RO85267B - Procedeu pentru prepararea unor derivati ai piperazinonei - Google Patents

Procedeu pentru prepararea unor derivati ai piperazinonei

Info

Publication number
RO85267B
RO85267B RO108482A RO10848282A RO85267B RO 85267 B RO85267 B RO 85267B RO 108482 A RO108482 A RO 108482A RO 10848282 A RO10848282 A RO 10848282A RO 85267 B RO85267 B RO 85267B
Authority
RO
Romania
Prior art keywords
preparing
piperazinone derivatives
piperazinone
derivatives
parenterally
Prior art date
Application number
RO108482A
Other languages
English (en)
Other versions
RO85267A (ro
Inventor
Rudi Beyerle
Heinz Bender
Ursula Schineler
Rolf Eberhard Nitz
Piero Antonio Martorana
Original Assignee
Cassella Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cassella Aktiengesellschaft filed Critical Cassella Aktiengesellschaft
Publication of RO85267A publication Critical patent/RO85267A/ro
Publication of RO85267B publication Critical patent/RO85267B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unor piperazinone cu formula generala I: (vezi formula) în care R1 este fenil, eventual substituit cu alcoxi cu 1 pîna la 4 atomi de carbon, fluor, alcoxialchil cu un total 2 pîna la 6 atomi de carbon sau dialchilaminoalcoxi cu, în total, 4 pîna la 8 atomi de carbon, 2-tienil, 3-piridil precum si un radical cu formula II: (vezi formula) în care R4 este hidrogen, alchil cu 1 pîna la 4 atomi de carbon, fenilalchil cu 1 sau 2 atomi de carbon, în restul alchil, eventual substituit cu clor, R5 este hidrogen sau alcoxi cu 1 pîna la 4 atomi de carbon, R6 este hidrogen sau fenil, R2 si R3 reprezinta fiecare hidrogen. Procedeul consta în aceea ca o hidropirazinona cu formula generala III: (vezi formula) în care R1 are semnificatia de mai sus, se reduce cu hidrogen, în prezenta de nichel sau cobalt Raney, platina coloidala, paladiu si oxizi de platina sau de paladiu, la o temperatura cuprinsa între 50 si 100 degree C în mediu de solvent ales dintre alcooli alifatici inferiori, acid acetic, acetat de etil, etillenglicol mono-sau dimetileteri, tetrahidrofuran, dioxan, toluen sau dimetilformamida, compusi obtinuti putînd fi transformati în mod cunoscut, în compusi în care R2 si R3 au alte semnificatii sau în saruri fiziologic acceptabile.
RO108482A 1981-08-20 1982-08-19 Procedeu pentru prepararea unor derivati ai piperazinonei RO85267B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813132882 DE3132882A1 (de) 1981-08-20 1981-08-20 Neue piperazinone, ihre herstellung und verwendung

Publications (2)

Publication Number Publication Date
RO85267A RO85267A (ro) 1984-09-29
RO85267B true RO85267B (ro) 1984-10-30

Family

ID=6139695

Family Applications (1)

Application Number Title Priority Date Filing Date
RO108482A RO85267B (ro) 1981-08-20 1982-08-19 Procedeu pentru prepararea unor derivati ai piperazinonei

Country Status (23)

