RO82052B1 - Saruri ale acizilor ariloxialchilcarboxilicisulfamidati cu n, n-dimetilbiguanida si procedeu de preparare a lor - Google Patents

Saruri ale acizilor ariloxialchilcarboxilicisulfamidati cu n, n-dimetilbiguanida si procedeu de preparare a lor

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Publication number
RO82052B1
RO82052B1 RO104369A RO10436981A RO82052B1 RO 82052 B1 RO82052 B1 RO 82052B1 RO 104369 A RO104369 A RO 104369A RO 10436981 A RO10436981 A RO 10436981A RO 82052 B1 RO82052 B1 RO 82052B1
Authority
RO
Romania
Prior art keywords
sulphamidated
dimethylbiguanide
carboxylic acids
preparation
ortho
Prior art date
Application number
RO104369A
Other languages
English (en)
Other versions
RO82052A2 (ro
Inventor
Corneliu Oniscu
Stefan Cilianu-Bibian
Steriana Braha
Mircea Simionovici
Niculina Boesteanu
Yvonne Cristescu
Original Assignee
Institutul De Cercetari Chimico-Farmaceutice
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institutul De Cercetari Chimico-Farmaceutice filed Critical Institutul De Cercetari Chimico-Farmaceutice
Priority to RO81104369A priority Critical patent/RO82052A2/ro
Publication of RO82052B1 publication Critical patent/RO82052B1/ro
Publication of RO82052A2 publication Critical patent/RO82052A2/ro

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Inventia se refera la saruri ale acizilor ariloxialchil carboxilici sulfamidati cu N, N- dimetil-biguamida cu structura chimica din formula generala I: (vezi formula) în care R este un atom de hidrogen, o grupa metil în pozitiile orto, meta sau para,un atom de clor în pozitiile orto, meta sau para, o grupa OCH3 în pozitia orto si la un procedeu de preparare a acestora prin tratarea acizilor ariloxialchil carboxilici sulfamidati cu N,N-dimetilbiguamido si prin care, în scopul extinderii gamei de substante cu actiune hipoglicemianta se supun reactiei acizii ariloxialchil carboxilici sulfamidati cu formula generala II: (vezi formula) în care R are semnificatia de mai sus, cu N,N-dimetilbiguanida în proportie echimolara, procesul realizîndu-se la temperatura de 60...75 degree C în metanol anhidru, iar separarea produsului efectuîndu-se prin distilarea solventului si racirea masei de reactie.
RO81104369A 1981-05-22 1981-05-22 Saruri ale acizilor ariloxialchilcarboxilici-sulfamidati cu n,n-dimetilbiguanida si procedeu de preparare a lor RO82052A2 (ro)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RO81104369A RO82052A2 (ro) 1981-05-22 1981-05-22 Saruri ale acizilor ariloxialchilcarboxilici-sulfamidati cu n,n-dimetilbiguanida si procedeu de preparare a lor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RO81104369A RO82052A2 (ro) 1981-05-22 1981-05-22 Saruri ale acizilor ariloxialchilcarboxilici-sulfamidati cu n,n-dimetilbiguanida si procedeu de preparare a lor

Publications (2)

Publication Number Publication Date
RO82052B1 true RO82052B1 (ro) 1983-06-30
RO82052A2 RO82052A2 (ro) 1983-07-07

Family

ID=20109980

Family Applications (1)

Application Number Title Priority Date Filing Date
RO81104369A RO82052A2 (ro) 1981-05-22 1981-05-22 Saruri ale acizilor ariloxialchilcarboxilici-sulfamidati cu n,n-dimetilbiguanida si procedeu de preparare a lor

Country Status (1)

Country Link
RO (1) RO82052A2 (ro)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2796551A1 (fr) * 1999-07-23 2001-01-26 Lipha Nouveaux sels de metformine, leur procede d'obtention et les compositions pharmaceutiques en renfermant
FR2796940A1 (fr) * 1999-07-26 2001-02-02 Lipha Nouveaux sels de metformine, leur procede d'obtention et les compositions pharmaceutiques en renfermant

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2796551A1 (fr) * 1999-07-23 2001-01-26 Lipha Nouveaux sels de metformine, leur procede d'obtention et les compositions pharmaceutiques en renfermant
FR2796940A1 (fr) * 1999-07-26 2001-02-02 Lipha Nouveaux sels de metformine, leur procede d'obtention et les compositions pharmaceutiques en renfermant

Also Published As

Publication number Publication date
RO82052A2 (ro) 1983-07-07

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