RS58977B1 - Genetički modifikovane mezenhimske matične ćelije koje ekprimiraju alfa-1 antitripsin (aat) - Google Patents
Genetički modifikovane mezenhimske matične ćelije koje ekprimiraju alfa-1 antitripsin (aat)Info
- Publication number
- RS58977B1 RS58977B1 RS20190634A RSP20190634A RS58977B1 RS 58977 B1 RS58977 B1 RS 58977B1 RS 20190634 A RS20190634 A RS 20190634A RS P20190634 A RSP20190634 A RS P20190634A RS 58977 B1 RS58977 B1 RS 58977B1
- Authority
- RS
- Serbia
- Prior art keywords
- antitrypsin
- aat
- stem cells
- cells expressing
- genetically modified
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/73—Hydrolases (EC 3.)
- C12N2501/734—Proteases (EC 3.4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/10041—Use of virus, viral particle or viral elements as a vector
- C12N2740/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15150454 | 2015-01-08 | ||
| EP15191934 | 2015-10-28 | ||
| EP16700404.3A EP3242933B1 (en) | 2015-01-08 | 2016-01-08 | Genetically modified mesenchymal stem cells expressing alpha-1 antitrypsin (aat) |
| PCT/EP2016/050271 WO2016110565A1 (en) | 2015-01-08 | 2016-01-08 | Genetically modified mesenchymal stem cells expressing alpha-1 antitrypsin (aat) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS58977B1 true RS58977B1 (sr) | 2019-08-30 |
Family
ID=55129837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20190634A RS58977B1 (sr) | 2015-01-08 | 2016-01-08 | Genetički modifikovane mezenhimske matične ćelije koje ekprimiraju alfa-1 antitripsin (aat) |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US20180000969A1 (sr) |
| EP (1) | EP3242933B1 (sr) |
| JP (4) | JP2018502579A (sr) |
| CN (1) | CN107208063A (sr) |
| AU (1) | AU2016206033B2 (sr) |
| CA (1) | CA2970993A1 (sr) |
| CY (1) | CY1122004T1 (sr) |
| DK (1) | DK3242933T3 (sr) |
| ES (1) | ES2727820T3 (sr) |
| HU (1) | HUE043478T2 (sr) |
| IL (1) | IL253063B (sr) |
| LT (1) | LT3242933T (sr) |
| PL (1) | PL3242933T3 (sr) |
| PT (1) | PT3242933T (sr) |
| RS (1) | RS58977B1 (sr) |
| SI (1) | SI3242933T1 (sr) |
| WO (1) | WO2016110565A1 (sr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210086662A (ko) * | 2018-10-29 | 2021-07-08 | 오타와 하스피털 리서치 인스티튜트 | Aoah를 과발현하는 유전자조작된 중간엽 줄기 세포 및 이의 용도 |
| CN109512893A (zh) * | 2018-11-05 | 2019-03-26 | 北京世纪劲得生物技术有限公司 | 间充质干细胞及其注射液和组合物在高尿酸血症中的应用 |
| US20220265787A1 (en) | 2019-07-31 | 2022-08-25 | StemRIM Inc. | Composition for promoting growth or suppressing decrease of mesenchymal stem cells |
| US20230058557A1 (en) * | 2020-01-15 | 2023-02-23 | The Regents Of The University Of California | Transplanted cell protection via inhibition of polymorphonuclear cells |
| EP3964265A1 (en) * | 2020-09-07 | 2022-03-09 | Fundacion Instituto De Investigacion Sanitaria Fundacion Jimenez Diaz | Mesenchymal stem cells co-expressing cxcr4 and il-10 and uses thereof |
| WO2024005157A1 (ja) * | 2022-06-30 | 2024-01-04 | 国立大学法人熊本大学 | 脂肪細胞活性化剤 |
| CN116173218B (zh) * | 2023-04-28 | 2023-08-04 | 北京大学口腔医学院 | 蛋白转运抑制剂在制备用于治疗或缓解牙周炎的药物中的用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5266491A (en) * | 1989-03-14 | 1993-11-30 | Mochida Pharmaceutical Co., Ltd. | DNA fragment and expression plasmid containing the DNA fragment |
| AU2003221745A1 (en) | 2002-04-19 | 2003-11-03 | University Of Florida | rAAV VECTOR-BASED COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF MAMMALIAN DISEASES |
| US20080095749A1 (en) * | 2004-03-22 | 2008-04-24 | Sudeepta Aggarwal | Mesenchymal stem cells and uses therefor |
