RU2001132323A - Антиокислительные аналоги витамина B6 - Google Patents
Антиокислительные аналоги витамина B6Info
- Publication number
- RU2001132323A RU2001132323A RU2001132323/04A RU2001132323A RU2001132323A RU 2001132323 A RU2001132323 A RU 2001132323A RU 2001132323/04 A RU2001132323/04 A RU 2001132323/04A RU 2001132323 A RU2001132323 A RU 2001132323A RU 2001132323 A RU2001132323 A RU 2001132323A
- Authority
- RU
- Russia
- Prior art keywords
- compound
- formula
- carbon atoms
- residue
- represents hydrogen
- Prior art date
Links
- 239000003963 antioxidant agent Substances 0.000 title 1
- 230000003078 antioxidant effect Effects 0.000 title 1
- 150000003697 vitamin B6 derivatives Chemical class 0.000 title 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000004432 carbon atom Chemical group C* 0.000 claims 8
- 150000002431 hydrogen Chemical class 0.000 claims 8
- 229960005070 ascorbic acid Drugs 0.000 claims 6
- 235000010323 ascorbic acid Nutrition 0.000 claims 6
- 239000011668 ascorbic acid Substances 0.000 claims 6
- 125000002252 acyl group Chemical group 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
- A61Q1/04—Preparations containing skin colorants, e.g. pigments for lips
- A61Q1/06—Lipsticks
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Claims (12)
1. Соединение формулы I
где R1 представляет собой водород, ацил с 2-22 атомами углерода (за исключением ретиноила) или остаток аскорбиновой кислоты;
R4 представляет собой водород, гидрокси или остаток аскорбиновой кислоты;
R5 представляет собой остаток аскорбиновой кислоты или
где R2 представляет собой водород или арил с 6-30 атомами углерода,
при условии, что по меньшей мере один из R1 или R не является водородом,
X1, Х2 и X3 представляют собой, независимо О, S или NR3;
R3 представляет собой водород, алкил с 1-6 атомами углерода или ацил с 2-6 атомами углерода;
Y представляет собой О, S или NH;
Z представляет собой СН или N;
и образованные от него фармацевтически приемлемые соли и сложные эфиры.
2. Соединение формулы
3. Соединение формулы
4. Соединение формулы
5. Соединение формулы
6. Соединение формулы
7. Соединение формулы
8. Соединение формулы
9. Фармацевтическая композиция, содержащая фармацевтически приемлемый эксципиент и терапевтически эффективное количество соединения по п.1.
10. Композиция для ухода за кожей, содержащая косметически приемлемый носитель и эффективное количество соединения по п.1.
11. Способ регуляции состояния кожи, включающий применение к коже млекопитающего безопасного и эффективного количества соединения по п.1.
12. Применение соединения формулы I
где R1 представляет собой водород, ацил с 2-22 атомами углерода (за исключением ретиноила) или остаток аскорбиновой кислоты;
R4 представляет собой водород, гидрокси или остаток аскорбиновой кислоты;
R5 представляет собой остаток аскорбиновой кислоты или
где R2 представляет собой водород или арил с 6-30 атомами углерода,
при условии, что по меньшей мере один из R1 и R2 не является водородом,
X1, X2 и X3 представляют собой, независимо, О, S или NR3;
R представляет собой водород, алкил с 1-6 атомами углерода или ацил с 2-6 атомами углерода;
Y представляет собой О, S или NH;
Z представляет собой СН или N,
и образованных от него фармацевтически приемлемых солей и эфиров при изготовлении лекарственного средства для ухода за кожей.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP99/02960 | 1999-04-30 | ||
| PCT/EP1999/002960 WO1999057124A1 (en) | 1998-05-04 | 1999-04-30 | Monomeric, oligomeric and polymeric knoevenagel condensation products |
| US09/437,627 US6369042B1 (en) | 1998-05-04 | 1999-11-10 | Antioxidative vitamin B6 analogs |
| US09/437,627 | 1999-11-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2001132323A true RU2001132323A (ru) | 2004-02-20 |
Family
ID=23737227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2001132323/04A RU2001132323A (ru) | 1999-04-30 | 2000-04-28 | Антиокислительные аналоги витамина B6 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1173451A1 (ru) |
| JP (1) | JP2002543209A (ru) |
| KR (1) | KR20020023941A (ru) |
| AU (1) | AU4559000A (ru) |
| CA (1) | CA2371653A1 (ru) |
| IL (1) | IL146184A0 (ru) |
| RU (1) | RU2001132323A (ru) |
| WO (1) | WO2000066599A1 (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2482320C (en) * | 2002-04-19 | 2010-02-09 | Georg T. Wondrak | Methods for modulating phototoxicity |
| ITRM20030590A1 (it) * | 2003-12-22 | 2005-06-23 | Univ Siena | Formulazione a base di polimetafosfati per la cura di artropatie microcristalline. |
| FR2913422B1 (fr) * | 2007-03-09 | 2009-04-17 | Oreal | Procede de traitement cosmetique employant des analogues d'ascorbigene, compositions cosmetiques et composes |
| KR101749091B1 (ko) | 2015-07-21 | 2017-06-21 | (주)코스몰 | 아스코르빈산이 결합된 피리독신 유도체의 제조방법 |
| US12097178B2 (en) * | 2021-12-10 | 2024-09-24 | Somerset Therapeutics, Llc | Methods of efficiently treating vitamin C deficiency-related diseases and other conditions |
| US12128025B2 (en) * | 2021-12-10 | 2024-10-29 | Somerset Therapeutics, Llc | Ready-to-use ascorbic acid compound compositions |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5612321A (en) * | 1995-06-22 | 1997-03-18 | Hercules Incorporated | Antioxidant grafted polysaccharides |
| DE19645974C1 (de) * | 1996-11-07 | 1998-08-13 | Andreas Johannes Kesel | (Z)-5-[[3-Hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinyl]methylen]-2-thioxo-4- thiazolidinon, Verfahren zu dessen Herstellung und Verwendung |
| CA2330811A1 (en) * | 1998-05-04 | 1999-11-11 | Andreas Johannes Kesel | Monomeric, oligomeric and polymeric knoevenagel condensation products |
-
2000
- 2000-04-28 CA CA002371653A patent/CA2371653A1/en not_active Withdrawn
- 2000-04-28 KR KR1020017013697A patent/KR20020023941A/ko not_active Application Discontinuation
- 2000-04-28 RU RU2001132323/04A patent/RU2001132323A/ru unknown
- 2000-04-28 EP EP00927098A patent/EP1173451A1/en not_active Withdrawn
- 2000-04-28 IL IL14618400A patent/IL146184A0/xx unknown
- 2000-04-28 JP JP2000615628A patent/JP2002543209A/ja active Pending
- 2000-04-28 AU AU45590/00A patent/AU4559000A/en not_active Withdrawn
- 2000-04-28 WO PCT/EP2000/003855 patent/WO2000066599A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002543209A (ja) | 2002-12-17 |
| IL146184A0 (en) | 2002-07-25 |
| KR20020023941A (ko) | 2002-03-29 |
| WO2000066599A1 (en) | 2000-11-09 |
| AU4559000A (en) | 2000-11-17 |
| EP1173451A1 (en) | 2002-01-23 |
| CA2371653A1 (en) | 2000-11-09 |
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