RU2003130082A - Новые пептидные лиганды лейкоцитарных интегринов - Google Patents
Новые пептидные лиганды лейкоцитарных интегринов Download PDFInfo
- Publication number
- RU2003130082A RU2003130082A RU2003130082/13A RU2003130082A RU2003130082A RU 2003130082 A RU2003130082 A RU 2003130082A RU 2003130082/13 A RU2003130082/13 A RU 2003130082/13A RU 2003130082 A RU2003130082 A RU 2003130082A RU 2003130082 A RU2003130082 A RU 2003130082A
- Authority
- RU
- Russia
- Prior art keywords
- peptide
- peptide according
- cysteines
- structural
- disulfide bond
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (12)
1. Пептид, содержащий структуру
LLG (SEQ ID No:1)
или его структурный или химический аналог.
2. Пептид, содержащий структуру
CXCXLLGCC (SEQ ID No:2),
где Х представляет собой любой аминокислотный остаток или его структурный или химический аналог.
3. Пептид, содержащий структуру
CPCFLLGCC (SEQ ID No:3)
или его структурный или химический аналог.
4. Пептид по п.2 или 3, где указанный пептид структурно ограничен двумя дисульфидными связями.
5. Пептид по п.4, где указанный пептид содержит одну дисульфидную связь между цистеинами С1 и С8 и вторую дисульфидную связь между цистеинами С3 и С9.
6. Пептид по п.4, где указанный пептид содержит одну дисульфидную связь между цистеинами С1 и С9 и вторую дисульфидную связь между цистеинами С3 и С8.
7. Пептид по любому из пп.1-6 для применения в качестве фармацевтического средства.
8. Фармацевтическая композиция, содержащая пептид по любому из пп.1-6 в сочетании с фармацевтически приемлемым носителем.
9. Применение пептида по любому из пп.1-6 для изготовления фармацевтической композиции для лечения воспалительных заболеваний и лейкозов человека.
10. Применение пептида по любому из пп.1-6 в качестве антагониста β 2-интегрина для процедур биохимического выделения и очистки различных разновидностей интегрина и различных типов лейкоцитарных клеток in vitro.
11. Способ терапевтического или профилактического лечения воспалительных заболеваний и лейкозов человека, который включает в себя введение терапевтически или профилактически эффективного количества пептида по любому из пп.1-6 субъекту, нуждающемуся в таком лечении.
12. Применение пептида, содержащего трипептидный мотив LLG, или его структурного или химического аналога для изготовления фармацевтических композиций для ингибирования адгезии и миграции лейкоцитарных клеток.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI20010491 | 2001-03-12 | ||
FI20010491A FI114710B (fi) | 2001-03-12 | 2001-03-12 | Leukosyytti-integriinien uusia peptidiligandeja |
Publications (1)
Publication Number | Publication Date |
---|---|
RU2003130082A true RU2003130082A (ru) | 2005-02-20 |
Family
ID=8560720
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2003130082/13A RU2003130082A (ru) | 2001-03-12 | 2002-03-11 | Новые пептидные лиганды лейкоцитарных интегринов |
Country Status (20)
Country | Link |
---|---|
US (1) | US7205383B2 (ru) |
EP (1) | EP1373303A1 (ru) |
JP (1) | JP2004536041A (ru) |
KR (1) | KR20030093238A (ru) |
CN (1) | CN1860129A (ru) |
BR (1) | BR0208364A (ru) |
CA (1) | CA2441210A1 (ru) |
CZ (1) | CZ20032632A3 (ru) |
EE (1) | EE200300443A (ru) |
FI (1) | FI114710B (ru) |
HR (1) | HRP20030708A2 (ru) |
HU (1) | HUP0402246A2 (ru) |
IL (1) | IL157831A0 (ru) |
NO (1) | NO20034002L (ru) |
NZ (1) | NZ528044A (ru) |
PL (1) | PL365108A1 (ru) |
RU (1) | RU2003130082A (ru) |
