RS58897B1 - Tečna inhalaciona formulacija koja sadrži rpl554 - Google Patents

Tečna inhalaciona formulacija koja sadrži rpl554

Info

Publication number
RS58897B1
RS58897B1 RS20190765A RSP20190765A RS58897B1 RS 58897 B1 RS58897 B1 RS 58897B1 RS 20190765 A RS20190765 A RS 20190765A RS P20190765 A RSP20190765 A RS P20190765A RS 58897 B1 RS58897 B1 RS 58897B1
Authority
RS
Serbia
Prior art keywords
rpl554
liquid pharmaceutical
pharmaceutical composition
concentration
particles
Prior art date
Application number
RS20190765A
Other languages
English (en)
Serbian (sr)
Inventor
Peter Lionel Spargo
Edward James French
Philip A Haywood
Original Assignee
Verona Pharma Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1416274.7A external-priority patent/GB201416274D0/en
Priority claimed from GBGB1504662.6A external-priority patent/GB201504662D0/en
Application filed by Verona Pharma Plc filed Critical Verona Pharma Plc
Publication of RS58897B1 publication Critical patent/RS58897B1/sr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RS20190765A 2014-09-15 2015-09-15 Tečna inhalaciona formulacija koja sadrži rpl554 RS58897B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1416274.7A GB201416274D0 (en) 2014-09-15 2014-09-15 Formulation
GBGB1504662.6A GB201504662D0 (en) 2015-03-19 2015-03-19 Formulation
EP17207623.4A EP3332767B1 (en) 2014-09-15 2015-09-15 Liquid inhalation formulation comprising rpl554

Publications (1)

Publication Number Publication Date
RS58897B1 true RS58897B1 (sr) 2019-08-30

Family

ID=54196992

Family Applications (3)

Application Number Title Priority Date Filing Date
RS20190765A RS58897B1 (sr) 2014-09-15 2015-09-15 Tečna inhalaciona formulacija koja sadrži rpl554
RS20211044A RS62252B1 (sr) 2014-09-15 2015-09-15 Tečna inhalaciona formulacija koja sadrži rpl554
RS20180519A RS57227B1 (sr) 2014-09-15 2015-09-15 Tečna inhalaciona formulacija koja sadrži rpl554

Family Applications After (2)

Application Number Title Priority Date Filing Date
RS20211044A RS62252B1 (sr) 2014-09-15 2015-09-15 Tečna inhalaciona formulacija koja sadrži rpl554
RS20180519A RS57227B1 (sr) 2014-09-15 2015-09-15 Tečna inhalaciona formulacija koja sadrži rpl554

Country Status (27)

Country Link
US (2) US9956171B2 (enExample)
EP (3) EP3332767B1 (enExample)
JP (2) JP6860477B2 (enExample)
KR (1) KR102379309B1 (enExample)
CN (3) CN111249260B (enExample)
AU (3) AU2015316592B2 (enExample)
CA (1) CA2959943C (enExample)
CY (3) CY1120264T1 (enExample)
DK (3) DK3494962T3 (enExample)
ES (3) ES2730810T3 (enExample)
HK (1) HK1249415B (enExample)
HR (3) HRP20180833T1 (enExample)
HU (3) HUE045303T2 (enExample)
IL (1) IL250895B (enExample)
LT (3) LT3193835T (enExample)
MX (1) MX2017003102A (enExample)
MY (1) MY196072A (enExample)
NO (1) NO3193835T3 (enExample)
PH (1) PH12017500479B1 (enExample)
PL (3) PL3332767T3 (enExample)
PT (3) PT3193835T (enExample)
RS (3) RS58897B1 (enExample)
RU (1) RU2699995C2 (enExample)
SG (1) SG11201701854WA (enExample)
SI (3) SI3193835T1 (enExample)
SM (3) SMT201800242T1 (enExample)
WO (1) WO2016042313A1 (enExample)

