AR020717A1 - THERAPEUTICALLY ACTIVE PROTEINS IN PLANTS. - Google Patents

THERAPEUTICALLY ACTIVE PROTEINS IN PLANTS.

Info

Publication number
AR020717A1
AR020717A1 ARP990105036A ARP990105036A AR020717A1 AR 020717 A1 AR020717 A1 AR 020717A1 AR P990105036 A ARP990105036 A AR P990105036A AR P990105036 A ARP990105036 A AR P990105036A AR 020717 A1 AR020717 A1 AR 020717A1
Authority
AR
Argentina
Prior art keywords
plants
therapeutically active
active proteins
host
transgenic plants
Prior art date
Application number
ARP990105036A
Other languages
Spanish (es)
Original Assignee
Syngenta Participations Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngenta Participations Ag filed Critical Syngenta Participations Ag
Publication of AR020717A1 publication Critical patent/AR020717A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H5/00—Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8214—Plastid transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Environmental Sciences (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pain & Pain Management (AREA)

Abstract

Plantas transgénicas que expresan proteínas terapéuticamente activas, de preferencia a partir de su genoma de plástido, o dirigidas hacia la vacuola. Laadministracion de estas plantas transgénicas a un hospedero que lo necesite, para la prevencion oel tratamiento de enfermedades. En una modalidad preferida,estas plantas o materia derivada a partir de estas plantas, se administran oralmente a un hospedero. Metodo de transformacion, vector y producto alimenticio.Transgenic plants that express therapeutically active proteins, preferably from their plastid genome, or directed towards the vacuole. The administration of these transgenic plants to a host that needs it, for the prevention or treatment of diseases. In a preferred embodiment, these plants or matter derived from these plants are administered orally to a host. Method of transformation, vector and food product.

ARP990105036A 1998-10-07 1999-10-05 THERAPEUTICALLY ACTIVE PROTEINS IN PLANTS. AR020717A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16823198A 1998-10-07 1998-10-07
US16736298A 1998-10-07 1998-10-07

Publications (1)

Publication Number Publication Date
AR020717A1 true AR020717A1 (en) 2002-05-22

Family

ID=26863095

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990105036A AR020717A1 (en) 1998-10-07 1999-10-05 THERAPEUTICALLY ACTIVE PROTEINS IN PLANTS.

Country Status (14)

