RO95046B1 - Procedeu de obtinere pe cale fermentativa a fenoximetilpenicilinei - Google Patents

Info

Publication number

RO95046B1

RO95046B1 RO123034A RO12303486A RO95046B1 RO 95046 B1 RO95046 B1 RO 95046B1 RO 123034 A RO123034 A RO 123034A RO 12303486 A RO12303486 A RO 12303486A RO 95046 B1 RO95046 B1 RO 95046B1

Authority

RO

Romania

Prior art keywords

iasi

biosynthesis

glucose

fermentation

phenoxyacetic acid

Prior art date

1986-04-18

Links

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• 229930195708 Penicillin V Natural products 0.000 title abstract 2
• 238000000855 fermentation Methods 0.000 title abstract 2
• 230000004151 fermentation Effects 0.000 title abstract 2
• 229940056367 penicillin v Drugs 0.000 title abstract 2
• BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 title abstract 2
• 238000004519 manufacturing process Methods 0.000 title 1
• LCPDWSOZIOUXRV-UHFFFAOYSA-N phenoxyacetic acid Chemical compound OC(=O)COC1=CC=CC=C1 LCPDWSOZIOUXRV-UHFFFAOYSA-N 0.000 abstract 4
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 3
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 3
• QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
• VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 2
• PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 abstract 2
• 230000015572 biosynthetic process Effects 0.000 abstract 2
• 239000008103 glucose Substances 0.000 abstract 2
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 abstract 1
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
• 241000228150 Penicillium chrysogenum Species 0.000 abstract 1
• 235000019486 Sunflower oil Nutrition 0.000 abstract 1
• 240000008042 Zea mays Species 0.000 abstract 1
• 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 abstract 1
• 235000002017 Zea mays subsp mays Nutrition 0.000 abstract 1
• 238000005273 aeration Methods 0.000 abstract 1
• 229910021529 ammonia Inorganic materials 0.000 abstract 1
• BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 abstract 1
• 229910052921 ammonium sulfate Inorganic materials 0.000 abstract 1
• 239000001166 ammonium sulphate Substances 0.000 abstract 1
• 235000011130 ammonium sulphate Nutrition 0.000 abstract 1
• 229910000019 calcium carbonate Inorganic materials 0.000 abstract 1
• JYYOBHFYCIDXHH-UHFFFAOYSA-N carbonic acid;hydrate Chemical class O.OC(O)=O JYYOBHFYCIDXHH-UHFFFAOYSA-N 0.000 abstract 1
• 239000003795 chemical substances by application Substances 0.000 abstract 1
• 235000005822 corn Nutrition 0.000 abstract 1
• 239000008121 dextrose Substances 0.000 abstract 1
• 239000000284 extract Substances 0.000 abstract 1
• 239000001963 growth medium Substances 0.000 abstract 1
• 239000008101 lactose Substances 0.000 abstract 1
• 239000002609 medium Substances 0.000 abstract 1
• 238000000034 method Methods 0.000 abstract 1
• 239000000203 mixture Substances 0.000 abstract 1
• 239000001488 sodium phosphate Substances 0.000 abstract 1
• 229910000162 sodium phosphate Inorganic materials 0.000 abstract 1
• 159000000000 sodium salts Chemical class 0.000 abstract 1
• 229910052938 sodium sulfate Inorganic materials 0.000 abstract 1
• 235000011152 sodium sulphate Nutrition 0.000 abstract 1
• 235000000346 sugar Nutrition 0.000 abstract 1
• 150000008163 sugars Chemical class 0.000 abstract 1
• 239000002600 sunflower oil Substances 0.000 abstract 1
• RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 abstract 1
• 235000015112 vegetable and seed oil Nutrition 0.000 abstract 1
• 239000008158 vegetable oil Substances 0.000 abstract 1