BR9915919A - Therapeutically active proteins in plants - Google Patents
Therapeutically active proteins in plantsInfo
- Publication number
- BR9915919A BR9915919A BR9915919-8A BR9915919A BR9915919A BR 9915919 A BR9915919 A BR 9915919A BR 9915919 A BR9915919 A BR 9915919A BR 9915919 A BR9915919 A BR 9915919A
- Authority
- BR
- Brazil
- Prior art keywords
- plants
- therapeutically active
- active proteins
- host
- present
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 230000009261 transgenic effect Effects 0.000 abstract 2
- 230000006806 disease prevention Effects 0.000 abstract 1
- 210000002706 plastid Anatomy 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- 210000003934 vacuole Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H5/00—Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8214—Plastid transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Botany (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Environmental Sciences (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Ophthalmology & Optometry (AREA)
- Physiology (AREA)
- Developmental Biology & Embryology (AREA)
- Pain & Pain Management (AREA)
Abstract
Patente de Invenção:<B>''PROTEìNAS TERAPEUTICAMENTE ATIVAS EM PLANTAS''<D>. A presente invenção descreve plantas transgênicas expressando proteínas terapeuticamente ativas, preferivelmente de seu genoma de plastídeo ou objetivado ao vacúolo. A presente invenção também descreve a administração de tais plantas transgênicas a um hospedeiro em necessidade disso para a prevenção de tratamento de doenças. Em uma modalidade preferida, tais plantas ou matérias derivadas de tais plantas são administradas oralmente a um hospedeiro.Invention Patent: <B> '' THERAPEUTICALLY ACTIVE PROTEINS IN PLANTS '' <D>. The present invention describes transgenic plants expressing therapeutically active proteins, preferably from their plastid genome or targeting the vacuole. The present invention also describes the administration of such transgenic plants to a host in need of it for the prevention of disease treatment. In a preferred embodiment, such plants or materials derived from such plants are administered orally to a host.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16736298A | 1998-10-07 | 1998-10-07 | |
US16823198A | 1998-10-07 | 1998-10-07 | |
PCT/EP1999/007414 WO2000020612A2 (en) | 1998-10-07 | 1999-10-05 | Therapeutically active proteins in plants |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9915919A true BR9915919A (en) | 2001-08-21 |
Family
ID=26863095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9915919-8A BR9915919A (en) | 1998-10-07 | 1999-10-05 | Therapeutically active proteins in plants |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP1117817A2 (en) |
JP (1) | JP2002526116A (en) |
KR (1) | KR20010085901A (en) |
CN (1) | CN1330718A (en) |
AR (1) | AR020717A1 (en) |
AU (2) | AU758817B2 (en) |
BR (1) | BR9915919A (en) |
CA (1) | CA2344269A1 (en) |
HU (1) | HUP0103616A3 (en) |
IL (1) | IL142041A0 (en) |
PL (1) | PL347904A1 (en) |
RU (2) | RU2001111881A (en) |
TR (1) | TR200101032T2 (en) |
WO (1) | WO2000020612A2 (en) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050032211A1 (en) * | 1996-09-26 | 2005-02-10 | Metabogal Ltd. | Cell/tissue culturing device, system and method |
