RU2000106749A - METHOD FOR SYNTHESIS OF TAXANS - Google Patents

METHOD FOR SYNTHESIS OF TAXANS

Info

Publication number
RU2000106749A
RU2000106749A RU2000106749/04A RU2000106749A RU2000106749A RU 2000106749 A RU2000106749 A RU 2000106749A RU 2000106749/04 A RU2000106749/04 A RU 2000106749/04A RU 2000106749 A RU2000106749 A RU 2000106749A RU 2000106749 A RU2000106749 A RU 2000106749A
Authority
RU
Russia
Prior art keywords
silylating agent
base
compound
taxans
synthesis
Prior art date
Application number
RU2000106749/04A
Other languages
Russian (ru)
Other versions
RU2219161C2 (en
Inventor
Роберт А. Холтон
Тофик ГАРБОИ
Винсент РЕБАУЛ
Original Assignee
Флорида Стейт Юниверсити
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Флорида Стейт Юниверсити filed Critical Флорида Стейт Юниверсити
Publication of RU2000106749A publication Critical patent/RU2000106749A/en
Application granted granted Critical
Publication of RU2219161C2 publication Critical patent/RU2219161C2/en

Links

Claims (6)

1. Способ получения соединения, формулы:
Figure 00000001

отличающийся тем, что включает обработку соединения формул:
Figure 00000002

основанием и силилирующим агентом.1. A method of obtaining a compound of the formula:
Figure 00000001

characterized in that it includes processing a compound of the formulas:
Figure 00000002

base and silylating agent. 2. Способ по п. 1, в котором основание выбирается из группы, состоящей из гидридных и амидных оснований. 2. The method of claim 1, wherein the base is selected from the group consisting of hydride and amide bases. 3. Способ по п. 1, в котором основание выбирается из группы, состоящей из гидрида калия и гексаметилдисилазида калия. 3. The method of claim 1, wherein the base is selected from the group consisting of potassium hydride and potassium hexamethyldisilazide. 4. Способ по п. 1, в котором силилирующим агентом является три(гидрокарбил)силилгалогенид. 4. The method of claim 1, wherein the silylating agent is tri (hydrocarbyl) silyl halide. 5. Способ по п. 1, в котором силилирующим агентом является триалкилсилилгалогенид, а указанные выше алкильные группы содержат от одного до четырех углеродных атомов. 5. The method of claim 1, wherein the silylating agent is a trialkylsilyl halide, and the above alkyl groups contain from one to four carbon atoms. 6. Способ по п. 1, в котором силилирующим агентом является триэтилсилилхлорид. 6. The method of claim 1, wherein the silylating agent is triethylsilyl chloride.
RU2000106749/04A 1997-08-21 1998-08-20 Taxane synthesis method RU2219161C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5621097P 1997-08-21 1997-08-21
US60/056,210 1997-08-21

Publications (2)

Publication Number Publication Date
RU2000106749A true RU2000106749A (en) 2002-02-27
RU2219161C2 RU2219161C2 (en) 2003-12-20

Family

ID=22002912

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2000106749/04A RU2219161C2 (en) 1997-08-21 1998-08-20 Taxane synthesis method
RU2003119879/04A RU2003119879A (en) 1997-08-21 2003-07-01 KETONE COMPOUND, INTERMEDIATE COMPOUND AND METHOD FOR PRODUCING THEREOF

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2003119879/04A RU2003119879A (en) 1997-08-21 2003-07-01 KETONE COMPOUND, INTERMEDIATE COMPOUND AND METHOD FOR PRODUCING THEREOF

Country Status (14)

