RO96848B1 - Procedeu de preparare a acidului 2[(3-clorfenil)amino]- benzoic - Google Patents
Procedeu de preparare a acidului 2[(3-clorfenil)amino]- benzoicInfo
- Publication number
- RO96848B1 RO96848B1 RO126712A RO12671287A RO96848B1 RO 96848 B1 RO96848 B1 RO 96848B1 RO 126712 A RO126712 A RO 126712A RO 12671287 A RO12671287 A RO 12671287A RO 96848 B1 RO96848 B1 RO 96848B1
- Authority
- RO
- Romania
- Prior art keywords
- chlorophenyl
- amino
- acid
- preparing benzoic
- benzoic
- Prior art date
Links
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
- OVMWPVYEBVFZHM-UHFFFAOYSA-N 2-(3-chloroanilino)benzoic acid Chemical compound OC(=O)C1=CC=CC=C1NC1=CC=CC(Cl)=C1 OVMWPVYEBVFZHM-UHFFFAOYSA-N 0.000 abstract 1
- IKCLCGXPQILATA-UHFFFAOYSA-N 2-chlorobenzoic acid Chemical compound OC(=O)C1=CC=CC=C1Cl IKCLCGXPQILATA-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000012043 crude product Substances 0.000 abstract 1
- 239000007857 degradation product Substances 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000001953 recrystallisation Methods 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Inventia se refera la un procedeu de preparare a acidului 2 [(3-clorfenil) amino] benzoic de înalta puritate, ce poate fi utilizat ca principiu activ în produse farmaceutice, prin condensarea acidului o-clorbenzoic cu m-cloarnilina în prezenta de catalizatori, urmata de extractia aminelor nereactionate si a produselor de degradare din amestecul de reactie, cu un solvent organic, izolarea produsului brut si purificare prin recristalizare.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO126712A RO96848B1 (ro) | 1987-01-23 | 1987-01-23 | Procedeu de preparare a acidului 2[(3-clorfenil)amino]- benzoic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO126712A RO96848B1 (ro) | 1987-01-23 | 1987-01-23 | Procedeu de preparare a acidului 2[(3-clorfenil)amino]- benzoic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO96848B1 true RO96848B1 (ro) | 1989-04-30 |
Family
ID=40905330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO126712A RO96848B1 (ro) | 1987-01-23 | 1987-01-23 | Procedeu de preparare a acidului 2[(3-clorfenil)amino]- benzoic |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO96848B1 (ro) |
-
1987
- 1987-01-23 RO RO126712A patent/RO96848B1/ro unknown
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