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SI3231444T1 (sl) 2014-05-12 2020-04-30 Verona Pharma Plc Novo zdravljenje
DK3494962T3 (da) * 2014-09-15 2021-06-21 Verona Pharma Plc Flydende inhalationsformulering omfattende RPL554
GB201502260D0 (en) 2015-02-11 2015-04-01 Verona Pharma Plc Salt of Pyrimido[6,1-A]Isoquinolin-4-one compound
HK1251593A1 (zh) 2015-07-24 2019-02-01 豪夫迈‧罗氏有限公司 Bace1抑制剂肽
GB201613054D0 (en) 2016-07-28 2016-09-14 Verona Pharma Plc New compound and process
GB2578093B (en) 2018-10-09 2020-11-18 Verona Pharma Plc Liquid pharmaceutical composition comprising RPL554 and HFA-134A
JP6994061B2 (ja) * 2019-02-15 2022-01-14 ノバルティス アーゲー 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤
GB201911517D0 (en) 2019-08-12 2019-09-25 Verona Pharma Plc Pharmaceutical composition
ES2995084T3 (en) * 2020-01-15 2025-02-05 Chia Tai Tianqing Pharmaceutical Group Co Ltd Pharmaceutical composition of tricyclic pde3/pde4 dual inhibitor compound
GB202002786D0 (en) * 2020-02-27 2020-04-15 Verona Pharma Plc Liquid pharmaceutical composition
GB202202297D0 (en) * 2022-02-21 2022-04-06 Verona Pharma Plc Formulation production process
KR20250048092A (ko) * 2022-08-08 2025-04-07 베로나 파마 피엘씨 만성 폐쇄성 폐질환 악화 빈도 및/또는 중증도 감소를 위한 엔시펜트린(rpl-554)
WO2024033627A1 (en) * 2022-08-08 2024-02-15 Verona Pharma Plc Liquid pharmaceutical composition
JP2025534762A (ja) * 2022-10-28 2025-10-17 江蘇恒瑞医薬股▲ふん▼有限公司 イソキノリノン系化合物を含む医薬組成物及びその調製方法
EP4378942A1 (en) 2022-12-02 2024-06-05 Sandoz AG Crystal form of a pde3/4 inhibitor
WO2025003643A1 (en) * 2023-06-26 2025-01-02 Verona Pharma Plc Particulate composition comprising ensifetrine
TW202506117A (zh) 2023-06-26 2025-02-16 英商維羅納製藥Plc公司 顆粒組成物
US20250073240A1 (en) * 2023-09-06 2025-03-06 Verona Pharma Plc New treatment
WO2025168546A1 (en) * 2024-02-05 2025-08-14 Verona Pharma Plc Ensifentrine for the treatment of copd
WO2025168706A1 (en) * 2024-02-07 2025-08-14 Verona Pharma Plc Pharmaceutical compositions of ensifentrine for chronic obstructive pulmonary disease
US20250249008A1 (en) * 2024-02-07 2025-08-07 Verona Pharma Plc Pharmaceutical compositions of ensifentrine for chronic obstructive pulmonary disease

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JP3676674B2 (ja) * 1997-10-09 2005-07-27 シェーリング コーポレイション 噴霧のためのモメタゾンフロエート懸濁液
SE9704186D0 (sv) 1997-11-14 1997-11-14 Astra Ab New composition of matter
EP1165558B1 (en) 1999-03-31 2003-09-24 Vernalis Limited Derivatives of pyrimido[6,1-a]isoquinolin-4-one
US6630169B1 (en) * 1999-03-31 2003-10-07 Nektar Therapeutics Particulate delivery systems and methods of use
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GB0122031D0 (en) 2001-09-12 2001-10-31 Pfizer Ltd Use of pde4 inhibitors in a dry powder inhaler
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ITMI20051999A1 (it) 2005-10-21 2007-04-22 Eratech S R L Formulazioni inalatorie di farmaci in fora di polvere secca per somministrazione come tale o con nebulizzatore e dotate di elevata erogabilita' respirabilita' e stabilita'
KR20130087405A (ko) * 2010-06-22 2013-08-06 키에시 파르마슈티시 엣스. 피. 에이. 알칼로이드 아미노에스테르 유도체 및 이의 의약 조성물
PH12013500261A1 (en) * 2010-08-09 2013-03-04 Verona Pharma Plc Crystalline form of pyrimidio[6,1-a]isoquinolin-4-one compound
US8945605B2 (en) 2011-06-07 2015-02-03 Parion Sciences, Inc. Aerosol delivery systems, compositions and methods
EP2717855A4 (en) * 2011-06-07 2014-11-12 Parion Sciences Inc PROCESSING METHODS
EP2647627A1 (en) * 2012-04-02 2013-10-09 Almirall, S.A. Salts of 5-[(1r)-2-({2-[4-(2,2-difluoro-2-phenylethoxy)phenyl] ethyl}amino)-1-hydroxyethyl]-8-hydroxyquinolin-2(1h)-one.
WO2014037727A1 (en) * 2012-09-06 2014-03-13 Verona Pharma Plc Carcainium salts
PT2968313T (pt) * 2013-03-15 2018-02-21 Verona Pharma Plc Combinação de fármacos
CN106105056B (zh) * 2014-03-11 2019-07-12 Lg电子株式会社 D2d用户设备在通信系统中发送发现信号的方法和设备
SI3231444T1 (sl) 2014-05-12 2020-04-30 Verona Pharma Plc Novo zdravljenje
DK3494962T3 (da) * 2014-09-15 2021-06-21 Verona Pharma Plc Flydende inhalationsformulering omfattende RPL554
GB201502260D0 (en) * 2015-02-11 2015-04-01 Verona Pharma Plc Salt of Pyrimido[6,1-A]Isoquinolin-4-one compound

