RO79494B - Procedeu de obtinere a amestecului de antibiotic a-42355 - Google Patents
Procedeu de obtinere a amestecului de antibiotic a-42355Info
- Publication number
- RO79494B RO79494B RO101322A RO10132280A RO79494B RO 79494 B RO79494 B RO 79494B RO 101322 A RO101322 A RO 101322A RO 10132280 A RO10132280 A RO 10132280A RO 79494 B RO79494 B RO 79494B
- Authority
- RO
- Romania
- Prior art keywords
- antibiotic
- factors
- antibiotic mixture
- pepons
- maltase
- Prior art date
Links
- 230000003115 biocidal effect Effects 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229920001353 Dextrin Polymers 0.000 abstract 1
- 239000004375 Dextrin Substances 0.000 abstract 1
- 241000264799 Emericella sp. ATCC 58397 Species 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
- 229910002651 NO3 Inorganic materials 0.000 abstract 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- 229930006000 Sucrose Natural products 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- 240000008042 Zea mays Species 0.000 abstract 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 abstract 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 abstract 1
- 102000016679 alpha-Glucosidases Human genes 0.000 abstract 1
- 108010028144 alpha-Glucosidases Proteins 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 239000005018 casein Substances 0.000 abstract 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 abstract 1
- 235000021240 caseins Nutrition 0.000 abstract 1
- 235000013339 cereals Nutrition 0.000 abstract 1
- 235000005822 corn Nutrition 0.000 abstract 1
- 235000012343 cottonseed oil Nutrition 0.000 abstract 1
- 239000002385 cottonseed oil Substances 0.000 abstract 1
- 235000019425 dextrin Nutrition 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 235000013312 flour Nutrition 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 229930195712 glutamate Natural products 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000008101 lactose Substances 0.000 abstract 1
- 235000013372 meat Nutrition 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 235000013379 molasses Nutrition 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 238000002791 soaking Methods 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000005720 sucrose Substances 0.000 abstract 1
- 235000013619 trace mineral Nutrition 0.000 abstract 1
- 239000011573 trace mineral Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/66—Aspergillus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/913—Aspergillus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/19—Antibiotic
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/27—Cyclic peptide or cyclic protein
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
Inventia se refera la un procedeu de obtinere a amestecului antibiotic A-42355, cuprinzând factorii A, B, D si H ai antibioticului A-30912, caracterizat prin aceea ca microorganismul Aspergillus nidulans var. roseus NRRL 11440 este supus cultivarii într-un mediu de cultura continând o sursa de carbon aleasa dintre glucoza, zaharoza, lactoza, dextrina, ulei de seminte de bumbac, amidonuri, melasa, maltaza, glicerol, acizi grasi, faina de cereale, o sursa de azot aleasa dintre peptone solubile de carne, hidrolizat de caseina, ape de la înmuirea porumbului, glutamat, azotati si oligoelemente, la temperaturi între 20 si 43 degree C de preferinta 30-70 degree C si la un pH initial de 6,5 - 6,7 în conditii aerobe submerse pâna la producerea unei activitati antibiotice substantiale dupa care se procedeaza la separarea amestecului antibiotic A-42355 si separaaarea succesiva a factorilor A, B, D, H de antibiotic A-30912.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4674479A | 1979-06-08 | 1979-06-08 | |
| US06/126,078 US4288549A (en) | 1979-06-08 | 1980-03-03 | Method of producing the A-30912 antibiotics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO79494A RO79494A (fr) | 1982-07-06 |
| RO79494B true RO79494B (ro) | 1987-08-31 |
Family
ID=26724253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO101322A RO79494B (ro) | 1979-06-08 | 1980-06-04 | Procedeu de obtinere a amestecului de antibiotic a-42355 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4288549A (ro) |
| EP (1) | EP0021684A1 (ro) |
| JP (1) | JPS5635988A (ro) |
| AR (1) | AR222553A1 (ro) |
| AU (1) | AU5901580A (ro) |
| CA (1) | CA1154695A (ro) |
| DD (1) | DD153213A5 (ro) |
| DK (1) | DK244680A (ro) |
| ES (1) | ES492227A0 (ro) |
