RO79969B - Process for preparing some kanamicine derivatives - Google Patents
Process for preparing some kanamicine derivativesInfo
- Publication number
- RO79969B RO79969B RO101733A RO10173377A RO79969B RO 79969 B RO79969 B RO 79969B RO 101733 A RO101733 A RO 101733A RO 10173377 A RO10173377 A RO 10173377A RO 79969 B RO79969 B RO 79969B
- Authority
- RO
- Romania
- Prior art keywords
- penta
- tetra
- kanamycin
- acyl groups
- kanamicine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se prepara un derivat al kanamicinei cu formula: (vezi formula) prin reactia dintre 1,3, 3'', 6'-tetra--N-benziloxicarbonil-kanamicina A si acid în exces la temperatura camerei, în mediu de piridina apoi produsul de reactie prezentat de penta-0-acetil-1,1,3'',6-tetra-N-benziloxicarbonilkanamicina A, este supus hidrogenolizei la temperatura de 60 degree C, în prezenta de 5% paladiu, în mediu de acetat de etil cu continut de acid acetic glacial, iar produsul rezultat reprezentat de penta-0-acetilkanamicina A, este supus neutralizarii pentru realizarea migrarii intramoleculara a grupelor acil de la oxigen la azot, iar dupa îndepartarea grupelor 0-acil ramase, se separa derivatul N-protejat, în mod cunoscut.A kanamycin derivative of the formula: (see formula) was prepared by reacting 1,3,3 ', 6'-tetra-N-benzyloxycarbonyl-kanamycin A and excess acid at room temperature in pyridine then the product the reaction of penta-O-acetyl-1,1,3 ', 6-tetra-N-benzyloxycarbonylkanamycin A is subjected to hydrogenolysis at 60 ° C in the presence of 5% palladium in ethyl acetate containing glacial acetic acid and the resulting product of penta-O-acetylkanamicin A is neutralized to effect intramolecular migration of the acyl groups from oxygen to nitrogen and after removal of the remaining O-acyl groups, the N-protected derivative , in a known manner.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB15421/76A GB1530201A (en) | 1976-04-14 | 1976-04-14 | Process for the preparation of aminoglycoside antibiotics and intermediates therefor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO79969B true RO79969B (en) | 1983-01-30 |
| RO79969A RO79969A (en) | 1983-02-01 |
Family
ID=10058845
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO7790001A RO74431A (en) | 1976-04-14 | 1977-04-12 | PROCESS FOR THE PREPARATION OF 1-N-SUBSTITUTED KANAMICIN DERIVATIVES |
| RO77101733A RO79969A (en) | 1976-04-14 | 1977-04-12 | PROCESS FOR THE PREPARATION OF KANAMICINE DERIVATIVES |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO7790001A RO74431A (en) | 1976-04-14 | 1977-04-12 | PROCESS FOR THE PREPARATION OF 1-N-SUBSTITUTED KANAMICIN DERIVATIVES |
Country Status (28)
| Country | Link |
|---|---|
| JP (2) | JPS52139044A (en) |
| AR (1) | AR219074A1 (en) |
| AT (1) | AT356267B (en) |
| AU (1) | AU497416B2 (en) |
| BE (1) | BE853564A (en) |
| BG (2) | BG27759A3 (en) |
| CA (1) | CA1083568A (en) |
| CH (1) | CH622528A5 (en) |
| CS (1) | CS202570B2 (en) |
| DD (2) | DD135496A5 (en) |
| DE (1) | DE2716533C3 (en) |
| DK (1) | DK164277A (en) |
| EG (1) | EG12909A (en) |
| ES (1) | ES457793A1 (en) |
| FI (1) | FI771144A (en) |
| FR (1) | FR2348223A1 (en) |
| GB (1) | GB1530201A (en) |
| GR (1) | GR68936B (en) |
| IE (1) | IE45030B1 (en) |
| IL (1) | IL51775A (en) |
| LU (1) | LU77108A1 (en) |
| NL (1) | NL7703567A (en) |
| NZ (1) | NZ183733A (en) |
| PH (1) | PH14029A (en) |
