RO95046B1 - Process for preparing phenoxymethyl penicillin by fermentation - Google Patents
Process for preparing phenoxymethyl penicillin by fermentationInfo
- Publication number
- RO95046B1 RO95046B1 RO123034A RO12303486A RO95046B1 RO 95046 B1 RO95046 B1 RO 95046B1 RO 123034 A RO123034 A RO 123034A RO 12303486 A RO12303486 A RO 12303486A RO 95046 B1 RO95046 B1 RO 95046B1
- Authority
- RO
- Romania
- Prior art keywords
- iasi
- biosynthesis
- glucose
- fermentation
- phenoxyacetic acid
- Prior art date
Links
- 229930195708 Penicillin V Natural products 0.000 title abstract 2
- 238000000855 fermentation Methods 0.000 title abstract 2
- 230000004151 fermentation Effects 0.000 title abstract 2
- 229940056367 penicillin v Drugs 0.000 title abstract 2
- BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- LCPDWSOZIOUXRV-UHFFFAOYSA-N phenoxyacetic acid Chemical compound OC(=O)COC1=CC=CC=C1 LCPDWSOZIOUXRV-UHFFFAOYSA-N 0.000 abstract 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 239000008103 glucose Substances 0.000 abstract 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 abstract 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
- 241000228150 Penicillium chrysogenum Species 0.000 abstract 1
- 235000019486 Sunflower oil Nutrition 0.000 abstract 1
- 240000008042 Zea mays Species 0.000 abstract 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 abstract 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 abstract 1
- 238000005273 aeration Methods 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 abstract 1
- 239000001166 ammonium sulphate Substances 0.000 abstract 1
- 235000011130 ammonium sulphate Nutrition 0.000 abstract 1
- 229910000019 calcium carbonate Inorganic materials 0.000 abstract 1
- JYYOBHFYCIDXHH-UHFFFAOYSA-N carbonic acid;hydrate Chemical class O.OC(O)=O JYYOBHFYCIDXHH-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 235000005822 corn Nutrition 0.000 abstract 1
- 239000008121 dextrose Substances 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 239000008101 lactose Substances 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000001488 sodium phosphate Substances 0.000 abstract 1
- 229910000162 sodium phosphate Inorganic materials 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- 229910052938 sodium sulfate Inorganic materials 0.000 abstract 1
- 235000011152 sodium sulphate Nutrition 0.000 abstract 1
- 235000000346 sugar Nutrition 0.000 abstract 1
- 150000008163 sugars Chemical class 0.000 abstract 1
- 239000002600 sunflower oil Substances 0.000 abstract 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 abstract 1
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract 1
- 239000008158 vegetable oil Substances 0.000 abstract 1
Landscapes
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Prezenta inventie se refera la un procedeu de obtinere, pe cale fermentativa, a fenoximetilpenicilinei, ce consta în aceea ca tulpina Penicillium chrysogenum H15 înregistrata în colectia IA Iasi la nr.51217/1967 se cultiva pe un mediu de cultura ce contine extract de porumb, fosfat de sodiu, sulfat de sodiu, carbonat de calciu, acid fenoxiacetic si ulei vegetal, la temperatura de 26...27 degree C si pH=6,0...6,6, dupa 10...15 h se începe adaugarea de hidrati de carbon alesi dintre dextroza, glucoza sau amestec de glucoza si lactoza în cantitate necesara pentru a mentine o concentratie în zaharuri de 0,2...1,2%, sulfat de amoniu în cantitate necesara pentru obtinerea de 0,02...0,04% amoniac, ulei de floarea-soarelui ca antispumant si sare de sodiu a acidului fenoxiacetic, temperatura pe tot parcursul biosintezei este de 24...25 degree C, aeratia este de 0,8...1,5 l/l mediu/min, iar timpul de biosinteza este 16...18 h.The present invention relates to a process for obtaining fermentation of phenoxymethylpenicillin, which consists in that the strain of Penicillium chrysogenum H15, registered in the Iasi Collection Iasi at No. 51217/1967, is grown on a culture medium containing corn extract, sodium phosphate, sodium sulphate, calcium carbonate, phenoxyacetic acid and vegetable oil at 26 ... 27 ° C and pH = 6.0 ... 6.6, after 10 ... 15 h starts the addition of carbonate hydrates selected from dextrose, glucose or a mixture of glucose and lactose in an amount necessary to maintain a concentration in sugars of 0.2 ... 1.2%, ammonium sulphate in the amount required to obtain 0.02 ... 0,04% ammonia, sunflower oil as an anti-sparking agent and sodium salt of phenoxyacetic acid, temperature throughout biosynthesis is 24 ... 25 ° C, aeration is 0,8 ... 1, 5 l / l medium / min, and the biosynthesis time is 16-18 h.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO123034A RO95046B1 (en) | 1986-04-18 | 1986-04-18 | Process for preparing phenoxymethyl penicillin by fermentation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO123034A RO95046B1 (en) | 1986-04-18 | 1986-04-18 | Process for preparing phenoxymethyl penicillin by fermentation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO95046A2 RO95046A2 (en) | 1988-08-15 |
| RO95046B1 true RO95046B1 (en) | 1988-08-17 |
Family
ID=20119289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO123034A RO95046B1 (en) | 1986-04-18 | 1986-04-18 | Process for preparing phenoxymethyl penicillin by fermentation |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO95046B1 (en) |
-
1986
- 1986-04-18 RO RO123034A patent/RO95046B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RO95046A2 (en) | 1988-08-15 |
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