IL155588A0 (en) * | 2003-04-27 | 2003-11-23 | Metabogal Ltd | Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby |
US7361331B2 (en) | 1996-10-18 | 2008-04-22 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food | Plant bioreactors |
WO2001007590A2 (en) * | 1999-07-27 | 2001-02-01 | Syngenta Participations Ag | Chimeric genes for plastid expression |
US7572466B1 (en) | 1999-10-13 | 2009-08-11 | Health Research, Inc. | Oral immunology using plant product containing a non-enteric pathogen antigen |
EP1268832A4 (en) * | 2000-02-29 | 2003-04-02 | Univ Auburn | Production of antibodies in transgenic plastids |
WO2001077353A2 (en) * | 2000-04-05 | 2001-10-18 | Syngenta Participations Ag | Expression of pollen allergens in plastids |
FR2809413B1 (en) * | 2000-05-29 | 2004-10-22 | Tabacs & Allumettes Ind | PRODUCTION OF RECOMBINANT ALLERGENS IN PLANT CELLS |
JP2002017186A (en) * | 2000-06-30 | 2002-01-22 | Hayashibara Biochem Lab Inc | Transgenic plant |
GB2364705A (en) * | 2000-07-14 | 2002-02-06 | Icgeb | Fusion protein expression in plastids |
DK1311696T3 (en) | 2000-08-11 | 2012-10-22 | Syngenta Participations Ag | Methods for stable transformation of plants |
WO2002083072A2 (en) * | 2001-04-13 | 2002-10-24 | Boyce Thompson Institute For Plant Research | Methods and compositions for stable transgenic plant pharmaceuticals and their use as contraceptives |
MXPA04010432A (en) * | 2002-04-23 | 2005-05-27 | Scripps Research Inst | Expression of polypeptides in chloroplasts, and compositions and methods for expressing same. |
FR2841906B1 (en) * | 2002-07-05 | 2006-08-18 | Stallergenes Sa | NUCLEIC ACID MOLECULE ENCODING AN ALLERGENE PREPROPROTEIN OF A MITER OF THE GENUS DERMATOPHAGOIDES OR EUROGLYPHUS AND USE THEREOF FOR THE PRODUCTION OF SAID ALLERGEN IN PLANTS |
PT1554387E (en) | 2002-10-15 | 2012-05-02 | Syngenta Participations Ag | Plastid transformation |
EP2192172B1 (en) | 2003-02-03 | 2014-12-03 | iBio, Inc. | System for expression of genes in plants |
AU2004213554A1 (en) * | 2003-02-18 | 2004-09-02 | Syngenta Participations Ag | Expression in plants of antibodies against enterotoxigenic escherichia coli |
GB0307989D0 (en) * | 2003-04-07 | 2003-05-14 | Mcewen Lab Ltd | Therapeutic composition |
US7951557B2 (en) | 2003-04-27 | 2011-05-31 | Protalix Ltd. | Human lysosomal proteins from plant cell culture |
ES2427641T3 (en) | 2003-05-22 | 2013-10-31 | Ibio, Inc. | Recombinant vehicle molecule for expression, delivery and purification of target polypeptides |
US8455717B2 (en) | 2004-09-29 | 2013-06-04 | Collplant Ltd. | Collagen producing plants and methods of generating and using same |
CA2615218A1 (en) * | 2005-07-18 | 2007-01-25 | Protalix Ltd. | Mucosal or enteral administration of biologically active macromolecules |
AU2012241058B2 (en) * | 2005-07-18 | 2014-04-17 | Protalix Ltd. | Mucosal or Enteral Administration of Biologically Active Macromolecules |
CA2616859C (en) | 2005-08-03 | 2015-04-14 | Fraunhofer Usa, Inc. | Compositions and methods for production of immunoglobulins |
EP1984405A4 (en) | 2006-02-13 | 2010-06-30 | Fraunhofer Usa Inc | Influenza antigens, vaccine compositions, and related methods |
GB0604966D0 (en) | 2006-03-11 | 2006-04-19 | Renovo Ltd | Medicaments and proteins |
GB0604964D0 (en) | 2006-03-11 | 2006-04-19 | Renovo Ltd | Protein folding |
