, Amb t V и Amb a II, аллерген ольхи Ain g I, аллерген лещины Cor a I, аллерген плевела Lol p V, аллерген джонсоновой травы Sor h I и аллерген березы Bet v I.8. The plant according to claim 7, where the pollen allergen is selected from the group comprising ragweed allergens Amb a I, Amb a I.1, Amb t V and Amb a II, Alder allergen Ain g I, Hazelnut allergen Cor a I, allergen chaff Lol p V, Johnson grass allergen Sor h I and birch allergen Bet v I. 9. Растение по п.5, где антиген выбирают из группы, включающей кошачий антиген Fel d I, собачий аллерген Can f II, аллергены комаров rAed a 1 и rAed а 2, аллергены клещей Der f I, Der f II, Der p I и Der p II, пептид аллергена яда пчелы PLA-2 и протеины мышиной мочи.9. The plant according to claim 5, where the antigen is selected from the group comprising feline antigen Fel d I, canine allergy Can f II, mosquito allergens rAed a 1 and rAed a 2, tick allergens Der f I, Der f II, Der p I and Der p II, PLA-2 bee venom allergen peptide and murine urine proteins. 10. Растение по п.3, где антиген представляет собой аутоантиген.10. The plant according to claim 3, where the antigen is an autoantigen. 11. Растение по 10, где аутоантиген, выбирают из группы, включающей коллаген, основной протеин миелина, протеолипидный протеин миелина, протеин, связывающий внутренний фоторецептор, ацетилхолиновый рецептор, S-антиген, инсулин, дегидрогеназа глутаминовой кислоты, антиген, специфичный для клеток островка, и тироглобулин.11. The plant of 10, where the autoantigen is selected from the group comprising collagen, basic myelin protein, myelin proteolipid protein, internal photoreceptor binding protein, acetylcholine receptor, S-antigen, insulin, glutamic acid dehydrogenase, islet-specific antigen, and thyroglobulin. 12. Растение по п.3, где антиген представляет собой связанный с трансплантацией антиген.12. The plant according to claim 3, where the antigen is an antigen associated with transplantation. 13. Растение по п.12, где связанный с трансплантацией антиген представляет собой протеин МНС.13. The plant of claim 12, wherein the transplant associated antigen is an MHC protein. 14. Растение по п.12, где связанный с трансплантацией антиген представляет собой протеин МНС класса II.14. The plant of claim 12, wherein the transplant-associated antigen is a MHC class II protein. 15. Растение по п.12, где связанный с трансплантацией антиген представляет собой а- или b-цепь МНС класса II.15. The plant of claim 12, wherein the transplant-associated antigen is an a- or b-chain of MHC class II. 16. Растение по п.3, где антиген происходит из патогена, причем, антиген обладает способностью иммунизировать хозяина в отношении патогена.16. The plant according to claim 3, where the antigen comes from a pathogen, moreover, the antigen has the ability to immunize the host against the pathogen. 17. Растение по п.1, где протеин представляет собой протеин крови, гормон, фактор роста, цитокин, фермент, рецептор, связывающий протеин, протеин иммунной системы, фактор трансляции или транскрипции, онкопротеин или протоонкопротеин, протеин молока, мышечный протеин, миелопротеин, нейроактивный пептид или протеин, подавляющий рост опухоли.17. The plant according to claim 1, where the protein is a blood protein, hormone, growth factor, cytokine, enzyme, receptor, binding protein, protein of the immune system, translation or transcription factor, oncoprotein or protonocoprotein, milk protein, muscle protein, myeloprotein, neuroactive peptide or protein that inhibits tumor growth. 18. Растение по п.1, где протеин представляет собой антисептический пептид.18. The plant according to claim 1, where the protein is an antiseptic peptide. 19. Растение по п.18, где антисептический пептид представляет собой бактерицидный, повышающий проницаемость протеин.19. The plant according to p, where the antiseptic peptide is a bactericidal, increases the permeability of the protein. 20. Растение по п.1, где протеин иммунной системы представляет собой антитело.20. The plant according to claim 1, where the protein of the immune system is an antibody. 21. Растение по п.1, где молекула ДНК функционально связана с промотором, обладающим способностью обеспечивать экспрессию молекулы ДНК в пластидах растения.21. The plant according to claim 1, where the DNA molecule is operably linked to a promoter having the ability to provide expression of the DNA molecule in the plastids of the plant. 22. Растение по п.21, где промотор представляет собой промотор с1рР.22. The plant of claim 21, wherein the promoter is a c1pP promoter. 23. Растение по п.21, где промотор представляет собой промотор гена 16S-рРНК.23. The plant according to item 21, where the promoter is a promoter of the 16S-rRNA gene. 24. Растение по п.21, где промотор представляется собой регулируемый трансактиватором промотор.24. The plant according to item 21, where the promoter is a transactivator-regulated promoter. 25. Растение по п.24, где регулируемый трансактиватором промотор представляет собой промотор гена 10 фага Т7.25. The plant according to paragraph 24, where the transactivator-controlled promoter is a promoter of the 10 phage T7 gene. 26. Растение по п.24, дополнительно включающее гетерологичную ядерную кассету экспрессии, содержащую последовательность ДНК, кодирующую трансактиватор.26. The plant according to paragraph 24, further comprising a heterologous nuclear expression cassette containing a DNA sequence encoding a transactivator. 