RU2002131153A - Композиции стабилизированного тетразолий-феназинового реагента и способы их применения - Google Patents
Композиции стабилизированного тетразолий-феназинового реагента и способы их применения Download PDFInfo
- Publication number
- RU2002131153A RU2002131153A RU2002131153/15A RU2002131153A RU2002131153A RU 2002131153 A RU2002131153 A RU 2002131153A RU 2002131153/15 A RU2002131153/15 A RU 2002131153/15A RU 2002131153 A RU2002131153 A RU 2002131153A RU 2002131153 A RU2002131153 A RU 2002131153A
- Authority
- RU
- Russia
- Prior art keywords
- composition
- specified
- composition according
- indicator strip
- analyte
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 13
- 239000003153 chemical reaction reagent Substances 0.000 title claims 4
- 238000000034 method Methods 0.000 title claims 2
- 239000012491 analyte Substances 0.000 claims 3
- 239000003381 stabilizer Substances 0.000 claims 3
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- VEPOHXYIFQMVHW-XOZOLZJESA-N 2,3-dihydroxybutanedioic acid (2S,3S)-3,4-dimethyl-2-phenylmorpholine Chemical compound OC(C(O)C(O)=O)C(O)=O.C[C@H]1[C@@H](OCCN1C)c1ccccc1 VEPOHXYIFQMVHW-XOZOLZJESA-N 0.000 claims 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims 1
- 239000004327 boric acid Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000012992 electron transfer agent Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Claims (10)
1. Композиция реагентов, содержащая тетразолиевый краситель, феназиновый агент переноса электронов, и эффективное количество соединения группы IIIA и/или флавинового стабилизирующего агента.
2. Композиция по п.1, в которой указанный флавиновый стабилизирующий агент представляет собой FAD.
3. Композиция по п.1 или 2, в которой указанный стабилизирующий агент группы IIIA представляет собой борат или борную кислоту.
4. Композиция по пп.1, 2 или 3, в которой указанная композиция реагентов содержит аналитическую систему, продуцирующую сигнал окисления.
5. Композиция по любому из пп.1-4, где указанная композиция представляет собой жидкую композицию.
6. Композиция по любому из пп.1-4, где указанная композиция представляет собой сухую композицию.
7. Реакционноспособная индикаторная полоска, содержащая субстрат, и композицию реагентов по любому из пп.1-6.
8. Аналитическая система обнаружения или измерения, включающая (А) реакционноспособную индикаторную полоску по п.7, и (В) автоматизированный прибор.
9. Способ определения наличия или измерения концентрации анализируемого соединения в образце, включающий (А) нанесение указанного физиологического образца на реакционноспособную индикаторную полоску по п.7 таким образом, чтобы образовалось пятно на указанной полоске, (В) выявление указанного пятна, и (С) сравнение указанного выявленного пятна для установления присутствия или концентрации указанного анализируемого соединения в указанном физиологическом образце.
