RS52608B - PROCEDURE FOR STEREOSELECTIVE PREPARATION (-) - HALOPHENATES AND ITS INTERMEDIATES - Google Patents

PROCEDURE FOR STEREOSELECTIVE PREPARATION (-) - HALOPHENATES AND ITS INTERMEDIATES

Info

Publication number
RS52608B
RS52608B RS20130001A RSP20130001A RS52608B RS 52608 B RS52608 B RS 52608B RS 20130001 A RS20130001 A RS 20130001A RS P20130001 A RSP20130001 A RS P20130001A RS 52608 B RS52608 B RS 52608B
Authority
RS
Serbia
Prior art keywords
formula
group
compatible solvent
compound
product
Prior art date
Application number
RS20130001A
Other languages
English (en)
Serbian (sr)
Inventor
Xin Chen
Yan Zhu
Peng Cheng
Jingyuan Ma
Zuchun Zhao
Original Assignee
Metabolex Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolex Inc. filed Critical Metabolex Inc.
Publication of RS52608B publication Critical patent/RS52608B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182Radicals derived from carboxylic acids
    • C07D295/185Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/301,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
RS20130001A 2005-09-23 2006-09-21 PROCEDURE FOR STEREOSELECTIVE PREPARATION (-) - HALOPHENATES AND ITS INTERMEDIATES RS52608B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72030005P 2005-09-23 2005-09-23
US11/525,200 US7714131B2 (en) 2005-09-23 2006-09-20 Process for the stereoselective preparation of (−)-halofenate and derivatives thereof
PCT/US2006/036928 WO2007038243A1 (en) 2005-09-23 2006-09-21 Process for the stereoselective preparation of (-)-halofenate and intermediates thereof

Publications (1)

Publication Number Publication Date
RS52608B true RS52608B (en) 2013-04-30

Family

ID=37894903

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20130001A RS52608B (en) 2005-09-23 2006-09-21 PROCEDURE FOR STEREOSELECTIVE PREPARATION (-) - HALOPHENATES AND ITS INTERMEDIATES

Country Status (18)

Country Link
US (1) US7714131B2 (US07714131-20100511-C00006.png)
EP (1) EP1940387B1 (US07714131-20100511-C00006.png)
JP (1) JP2009515817A (US07714131-20100511-C00006.png)
KR (1) KR101309605B1 (US07714131-20100511-C00006.png)
AU (1) AU2006294950A1 (US07714131-20100511-C00006.png)
BR (1) BRPI0616188A2 (US07714131-20100511-C00006.png)
CA (1) CA2623350C (US07714131-20100511-C00006.png)
DK (1) DK1940387T3 (US07714131-20100511-C00006.png)
EA (1) EA015673B1 (US07714131-20100511-C00006.png)
ES (1) ES2394973T3 (US07714131-20100511-C00006.png)
HK (1) HK1119953A1 (US07714131-20100511-C00006.png)
HR (1) HRP20130001T1 (US07714131-20100511-C00006.png)
IL (1) IL190325A (US07714131-20100511-C00006.png)
PL (1) PL1940387T3 (US07714131-20100511-C00006.png)
PT (1) PT1940387E (US07714131-20100511-C00006.png)
RS (1) RS52608B (US07714131-20100511-C00006.png)
SI (1) SI1940387T1 (US07714131-20100511-C00006.png)
WO (1) WO2007038243A1 (US07714131-20100511-C00006.png)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009121940A1 (en) * 2008-04-03 2009-10-08 Janssen Pharmaceutica Nv Process for the preparation of (-)-(4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester
WO2009148046A1 (ja) * 2008-06-03 2009-12-10 株式会社カネカ 光学活性アミノ酸誘導体の製造方法
US9060987B2 (en) 2011-11-04 2015-06-23 Cymabay Therapeutics, Inc. Methods for treating gout flares
US9023856B2 (en) 2011-11-04 2015-05-05 Cymabay Therapeutics, Inc. Methods for treating hyperuricemia in patients with gout using halofenate or halogenic acid and a second urate-lowering agent
WO2021236394A1 (en) 2020-05-18 2021-11-25 Cymabay Therapeutics, Inc. Cb-0406 tromethamine salt
US20210355066A1 (en) 2020-05-18 2021-11-18 Cymabay Therapeutics, Inc. CB-0406 choline salt