Country Link
EP (1) EP1117817A2 (en)
JP (1) JP2002526116A (en)
KR (1) KR20010085901A (en)
CN (1) CN1330718A (en)
AR (1) AR020717A1 (en)
AU (2) AU758817B2 (en)
BR (1) BR9915919A (en)
CA (1) CA2344269A1 (en)
HU (1) HUP0103616A3 (en)
IL (1) IL142041A0 (en)
PL (1) PL347904A1 (en)
RU (2) RU2001111881A (en)
TR (1) TR200101032T2 (en)
WO (1) WO2000020612A2 (en)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050032211A1 (en) * 1996-09-26 2005-02-10 Metabogal Ltd. Cell/tissue culturing device, system and method
IL155588A0 (en) * 2003-04-27 2003-11-23 Metabogal Ltd Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby
US7361331B2 (en) 1996-10-18 2008-04-22 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food Plant bioreactors
AU6277600A (en) * 1999-07-27 2001-02-13 Syngenta Participations Ag Novel chimeric genes
US7572466B1 (en) 1999-10-13 2009-08-11 Health Research, Inc. Oral immunology using plant product containing a non-enteric pathogen antigen
CA2401965A1 (en) * 2000-02-29 2001-09-07 Auburn University Production of antibodies in transgenic plastids
AU2001252246A1 (en) * 2000-04-05 2001-10-23 Syngenta Participations Ag Therapeutically active proteins in plants
FR2809413B1 (en) * 2000-05-29 2004-10-22 Tabacs & Allumettes Ind PRODUCTION OF RECOMBINANT ALLERGENS IN PLANT CELLS
JP2002017186A (en) * 2000-06-30 2002-01-22 Hayashibara Biochem Lab Inc Transgenic plant
GB2364705A (en) * 2000-07-14 2002-02-06 Icgeb Fusion protein expression in plastids
JP2004506427A (en) 2000-08-11 2004-03-04 シンジェンタ　パーティシペーションズ　アクチェンゲゼルシャフト Method for stable transformation of plants
KR20030096319A (en) * 2001-04-13 2003-12-24 보이스 톰슨 인스터튜트 포 플랜트 리서치 Methods and compositions for stable transgenic plant pharmaceuticals and their use as contraceptives
MXPA04010432A (en) * 2002-04-23 2005-05-27 Scripps Research Inst Expression of polypeptides in chloroplasts, and compositions and methods for expressing same.
FR2841906B1 (en) * 2002-07-05 2006-08-18 Stallergenes Sa NUCLEIC ACID MOLECULE ENCODING AN ALLERGENE PREPROPROTEIN OF A MITER OF THE GENUS DERMATOPHAGOIDES OR EUROGLYPHUS AND USE THEREOF FOR THE PRODUCTION OF SAID ALLERGEN IN PLANTS
ES2381667T3 (en) 2002-10-15 2012-05-30 Syngenta Participations Ag Plaster transformation
US7491509B2 (en) 2003-02-03 2009-02-17 Fraunhofer Usa, Inc. System for expression of genes in plants
CA2516286A1 (en) * 2003-02-18 2004-09-02 Devon Brown Expression in plants of antibodies against enterotoxigenic escherichia coli
GB0307989D0 (en) * 2003-04-07 2003-05-14 Mcewen Lab Ltd Therapeutic composition
US7951557B2 (en) 2003-04-27 2011-05-31 Protalix Ltd. Human lysosomal proteins from plant cell culture
BRPI0410562B8 (en) 2003-05-22 2021-05-25 Fralunhofer Usa Inc carrier protein and its production method in a plant, isolated nucleic acid, expression vector and host cell
US8455717B2 (en) 2004-09-29 2013-06-04 Collplant Ltd. Collagen producing plants and methods of generating and using same
WO2007010533A2 (en) * 2005-07-18 2007-01-25 Protalix Ltd. Mucosal or enteral administration of biologically active macromolecules
AU2012241058B2 (en) * 2005-07-18 2014-04-17 Protalix Ltd. Mucosal or Enteral Administration of Biologically Active Macromolecules
CA2616859C (en) 2005-08-03 2015-04-14 Fraunhofer Usa, Inc. Compositions and methods for production of immunoglobulins
BRPI0707733B1 (en) 2006-02-13 2019-12-31 Fraunhofer Usa Inc isolated antigen, vaccine composition, use of said composition and method for producing an antigen protein
GB0604938D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Proteins, nucleic acids and medicaments
GB0604966D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Medicaments and proteins
GB0604964D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Protein folding
GB0617816D0 (en) * 2006-09-11 2006-10-18 Renovo Ltd Nucleic acids and methods of protein expression
EP2150608B1 (en) 2007-05-07 2017-11-29 Protalix Ltd. Large scale disposable bioreactor
GB2449466B (en) * 2007-05-23 2009-11-18 Algentech Ltd Production of proteins in plant tissue
US8404252B2 (en) 2007-07-11 2013-03-26 Fraunhofer Usa, Inc. Yersinia pestis antigens, vaccine compositions, and related methods
CN101951951A (en) * 2007-10-31 2011-01-19 中佛罗里达大学研究基金有限公司 The deutero-human malaria vaccine antigen of chloroplast
BRPI0913983A2 (en) * 2008-06-30 2015-10-20 Orf Liftaekni Hf cosmetic and / or therapeutic composition, and method for making a topical skin care product
WO2010037046A1 (en) 2008-09-28 2010-04-01 Fraunhofer Usa, Inc. Humanized neuraminidase antibody and methods of use thereof
US9175300B2 (en) 2008-11-27 2015-11-03 Vanga Siva Reddy Method of expressing foreign protein in plastids
US9551005B2 (en) * 2009-07-16 2017-01-24 Kenneth John Piller Immunoassay for detecting thyroglobulin utilizing soybean produced recombinant thyroglobulin
CA2776144C (en) 2009-09-29 2020-10-27 Fraunhofer Usa, Inc. Influenza hemagglutinin antibodies, compositions, and related methods
AU2010321676B2 (en) * 2009-11-18 2015-02-26 Agriculture Victoria Services Pty Ltd Angiogenin expression in plants
WO2012170678A1 (en) 2011-06-07 2012-12-13 Fraunhofer Usa, Inc. In vivo de-glycosylation of recombinant proteins by co-expression with pngase f
JP2013040138A (en) * 2011-08-17 2013-02-28 Univ Of Tsukuba Method of producing activated recombinant pollen allergen
TR201814868T4 (en) 2012-08-23 2018-10-22 Transalgae Israel Ltd Transgenic microalgae and their use for oral uptake of proteins.
CN106029091B (en) 2014-02-12 2020-02-11 特郎萨格以色列有限公司 Algal-based edible vaccines
US10988795B2 (en) 2014-05-14 2021-04-27 Ruprecht-Karls-Universitat Heidelberg Synthesis of double-stranded nucleic acids
FR3021328B1 (en) * 2014-05-23 2018-01-05 Angany Inc. COMMERCIAL PRODUCTION OF ALLERGEN AMB A1 BY TRANSIENT EXPRESSION IN PLANTS
CN104561353B (en) * 2015-01-29 2017-01-11 中国农业科学院蔬菜花卉研究所 InDel marker in close linkage with cabbage fertility as well as detection method and application of InDel marker
US11332754B2 (en) * 2016-03-20 2022-05-17 The Trustees Of The University Of Pennsylvania Codon optimization for increasing transgene expression in chloroplasts of higher seed plants