10. Набор для применения при определении концентрации анализируемого соединения в физиологическом образце, включающий (А) реакционноспособную индикаторную полоску по п.7, и (В) по меньшей мере, одно из (i) средств получения указанного физиологического образца и (ii) аналитического стандарта.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/988,494 US6939685B2 (en) | 2001-11-20 | 2001-11-20 | Stabilized tetrazolium phenazine reagent compositions and methods for using the same |
| US09/988,494 | 2001-11-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2002131153A true RU2002131153A (ru) | 2004-07-10 |
Family
ID=25534172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002131153/15A RU2002131153A (ru) | 2001-11-20 | 2002-11-19 | Композиции стабилизированного тетразолий-феназинового реагента и способы их применения |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6939685B2 (ru) |
| EP (1) | EP1312921A1 (ru) |
| JP (1) | JP2004000129A (ru) |
| KR (1) | KR20030041809A (ru) |
| CN (1) | CN1432653A (ru) |
| AR (1) | AR037544A1 (ru) |
| BR (1) | BR0204761A (ru) |
| CA (1) | CA2412198A1 (ru) |
| HK (1) | HK1052969A1 (ru) |
| IL (1) | IL152918A0 (ru) |
| MX (1) | MXPA02011478A (ru) |
| NO (1) | NO20025489L (ru) |
| PL (1) | PL357203A1 (ru) |
| RU (1) | RU2002131153A (ru) |
| SG (1) | SG115506A1 (ru) |
| TW (1) | TW200303864A (ru) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
| US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
| DE60238119D1 (de) | 2001-06-12 | 2010-12-09 | Pelikan Technologies Inc | Elektrisches betätigungselement für eine lanzette |
| US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
| AU2002315177A1 (en) | 2001-06-12 | 2002-12-23 | Pelikan Technologies, Inc. | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties |
| US7025774B2 (en) | 2001-06-12 | 2006-04-11 | Pelikan Technologies, Inc. | Tissue penetration device |
| US7344507B2 (en) | 2002-04-19 | 2008-03-18 | Pelikan Technologies, Inc. | Method and apparatus for lancet actuation |
| US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
| US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
| US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| EP1404235A4 (en) | 2001-06-12 | 2008-08-20 | Pelikan Technologies Inc | METHOD AND DEVICE FOR A LANZETTING DEVICE INTEGRATED ON A BLOOD CARTRIDGE CARTRIDGE |
| US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| US6586199B2 (en) * | 2001-11-20 | 2003-07-01 | Lifescan, Inc. | Stabilized tetrazolium reagent compositions and methods for using the same |
| US7892185B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
| US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
| US7547287B2 (en) | 2002-04-19 | 2009-06-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7297122B2 (en) | 2002-04-19 | 2007-11-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
| US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| US7491178B2 (en) | 2002-04-19 | 2009-02-17 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7229458B2 (en) | 2002-04-19 | 2007-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7226461B2 (en) | 2002-04-19 | 2007-06-05 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
| US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
| US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
| US7232451B2 (en) | 2002-04-19 | 2007-06-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
| US7901362B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US8360992B2 (en) | 2002-04-19 | 2013-01-29 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
| US7331931B2 (en) | 2002-04-19 | 2008-02-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
| ATE476137T1 (de) | 2003-05-30 | 2010-08-15 | Pelikan Technologies Inc | Verfahren und vorrichtung zur injektion von flüssigkeit |
| US7850621B2 (en) | 2003-06-06 | 2010-12-14 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
| WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
| EP1671096A4 (en) | 2003-09-29 | 2009-09-16 | Pelikan Technologies Inc | METHOD AND APPARATUS FOR PROVIDING IMPROVED SAMPLE CAPTURING DEVICE |
| EP1680014A4 (en) | 2003-10-14 | 2009-01-21 | Pelikan Technologies Inc | METHOD AND APPARATUS PROVIDING A VARIABLE USER INTERFACE |
| US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
