RO82052B1 - Saruri ale acizilor ariloxialchilcarboxilicisulfamidati cu n, n-dimetilbiguanida si procedeu de preparare a lor - Google Patents
Saruri ale acizilor ariloxialchilcarboxilicisulfamidati cu n, n-dimetilbiguanida si procedeu de preparare a lorInfo
- Publication number
- RO82052B1 RO82052B1 RO104369A RO10436981A RO82052B1 RO 82052 B1 RO82052 B1 RO 82052B1 RO 104369 A RO104369 A RO 104369A RO 10436981 A RO10436981 A RO 10436981A RO 82052 B1 RO82052 B1 RO 82052B1
- Authority
- RO
- Romania
- Prior art keywords
- sulphamidated
- dimethylbiguanide
- carboxylic acids
- preparation
- ortho
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- -1 aryloxyalkyl carboxylic acids Chemical class 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 2
- 208000013016 Hypoglycemia Diseases 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 238000004821 distillation Methods 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Inventia se refera la saruri ale acizilor ariloxialchil carboxilici sulfamidati cu N, N- dimetil-biguamida cu structura chimica din formula generala I: (vezi formula) în care R este un atom de hidrogen, o grupa metil în pozitiile orto, meta sau para,un atom de clor în pozitiile orto, meta sau para, o grupa OCH3 în pozitia orto si la un procedeu de preparare a acestora prin tratarea acizilor ariloxialchil carboxilici sulfamidati cu N,N-dimetilbiguamido si prin care, în scopul extinderii gamei de substante cu actiune hipoglicemianta se supun reactiei acizii ariloxialchil carboxilici sulfamidati cu formula generala II: (vezi formula) în care R are semnificatia de mai sus, cu N,N-dimetilbiguanida în proportie echimolara, procesul realizîndu-se la temperatura de 60...75 degree C în metanol anhidru, iar separarea produsului efectuîndu-se prin distilarea solventului si racirea masei de reactie.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO81104369A RO82052A2 (ro) | 1981-05-22 | 1981-05-22 | Saruri ale acizilor ariloxialchilcarboxilici-sulfamidati cu n,n-dimetilbiguanida si procedeu de preparare a lor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO81104369A RO82052A2 (ro) | 1981-05-22 | 1981-05-22 | Saruri ale acizilor ariloxialchilcarboxilici-sulfamidati cu n,n-dimetilbiguanida si procedeu de preparare a lor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO82052B1 true RO82052B1 (ro) | 1983-06-30 |
| RO82052A2 RO82052A2 (ro) | 1983-07-07 |
Family
ID=20109980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO81104369A RO82052A2 (ro) | 1981-05-22 | 1981-05-22 | Saruri ale acizilor ariloxialchilcarboxilici-sulfamidati cu n,n-dimetilbiguanida si procedeu de preparare a lor |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO82052A2 (ro) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2796551A1 (fr) * | 1999-07-23 | 2001-01-26 | Lipha | Nouveaux sels de metformine, leur procede d'obtention et les compositions pharmaceutiques en renfermant |
| FR2796940A1 (fr) * | 1999-07-26 | 2001-02-02 | Lipha | Nouveaux sels de metformine, leur procede d'obtention et les compositions pharmaceutiques en renfermant |
-
1981
- 1981-05-22 RO RO81104369A patent/RO82052A2/ro unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2796551A1 (fr) * | 1999-07-23 | 2001-01-26 | Lipha | Nouveaux sels de metformine, leur procede d'obtention et les compositions pharmaceutiques en renfermant |
| FR2796940A1 (fr) * | 1999-07-26 | 2001-02-02 | Lipha | Nouveaux sels de metformine, leur procede d'obtention et les compositions pharmaceutiques en renfermant |
Also Published As
| Publication number | Publication date |
|---|---|
| RO82052A2 (ro) | 1983-07-07 |
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