KR102214694B1 - 선택적인 엘라스타제 저해제로서 β-헤어핀 펩타이드 모방체 - Google Patents

선택적인 엘라스타제 저해제로서 β-헤어핀 펩타이드 모방체 Download PDF

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KR102214694B1
KR102214694B1 KR1020167020452A KR20167020452A KR102214694B1 KR 102214694 B1 KR102214694 B1 KR 102214694B1 KR 1020167020452 A KR1020167020452 A KR 1020167020452A KR 20167020452 A KR20167020452 A KR 20167020452A KR 102214694 B1 KR102214694 B1 KR 102214694B1
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KR20160102313A (ko
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프랭크 오토 검벌트
다니엘 오브레흐트
오딜 셀리에-케슬러
알렉산더 레더러
크리스티안 루딘
마누엘라 슈미트-빌레
스테픈 바인브레너
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폴리포 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
KR1020167020452A 2013-12-27 2013-12-27 선택적인 엘라스타제 저해제로서 β-헤어핀 펩타이드 모방체 Expired - Fee Related KR102214694B1 (ko)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2013/078073 WO2015096873A1 (en) 2013-12-27 2013-12-27 Beta-hairpin peptidomimetics as selective elastase inhibitors

Publications (2)

Publication Number Publication Date
KR20160102313A KR20160102313A (ko) 2016-08-29
KR102214694B1 true KR102214694B1 (ko) 2021-02-10

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KR1020167020452A Expired - Fee Related KR102214694B1 (ko) 2013-12-27 2013-12-27 선택적인 엘라스타제 저해제로서 β-헤어핀 펩타이드 모방체

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US (1) US10273267B2 (enExample)
EP (1) EP3087094B1 (enExample)
JP (1) JP6499183B2 (enExample)
KR (1) KR102214694B1 (enExample)
CN (1) CN106029689B (enExample)
AU (1) AU2013409200B2 (enExample)
BR (1) BR112016014916B1 (enExample)
CA (1) CA2933660C (enExample)
DK (1) DK3087094T3 (enExample)
EA (1) EA201691330A1 (enExample)
ES (1) ES2925747T3 (enExample)
HR (1) HRP20221046T1 (enExample)
HU (1) HUE059846T2 (enExample)
IL (1) IL246175B (enExample)
LT (1) LT3087094T (enExample)
MX (1) MX389053B (enExample)
NZ (1) NZ722025A (enExample)
PL (1) PL3087094T3 (enExample)
PT (1) PT3087094T (enExample)
RS (1) RS63543B1 (enExample)
SG (1) SG11201605122WA (enExample)
SI (1) SI3087094T1 (enExample)
SM (1) SMT202200393T1 (enExample)
WO (1) WO2015096873A1 (enExample)
ZA (1) ZA201604821B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5140686B2 (ja) 2007-02-28 2013-02-06 ポリファー リミテッド テンプレート固定ペプチド模倣薬
MX2016008468A (es) * 2013-12-27 2016-09-26 Polyphor Ag Peptidomimeticos de horquilla beta como inhibidores de elastasa selectivos.
US10676723B2 (en) * 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
EP3370518B1 (en) 2015-10-14 2023-08-23 X-Therma, Inc. Compositions and methods for reducing ice crystal formation
HRP20221194T1 (hr) 2016-05-31 2022-12-09 Spexis Ag Beta-ukosnica peptidomimetik s inhibitorskom aktivnošću elastase i njegovi oblici doziranja aerosolom
AU2020349353A1 (en) 2019-09-17 2022-04-14 Duke University Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
ES2962498T3 (es) 2020-04-16 2024-03-19 Mereo Biopharma 4 Ltd Métodos que implican el inhibidor de elastasa de neutrófilos alvelestat para el tratamiento de enfermedades respiratorias mediadas por deficiencia de alfa-1 antitripsina
CN114573686A (zh) * 2020-11-30 2022-06-03 中国医学科学院药物研究所 含有二硫键且具有抑制丝氨酸蛋白酶活性的多肽及其应用
KR20240090272A (ko) 2021-10-20 2024-06-21 메레오 바이오파마 4 리미티드 섬유화 치료에 사용하기 위한 호중구 엘라스테이스 억제제

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000031139A1 (en) 1998-11-25 2000-06-02 University Of Bristol Peptide inhibitor of browman-birk type
JP2005524613A (ja) 2001-12-11 2005-08-18 ポリファー リミテッド セリンプロテアーゼ阻害剤としてのテンプレート結合ペプチド擬似体
WO2006087001A1 (en) 2005-02-17 2006-08-24 Polyphor Ltd. Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595756A (en) * 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
MX2016008468A (es) * 2013-12-27 2016-09-26 Polyphor Ag Peptidomimeticos de horquilla beta como inhibidores de elastasa selectivos.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000031139A1 (en) 1998-11-25 2000-06-02 University Of Bristol Peptide inhibitor of browman-birk type
JP2005524613A (ja) 2001-12-11 2005-08-18 ポリファー リミテッド セリンプロテアーゼ阻害剤としてのテンプレート結合ペプチド擬似体
WO2006087001A1 (en) 2005-02-17 2006-08-24 Polyphor Ltd. Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity
JP2008531485A (ja) * 2005-02-17 2008-08-14 ポリファー リミテッド プロテアーゼ阻害活性を有するテンプレート固定β−ヘアピンペプチド擬似体

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CA2933660A1 (en) 2015-07-02
BR112016014916B1 (pt) 2022-10-04
AU2013409200B2 (en) 2019-08-15
EP3087094B1 (en) 2022-06-01
DK3087094T3 (da) 2022-08-29
RS63543B1 (sr) 2022-09-30
CA2933660C (en) 2023-05-09
PT3087094T (pt) 2022-09-05
US10273267B2 (en) 2019-04-30
CN106029689B (zh) 2021-09-28
NZ722025A (en) 2019-06-28
KR20160102313A (ko) 2016-08-29
LT3087094T (lt) 2022-09-26
SMT202200393T1 (it) 2022-11-18
HUE059846T2 (hu) 2023-01-28
CN106029689A (zh) 2016-10-12
ES2925747T3 (es) 2022-10-19
AU2013409200A1 (en) 2016-07-21
WO2015096873A1 (en) 2015-07-02
IL246175B (en) 2022-04-01
PL3087094T3 (pl) 2022-09-26
JP2017504620A (ja) 2017-02-09
EP3087094A1 (en) 2016-11-02
SG11201605122WA (en) 2016-07-28
MX389053B (es) 2025-03-20
US20160333053A1 (en) 2016-11-17
MX2016008318A (es) 2016-10-13
BR112016014916A2 (enExample) 2017-08-08
SI3087094T1 (sl) 2022-11-30
EA201691330A1 (ru) 2016-10-31
ZA201604821B (en) 2017-09-27
HRP20221046T1 (hr) 2023-01-20
JP6499183B2 (ja) 2019-04-10
IL246175A0 (en) 2016-07-31

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