RO62762A - Procede pour la preparation des(1,5a)-pyrimidines 3,5,7-tri-substitues - Google Patents

Procede pour la preparation des(1,5a)-pyrimidines 3,5,7-tri-substitues

Info

Publication number
RO62762A
RO62762A RO7200073093A RO7309372A RO62762A RO 62762 A RO62762 A RO 62762A RO 7200073093 A RO7200073093 A RO 7200073093A RO 7309372 A RO7309372 A RO 7309372A RO 62762 A RO62762 A RO 62762A
Authority
RO
Romania
Prior art keywords
pyrimidines
tri
substituted
preparation
Prior art date
Application number
RO7200073093A
Other languages
English (en)
French (fr)
Romanian (ro)
Inventor
Roland K Robins
Darrel E O'brien
Thomas Novinson
Robert H Springer
Original Assignee
Icn Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US245870A external-priority patent/US3925385A/en
Application filed by Icn Pharmaceutical Inc filed Critical Icn Pharmaceutical Inc
Publication of RO62762A publication Critical patent/RO62762A/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RO7200073093A 1971-12-09 1972-12-09 Procede pour la preparation des(1,5a)-pyrimidines 3,5,7-tri-substitues RO62762A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US20653871A 1971-12-09 1971-12-09
US245870A US3925385A (en) 1972-04-20 1972-04-20 6-Carbethoxy-3,7-disubstitutedpyrazolo{8 1,5a{9 pyrimidines
US27346572A 1972-07-20 1972-07-20
US29984072A 1972-10-24 1972-10-24

Publications (1)

Publication Number Publication Date
RO62762A true RO62762A (fr) 1978-05-15

Family

ID=27498614

Family Applications (1)

Application Number Title Priority Date Filing Date
RO7200073093A RO62762A (fr) 1971-12-09 1972-12-09 Procede pour la preparation des(1,5a)-pyrimidines 3,5,7-tri-substitues

Country Status (15)