Country Link
US (1) US4598079A (ro)
EP (1) EP0072932B1 (ro)
JP (1) JPS5839673A (ro)
KR (1) KR880001622B1 (ro)
AT (1) ATE49596T1 (ro)
AU (1) AU556064B2 (ro)
BG (1) BG40142A3 (ro)
CA (1) CA1190227A (ro)
DD (1) DD206991A5 (ro)
DE (2) DE3132882A1 (ro)
DK (1) DK154765C (ro)
ES (1) ES8305739A1 (ro)
FI (1) FI76325C (ro)
GR (1) GR78362B (ro)
HU (1) HU190696B (ro)
IL (1) IL66566A (ro)
NO (1) NO822643L (ro)
NZ (1) NZ200761A (ro)
PH (1) PH18447A (ro)
PL (1) PL139405B1 (ro)
PT (1) PT75444B (ro)
RO (1) RO85267B (ro)
ZA (1) ZA826031B (ro)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4772705A (en) * 1985-07-25 1988-09-20 Pennwalt Corporation Processes for the preparation of trans 1,3,4,6,7,11b-hexahydro-7-aryl-2H-pyrazinol[2,1-a]isoquinolines
JPS62198671A (ja) * 1986-02-25 1987-09-02 Toyo Jozo Co Ltd １−置換アルキル１，２−ジヒドロ−２−ピラジノン誘導体
DE3817198A1 (de) * 1988-05-20 1989-11-30 Cassella Ag Thienyl-piperazinone, ihre herstellung und verwendung
US5238938A (en) * 1989-02-10 1993-08-24 Otsuka Pharmaceutical Co., Ltd. Indole derivatives
WO1990009380A1 (fr) * 1989-02-10 1990-08-23 Otsuka Pharmaceutical Co., Ltd. Derives d'indole, leur preparation et medicament les contenant destine a la prevention et au traitement de la nephrite
DE3908547A1 (de) * 1989-03-16 1990-09-20 Cassella Ag Thienylessigsaeurederivate, verfahren zu ihrer herstellung, ihre verwendung sowie diese enthaltende arzneimittel und deren herstellung
DE3909379A1 (de) * 1989-03-22 1990-09-27 Cassella Ag Thienylpiperazine, verfahren zu ihrer herstellung, ihre verwendung sowie diese enthaltende arzneimittel und deren herstellung
US5635510A (en) * 1993-05-06 1997-06-03 Merrell Pharmaceuticals Inc. Substituted pyrrolidin-3-yl-alkyl-piperidines
IL111730A (en) * 1993-11-29 1998-12-06 Fujisawa Pharmaceutical Co Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
US5883098A (en) * 1993-11-29 1999-03-16 Fujisawa Pharmaceutical Co., Ltd. Piperazine derivatives
DE4408530A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Verfahren zur Herstellung von Aminoethylglycin
CA2198084C (en) 1994-08-25 2000-03-28 Timothy P. Burkholder Novel substituted piperidines useful for the treatment of allergic diseases
FI973671A0 (fi) * 1995-03-15 1997-09-12 Hoechst Marion Roussel Inc Heterosyklisen substituentin sisältäviä piperatsinonijohdoksia takykiniinireseptoriantagonisteina
JP3950170B2 (ja) * 1995-04-13 2007-07-25 アベンティス・ファーマスーティカルズ・インコーポレイテッド タキキニン受容体アンタゴニスト活性を有する新規な置換されたピペラジン誘導体
GB9510600D0 (en) * 1995-05-25 1995-07-19 Fujisawa Pharmaceutical Co Piperazine derivatives
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
WO1997036591A1 (en) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
SE9603283D0 (sv) * 1996-09-10 1996-09-10 Astra Ab New compounds
TW472045B (en) * 1996-09-25 2002-01-11 Astra Ab Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation
AR017200A1 (es) 1997-12-23 2001-08-22 Astrazeneca Ab Compuestos inhibidores de la proteina cinasa c, sales farmaceuticamente aceptables de los mismos, formulaciones farmaceuitcas que los comprenden, usode las mismas y proceso para la sintesis de dichos compuestos
SE9800835D0 (sv) 1998-03-13 1998-03-13 Astra Ab New Compounds
US6492406B1 (en) 1999-05-21 2002-12-10 Astrazeneca Ab Pharmaceutically active compounds
US6346625B1 (en) 1999-06-23 2002-02-12 Astrazeneca Ab Protein kinase inhibitors
IN190478B (ro) * 2000-11-07 2003-08-02 Sun Pharmaceutical Ind Ltd
WO2003024401A2 (en) * 2001-09-18 2003-03-27 Bristol-Myers Squibb Company Piperizinones as modulators of chemokine receptor activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1197089B (de) * 1962-01-25 1965-07-22 Richardson Merrell Inc Verfahren zur Herstellung von 2-Oxo-1, 2, 5, 6-tetrahydropyrazinen
US3390139A (en) * 1964-03-04 1966-03-11 Rohm & Haas Nu-vinyl-2-piperazinones
US3935214A (en) * 1968-07-26 1976-01-27 Donau-Pharmazie Gesellschaft M.B.H. 2-or 3 keto-3-or-2-phenyl-1,4-disubstituted piperazines
DE2438619A1 (de) * 1974-08-12 1976-02-26 Knoll Ag Verfahren zur herstellung von substituierten 2-ketopiperazin-derivaten
AT356122B (de) * 1978-10-17 1980-04-10 Yoshitomi Pharmaceutical Verfahren zur herstellung von neuen pyridazinonderivaten und ihren salzen mit saeuren

Also Published As

Publication number Publication date
FI76325C (fi) 1988-10-10
AU8742282A (en) 1983-02-24
DD206991A5 (de) 1984-02-15
JPS5839673A (ja) 1983-03-08
KR840001158A (ko) 1984-03-28
ES515120A0 (es) 1983-05-01
DE3280088D1 (de) 1990-02-22
DK342382A (da) 1983-02-21
PT75444B (de) 1985-01-04
HU190696B (en) 1986-10-28
ES8305739A1 (es) 1983-05-01
EP0072932B1 (de) 1990-01-17
FI822698A0 (fi) 1982-08-02
PL139405B1 (en) 1987-01-31
EP0072932A3 (en) 1984-03-21
DK154765C (da) 1989-05-16
DK154765B (da) 1988-12-19
NZ200761A (en) 1985-04-30
BG40142A3 (en) 1986-10-15
PT75444A (de) 1982-09-01
AU556064B2 (en) 1986-10-23
US4598079A (en) 1986-07-01
FI822698L (fi) 1983-02-21
NO822643L (no) 1983-02-21
RO85267A (ro) 1984-09-29
PL237952A1 (en) 1983-03-14
FI76325B (fi) 1988-06-30
IL66566A0 (en) 1982-12-31
ATE49596T1 (de) 1990-02-15
EP0072932A2 (de) 1983-03-02
GR78362B (ro) 1984-09-26
ZA826031B (en) 1983-07-27
PH18447A (en) 1985-07-08
IL66566A (en) 1985-12-31
KR880001622B1 (ko) 1988-09-02
DE3132882A1 (de) 1983-03-03
CA1190227A (en) 1985-07-09

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