Country Link
US (3) US6111144A (en)
EP (1) EP1019347B1 (en)
CN (2) CN1150149C (en)
AT (1) ATE234800T1 (en)
AU (1) AU739303B2 (en)
CA (1) CA2302699A1 (en)
DE (1) DE69812395T2 (en)
DK (1) DK1019347T3 (en)
ES (1) ES2195378T3 (en)
NZ (1) NZ503206A (en)
PT (1) PT1019347E (en)
RU (2) RU2219161C2 (en)
WO (1) WO1999008986A1 (en)
ZA (1) ZA987609B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW554254B (en) * 1999-08-06 2003-09-21 Hyundai Electronics Ind Novel photoresist monomers, polymers thereof and photoresist compositions using the same
US20030023427A1 (en) * 2001-07-26 2003-01-30 Lionel Cassin Devices, methods and a system for implementing a media content delivery and playback scheme
US20080220074A1 (en) * 2002-10-04 2008-09-11 Elan Corporation Plc Gamma radiation sterilized nanoparticulate docetaxel compositions and methods of making same
JP2010522207A (en) * 2007-03-23 2010-07-01 エラン・ファルマ・インターナショナル・リミテッド Gamma-irradiated sterile nanoparticulate docetaxel composition and method for making the composition
EP2543793B1 (en) 2011-07-05 2014-02-26 Matthias Sommer Method for producing and laying a floor strip
CN107129572B (en) * 2017-05-10 2019-06-14 南京工业大学 A kind of biological poly amide and preparation method thereof

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US34277A (en) * 1862-01-28 Improvement in lamps
FR2601676B1 (en) * 1986-07-17 1988-09-23 Rhone Poulenc Sante PROCESS FOR THE PREPARATION OF TAXOL AND DESACETYL-10 TAXOL
FR2629818B1 (en) * 1988-04-06 1990-11-16 Centre Nat Rech Scient PROCESS FOR THE PREPARATION OF TAXOL
USRE34277E (en) 1988-04-06 1993-06-08 Centre National De La Recherche Scientifique Process for preparing taxol
FR2629819B1 (en) * 1988-04-06 1990-11-16 Rhone Poulenc Sante PROCESS FOR THE PREPARATION OF BACCATIN III AND DESACETYL-10 BACCATIN III DERIVATIVES
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
MY110249A (en) * 1989-05-31 1998-03-31 Univ Florida State Method for preparation of taxol using beta lactam
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
FR2678930B1 (en) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa PROCESS FOR THE PREPARATION OF DERIVATIVES OF BACCATIN III AND DESACETYL-10 BACCATIN III.
CA2071160A1 (en) * 1991-07-31 1993-02-01 Vittorio Farina Asymmetric synthesis of taxol side chain
US5284865A (en) * 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
US5399726A (en) * 1993-01-29 1995-03-21 Florida State University Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
US5338872A (en) * 1993-01-15 1994-08-16 Florida State University Process for the preparation of 10-desacetoxybaccatin III and 10-desacetoxytaxol and derivatives thereof
US5430160A (en) * 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5654447A (en) * 1991-09-23 1997-08-05 Florida State University Process for the preparation of 10-desacetoxybaccatin III
JP2569455B2 (en) * 1992-03-06 1997-01-08 田辺製薬株式会社 Preparation of β-lactam derivatives
FR2688499B1 (en) * 1992-03-10 1994-05-06 Rhone Poulenc Rorer Sa PROCESS FOR THE PREPARATION OF BETA-PHENYLISOSERINE AND ITS ANALOGS.
US5200534A (en) * 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
US5416225A (en) * 1992-03-30 1995-05-16 Sloan-Kettering Institute For Cancer Research Total synthesis of taxol
US5597931A (en) * 1992-03-30 1997-01-28 Sloan-Kettering Institute For Cancer Research Total synthesis of taxol and analogues thereof
US5488116A (en) * 1992-03-30 1996-01-30 Sloan-Kettering Institute For Cancer Research Total synthesis of taxol and analogues thereof
US5254703A (en) * 1992-04-06 1993-10-19 Florida State University Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones
WO1993021173A1 (en) * 1992-04-17 1993-10-28 Abbott Laboratories Taxol derivatives
US5440056A (en) * 1992-04-17 1995-08-08 Abbott Laboratories 9-deoxotaxane compounds
US5481007A (en) * 1992-06-23 1996-01-02 The Scripps Research Institute Taxoid synthesis
US5461169A (en) * 1992-06-23 1995-10-24 The Scripps Research Institute Total synthesis of taxol and taxol analogs
FR2696463B1 (en) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Process for obtaining 10-deacetyl baccatin III.
FR2696462B1 (en) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Process for obtaining 10-deacetyl baccatin III.
FR2696458B1 (en) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Process for the preparation of taxane derivatives.
FR2696460B1 (en) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Process for the preparation of taxane derivatives.
FR2698363B1 (en) * 1992-11-23 1994-12-30 Rhone Poulenc Rorer Sa New taxane derivatives, their preparation and the compositions containing them.
FR2698871B1 (en) * 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa New taxoids, their preparation and the pharmaceutical compositions containing them.
US5703247A (en) * 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
US5405972A (en) * 1993-07-20 1995-04-11 Florida State University Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes
FR2718137B1 (en) * 1994-04-05 1996-04-26 Rhone Poulenc Rorer Sa Process for the preparation of trialcoylsilyl-7 baccatine III.
US5449790A (en) * 1994-04-06 1995-09-12 Hauser Chemical Research, Inc. Preparation of 10-deacetylbaccatin III and 7-protected-10-deacetylbaccatin III derivatives from 10-deacetyl taxol A, 10-deacetyl taxol B, and 10-deacetyl taxol C
US5508447A (en) * 1994-05-24 1996-04-16 Board Of Regents, The University Of Texas System Short synthetic route to taxol and taxol derivatives
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
US5675025A (en) * 1995-06-07 1997-10-07 Napro Biotherapeutics, Inc. Paclitaxel synthesis from precursor compounds and methods of producing the same
US5688977A (en) * 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
WO1997042181A1 (en) * 1996-05-06 1997-11-13 Florida State University 1-deoxy baccatin iii, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof

Similar Documents

Publication Publication Date Title
RU2221798C2 (en) Imidazonaphthyridines, pharmaceutical composition based on thereof, method for stimulating biosynthesis of cytokine and intermediate compounds
CA2248143A1 (en) Process to prepare oxazolidinones
RU96122244A (en) METHOD OF DIASTEREOELECTIVE SYNTHESIS OF NUCLEOSIDE ANALOGUES
Somei et al. Selective mono-alkylation of carbon nucleopiles with gramine1
FR2392466B1 (en) APPARATUS FOR POSITIONING LOW MASS OBJECTS
ES8506324A1 (en) Process for producing 4'-demethyl-epipodophyllotoxin-beta-D-ethylidene-glucoside and acyl-derivative thereof.
RU2000106749A (en) METHOD FOR SYNTHESIS OF TAXANS
RO77565A (en) PROCESS FOR THE PREPARATION OF 9 (2-HYDROXYALKYL) -HYPOXANTHINES
RU95121634A (en) METHOD OF OBTAINING ACRYL-PIPERIDINICARBINOLS
CA2353822A1 (en) Camptothecin analogs and methods of preparation thereof
RU93036551A (en) METHOD FOR PRODUCING II-KETO-STEROID DERIVATIVES
CA2090509A1 (en) Process for preparing fibrinogen receptor antagonists
RU95122287A (en) NIPECOTINIC ACID DERIVATIVES AS SUBSTANCES THAT IMPEDE THE DISTRIBUTION
RU2003119879A (en) KETONE COMPOUND, INTERMEDIATE COMPOUND AND METHOD FOR PRODUCING THEREOF
RU97112894A (en) DERIVATIVES 10-DEACETYL-14BETA-HYDROXYBACACATINE III, METHOD FOR THEIR OBTAINING AND COMPOSITIONS CONTAINING THESE COMPOUNDS
KR950032234A (en) Method for producing silacyclohexane-based liquid crystal using silacyclohexane carboaldehyde compound and carboaldehyde compound
RU93045021A (en) METHOD OF OBTAINING SUBSTITUTED INDANONS
TW371300B (en) Process for converting 2,4-dichloropyridines into 2-aryloxy-4-chloropyridines
ES2143517T3 (en) PROCEDURE TO PREPARE A COMPLEX COMPLEX OF HIGHER ORDER.
RU99116252A (en) METHOD OF OBTAINING IMIDAZOL DERIVATIVES
RU95121995A (en) METHOD OF OBTAINING DIARYLOSPHITES WITH VARIOUS RADICALS
RU96121513A (en) EQUILINE ISOMERIZATION
RU2005101336A (en) METHOD FOR PRODUCING SYNTHETIC INTERMEDIATE INDOLINE COMPOUNDS
JPS5686190A (en) Novel silylating agent and its preparation
JPH0395193A (en) Novel method for preparation of 2-diazo-3- trisubstituted silyloxy-3-butenoate