| FI (1) | FI801772A7 (ro) |
| FR (1) | FR2458587A1 (ro) |
| GB (1) | GB2058078A (ro) |
| GR (1) | GR69261B (ro) |
| IT (1) | IT1209228B (ro) |
| PL (1) | PL224774A1 (ro) |
| PT (1) | PT71349A (ro) |
| RO (1) | RO79494B (ro) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4968608A (en) * | 1987-10-07 | 1990-11-06 | Merck & Co., Inc. | Process for antifungal fermentation product |
| US4931352A (en) * | 1987-10-07 | 1990-06-05 | Merck & Co., Inc. | Antifungal fermentation product |
| US5166135A (en) * | 1988-09-12 | 1992-11-24 | Merck & Company, Inc. | Method for the control of pneumocystis carinii |
| US5021341A (en) * | 1990-03-12 | 1991-06-04 | Merck & Co., Inc. | Antibiotic agent produced by the cultivation of Zalerion microorganism in the presence of mannitol |
| US5202309A (en) * | 1989-06-30 | 1993-04-13 | Merck & Co., Inc. | Antibiotic cyclopeptide fermentation product |
| JPH0370872U (ro) * | 1989-11-06 | 1991-07-17 | ||
| US5386009A (en) * | 1990-03-19 | 1995-01-31 | Merck & Co. Inc. | Lipopeptide derivatives |
| IE910892A1 (en) * | 1990-03-19 | 1991-09-25 | Merck & Co Inc | Lipopeptide compounds |
| US5049546A (en) * | 1990-03-19 | 1991-09-17 | Merck & Co., Inc. | Antibiotic agents |
| US5310726A (en) * | 1990-03-19 | 1994-05-10 | Merck & Co., Inc. | Lipopeptide compounds |
| US5021403A (en) * | 1990-03-19 | 1991-06-04 | Merck & Co., Inc. | Antibiotic agents |
| US5330973A (en) * | 1990-03-19 | 1994-07-19 | Merck & Co., Inc. | Lipopeptide derivatives |
| US5369093A (en) * | 1991-03-15 | 1994-11-29 | Merck & Co., Inc. | Lipopeptide derivatives |
| US8560369B2 (en) * | 2007-11-01 | 2013-10-15 | Red Hat, Inc. | Systems and methods for technical support based on a flock structure |
| US10282701B2 (en) * | 2007-11-20 | 2019-05-07 | Red Hat, Inc. | Web-based technical issue assignments based on technical support groups having handled a highest number of technical requests |
| EP2240507A2 (en) * | 2008-06-25 | 2010-10-20 | TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Processes for preparing high purity aza cyclohexapeptides |
| CN103387975A (zh) | 2012-05-11 | 2013-11-13 | 上海天伟生物制药有限公司 | 一种固定化环脂肽酰基转移酶及其制备方法和用途 |
| CN103724403B (zh) * | 2012-10-12 | 2018-02-16 | 重庆乾泰生物医药有限公司 | 一种棘白菌素b的分离纯化方法和用途 |
| CN114907989B (zh) * | 2022-05-09 | 2023-06-27 | 中国科学院青岛生物能源与过程研究所 | 一种阿尼芬净前体棘白菌素b高产菌株及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4024245A (en) * | 1975-10-02 | 1977-05-17 | Eli Lilly And Company | Antibiotic A-30912 and process for production thereof |
| US4024246A (en) * | 1975-10-02 | 1977-05-17 | Eli Lilly And Company | Antibiotic A-22082 and process for production thereof |
-
1980
- 1980-03-03 US US06/126,078 patent/US4288549A/en not_active Expired - Lifetime
- 1980-06-02 FR FR8012211A patent/FR2458587A1/fr not_active Withdrawn
- 1980-06-02 FI FI801772A patent/FI801772A7/fi not_active Application Discontinuation
- 1980-06-03 AU AU59015/80A patent/AU5901580A/en not_active Abandoned
- 1980-06-04 CA CA000353367A patent/CA1154695A/en not_active Expired
- 1980-06-04 PT PT71349A patent/PT71349A/pt unknown
- 1980-06-04 RO RO101322A patent/RO79494B/ro unknown
- 1980-06-05 IT IT8022585A patent/IT1209228B/it active
- 1980-06-06 DD DD80221644A patent/DD153213A5/de unknown
- 1980-06-06 GB GB8018640A patent/GB2058078A/en not_active Withdrawn
- 1980-06-06 JP JP7758980A patent/JPS5635988A/ja active Pending
- 1980-06-06 PL PL22477480A patent/PL224774A1/xx unknown
- 1980-06-06 GR GR62149A patent/GR69261B/el unknown
- 1980-06-06 EP EP80301912A patent/EP0021684A1/en not_active Withdrawn
- 1980-06-06 ES ES492227A patent/ES492227A0/es active Granted
- 1980-06-06 DK DK244680A patent/DK244680A/da unknown
- 1980-06-06 AR AR281322A patent/AR222553A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| CA1154695A (en) | 1983-10-04 |
| ES8105149A1 (es) | 1981-05-16 |
| PL224774A1 (ro) | 1981-03-13 |
| EP0021684A1 (en) | 1981-01-07 |
| PT71349A (en) | 1980-07-01 |
| ES492227A0 (es) | 1981-05-16 |
| AR222553A1 (es) | 1981-05-29 |
| FI801772A7 (fi) | 1981-01-01 |
| DD153213A5 (de) | 1981-12-30 |
| DK244680A (da) | 1980-12-09 |
| AU5901580A (en) | 1981-01-22 |
| IT1209228B (it) | 1989-07-16 |
| JPS5635988A (en) | 1981-04-08 |
| RO79494A (fr) | 1982-07-06 |
| GB2058078A (en) | 1981-04-08 |
| US4288549A (en) | 1981-09-08 |
| IT8022585A0 (it) | 1980-06-05 |
| GR69261B (ro) | 1982-05-12 |
| FR2458587A1 (fr) | 1981-01-02 |
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