RS63543B1 - Peptidomimetici strukture beta-ukosnice kao selektivni inhibitori elastaze - Google Patents

Peptidomimetici strukture beta-ukosnice kao selektivni inhibitori elastaze

Info

Publication number
RS63543B1
RS63543B1 RS20220817A RSP20220817A RS63543B1 RS 63543 B1 RS63543 B1 RS 63543B1 RS 20220817 A RS20220817 A RS 20220817A RS P20220817 A RSP20220817 A RS P20220817A RS 63543 B1 RS63543 B1 RS 63543B1
Authority
RS
Serbia
Prior art keywords
pro
thr
lys
ser
glu
Prior art date
Application number
RS20220817A
Other languages
English (en)
Serbian (sr)
Inventor
Frank Otto Gombert
Daniel Obrecht
Odile Sellier-Kessler
Alexander Lederer
Christian Ludin
Manuella Schmitt-Billet
Steffen Weinbrenner
Original Assignee
Spexis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spexis Ag filed Critical Spexis Ag
Publication of RS63543B1 publication Critical patent/RS63543B1/sr

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811Serine protease (E.C. 3.4.21) inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64Cyclic peptides containing only normal peptide links
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
RS20220817A 2013-12-27 2013-12-27 Peptidomimetici strukture beta-ukosnice kao selektivni inhibitori elastaze RS63543B1 (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13815527.0A EP3087094B1 (en) 2013-12-27 2013-12-27 Beta-hairpin peptidomimetics as selective elastase inhibitors
PCT/EP2013/078073 WO2015096873A1 (en) 2013-12-27 2013-12-27 Beta-hairpin peptidomimetics as selective elastase inhibitors

Publications (1)

Publication Number Publication Date
RS63543B1 true RS63543B1 (sr) 2022-09-30

Family

ID=49911533

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20220817A RS63543B1 (sr) 2013-12-27 2013-12-27 Peptidomimetici strukture beta-ukosnice kao selektivni inhibitori elastaze

Country Status (25)

Country Link
US (1) US10273267B2 (enExample)
EP (1) EP3087094B1 (enExample)
JP (1) JP6499183B2 (enExample)
KR (1) KR102214694B1 (enExample)
CN (1) CN106029689B (enExample)
AU (1) AU2013409200B2 (enExample)
BR (1) BR112016014916B1 (enExample)
CA (1) CA2933660C (enExample)
DK (1) DK3087094T3 (enExample)
EA (1) EA201691330A1 (enExample)
ES (1) ES2925747T3 (enExample)
HR (1) HRP20221046T1 (enExample)
HU (1) HUE059846T2 (enExample)
IL (1) IL246175B (enExample)
LT (1) LT3087094T (enExample)
MX (1) MX389053B (enExample)
NZ (1) NZ722025A (enExample)
PL (1) PL3087094T3 (enExample)
PT (1) PT3087094T (enExample)
RS (1) RS63543B1 (enExample)
SG (1) SG11201605122WA (enExample)
SI (1) SI3087094T1 (enExample)
SM (1) SMT202200393T1 (enExample)
WO (1) WO2015096873A1 (enExample)
ZA (1) ZA201604821B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0721259C1 (pt) 2007-02-28 2021-05-25 Polyphor Ltd composto, composição farmacêutica, uso de composto, e, processo para a fabricação de composto
CN105873939B (zh) * 2013-12-27 2021-08-27 波利弗尔股份公司 作为选择性弹性蛋白酶抑制剂的β-发夹肽模拟物
US10676723B2 (en) * 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
SG11201802777XA (en) 2015-10-14 2018-05-30 X Therma Inc Compositions and methods for reducing ice crystal formation
ES2928050T3 (es) 2016-05-31 2022-11-15 Spexis Ag Peptidomimético de horquilla beta con actividad inhibidora de elastasa y formas de dosificación en aerosol del mismo
BR112022004861A2 (pt) 2019-09-17 2022-06-07 Univ Duke Alvelestat para uso no tratamento de rejeição de transplante, síndrome de bronquiolite obliterante e doença de transplante versus hospedeiro
US20230190723A1 (en) 2020-04-16 2023-06-22 Mereo Biopharma 4 Limited Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency
CN114573686A (zh) * 2020-11-30 2022-06-03 中国医学科学院药物研究所 含有二硫键且具有抑制丝氨酸蛋白酶活性的多肽及其应用
AU2022373971A1 (en) 2021-10-20 2024-04-04 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595756A (en) * 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
GB9825854D0 (en) 1998-11-25 1999-01-20 Univ Bristol Peptide
CN101157924A (zh) 2001-12-11 2008-04-09 人体基因组科学有限公司 嗜中性白细胞因子α
CA2915175C (en) * 2005-02-17 2019-04-09 Polyphor Ltd. Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity
CN105873939B (zh) * 2013-12-27 2021-08-27 波利弗尔股份公司 作为选择性弹性蛋白酶抑制剂的β-发夹肽模拟物

Also Published As

Publication number Publication date
BR112016014916A2 (enExample) 2017-08-08
SMT202200393T1 (it) 2022-11-18
IL246175A0 (en) 2016-07-31
EP3087094A1 (en) 2016-11-02
CN106029689B (zh) 2021-09-28
EP3087094B1 (en) 2022-06-01
ZA201604821B (en) 2017-09-27
PT3087094T (pt) 2022-09-05
ES2925747T3 (es) 2022-10-19
AU2013409200B2 (en) 2019-08-15
EA201691330A1 (ru) 2016-10-31
IL246175B (en) 2022-04-01
MX389053B (es) 2025-03-20
WO2015096873A1 (en) 2015-07-02
AU2013409200A1 (en) 2016-07-21
MX2016008318A (es) 2016-10-13
US20160333053A1 (en) 2016-11-17
KR20160102313A (ko) 2016-08-29
NZ722025A (en) 2019-06-28
JP2017504620A (ja) 2017-02-09
SG11201605122WA (en) 2016-07-28
US10273267B2 (en) 2019-04-30
CN106029689A (zh) 2016-10-12
SI3087094T1 (sl) 2022-11-30
LT3087094T (lt) 2022-09-26
HUE059846T2 (hu) 2023-01-28
HRP20221046T1 (hr) 2023-01-20
DK3087094T3 (da) 2022-08-29
CA2933660C (en) 2023-05-09
KR102214694B1 (ko) 2021-02-10
CA2933660A1 (en) 2015-07-02
BR112016014916B1 (pt) 2022-10-04
JP6499183B2 (ja) 2019-04-10
PL3087094T3 (pl) 2022-09-26

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