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3444299A (en) 1964-02-07 1969-05-13 American Cyanamid Co Methods for the control and prevention of helminths with phenylbenzothiazolium compounds
GB1097053A (en) 1964-03-16 1967-12-29 Dow Chemical Co Substituted benzothiazolium compounds and complexes thereof for use in animal husbandry
US3517051A (en) 1964-03-20 1970-06-23 Merck & Co Inc Phenoxy substituted phenylacetic acids
US3378582A (en) 1964-03-20 1968-04-16 Merck & Co Inc (alpha-phenoxy)-and (alpha-phenylthio)-omegaphenyl-alkanoic acids
US3517050A (en) 1966-10-03 1970-06-23 Merck & Co Inc Ester and amide derivative of (3-trifluoromethylphenoxy) (4 - halophenyl)acetic acid
NL6712585A (US07714131-20100511-C00006.png) 1966-10-03 1968-04-04
US3558778A (en) 1966-10-27 1971-01-26 Dow Chemical Co Methods and compositions for use in animal husbandry
US3674836A (en) 1968-05-21 1972-07-04 Parke Davis & Co 2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof
BE754245A (fr) 1969-08-01 1970-12-31 Sumitomo Chemical Co Derives d'acides phenoxy carboxyliques
DK133742B (da) 1970-10-30 1976-07-12 Merck & Co Inc Fremgangsmåde til fremstilling af 2-acetamidoethyl-(3-trifluormethylphenoxy)-(4-chlorphenyl)-acetat.
US3923855A (en) 1972-07-13 1975-12-02 Merck & Co Inc 2-sulfonyloxyethyl 3-trifluoromethylphenoxy-4{40 -chlorophenyl acetate
US3953490A (en) 1972-07-13 1976-04-27 Merck & Co., Inc. Preparation of (3-trifluoromethylphenoxy)(4-chlorophenyl)acetonitrile
US3860628A (en) 1972-07-13 1975-01-14 Merck & Co Inc Cyanomethyl(3-trifluoromethylphenoxy)(4-chlorophenyl)acetate
NL7309571A (US07714131-20100511-C00006.png) 1972-07-28 1974-01-30
US4110351A (en) 1973-04-02 1978-08-29 Richardson-Merrell Inc. Hypolipidemic agents RO- or RS- substituted furoic acids, esters and salts
US3876791A (en) 1973-11-30 1975-04-08 Uniroyal Inc Control of acarids using certain benzothiazoles or benzothiazolines
US4001268A (en) 1974-08-07 1977-01-04 The United States Of America As Represented By The Secretary Of The Air Force Substituted phenyl-benzimidazo compounds
IL48707A0 (en) 1974-12-30 1976-02-29 Synthelabo Novel phenylacetic acid derivatives,their preparation and pharmaceutical compositions containing them
JPS6039072B2 (ja) 1976-07-28 1985-09-04 藤沢薬品工業株式会社 N−置換フエニルアミノ脂肪酸誘導体
JPS5371071A (en) 1976-12-08 1978-06-24 Teijin Ltd Alpha-phenoxyacetic acid derivs.
US4250191A (en) 1978-11-30 1981-02-10 Edwards K David Preventing renal failure
US4214095A (en) 1979-01-25 1980-07-22 Siegfried Aktiengesellschaft Chlorobenzyl phenoxy alkoxylates
SE8003278L (sv) 1979-05-04 1980-11-05 Continental Pharma Fenyletylaminderivat
US4532135A (en) 1981-02-09 1985-07-30 Edwards K David G Renoprotective treatments employing vasodilator compounds
US4508882A (en) 1981-08-24 1985-04-02 Asahi Glass Company Ltd. Benzotriazole compound and homopolymer or copolymers thereof
EP0077938A3 (en) 1981-10-23 1983-08-24 Mitsubishi Kasei Corporation N-(3-substituted aminophenyl) tetrahydrophthalimides and herbicidal composition
DE3236730A1 (de) 1982-10-04 1984-04-05 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von benzoxazolyl- und benzthiazolyloxyphenoxypropionsaeurederivaten