27. Растение по п.25, где трансактиватор представляет собой полимеразу фага Т7.27. The plant of claim 25, wherein the transactivator is a T7 phage polymerase. 28. Растение, в ядерный геном которого включена молекула ДНК-, кодирующая протеин, который является терапевтически активным при введении хозяину, нуждающемуся в этом, в терапевтически эффективном количестве, где терапевтически активный протеин выбирают из группы, включающей аллергены28. A plant whose nuclear genome includes a DNA molecule encoding a protein that is therapeutically active when administered to a host in need thereof, in a therapeutically effective amount, wherein the therapeutically active protein is selected from the group consisting of allergens комаров rAed a 1 и rAed a 2, бактерицидный, повышающий проницаемость протеин (BPI) и аллергены пыльцы Amb a I, Amb a I.1, Amb t V, Amb a II, Ain g I, Cor a I, Lol p V, Sor h I и Bet v I.mosquitoes rAed a 1 and rAed a 2, a bactericidal permeability increasing protein (BPI) and pollen allergens Amb a I, Amb a I.1, Amb t V, Amb a II, Ain g I, Cor a I, Lol p V, Sor h I and Bet v I. 29. Растение, в ядерный геном которого включена молекула ДНК, кодирующая протеин, который является терапевтически активным при введении хозяину, нуждающемуся в этом, в терапевтически эффективном количестве, где терапевтически активный протеин направленно переносится в субклеточную органеллу растения.29. A plant whose nuclear genome includes a DNA molecule encoding a protein that is therapeutically active when administered to a host in need thereof, in a therapeutically effective amount, where the therapeutically active protein is directed into the subcellular organelle of the plant. 30. Растение по п.29, где субклеточная органелла представляет собой вакуоль.30. The plant according to clause 29, where the subcellular organelle is a vacuole. 31. Растение по любому из пп.1 или 28-30, где растение представляет собой двудольное растение.31. The plant according to any one of claims 1 or 28-30, where the plant is a dicotyledonous plant. 32. Растение по п.31, где растение представляет собой табак, томаты, сою или шпинат.32. The plant according to p, where the plant is a tobacco, tomatoes, soy or spinach. 33. Растение по любому из пп.1 или 28-30, где растение представляет собой однодольное растение.33. The plant according to any one of claims 1 or 28-30, where the plant is a monocotyledonous plant. 34. Растение по п.33, где растение представляет собой кукурузу или рис.34. The plant according to p. 33, where the plant is a corn or rice. 35. Растение по любому из п.31 или 33, где растение представляет собой съедобное растение.35. The plant according to any one of p or 33, where the plant is an edible plant. 36. Растение по любому из пп.1 или 28-30, где экспрессия протеина в растение является химически регулируемой.36. The plant according to any one of claims 1 or 28-30, where the expression of the protein in the plant is chemically regulated. 37. Растение по любому из пп.1 или 28-30, где экспрессия протеина в растение является конститутивной.37. The plant according to any one of claims 1 or 28-30, where the expression of the protein in the plant is constitutive. 38. Растение по любому из пп.1 или 28-30, где экспрессия протеина в растение является тканеспецифичной.38. The plant according to any one of claims 1 or 28-30, where the expression of the protein in the plant is tissue-specific. 39. Растение по любому из пп.1 или 28-30, где хозяин представляет собой позвоночное животное.39. The plant according to any one of claims 1 or 28-30, where the host is a vertebrate. 40. Растение по п.39, где позвоночное животное представляет собой млекопитающее.40. The plant according to § 39, where the vertebrate is a mammal. 41. Растение по п.40, где млекопитающее представляет собой человека, корову, овцу, свинью, собаку или кошку.41. The plant of claim 40, wherein the mammal is a human, cow, sheep, pig, dog or cat. 42. Растение, включающее растительную клетку, содержащую пластиду, включающую пластидный трансформирующий вектор, включающий молекулу ДНК, кодирующую протеин, который является терапевтически активным при введении хозяину, где молекула ДНК функционально связана с промотором, который обладает способностью обеспечивать экспрессию молекулы ДНК в пластиде растения, а растительная клетка обладает способностью продуцировать протеин.42. A plant comprising a plant cell containing a plastid comprising a plastid transforming vector comprising a DNA molecule encoding a protein that is therapeutically active when administered to a host, where the DNA molecule is operably linked to a promoter that is capable of expressing the DNA molecule in the plant plastid, and a plant cell has the ability to produce protein.
RU2003131696/13A 1998-10-07 2003-10-27 TRANSGENIC PLANTS EXPRESSING THERAPEUTICALLY ACTIVE PROTEINS RU2003131696A (en)

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US16823198A 1998-10-07 1998-10-07
US16736298A 1998-10-07 1998-10-07
US09/168,231 1998-10-07
US09/167,362 1998-10-07

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