RO85547B1 - Derivat de meclofenoxat si procedeu de obtinere a acestuia - Google Patents
Derivat de meclofenoxat si procedeu de obtinere a acestuiaInfo
- Publication number
- RO85547B1 RO85547B1 RO109411A RO10941182A RO85547B1 RO 85547 B1 RO85547 B1 RO 85547B1 RO 109411 A RO109411 A RO 109411A RO 10941182 A RO10941182 A RO 10941182A RO 85547 B1 RO85547 B1 RO 85547B1
- Authority
- RO
- Romania
- Prior art keywords
- oxo
- chloro
- ethanol
- pyrrolidine
- phenoxyacetate
- Prior art date
Links
- XZTYGFHCIAKPGJ-UHFFFAOYSA-N Meclofenoxate Chemical class CN(C)CCOC(=O)COC1=CC=C(Cl)C=C1 XZTYGFHCIAKPGJ-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 5
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical class O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- FIVHOHCAXWQPGC-UHFFFAOYSA-N 2-[2-(4-chlorophenoxy)acetyl]oxyethyl-dimethylazanium;chloride Chemical compound Cl.CN(C)CCOC(=O)COC1=CC=C(Cl)C=C1 FIVHOHCAXWQPGC-UHFFFAOYSA-N 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 238000010790 dilution Methods 0.000 abstract 1
- 239000012895 dilution Substances 0.000 abstract 1
- -1 dimethylammonium-ethyl 4-chloro-phenoxyacetate Chemical compound 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 238000004821 distillation Methods 0.000 abstract 1
- 239000012153 distilled water Substances 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000000376 reactant Substances 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Inventia se refera la un derivat de meclofenoxat cu actiune energizanta asupra sistemului nervos central care este sarea cu 2-oxo-pirolidina a 4-clor-fenoxiacetatului de dimetilamoniu-etil si are structura chimica din formula generala I: (vezi formula) pulbere cristalina alba, cu punct de topire de 42 degree C si continut de azot de 7,92%; procedeul de obtinere a derivatului consta din tratarea 2-oxo-pirolidinei sau sarii de sodiu a acesteia, în mediu de etoxid de sodiu respectiv de etanol cu clorhidrat de 4-clor-fenoxiacetat de dimetilaminotil, la temperatura de 80 degree C, timp de 1...2h, raportul molar între reactanti fiind de 1:1, dupa care produsul obtinut se separa din mediul de reactie prin distilarea alcoolului si diluarea cu apa distilata, urmata de purificare prin dizolvare în etanol, tratare cu carbune activ si precipitare cu apa distilata.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO109411A RO85547B1 (ro) | 1982-12-21 | 1982-12-21 | Derivat de meclofenoxat si procedeu de obtinere a acestuia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO109411A RO85547B1 (ro) | 1982-12-21 | 1982-12-21 | Derivat de meclofenoxat si procedeu de obtinere a acestuia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO85547A2 RO85547A2 (ro) | 1984-10-31 |
| RO85547B1 true RO85547B1 (ro) | 1984-11-30 |
Family
ID=20112405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO109411A RO85547B1 (ro) | 1982-12-21 | 1982-12-21 | Derivat de meclofenoxat si procedeu de obtinere a acestuia |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO85547B1 (ro) |
-
1982
- 1982-12-21 RO RO109411A patent/RO85547B1/ro unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RO85547A2 (ro) | 1984-10-31 |
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