GB0604938D0 (en) | 2006-03-11 | 2006-04-19 | Renovo Ltd | Proteins, nucleic acids and medicaments |
GB0617816D0 (en) * | 2006-09-11 | 2006-10-18 | Renovo Ltd | Nucleic acids and methods of protein expression |
SI2150608T1 (en) | 2007-05-07 | 2018-04-30 | Protalix Ltd. | Large scale disposable bioreactor |
GB2449466B (en) * | 2007-05-23 | 2009-11-18 | Algentech Ltd | Production of proteins in plant tissue |
CA2692933C (en) | 2007-07-11 | 2016-10-18 | Fraunhofer Usa, Inc. | Yersinia pestis antigens, vaccine compositions, and related methods |
WO2009058355A2 (en) * | 2007-10-31 | 2009-05-07 | University Of Central Florida Research Foundation, Inc. | Chloroplast-derived human vaccine antigens against malaria |
MX2011000047A (en) * | 2008-06-30 | 2011-06-16 | Orf Liftaekni Hf | Use of plant-derived recombinant growth factors in skin care. |
US8734803B2 (en) | 2008-09-28 | 2014-05-27 | Ibio Inc. | Humanized neuraminidase antibody and methods of use thereof |
WO2010061404A1 (en) * | 2008-11-27 | 2010-06-03 | International Centre For Genetic Engineering And Biotechnology | A method of expressing foreign protein in plastids |
US9551005B2 (en) * | 2009-07-16 | 2017-01-24 | Kenneth John Piller | Immunoassay for detecting thyroglobulin utilizing soybean produced recombinant thyroglobulin |
CA2776144C (en) | 2009-09-29 | 2020-10-27 | Fraunhofer Usa, Inc. | Influenza hemagglutinin antibodies, compositions, and related methods |
EP2501219B1 (en) * | 2009-11-18 | 2017-08-09 | Agriculture Victoria Services Pty Ltd | Angiogenin expression in plants |
US11673926B2 (en) | 2011-06-07 | 2023-06-13 | Ibio, Inc. | In vivo de-glycosylation of recombinant proteins by co-expression with PNGase F |
JP2013040138A (en) * | 2011-08-17 | 2013-02-28 | Univ Of Tsukuba | Method of producing activated recombinant pollen allergen |
CN108929855A (en) | 2012-08-23 | 2018-12-04 | 特郎萨格以色列有限公司 | Transgenic Microalgae and its purposes for being used for oral delivery protein |
CA2935635C (en) | 2014-02-12 | 2023-05-09 | Transalgae Israel Ltd. | Algal based edible vaccines |
AU2015261440A1 (en) | 2014-05-14 | 2017-01-05 | Barbara BURWINKEL | Synthesis of double-stranded nucleic acids |
FR3021328B1 (en) * | 2014-05-23 | 2018-01-05 | Angany Inc. | COMMERCIAL PRODUCTION OF ALLERGEN AMB A1 BY TRANSIENT EXPRESSION IN PLANTS |
CN104561353B (en) * | 2015-01-29 | 2017-01-11 | 中国农业科学院蔬菜花卉研究所 | InDel marker in close linkage with cabbage fertility as well as detection method and application of InDel marker |
EP3432902A4 (en) * | 2016-03-20 | 2019-08-28 | The Trustees of The University of Pennsylvania | Codon optimization and ribosome profiling for increasing transgene expression in chloroplasts of higher plants |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5451513A (en) * | 1990-05-01 | 1995-09-19 | The State University of New Jersey Rutgers | Method for stably transforming plastids of multicellular plants |
GB9319429D0 (en) * | 1993-09-21 | 1993-11-03 | London Health Ass | Methods and products for controlling immune responses in mammals |
US5576198A (en) * | 1993-12-14 | 1996-11-19 | Calgene, Inc. | Controlled expression of transgenic constructs in plant plastids |
FR2736930B1 (en) * | 1995-07-17 | 1997-09-19 | Biocem | PROCESS FOR THE PRODUCTION, BY PLANT CELLS, OF HEMINIC PROTEINS, PROTEINS THUS OBTAINED AND PRODUCTS CONTAINING THE SAME |
