RO85285B1 - Procedeu pentru prepararea sarurilor stabile de s-adenosilmetionina - Google Patents
Procedeu pentru prepararea sarurilor stabile de s-adenosilmetioninaInfo
- Publication number
- RO85285B1 RO85285B1 RO108564A RO10856482A RO85285B1 RO 85285 B1 RO85285 B1 RO 85285B1 RO 108564 A RO108564 A RO 108564A RO 10856482 A RO10856482 A RO 10856482A RO 85285 B1 RO85285 B1 RO 85285B1
- Authority
- RO
- Romania
- Prior art keywords
- acid
- sam
- salt
- amount
- solution
- Prior art date
Links
- MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 title abstract 5
- 150000003839 salts Chemical class 0.000 title abstract 4
- 229960001570 ademetionine Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 5
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- DPEYHNFHDIXMNV-UHFFFAOYSA-N (9-amino-3-bicyclo[3.3.1]nonanyl)-(4-benzyl-5-methyl-1,4-diazepan-1-yl)methanone dihydrochloride Chemical compound Cl.Cl.CC1CCN(CCN1Cc1ccccc1)C(=O)C1CC2CCCC(C1)C2N DPEYHNFHDIXMNV-UHFFFAOYSA-N 0.000 abstract 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 229920001429 chelating resin Polymers 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 238000005342 ion exchange Methods 0.000 abstract 1
- 239000003456 ion exchange resin Substances 0.000 abstract 1
- 229920003303 ion-exchange polymer Polymers 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229960004889 salicylic acid Drugs 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Landscapes
- Saccharide Compounds (AREA)
Abstract
Inventia se refera la un procedeu de preparare a sarurilor stabile de S-adenosilmetionina cu formula generala: (vezi formula) în care X este Cl-SO4 sau H2PO4 si n este 4,5 sau 6. Procedeul consta în aceea ca se purifica o solutie apoasa concentrata de sare SAM bruta, cu pH-ul reglat între 6 si 7, de preferinta la 6,5 la trecerea printr-o coloana schimbatoare de ioni slab acida, Amberlite IRC 50 sau Amberlite CG 50, SAM este eluat cu o solutie apoasa diluata din acidul HX corespunzator, avînd o concentratie de 0,1 N, la eluat se adauga cantitatea de acid necesara pentru a atinge cantitatea de acid necesara pentru a atinge cantitatea stoichiometric corespunzatoare sarii urmarite, acidul suplimentar fiind adaugat sub forma solutiei apoase concentrate comerciale si, daca eluatul contine un exces de acid HX fata de cantitatea stoichiometrica necesara, acest exces eliminat cu rasina schimbatoare de ioni puternic bazica, Amberlit IRA-401, apoi solutia este concentrata la o valoare între 50 si 100g/l SAM, iar sarea se separa prin liofilizare, efectuata în prezenta unei substante inerte, de preferinta manitol sau acid salicilic pulverizat.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO108564A RO85285B1 (ro) | 1982-09-03 | 1982-09-03 | Procedeu pentru prepararea sarurilor stabile de s-adenosilmetionina |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO108564A RO85285B1 (ro) | 1982-09-03 | 1982-09-03 | Procedeu pentru prepararea sarurilor stabile de s-adenosilmetionina |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO85285B1 true RO85285B1 (ro) | 1984-10-30 |
Family
ID=40903492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO108564A RO85285B1 (ro) | 1982-09-03 | 1982-09-03 | Procedeu pentru prepararea sarurilor stabile de s-adenosilmetionina |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO85285B1 (ro) |
-
1982
- 1982-09-03 RO RO108564A patent/RO85285B1/ro unknown
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