US4528311A (en) 1983-07-11 1985-07-09 Iolab Corporation Ultraviolet absorbing polymers comprising 2-hydroxy-5-acrylyloxyphenyl-2H-benzotriazoles
JPS60109578A (ja) 1983-11-17 1985-06-15 Mitsubishi Chem Ind Ltd 3−(置換フエニル)−5−置換−1,3,4−オキサゾリン−2−オン類およびこれを有効成分とする除草剤
DE3525284A1 (de) 1985-07-16 1987-01-29 Boehringer Mannheim Gmbh Neue carbonsaeurederivate, verfahren zu ihrer herstellung, ihre verwendung sowie arzneimittel, die diese verbindungen enthalten
US4714762A (en) 1986-10-31 1987-12-22 Warner-Lambert Company Antiarteriosclerotic substituted benzimidazol-2-yl-and 3H-imidazo[4,5-b]pyridin-2-yl-phenoxy-alkanoic acids and salts and esters thereof
US4786731A (en) 1987-08-05 1988-11-22 The Dow Chemical Company Resolution of enantiomers of 2-(phenyl or phenoxy/propionic acids using optically active alkanolamines
JPH0670025B2 (ja) 1987-08-07 1994-09-07 鐘紡株式会社 ベンゾチアゾ−ル誘導体および該化合物を有効成分とする抗リウマチ剤
GB8720365D0 (en) 1987-08-28 1987-10-07 Sandoz Ltd Organic compounds
US4863802A (en) 1987-12-31 1989-09-05 General Electric Company UV-stabilized coatings
JPH01305069A (ja) 1988-05-31 1989-12-08 Shionogi & Co Ltd ベンゾトリアゾール誘導体およびそれを含有する発螢光試薬
CA2034309C (en) 1990-01-22 1997-04-01 Takashi Iwaki Mesomorphic compound, liquid crystal composition containing same, liquid crystal device using same and display apparatus
US5278314A (en) 1991-02-12 1994-01-11 Ciba-Geigy Corporation 5-thio-substituted benzotriazole UV-absorbers
DE4111026A1 (de) 1991-04-05 1992-10-08 Boehringer Mannheim Gmbh Optisch aktive carbonsaeuren sowie diese enthaltende arzneimittel
US5605930A (en) 1991-10-21 1997-02-25 The United States Of America As Represented By The Department Of Health And Human Services Compositions and methods for treating and preventing pathologies including cancer
EP0559927B1 (en) 1992-03-09 1997-03-05 Hoechst Aktiengesellschaft A simplified method for the production of vinyl glycine (2-aminobut-3-enioc acid) and a convenient resolution of a derivative
DE4303676A1 (de) 1993-02-09 1994-08-11 Bayer Ag 1-Aryltriazolin(thi)one
US5874431A (en) 1993-08-28 1999-02-23 Cancer Research Campaign Technology Limited Benzazole compounds
US5496826A (en) 1994-09-02 1996-03-05 Bristol-Myers Squibb Company Pharmaceutical methods of using heterocyclic derivatives of N-phenylamides
US5455152A (en) 1994-09-27 1995-10-03 Eastman Kodak Company Benzotriazole based UV absorbing monomers and photographic elements containing polymers formed from them
US5700819A (en) 1994-11-29 1997-12-23 Grelan Pharmaceutical Co., Ltd. 2-substituted benzothiazole derivatives and prophylactic and therapeutic agents for the treatment of diabetic complications
US5783738A (en) 1994-12-28 1998-07-21 Rhone-Poulenc Chimie Optically active diphosphines, preparation thereof according to a process for the resolution of the racemic mixture and use thereof
GB9503946D0 (en) 1995-02-28 1995-04-19 Cancer Res Campaign Tech Benzazole compounds
US5500332A (en) 1995-04-26 1996-03-19 Eastman Kodak Company Benzotriazole based UV absorbers and photographic elements containing them
US5708186A (en) * 1995-12-12 1998-01-13 Merck & Co Inc Stereoselective process