WO1997004123A1 (en) * | 1995-07-19 | 1997-02-06 | Gel Tech Group Inc. | Collagen compound production in plants |
ZA965786B (en) * | 1995-07-19 | 1997-01-27 | Kimberly Clark Co | Nonwoven barrier and method of making the same |
WO1997006250A1 (en) * | 1995-08-10 | 1997-02-20 | Rutgers University | Nuclear-encoded transcription system in plastids of higher plants |
DE69733881T2 (en) * | 1996-03-06 | 2006-05-24 | Rutgers University | PLASTIC TRANSFORMATION IN ARABIDOPSIS THALIANA |
BR9713462A (en) * | 1996-08-09 | 2000-03-28 | Calgene Inc | Methods for producing carotenoid compounds and special oils in plant seeds. |
EP0939826A2 (en) * | 1996-08-15 | 1999-09-08 | Agrivax Incorporated | Delivery of tolerogenic antigens via edible plants or plant-derived products |
AU728348B2 (en) * | 1996-09-12 | 2001-01-04 | Syngenta Participations Ag | Transgenic plants expressing cellulolytic enzymes |
JP2002513283A (en) * | 1997-01-17 | 2002-05-08 | ザ スクリップス リサーチ インスティテュート | RNA binding proteins and binding sites useful for expression of recombinant molecules |
JP2002524023A (en) * | 1997-08-07 | 2002-08-06 | オーバーン・ユニバーシティ | Universal chloroplast integration and expression vector, transformed plant and product thereof |
JP2002520019A (en) * | 1998-07-10 | 2002-07-09 | カルジーン エルエルシー | Expression of eukaryotic peptides in plant plastids |
-
1999
- 1999-10-05 AR ARP990105036A patent/AR020717A1/en unknown
- 1999-10-05 PL PL99347904A patent/PL347904A1/en not_active Application Discontinuation
- 1999-10-05 AU AU63340/99A patent/AU758817B2/en not_active Ceased
- 1999-10-05 EP EP99950626A patent/EP1117817A2/en not_active Withdrawn
- 1999-10-05 KR KR1020017004448A patent/KR20010085901A/en not_active Application Discontinuation
- 1999-10-05 CA CA002344269A patent/CA2344269A1/en not_active Abandoned
- 1999-10-05 JP JP2000574707A patent/JP2002526116A/en active Pending
- 1999-10-05 CN CN99813154A patent/CN1330718A/en active Pending
- 1999-10-05 RU RU2001111881/13A patent/RU2001111881A/en not_active Application Discontinuation
- 1999-10-05 BR BR9915919-8A patent/BR9915919A/en not_active IP Right Cessation
- 1999-10-05 IL IL14204199A patent/IL142041A0/en unknown
- 1999-10-05 HU HU0103616A patent/HUP0103616A3/en unknown
- 1999-10-05 WO PCT/EP1999/007414 patent/WO2000020612A2/en not_active Application Discontinuation
- 1999-10-05 TR TR2001/01032T patent/TR200101032T2/en unknown
-
2003
- 2003-01-15 AU AU2003200126A patent/AU2003200126A1/en not_active Abandoned
- 2003-10-27 RU RU2003131696/13A patent/RU2003131696A/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PL347904A1 (en) | 2002-04-22 |
AU2003200126A1 (en) | 2003-04-17 |
WO2000020612A3 (en) | 2000-07-06 |
RU2003131696A (en) | 2005-04-20 |
AR020717A1 (en) | 2002-05-22 |
IL142041A0 (en) | 2002-03-10 |
AU758817B2 (en) | 2003-04-03 |
HUP0103616A2 (en) | 2002-01-28 |
EP1117817A2 (en) | 2001-07-25 |
HUP0103616A3 (en) | 2003-07-28 |
TR200101032T2 (en) | 2001-10-22 |
RU2001111881A (en) | 2003-06-20 |
KR20010085901A (en) | 2001-09-07 |
JP2002526116A (en) | 2002-08-20 |
AU6334099A (en) | 2000-04-26 |
CN1330718A (en) | 2002-01-09 |
WO2000020612A2 (en) | 2000-04-13 |
AU2003200126A9 (en) | 2003-04-17 |
CA2344269A1 (en) | 2000-04-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1942 DE 25/03/2008. |