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5451513A (en) * 1990-05-01 1995-09-19 The State University of New Jersey Rutgers Method for stably transforming plastids of multicellular plants
GB9319429D0 (en) * 1993-09-21 1993-11-03 London Health Ass Methods and products for controlling immune responses in mammals
US5576198A (en) * 1993-12-14 1996-11-19 Calgene, Inc. Controlled expression of transgenic constructs in plant plastids
FR2736930B1 (en) * 1995-07-17 1997-09-19 Biocem PROCESS FOR THE PRODUCTION, BY PLANT CELLS, OF HEMINIC PROTEINS, PROTEINS THUS OBTAINED AND PRODUCTS CONTAINING THE SAME
ZA965786B (en) * 1995-07-19 1997-01-27 Kimberly Clark Co Nonwoven barrier and method of making the same
WO1997004123A1 (en) * 1995-07-19 1997-02-06 Gel Tech Group Inc. Collagen compound production in plants
WO1997006250A1 (en) * 1995-08-10 1997-02-20 Rutgers University Nuclear-encoded transcription system in plastids of higher plants
JP2000506019A (en) * 1996-03-06 2000-05-23 ラトガーズ・ユニバーシティ Plastid transformation in Arabidopsis thaliana
AU4058497A (en) * 1996-08-09 1998-03-06 Calgene Llc Methods for producing carotenoid compounds and speciality oils in plant seeds
WO1998006861A2 (en) * 1996-08-15 1998-02-19 Agrivax Incorporated Delivery of tolerogenic antigens via edible plants or plant-derived products
AU728348B2 (en) * 1996-09-12 2001-01-04 Syngenta Participations Ag Transgenic plants expressing cellulolytic enzymes
JP2002513283A (en) * 1997-01-17 2002-05-08 ザ スクリップス リサーチ インスティテュート RNA binding proteins and binding sites useful for expression of recombinant molecules
ATE296355T1 (en) * 1997-08-07 2005-06-15 Univ Auburn UNIVERSAL INTEGRATION AND EXPRESSION VECTORS FOR CHLOROPLASTS, TRANSFORMED PLANTS AND PRODUCTS THEREOF
ES2286886T3 (en) * 1998-07-10 2007-12-01 Calgene Llc EXPRESSION OF EUCARIOUS PEPTIDES IN PLASTIDES OF PLANTS.

