RO99330B1 - Process for purifying adenosine triphosphoric acid - Google Patents
Process for purifying adenosine triphosphoric acidInfo
- Publication number
- RO99330B1 RO99330B1 RO130673A RO13067387A RO99330B1 RO 99330 B1 RO99330 B1 RO 99330B1 RO 130673 A RO130673 A RO 130673A RO 13067387 A RO13067387 A RO 13067387A RO 99330 B1 RO99330 B1 RO 99330B1
- Authority
- RO
- Romania
- Prior art keywords
- parts
- volume
- solution
- triphosphoric acid
- treating
- Prior art date
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- Saccharide Compounds (AREA)
Abstract
Inventia se fata se refera la un procedeu de purificare a acidului adenozintrifosforic, utilizat în scopuri farmaceutice, prin tratarea acestora cu o solutie continând la 1000 parti apa distilata, 250 parti NaCl, 10 parti fosfat de sodiu si 0,01 parti amoniac, partile fiind exprimate în greutate, dupa care solutia se aduce la pH=9 si apoi se amesteca cu un volum egal de alcool etilic, dupa filtrare adauzgându-se un volum de apa distilata egal cu volumul de solutie obtinuta de la filtrare, se aduce la pH=1,2...1,5 cu HCl 18% si acidul adenozintrifoforic rezultat se cristalizeaza cu un volum egal de alcool etilic, tratarea cu solutia de mai sus efectuându-se în eluatul alcalin al ATP-ului adsorbit pe un schimbator anionic slab bazic.The present invention relates to a process for the purification of adenosine triphosphoric acid used for pharmaceutical purposes by treating it with a solution containing 1000 parts distilled water, 250 parts of NaCl, 10 parts of sodium phosphate and 0.01 parts of ammonia, the parts being by weight, after which the solution is brought to pH = 9 and then mixed with an equal volume of ethyl alcohol, after filtration adding a volume of distilled water equal to the volume of solution obtained from the filtration is brought to pH = 1.2 ... 1.5 with 18% HCl and the resulting adenosine difluoride acid crystallized with an equal volume of ethyl alcohol, treating with the above solution in the alkaline eluate of ATP adsorbed on a weakly basic anion exchanger .
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO130673A RO99330B1 (en) | 1987-11-30 | 1987-11-30 | Process for purifying adenosine triphosphoric acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO130673A RO99330B1 (en) | 1987-11-30 | 1987-11-30 | Process for purifying adenosine triphosphoric acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO99330B1 true RO99330B1 (en) | 1990-07-30 |
Family
ID=40907405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO130673A RO99330B1 (en) | 1987-11-30 | 1987-11-30 | Process for purifying adenosine triphosphoric acid |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO99330B1 (en) |
-
1987
- 1987-11-30 RO RO130673A patent/RO99330B1/en unknown
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