US6242464B1 (en) 1996-01-22 2001-06-05 Chiroscience Limited Single isomer methylphenidate and resolution process
US5859051A (en) 1996-02-02 1999-01-12 Merck & Co., Inc. Antidiabetic agents
US5766834A (en) 1996-05-17 1998-06-16 Eastman Kodak Company Photographic element containing ultraviolet absorbing polymer
US5716987A (en) 1996-06-21 1998-02-10 Bristol-Myers Squibb Company Prophylactic and therapeutic treatment of skin sensitization and irritation
JP2000516611A (ja) 1996-08-14 2000-12-12 ワーナー―ランバート・コンパニー Mcp―1アンタゴニストとしての2―フェニルベンズイミダゾール誘導体
KR100496318B1 (ko) 1996-11-22 2005-06-20 시바 스페셜티 케미칼스 홀딩 인크. 사람 및 동물의 피부 및 모발을 자외선의 유해한 영향으로부터보호하기 위한, 선택된 벤조트리아졸 유도체의 용도
US5942532A (en) 1997-09-05 1999-08-24 Ortho Pharmaceutical Corporation 2-substituted phenyl-benzimidazole antibacterial agents
PT974589E (pt) 1997-11-07 2004-05-31 Taiho Pharmaceutical Co Ltd Derivados de benzimidazol e os seus sais aceitaveis sob o ponto de vista farmaceutico
AU4229999A (en) 1998-06-05 1999-12-20 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents
US6013659A (en) 1998-09-04 2000-01-11 University Of Pittsburgh Methods of reducing tumor colony number using novel benzothiazole compounds
DE19844876A1 (de) 1998-09-30 2000-04-06 Basf Ag Verfahren zur Racematspaltung von Arylalkylcarbonsäureestern
IN189741B (US07714131-20100511-C00006.png) 1998-11-09 2003-04-19 Council Scient Ind Res
CZ20012006A3 (cs) 1998-12-18 2002-03-13 Axys Pharmaceuticals, Inc. Sloučenina a farmaceutický prostředek
US7576131B2 (en) 1999-06-04 2009-08-18 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
US6624194B1 (en) 1999-06-04 2003-09-23 Metabolex, Inc. Use of (−) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
US6262118B1 (en) 1999-06-04 2001-07-17 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia
TR200103147T1 (tr) 1999-12-27 2002-06-21 Japan Tobacco Inc. Kaynaşık halkalı bileşikler ve bunların ilaç olarak kullanımı.
WO2004078113A2 (en) 2003-03-04 2004-09-16 Pharmacia Corporation Treatment and prevention of obesity with cox-2 inhibitors alone or in combination with weight-loss agents
CA2529774C (en) 2003-06-20 2014-05-27 Metabolex, Inc. Resolution of .alpha.-(phenoxy)phenylacetic acid derivatives
US7199259B2 (en) 2003-06-20 2007-04-03 Metabolex, Inc. Resolution of α-(phenoxy)phenylacetic acid derivatives

Also Published As

Publication number Publication date
CA2623350A1 (en) 2007-04-05
PT1940387E (pt) 2012-12-17
IL190325A0 (en) 2009-09-22
EA015673B1 (ru) 2011-10-31
PL1940387T3 (pl) 2013-02-28
IL190325A (en) 2013-04-30
HRP20130001T1 (hr) 2013-02-28
EP1940387A1 (en) 2008-07-09
HK1119953A1 (en) 2009-03-20
EP1940387B1 (en) 2012-11-28
EA200800884A1 (ru) 2008-12-30
AU2006294950A1 (en) 2007-04-05
WO2007038243A1 (en) 2007-04-05
KR101309605B1 (ko) 2013-09-17
EP1940387A4 (en) 2010-11-03
BRPI0616188A2 (pt) 2011-06-14
KR20080050527A (ko) 2008-06-05
DK1940387T3 (da) 2013-01-02
ES2394973T3 (es) 2013-02-07
US7714131B2 (en) 2010-05-11
CA2623350C (en) 2014-08-19
JP2009515817A (ja) 2009-04-16
SI1940387T1 (sl) 2013-04-30
US20070072858A1 (en) 2007-03-29

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