SK (1) | SK12762003A3 (ru) |
WO (1) | WO2002072618A1 (ru) |
YU (1) | YU70903A (ru) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI115035B (fi) * | 2003-05-02 | 2005-02-28 | Ctt Cancer Targeting Tech Oy | In vivo -kuvantaminen käyttäen peptidijohdannaisia |
DK2683393T3 (en) * | 2011-02-11 | 2018-07-23 | Univ Michigan Regents | TRIPEPTIME COMPOSITIONS AND THEIR USE IN TREATING DIABETES |
AU2012291972B2 (en) * | 2011-08-04 | 2017-03-09 | Pharis Biotec Gmbh | Process for preparing human relaxin-2 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5877275A (en) | 1988-06-28 | 1999-03-02 | The General Hospital Corporation | Controlling cellular immune/inflammatory responses with β2 integrins |
GB9213077D0 (en) * | 1992-06-19 | 1992-08-05 | Erba Carlo Spa | Polymerbound taxol derivatives |
US5840485A (en) * | 1993-05-27 | 1998-11-24 | Selectide Corporation | Topologically segregated, encoded solid phase libraries |
US5821329A (en) * | 1996-06-06 | 1998-10-13 | Tanabe Seiyaku Co., Ltd. | Cyclic peptide inhibitors of β1 and β2 integrin-mediated adhesion |
-
2001
- 2001-03-12 FI FI20010491A patent/FI114710B/fi active
-
2002
- 2002-03-11 KR KR10-2003-7011968A patent/KR20030093238A/ko not_active Application Discontinuation
- 2002-03-11 SK SK1276-2003A patent/SK12762003A3/sk not_active Application Discontinuation
- 2002-03-11 RU RU2003130082/13A patent/RU2003130082A/ru not_active Application Discontinuation
- 2002-03-11 JP JP2002571531A patent/JP2004536041A/ja active Pending
- 2002-03-11 US US10/469,131 patent/US7205383B2/en not_active Expired - Fee Related
- 2002-03-11 CN CNA028065123A patent/CN1860129A/zh active Pending
- 2002-03-11 CZ CZ20032632A patent/CZ20032632A3/cs unknown
- 2002-03-11 PL PL02365108A patent/PL365108A1/xx not_active Application Discontinuation
- 2002-03-11 NZ NZ528044A patent/NZ528044A/en unknown
- 2002-03-11 CA CA002441210A patent/CA2441210A1/en not_active Abandoned
- 2002-03-11 BR BR0208364-7A patent/BR0208364A/pt not_active IP Right Cessation
- 2002-03-11 IL IL15783102A patent/IL157831A0/xx unknown
- 2002-03-11 HU HU0402246A patent/HUP0402246A2/hu unknown
- 2002-03-11 WO PCT/FI2002/000188 patent/WO2002072618A1/en not_active Application Discontinuation
- 2002-03-11 YU YU70903A patent/YU70903A/sh unknown
- 2002-03-11 EP EP02706788A patent/EP1373303A1/en not_active Withdrawn
- 2002-03-11 EE EEP200300443A patent/EE200300443A/xx unknown
-
2003
- 2003-09-05 HR HR20030708A patent/HRP20030708A2/xx not_active Application Discontinuation
- 2003-09-10 NO NO20034002A patent/NO20034002L/no unknown
Also Published As
Publication number | Publication date |
---|---|
NZ528044A (en) | 2005-01-28 |
CA2441210A1 (en) | 2002-09-19 |
SK12762003A3 (sk) | 2004-02-03 |
FI20010491A (fi) | 2002-09-13 |
BR0208364A (pt) | 2004-03-09 |
YU70903A (sh) | 2006-05-25 |
KR20030093238A (ko) | 2003-12-06 |
PL365108A1 (en) | 2004-12-27 |
FI114710B (fi) | 2004-12-15 |
US7205383B2 (en) | 2007-04-17 |
CN1860129A (zh) | 2006-11-08 |
NO20034002L (no) | 2003-11-12 |
WO2002072618A1 (en) | 2002-09-19 |
EP1373303A1 (en) | 2004-01-02 |
HRP20030708A2 (en) | 2005-04-30 |
CZ20032632A3 (cs) | 2003-12-17 |
HUP0402246A2 (hu) | 2005-01-28 |
IL157831A0 (en) | 2004-03-28 |
NO20034002D0 (no) | 2003-09-10 |
JP2004536041A (ja) | 2004-12-02 |
FI20010491A0 (fi) | 2001-03-12 |
US20040259798A1 (en) | 2004-12-23 |
EE200300443A (et) | 2003-12-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20060619 |