RS55732B1 - Supstituisani benzamidi sa aktivnošću prema ep4 receptorima - Google Patents
Supstituisani benzamidi sa aktivnošću prema ep4 receptorimaInfo
- Publication number
- RS55732B1 RS55732B1 RS20170161A RSP20170161A RS55732B1 RS 55732 B1 RS55732 B1 RS 55732B1 RS 20170161 A RS20170161 A RS 20170161A RS P20170161 A RSP20170161 A RS P20170161A RS 55732 B1 RS55732 B1 RS 55732B1
- Authority
- RS
- Serbia
- Prior art keywords
- receptors
- activity towards
- substituted benzamides
- benzamides
- substituted
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13382037.3A EP2765128A1 (en) | 2013-02-07 | 2013-02-07 | Substituted benzamides with activity towards EP4 receptors |
US201361770096P | 2013-02-27 | 2013-02-27 | |
EP14706498.4A EP2953927B1 (en) | 2013-02-07 | 2014-02-07 | Substituted benzamides with activity towards ep4 receptors |
PCT/EP2014/052437 WO2014122267A1 (en) | 2013-02-07 | 2014-02-07 | Substituted benzamides with activity towards ep4 receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
RS55732B1 true RS55732B1 (sr) | 2017-07-31 |
Family
ID=47715954
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RS20170161A RS55732B1 (sr) | 2013-02-07 | 2014-02-07 | Supstituisani benzamidi sa aktivnošću prema ep4 receptorima |
Country Status (20)
Country | Link |
---|---|
US (1) | US9926276B2 (sr) |
EP (2) | EP2765128A1 (sr) |
JP (1) | JP6495831B2 (sr) |
AR (1) | AR094735A1 (sr) |
CA (1) | CA2900599C (sr) |
CL (1) | CL2015002202A1 (sr) |
CY (1) | CY1119047T1 (sr) |
DK (1) | DK2953927T3 (sr) |
ES (1) | ES2615742T3 (sr) |
HR (1) | HRP20170221T1 (sr) |
HU (1) | HUE031453T2 (sr) |
IL (1) | IL240417B (sr) |
LT (1) | LT2953927T (sr) |
PL (1) | PL2953927T3 (sr) |
PT (1) | PT2953927T (sr) |
RS (1) | RS55732B1 (sr) |
SI (1) | SI2953927T1 (sr) |
SM (1) | SMT201700118B (sr) |
TW (1) | TWI641583B (sr) |
WO (1) | WO2014122267A1 (sr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201314926D0 (en) * | 2013-08-20 | 2013-10-02 | Takeda Pharmaceutical | Novel Compounds |
MX368178B (es) * | 2013-12-17 | 2019-09-23 | Lilly Co Eli | Compuestos de ácido dimetilbenzoico. |
CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
TWI741040B (zh) * | 2016-10-20 | 2021-10-01 | 德商拜耳作物科學公司 | 製備3-烷基硫基-2-氯-n-(1-烷基-1h-四唑-5-基)-4-三氟甲基苯甲醯胺之方法 |
US11446298B2 (en) | 2017-05-18 | 2022-09-20 | Idorsia Pharmaceuticals Ltd | Pyrimidine derivatives |
US11712438B2 (en) | 2017-05-18 | 2023-08-01 | Idorsia Pharmaceuticals Ltd | Phenyl derivatives as PGE2 receptor modulators |
KR102650756B1 (ko) | 2017-05-18 | 2024-03-22 | 이도르시아 파마슈티컬스 리미티드 | N-치환된 인돌 유도체 |
RS62398B1 (sr) | 2017-05-18 | 2021-10-29 | Idorsia Pharmaceuticals Ltd | Derivati pirimidina kao modulatori receptora pge2 |
CN110621671A (zh) | 2017-05-18 | 2019-12-27 | 爱杜西亚药品有限公司 | 作为pge2受体调节剂的苯并呋喃及苯并噻吩衍生物 |
CN112638871A (zh) * | 2018-07-12 | 2021-04-09 | 罗达制药生物技术有限责任公司 | 作为ep4受体拮抗剂的(r)-4-(1-(1-(4-(三氟甲基)苄基)吡咯烷-2-甲酰胺)环丙基)苯甲酸 |
EP3693359A1 (en) * | 2019-02-08 | 2020-08-12 | Medibiofarma, S.L. | New n-benzyl-2-phenoxybenzamide derivatives as prostaglandin e2 (pge2) receptors modulators |
WO2024033374A1 (en) | 2022-08-11 | 2024-02-15 | Syngenta Crop Protection Ag | Novel arylcarboxamide or arylthioamide compounds |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2708678A (en) * | 1954-01-15 | 1955-05-17 | Schering Corp | Iodinated acyl derivatives of 2, 4, 6-trhodometa-aminobenzoic acid |
