RO85548B1 - Derivat de pirolidina si procedeu de obtinere a acestuia - Google Patents
Derivat de pirolidina si procedeu de obtinere a acestuiaInfo
- Publication number
- RO85548B1 RO85548B1 RO109410A RO10941082A RO85548B1 RO 85548 B1 RO85548 B1 RO 85548B1 RO 109410 A RO109410 A RO 109410A RO 10941082 A RO10941082 A RO 10941082A RO 85548 B1 RO85548 B1 RO 85548B1
- Authority
- RO
- Romania
- Prior art keywords
- pyrrolidine
- derivative
- oxo
- benzene
- preparing
- Prior art date
Links
- FKCMADOPPWWGNZ-YUMQZZPRSA-N [(2r)-1-[(2s)-2-amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid Chemical compound CC(C)[C@H](N)C(=O)N1CCC[C@H]1B(O)O FKCMADOPPWWGNZ-YUMQZZPRSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- AKBAKSSCWXYXFO-UHFFFAOYSA-N 1-[2-(4-chlorophenoxy)acetyl]pyrrolidin-2-one Chemical compound C1=CC(Cl)=CC=C1OCC(=O)N1C(=O)CCC1 AKBAKSSCWXYXFO-UHFFFAOYSA-N 0.000 abstract 1
- VRBVHQUSAOKVDH-UHFFFAOYSA-N 2-(4-chlorophenoxy)acetyl chloride Chemical compound ClC(=O)COC1=CC=C(Cl)C=C1 VRBVHQUSAOKVDH-UHFFFAOYSA-N 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000376 reactant Substances 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
- 238000001953 recrystallisation Methods 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Inventia se refera la un derivat de pirolidina cu actiune stimulatoare asupra sistemului nervos central constînd din 2-oxo-1-(p-clorfenoxiacetil) pirolidina cu structura chimica din formula generala I: (vezi formula) substanta solida cu punct de topire de 149 degree C; procedeul de obtinere a derivatului consta din aceea ca 2-oxo-pirolidina sau sarea de sodiu a acesteia se trateaza cu clorura acidului p-clor-fenoxiacetic, în benzen ca mediu de reactie, la temperatura de 80 degree C, timp de 2...6h, raportul molar între reactanti fiind de 1:1, dupa care produsul obtinut se separa prin îndepartarea solventului si racire si se purifica prin recristalizare din benzen, dimetilformamida si alcool izopropilic.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO109410A RO85548B1 (ro) | 1982-12-21 | 1982-12-21 | Derivat de pirolidina si procedeu de obtinere a acestuia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO109410A RO85548B1 (ro) | 1982-12-21 | 1982-12-21 | Derivat de pirolidina si procedeu de obtinere a acestuia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO85548A2 RO85548A2 (ro) | 1984-10-31 |
| RO85548B1 true RO85548B1 (ro) | 1984-11-30 |
Family
ID=20112404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO109410A RO85548B1 (ro) | 1982-12-21 | 1982-12-21 | Derivat de pirolidina si procedeu de obtinere a acestuia |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO85548B1 (ro) |
-
1982
- 1982-12-21 RO RO109410A patent/RO85548B1/ro unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RO85548A2 (ro) | 1984-10-31 |
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