| EP1706026B1 (en) | 2003-12-31 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Method and apparatus for improving fluidic flow and sample capture |
| EP1751546A2 (en) | 2004-05-20 | 2007-02-14 | Albatros Technologies GmbH & Co. KG | Printable hydrogel for biosensors |
| US9775553B2 (en) | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
| WO2005120365A1 (en) | 2004-06-03 | 2005-12-22 | Pelikan Technologies, Inc. | Method and apparatus for a fluid sampling device |
| US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
| EP2178531A4 (en) * | 2007-07-02 | 2012-01-11 | Yu Ming | METHODS AND COMPOSITIONS, TARGETS FOR COMBINED CANCER TREATMENTS |
| US8008037B2 (en) | 2008-03-27 | 2011-08-30 | Roche Diagnostics Operations, Inc. | Matrix composition with alkylphenazine quaternary salt and a nitrosoaniline |
| WO2009126900A1 (en) | 2008-04-11 | 2009-10-15 | Pelikan Technologies, Inc. | Method and apparatus for analyte detecting device |
| US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
| US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2147466C3 (de) | 1971-09-23 | 1980-06-26 | Boehringer Mannheim Gmbh, 6800 Mannheim | 5- (4-N-trimethyl-ammonium-phenyl) tetrazoliumsalze |
| DE3048662A1 (de) | 1980-12-23 | 1982-07-22 | Boehringer Mannheim Gmbh, 6800 Mannheim | Stabilisierte zubereitung von tetrazoliumsalzen |
| DE3231288C2 (de) * | 1982-08-23 | 1984-06-28 | MEDI-PHARMA Vertriebsgesellschaft mbH, 5000 Köln | Diagnostische Vorrichtung und ihre Verwendung |
| JPS6070861A (ja) * | 1983-09-27 | 1985-04-22 | Fujitsu Ltd | デ−タ送受信装置 |
| US5126247A (en) | 1988-02-26 | 1992-06-30 | Enzymatics, Inc. | Method, system and devices for the assay and detection of biochemical molecules |
| EP0648278B1 (en) | 1992-07-02 | 1999-12-08 | Roche Diagnostics Corporation | Stabilizing tetrazolium salts in a reagent |
| EP0654079B1 (en) | 1992-07-02 | 2000-03-22 | Roche Diagnostics Corporation | A reagent stabilized by bivalent metal salts |
| JP2757348B2 (ja) | 1996-04-18 | 1998-05-25 | 株式会社同仁化学研究所 | 新規水溶性テトラゾリウム塩化合物 |
| US5902731A (en) | 1998-09-28 | 1999-05-11 | Lifescan, Inc. | Diagnostics based on tetrazolium compounds |
| US6656697B1 (en) | 1998-09-28 | 2003-12-02 | Lifescan, Inc. | Diagnostics based on tetrazolium compounds |
-
2001
- 2001-11-20 US US09/988,494 patent/US6939685B2/en not_active Expired - Lifetime
-
2002
- 2002-11-14 SG SG200206874A patent/SG115506A1/en unknown
- 2002-11-15 NO NO20025489A patent/NO20025489L/no not_active Application Discontinuation
- 2002-11-18 AR ARP020104420A patent/AR037544A1/es unknown
- 2002-11-18 IL IL15291802A patent/IL152918A0/xx unknown
- 2002-11-19 CN CN02139980A patent/CN1432653A/zh active Pending
- 2002-11-19 EP EP02257964A patent/EP1312921A1/en not_active Withdrawn
- 2002-11-19 KR KR1020020071962A patent/KR20030041809A/ko not_active Application Discontinuation
- 2002-11-19 TW TW091133666A patent/TW200303864A/zh unknown
- 2002-11-19 RU RU2002131153/15A patent/RU2002131153A/ru not_active Application Discontinuation
- 2002-11-19 PL PL02357203A patent/PL357203A1/xx not_active Application Discontinuation
- 2002-11-19 MX MXPA02011478A patent/MXPA02011478A/es unknown
- 2002-11-19 JP JP2002335506A patent/JP2004000129A/ja active Pending
- 2002-11-19 CA CA002412198A patent/CA2412198A1/en not_active Abandoned
- 2002-11-21 BR BR0204761-6A patent/BR0204761A/pt not_active Application Discontinuation
-
2003
- 2003-03-12 US US10/388,145 patent/US20030170772A1/en not_active Abandoned
- 2003-07-15 HK HK03105121.8A patent/HK1052969A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1052969A1 (zh) | 2003-10-03 |
| NO20025489D0 (no) | 2002-11-15 |
| US20030096389A1 (en) | 2003-05-22 |
| AR037544A1 (es) | 2004-11-17 |
| KR20030041809A (ko) | 2003-05-27 |
| IL152918A0 (en) | 2003-06-24 |
| CA2412198A1 (en) | 2003-05-20 |
| EP1312921A1 (en) | 2003-05-21 |
| TW200303864A (en) | 2003-09-16 |
| US20030170772A1 (en) | 2003-09-11 |
| US6939685B2 (en) | 2005-09-06 |
| NO20025489L (no) | 2003-05-21 |
| JP2004000129A (ja) | 2004-01-08 |
| SG115506A1 (en) | 2005-10-28 |
| MXPA02011478A (es) | 2004-12-13 |
| CN1432653A (zh) | 2003-07-30 |
| BR0204761A (pt) | 2003-09-16 |
| PL357203A1 (en) | 2003-06-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20061208 |