AR194032A1 (es) * | 1972-01-22 | 1973-06-12 | Hoechst Ag | Nuevos acidos n-(aminobenzoil)-aminoaril-sulfonicos y procedimiento para su preparacion |
US5516774A (en) * | 1993-07-29 | 1996-05-14 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
EA015931B1 (ru) * | 2006-12-15 | 2011-12-30 | Глэксо Груп Лимитед | Бензамидные производные как агонисты ер-рецепторов |
CA2692265A1 (en) * | 2007-07-03 | 2009-01-08 | Astellas Pharma Inc. | Amide compounds |
GB0721611D0 (en) | 2007-11-02 | 2007-12-12 | Glaxo Group Ltd | Novel compounds |
US9457084B2 (en) * | 2010-02-22 | 2016-10-04 | Raqualia Pharma Inc. | Use of EP4 receptor antagonists in the treatment of IL-23 mediated diseases |
TWI572597B (zh) * | 2012-06-29 | 2017-03-01 | 美國禮來大藥廠 | 二甲基-苯甲酸化合物 |
-
2013
- 2013-02-07 EP EP13382037.3A patent/EP2765128A1/en not_active Withdrawn
-
2014
- 2014-02-07 PT PT147064984T patent/PT2953927T/pt unknown
- 2014-02-07 ES ES14706498.4T patent/ES2615742T3/es active Active
- 2014-02-07 DK DK14706498.4T patent/DK2953927T3/en active
- 2014-02-07 LT LTEP14706498.4T patent/LT2953927T/lt unknown
- 2014-02-07 WO PCT/EP2014/052437 patent/WO2014122267A1/en active Application Filing
- 2014-02-07 CA CA2900599A patent/CA2900599C/en active Active
- 2014-02-07 US US14/766,654 patent/US9926276B2/en active Active
- 2014-02-07 SI SI201430150A patent/SI2953927T1/sl unknown
- 2014-02-07 PL PL14706498T patent/PL2953927T3/pl unknown
- 2014-02-07 TW TW103104010A patent/TWI641583B/zh active
- 2014-02-07 RS RS20170161A patent/RS55732B1/sr unknown
- 2014-02-07 HU HUE14706498A patent/HUE031453T2/en unknown
- 2014-02-07 JP JP2015556508A patent/JP6495831B2/ja active Active
- 2014-02-07 AR ARP140100409A patent/AR094735A1/es active IP Right Grant
- 2014-02-07 EP EP14706498.4A patent/EP2953927B1/en active Active
-
2015
- 2015-08-06 IL IL240417A patent/IL240417B/en active IP Right Grant
- 2015-08-06 CL CL2015002202A patent/CL2015002202A1/es unknown
-
2017
- 2017-02-02 CY CY20171100149T patent/CY1119047T1/el unknown
- 2017-02-10 HR HRP20170221TT patent/HRP20170221T1/hr unknown
- 2017-02-21 SM SM201700118T patent/SMT201700118B/it unknown
Also Published As
Publication number | Publication date |
---|---|
TWI641583B (zh) | 2018-11-21 |
HUE031453T2 (en) | 2017-07-28 |
HRP20170221T1 (hr) | 2017-05-05 |
IL240417B (en) | 2019-02-28 |
PL2953927T3 (pl) | 2017-09-29 |
EP2953927A1 (en) | 2015-12-16 |
DK2953927T3 (en) | 2017-02-20 |
CA2900599C (en) | 2021-07-13 |
CA2900599A1 (en) | 2014-08-14 |
WO2014122267A1 (en) | 2014-08-14 |
US9926276B2 (en) | 2018-03-27 |
CY1119047T1 (el) | 2018-01-10 |
US20150376129A1 (en) | 2015-12-31 |
JP2016507544A (ja) | 2016-03-10 |
LT2953927T (lt) | 2017-03-10 |
CL2015002202A1 (es) | 2016-04-29 |
IL240417A0 (en) | 2015-09-24 |
EP2953927B1 (en) | 2016-11-16 |
ES2615742T3 (es) | 2017-06-08 |
JP6495831B2 (ja) | 2019-04-03 |
BR112015018930A2 (pt) | 2017-07-18 |
SMT201700118B (it) | 2017-03-08 |
PT2953927T (pt) | 2017-02-13 |
SI2953927T1 (sl) | 2017-07-31 |
AR094735A1 (es) | 2015-08-26 |
TW201443003A (zh) | 2014-11-16 |
EP2765128A1 (en) | 2014-08-13 |
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