| US9457070B2 (en) * | 2005-06-07 | 2016-10-04 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses of alpha 1-antitrypsin for early intervention in bone marrow transplantation and treatment of graft versus host disease |
| EP2185689A2 (en) | 2007-08-09 | 2010-05-19 | Genzyme Corporation | Method of treating autoimmune disease with mesenchymal stem cells |
| WO2009046015A2 (en) | 2007-09-30 | 2009-04-09 | University Of Florida Research Foundation, Inc. | Combination therapies for treating type 1 diabetes |
| EP2626369A1 (en) * | 2011-11-24 | 2013-08-14 | Fundació Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Engineered mesenchymal stem cells and their therapeutic use |
| KR20140132706A (ko) * | 2011-12-19 | 2014-11-18 | 엘에프비 유에스에이, 인크. | 염증성 장애의 치료를 위한 재조합 인간 알파-1-안티트립신 |
| CN102920735A (zh) | 2012-11-14 | 2013-02-13 | 青岛奥克生物开发有限公司 | 一种间充质干细胞注射液及其制备方法和在制备治疗糖尿病药物中的应用 |
| CN105456293A (zh) | 2014-09-05 | 2016-04-06 | 深圳市北科生物科技有限公司 | 一种用于治疗糖尿病的干细胞制剂及其制备方法 |
-
2016
- 2016-01-08 CA CA2970993A patent/CA2970993A1/en active Pending
- 2016-01-08 AU AU2016206033A patent/AU2016206033B2/en active Active
- 2016-01-08 RS RS20190634A patent/RS58977B1/sr unknown
- 2016-01-08 LT LTEP16700404.3T patent/LT3242933T/lt unknown
- 2016-01-08 JP JP2017536359A patent/JP2018502579A/ja active Pending
- 2016-01-08 PL PL16700404T patent/PL3242933T3/pl unknown
- 2016-01-08 DK DK16700404.3T patent/DK3242933T3/da active
- 2016-01-08 ES ES16700404T patent/ES2727820T3/es active Active
- 2016-01-08 CN CN201680005202.2A patent/CN107208063A/zh active Pending
- 2016-01-08 EP EP16700404.3A patent/EP3242933B1/en active Active
- 2016-01-08 WO PCT/EP2016/050271 patent/WO2016110565A1/en active Application Filing
- 2016-01-08 SI SI201630262T patent/SI3242933T1/sl unknown
- 2016-01-08 US US15/542,031 patent/US20180000969A1/en not_active Abandoned
- 2016-01-08 HU HUE16700404A patent/HUE043478T2/hu unknown
- 2016-01-08 PT PT16700404T patent/PT3242933T/pt unknown
-
2017
- 2017-06-21 IL IL253063A patent/IL253063B/en active IP Right Grant
-
2019
- 2019-05-24 CY CY20191100553T patent/CY1122004T1/el unknown
-
2020
- 2020-02-25 US US16/800,840 patent/US20200282078A1/en not_active Abandoned
- 2020-12-01 JP JP2020199368A patent/JP2021046416A/ja active Pending
-
2022
- 2022-10-17 JP JP2022166094A patent/JP7374527B2/ja active Active
-
2023
- 2023-03-31 US US18/194,383 patent/US20230226222A1/en active Pending
- 2023-10-18 JP JP2023179480A patent/JP2024010006A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| PL3242933T3 (pl) | 2019-08-30 |
| DK3242933T3 (da) | 2019-06-03 |
| HUE043478T2 (hu) | 2019-08-28 |
| IL253063A0 (en) | 2017-08-31 |
| SI3242933T1 (sl) | 2019-08-30 |
| JP2021046416A (ja) | 2021-03-25 |
| ES2727820T3 (es) | 2019-10-18 |
| JP2023002657A (ja) | 2023-01-10 |
| IL253063B (en) | 2019-06-30 |
| CA2970993A1 (en) | 2016-07-14 |
| EP3242933B1 (en) | 2019-02-27 |
| LT3242933T (lt) | 2019-06-25 |
| US20230226222A1 (en) | 2023-07-20 |
| JP2018502579A (ja) | 2018-02-01 |
| WO2016110565A1 (en) | 2016-07-14 |
| JP7374527B2 (ja) | 2023-11-07 |
| AU2016206033A1 (en) | 2017-07-06 |
| EP3242933A1 (en) | 2017-11-15 |
| JP2024010006A (ja) | 2024-01-23 |
| US20180000969A1 (en) | 2018-01-04 |
| US20200282078A1 (en) | 2020-09-10 |
| CY1122004T1 (el) | 2020-10-14 |
| AU2016206033B2 (en) | 2022-06-16 |
| CN107208063A (zh) | 2017-09-26 |
| PT3242933T (pt) | 2019-06-05 |
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