| PL (2) | PL197372A1 (en) |
| PT (1) | PT66422B (en) |
| RO (2) | RO74431A (en) |
| ZA (1) | ZA771944B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2924659A1 (en) * | 1979-06-19 | 1981-01-22 | Bayer Ag | PSEUDOTRISACCHARIDE, THEIR PRODUCTION AND USE AS A MEDICINAL PRODUCT |
| JPH0414628Y2 (en) * | 1984-12-13 | 1992-04-02 | ||
| JPS61191642U (en) * | 1985-05-20 | 1986-11-28 | ||
| IT1225484B (en) * | 1987-11-27 | 1990-11-14 | Pierrel Spa | SYNTHESIS PROCEDURE OF AMIKACINA |
| CN101481397B (en) * | 2009-01-23 | 2012-10-31 | 北京大学 | Novel kanamycin A derivative, and preparation and use thereof |
| SI2637668T1 (en) | 2010-11-08 | 2016-11-30 | Albiero Ab | Ibat inhibitors for the treatment of liver diseases |
| US10709755B2 (en) | 2014-06-25 | 2020-07-14 | Elobix Ab | Solid formulation and method for preventing or reducing coloration thereof |
| CN106573033A (en) | 2014-06-25 | 2017-04-19 | Ea制药株式会社 | Solid preparation and method for stabilizing same |
| EP3012252A1 (en) | 2014-10-24 | 2016-04-27 | Ferring BV | Crystal modifications of elobixibat |
| US10441604B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
| US10441605B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10786529B2 (en) | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
-
1976
- 1976-04-14 GB GB15421/76A patent/GB1530201A/en not_active Expired
-
1977
- 1977-03-29 IL IL51775A patent/IL51775A/en unknown
- 1977-03-29 AU AU23721/77A patent/AU497416B2/en not_active Expired
- 1977-03-30 ZA ZA00771944A patent/ZA771944B/en unknown
- 1977-03-30 NZ NZ183733A patent/NZ183733A/en unknown
- 1977-04-01 NL NL7703567A patent/NL7703567A/en not_active Application Discontinuation
- 1977-04-12 FI FI771144A patent/FI771144A/fi not_active Application Discontinuation
- 1977-04-12 RO RO7790001A patent/RO74431A/en unknown
- 1977-04-12 GR GR53193A patent/GR68936B/el unknown
- 1977-04-12 PH PH19649A patent/PH14029A/en unknown
- 1977-04-12 PT PT66422A patent/PT66422B/en unknown
- 1977-04-12 RO RO77101733A patent/RO79969A/en unknown
- 1977-04-12 LU LU77108A patent/LU77108A1/xx unknown
- 1977-04-13 JP JP4246577A patent/JPS52139044A/en active Granted
- 1977-04-13 CH CH457377A patent/CH622528A5/en not_active IP Right Cessation
- 1977-04-13 PL PL19737277A patent/PL197372A1/en unknown
- 1977-04-13 CA CA276,055A patent/CA1083568A/en not_active Expired
- 1977-04-13 IE IE761/77A patent/IE45030B1/en unknown
- 1977-04-13 BE BE176696A patent/BE853564A/en unknown
- 1977-04-13 FR FR7711108A patent/FR2348223A1/en not_active Withdrawn
- 1977-04-13 EG EG217/77A patent/EG12909A/en active
- 1977-04-13 PL PL1977215139A patent/PL112867B1/en unknown
- 1977-04-13 DK DK164277A patent/DK164277A/en not_active IP Right Cessation
- 1977-04-13 AR AR267190A patent/AR219074A1/en active
- 1977-04-14 CS CS772453A patent/CS202570B2/en unknown
- 1977-04-14 BG BG036000A patent/BG27759A3/en unknown
- 1977-04-14 DD DD77204695A patent/DD135496A5/en unknown
- 1977-04-14 DD DD7700198399A patent/DD130661A5/en unknown
- 1977-04-14 ES ES457793A patent/ES457793A1/en not_active Expired
- 1977-04-14 AT AT261477A patent/AT356267B/en not_active IP Right Cessation
- 1977-04-14 DE DE2716533A patent/DE2716533C3/en not_active Expired
- 1977-04-14 BG BG037121A patent/BG28072A4/en unknown
- 1977-06-23 JP JP7490277A patent/JPS535141A/en active Granted
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