Also Published As

Publication number Publication date
AU2003200126A9 (en) 2003-04-17
PL347904A1 (en) 2002-04-22
TR200101032T2 (en) 2001-10-22
AU2003200126A1 (en) 2003-04-17
WO2000020612A2 (en) 2000-04-13
IL142041A0 (en) 2002-03-10
CA2344269A1 (en) 2000-04-13
JP2002526116A (en) 2002-08-20
HUP0103616A2 (en) 2002-01-28
CN1330718A (en) 2002-01-09
AU758817B2 (en) 2003-04-03
EP1117817A2 (en) 2001-07-25
BR9915919A (en) 2001-08-21
RU2003131696A (en) 2005-04-20
KR20010085901A (en) 2001-09-07
RU2001111881A (en) 2003-06-20
HUP0103616A3 (en) 2003-07-28
WO2000020612A3 (en) 2000-07-06
AU6334099A (en) 2000-04-26

Similar Documents

Publication Publication Date Title
AR020717A1 (en) THERAPEUTICALLY ACTIVE PROTEINS IN PLANTS.
ITRM20000294A0 (en) METHOD OF EXTRACTION OF PRODUCTS WITH PHARMACEUTICAL ACTIVITY FROM SPERMATOPHYTE PLANTS, PRODUCTS SO OBTAINED AND THEIR USE IN MEDICINE, IN PA
PL342650A1 (en) Method of treating capsules and dry powdered pharmacological preparations
WO2002000266A3 (en) A method of treating and preventing infectious diseases
ATE129894T1 (en) SHORT-BED, MONOUNSATURATED FATTY ACIDS CONTAINING FOODS AND PHARMACEUTICAL COMPOSITIONS AND THEIR APPLICATIONS.
WO2002024145A3 (en) Antiviral substances from plant cuticular and epicuticular material
ITRM20000293A0 (en) METHOD OF EXTRACTION OF PRODUCTS WITH PHARMACEUTICAL ACTIVITY FROM SPERMAPHITE PLANTS, PRODUCTS SO OBTAINED AND THEIR USE IN MEDICINE, IN PART
WO2002056708A3 (en) Preparation for improved dietary utilisation
BR0011447A (en) Composition comprising alkaline sphingomyelinase for application as a dietary preparation, food supplement or pharmaceutical product
EE9900162A (en) Method of preventing breast cancer, pharmaceutical preparation and product, and use of the active ingredient
ATE293895T1 (en) FIBROUS LIPO NUTRITIONAL COMPLEXES AND COMPOSITIONS CONTAINING SAME
WO2003018535A3 (en) Novel aminobenzoephenones
WO2002015721A3 (en) Foodstuff and animal feedstuff supplement compositions
WO2003022218A3 (en) Carboxylate-gated-nitroxide (cgn) compounds and compositions and methods of use thereof
HK1075654A1 (en) Hyperforin derivatives, the use thereof and formulations containing them
FR2679777B1 (en) MICROCAPSULES CONTAINING AMPHIPHILIC AND WATER-SOLUBLE SUBSTANCES, THEIR PREPARATION PROCESS AND THEIR APPLICATIONS IN SURGERY AND MEDICINE.
EP1180367A4 (en) Intestinal fermentation sulfide deodorizers
WO2003097033A3 (en) Novel neutracetical and pharmaceutical compositions and their uses
AU4115800A (en) Method for utilizing the nutritional, chemical-organic, pharmaceutical, herbal, cosmetic and/or energetic potential of vegetable agricultural products
Servilio PCM-4, OTC hopeful?
PT998296E (en) PHARMACEUTICAL USES OF CYPRESS
UA32111A (en) Method for manufacturing medicinal product for treating diseases of locomotor system
GEP20002312B (en) Ointment for Treatment of Osteoarticular System with Herbs
GR1002955B (en) Products derived from the cypress plant and similar ciniferous trees and used for the prevention and therapy of high cholesterol and disorder of the lipid's concentration in the blood of humans and animals
WO2002024173A3 (en) Oral dosage forms of boswellia extracts

Legal Events

Date Code Title Description
FB Suspension of granting procedure