RO71556B - Procedeu pentru prepararea unui inhibitor de pepsina - Google Patents

Procedeu pentru prepararea unui inhibitor de pepsina

Info

Publication number
RO71556B
RO71556B RO76141A RO7614170A RO71556B RO 71556 B RO71556 B RO 71556B RO 76141 A RO76141 A RO 76141A RO 7614170 A RO7614170 A RO 7614170A RO 71556 B RO71556 B RO 71556B
Authority
RO
Romania
Prior art keywords
inhibitor
strain
pepsine
preparing
nitrogen
Prior art date
Application number
RO76141A
Other languages
English (en)
Other versions
RO71556A (ro
Inventor
Hamao Umezawa
Tomio Takeuchi
Takaaki Aoyagi
Masa Hamada
Kenji Maeda
Yoshiro Okami
Original Assignee
Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai filed Critical Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
Publication of RO71556A publication Critical patent/RO71556A/ro
Publication of RO71556B publication Critical patent/RO71556B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8142—Aspartate protease (E.C. 3.4.23) inhibitors, e.g. HIV protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/803—Physical recovery methods, e.g. chromatography, grinding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • AIDS & HIV (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Conform inventiei, prepararea peptatinului se face supunand cultivarii tulpina de Streptomyces argenteolus var.toyonakensis ATCC nr. 21468 într.un mediu nutritiv continînd surse asimilabile de carbon si azot incubarea avînd loc timp de 4....7 zile la temperaturi de 25....35 degree C, în conditii aerobe recuperarea din mediul de cultura a inhibitorului la atingerea pH-ului de 7,7 prin metode cunoscute mediul de cultivare a tulpinei de Streptomyces continînd pe lîngî surse asimilabile de carbon si azot cunoscute 0,2% NaCl 0,05% MgSO4.7H2O, 0,08% K2HPO4 si 0,32 CaCO3.
RO76141A 1969-06-13 1970-06-13 Procedeu pentru prepararea unui inhibitor de pepsina RO71556B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4616669 1969-06-13

Publications (2)

Publication Number Publication Date
RO71556A RO71556A (ro) 1984-05-23
RO71556B true RO71556B (ro) 1984-07-30

Family

ID=12739413

Family Applications (1)

Application Number Title Priority Date Filing Date
RO76141A RO71556B (ro) 1969-06-13 1970-06-13 Procedeu pentru prepararea unui inhibitor de pepsina

Country Status (23)

Country Link
US (1) US3740319A (ro)
AT (1) AT295454B (ro)
AU (1) AU1584970A (ro)
BE (1) BE751931A (ro)
CA (1) CA928238A (ro)
CH (1) CH550247A (ro)
CS (1) CS171685B2 (ro)
DE (1) DE2028403C3 (ro)
DK (1) DK128124B (ro)
ES (1) ES380545A1 (ro)
FI (2) FI47498C (ro)
FR (1) FR2052964B1 (ro)
GB (1) GB1314231A (ro)
IE (1) IE34196B1 (ro)
IL (1) IL34543A (ro)
LU (1) LU61119A1 (ro)
NL (1) NL166279C (ro)
NO (1) NO129682B (ro)
PH (2) PH9382A (ro)
PL (1) PL81272B1 (ro)
RO (1) RO71556B (ro)
SE (1) SE381673B (ro)
YU (1) YU35272B (ro)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5022116B1 (ro) * 1970-04-28 1975-07-28
JPS5434837B2 (ro) * 1972-02-08 1979-10-29
DK132899C (da) * 1972-04-07 1976-07-26 Takeda Chemical Industries Ltd Fremgangsmade til fremstilling af de proteaseinhiberende stoffer pepsinostreptiner eller salte deraf
US3963579A (en) * 1973-10-17 1976-06-15 Sanraku-Ocean Co., Ltd. Microbiological process for the production of pepstatins
US4206283A (en) * 1975-09-12 1980-06-03 Sumitomo Chemical Company, Limited Protease inhibitors
US4101650A (en) * 1977-04-06 1978-07-18 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Pepstatin floating minicapsules
US5833946A (en) * 1995-06-06 1998-11-10 Bayer Corporation Dissemination of fungal infections: animal model and method of prophylaxis
GB0807621D0 (en) * 2008-04-25 2008-06-04 Ineos Healthcare Ltd Use

Also Published As

Publication number Publication date
SE381673B (sv) 1975-12-15
NL166279B (nl) 1981-02-16
AT295454B (de) 1972-01-10
IL34543A (en) 1974-03-14
FI47498B (ro) 1973-08-31
ES380545A1 (es) 1972-10-01
AU1584970A (en) 1971-12-09
PH9382A (en) 1975-10-22
PH10881A (en) 1977-09-26
FI47498C (fi) 1973-12-10
PL81272B1 (ro) 1975-08-30
RO71556A (ro) 1984-05-23
FR2052964A1 (ro) 1971-04-16
CA928238A (en) 1973-06-12
DE2028403B2 (de) 1975-04-24
GB1314231A (en) 1973-04-18
IE34196L (en) 1970-12-13
CH550247A (de) 1974-06-14
NL166279C (nl) 1981-07-15
US3740319A (en) 1973-06-19
DK128124B (da) 1974-03-04
FR2052964B1 (ro) 1974-10-11
NL7008657A (ro) 1970-12-15
DE2028403C3 (de) 1975-11-27
DE2028403A1 (de) 1971-01-28
YU35272B (en) 1980-10-31
IE34196B1 (en) 1975-03-05
NO129682B (ro) 1974-05-13
IL34543A0 (en) 1970-07-19
YU146270A (en) 1980-04-30
CS171685B2 (ro) 1976-10-29
BE751931A (fr) 1970-11-16
LU61119A1 (ro) 1970-08-12

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