Also Published As

Publication number Publication date
DK3494962T3 (da) 2021-06-21
NO3193835T3 (enExample) 2018-08-04
EP3332767B1 (en) 2019-03-20
EP3193835B1 (en) 2018-03-07
RS62252B1 (sr) 2021-09-30
CN106794157A (zh) 2017-05-31
SMT202100479T1 (it) 2021-09-14
PT3332767T (pt) 2019-06-27
AU2015316592A1 (en) 2017-03-23
EP3494962B1 (en) 2021-05-26
PL3193835T3 (pl) 2018-07-31
PH12017500479A1 (en) 2017-07-31
ES2875584T3 (es) 2021-11-10
ES2670025T3 (es) 2018-05-29
PH12017500479B1 (en) 2021-07-21
CY1121698T1 (el) 2020-07-31
SI3193835T1 (en) 2018-06-29
PL3494962T3 (pl) 2021-12-06
US9956171B2 (en) 2018-05-01
SI3332767T1 (sl) 2019-07-31
LT3332767T (lt) 2019-06-25
EP3193835A1 (en) 2017-07-26
DK3332767T3 (da) 2019-06-24
BR112017005050A2 (pt) 2018-01-23
JP6860477B2 (ja) 2021-04-14
IL250895A0 (en) 2017-04-30
JP2017528479A (ja) 2017-09-28
HRP20180833T1 (hr) 2018-06-29
NZ767295A (en) 2024-01-26
AU2018286571A1 (en) 2019-01-24
CN111249260A (zh) 2020-06-09
PT3193835T (pt) 2018-03-27
CY1120264T1 (el) 2019-07-10
EP3332767A1 (en) 2018-06-13
AU2020203081B2 (en) 2021-08-05
US20170239178A1 (en) 2017-08-24
KR20170054406A (ko) 2017-05-17
LT3494962T (lt) 2021-07-26
US20180369139A1 (en) 2018-12-27
AU2015316592B2 (en) 2020-04-02
KR102379309B1 (ko) 2022-03-28
HUE045303T2 (hu) 2019-12-30
LT3193835T (lt) 2018-06-11
CN110051627A (zh) 2019-07-26
CA2959943A1 (en) 2016-03-24
RS57227B1 (sr) 2018-07-31
IL250895B (en) 2019-08-29
CN111249260B (zh) 2023-01-10
NZ767296A (en) 2024-01-26
ES2730810T3 (es) 2019-11-12
EP3494962A1 (en) 2019-06-12
HRP20191122T1 (hr) 2019-09-20
CY1124546T1 (el) 2022-07-22
SI3494962T1 (sl) 2021-09-30
NZ729796A (en) 2024-01-26
JP6795574B2 (ja) 2020-12-02
JP2019069978A (ja) 2019-05-09
RU2699995C2 (ru) 2019-09-12
MY196072A (en) 2023-03-13
RU2017108432A3 (enExample) 2019-04-01
SMT201900340T1 (it) 2019-07-11
DK3193835T3 (en) 2018-05-07
SG11201701854WA (en) 2017-04-27
CN106794157B (zh) 2021-03-09
PT3494962T (pt) 2021-06-22
PL3332767T3 (pl) 2019-10-31
HUE038433T2 (hu) 2018-10-29
RU2017108432A (ru) 2018-10-17
SMT201800242T1 (it) 2018-07-17
MX2017003102A (es) 2017-06-14
US10945950B2 (en) 2021-03-16
HK1249415B (en) 2019-11-22
HUE055527T2 (hu) 2021-12-28
AU2020203081A1 (en) 2020-05-28
CA2959943C (en) 2022-08-16
HRP20211035T1 (hr) 2021-09-17
AU2018286571B2 (en) 2020-04-02
WO2016042313A1 (en) 2016-03-24

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