Country Link
JP (1) JPS4864097A (enrdf_load_stackoverflow)
BE (1) BE792533A (enrdf_load_stackoverflow)
BG (1) BG22401A3 (enrdf_load_stackoverflow)
CH (1) CH603652A5 (enrdf_load_stackoverflow)
DD (1) DD104530A5 (enrdf_load_stackoverflow)
DE (1) DE2257547A1 (enrdf_load_stackoverflow)
GB (1) GB1412017A (enrdf_load_stackoverflow)
HU (1) HU168530B (enrdf_load_stackoverflow)
IE (1) IE37189B1 (enrdf_load_stackoverflow)
IL (1) IL40895A (enrdf_load_stackoverflow)
LU (1) LU66597A1 (enrdf_load_stackoverflow)
NL (1) NL7216539A (enrdf_load_stackoverflow)
NO (1) NO137012C (enrdf_load_stackoverflow)
RO (1) RO62762A (enrdf_load_stackoverflow)
SE (1) SE398751B (enrdf_load_stackoverflow)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281000A (en) * 1979-07-09 1981-07-28 American Cyanamid Company Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents
AU557300B2 (en) * 1982-03-16 1986-12-18 Farmitalia Carlo Erba S.P.A. Substituted 1h-pyrazolo(1,5-alpha)pyrimidines and processes for their preparation
ZA831407B (en) * 1982-03-25 1983-11-30 Erba Farmitalia Substituted ethenyl derivatives of 1h-pyrazolo(1,5-a)pyrimidine and process for their preparation
NZ208554A (en) * 1983-06-23 1987-06-30 American Cyanamid Co (aryl and heteroaryl)-(7-(aryl and heteroaryl)-pyrazolo (1,5-a) pyrimidin-3-yl)-methanone derivatives and pharmaceutical compositions
DE3533050A1 (de) * 1985-09-17 1987-03-26 Basf Ag 7-amino-azolo(1,5-a)pyrimidine, verfahren zu ihrer herstellung und diese enthaltende fungizide, bzw. deren verwendung als fungizide
CA1330079C (en) * 1988-10-13 1994-06-07 Michihiko Tsujitani Pyrrolo (3,2-e)pyrazolo(1,5-a)pyrimidine derivative and medicine comprising the same
EP0591528B1 (en) * 1991-04-22 1998-12-23 Otsuka Pharmaceutical Factory, Inc. PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVE AND ANTI-INFLAMMATORY CONTAINING THE SAME
DE4333705C2 (de) * 1993-10-02 2003-10-30 Guenter Ege Arylmethylsubstituierte Pyrazolo-azine, insbesondere 3-Arylmethylpyrazolo[1,5-a]pyrimidine und Verfahren zur Herstellung von 8-Arylmethyl-pyrazolo[5,1-c][1,2,4]triazinen
PT714898E (pt) * 1994-06-21 2002-04-29 Otsuka Pharma Co Ltd Derivado de pirazolo¬1,5-a|pirimidina
AU707530B2 (en) * 1995-09-28 1999-07-15 Otsuka Pharmaceutical Factory, Inc. Analgesic composition
FR2771631B1 (fr) * 1997-12-03 2001-02-02 Oreal Compositions de teinture des fibres keratiniques contenant des 3-amino pyrazolo-[1,5-a]-pyrimidines, procede de teinture, nouvelles 3-amino pyrazolo- [1,5-a]-pyrimidines et leur procede de preparation
US7119200B2 (en) * 2002-09-04 2006-10-10 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7161003B1 (en) 2002-09-04 2007-01-09 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
CA2497440C (en) * 2002-09-04 2011-03-22 Schering Corporation Pyrazolopyrimidines as cyclin-dependent kinase inhibitors
TWI252851B (en) * 2003-07-24 2006-04-11 Ferrer Int 7-substituted 3-nitro-pyrazolo[1,5-a]pyrimidines and compositions and methods related thereto
ES2222813B1 (es) * 2003-07-24 2005-12-16 Ferrer Internacional, S.A. N-(3-(3-sustituidas-pirazolo(1,5-a)pirimidin-7-il)-fenil)-sulfonamidas y composiciones y metodos relacionados.
PT2989106T (pt) 2013-04-25 2017-03-15 Beigene Ltd Compostos heterocíclicos fundidos como inibidores da proteína quinase
PL3044234T3 (pl) 2013-09-13 2020-10-19 Beigene Switzerland Gmbh Przeciwciała anty-PD1 i ich zastosowanie jako środków terapeutycznych i diagnostycznych
TWI726608B (zh) 2014-07-03 2021-05-01 英屬開曼群島商百濟神州有限公司 抗pd-l1抗體及其作為治療及診斷之用途
CN109475536B (zh) 2016-07-05 2022-05-27 百济神州有限公司 用于治疗癌症的PD-l拮抗剂和RAF抑制剂的组合
CA3033827A1 (en) 2016-08-16 2018-02-22 Beigene, Ltd. Crystalline form of (s)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl )-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide,preparation, and uses thereof
DK3500299T3 (da) 2016-08-19 2024-01-29 Beigene Switzerland Gmbh Kombination af zanubrutinib med et anti-CD20- eller et anti-PD-1-antistof til anvendelse i behandling af cancer
TWI774726B (zh) 2017-01-25 2022-08-21 英屬開曼群島商百濟神州有限公司 (S)-7-(1-(丁-2-炔醯基)哌啶-4-基)-2-(4-苯氧基苯基)-4,5,6,7-四氫吡唑并[1,5-a]嘧啶-3-甲醯胺的晶型、及其製備和用途
CN110799543A (zh) 2017-06-26 2020-02-14 百济神州有限公司 肝细胞癌的免疫治疗
CN110997677A (zh) 2017-08-12 2020-04-10 百济神州有限公司 具有改进的双重选择性的Btk抑制剂
CN111801334B (zh) 2017-11-29 2023-06-09 百济神州瑞士有限责任公司 使用包含btk抑制剂的组合治疗惰性或侵袭性b-细胞淋巴瘤
TW202446397A (zh) 2019-06-10 2024-12-01 瑞士商百濟神州瑞士有限責任公司 一種含有布魯頓氏酪胺酸激酶抑制劑的口服固體錠劑及其製備方法
US11786531B1 (en) 2022-06-08 2023-10-17 Beigene Switzerland Gmbh Methods of treating B-cell proliferative disorder

Also Published As

Publication number Publication date
GB1412017A (en) 1975-10-29
BG22401A3 (bg) 1977-02-20
IL40895A (en) 1976-12-31
HU168530B (enrdf_load_stackoverflow) 1976-05-28
IE37189B1 (en) 1977-05-25
SE398751B (sv) 1978-01-16
BE792533A (fr) 1973-06-08
DD104530A5 (enrdf_load_stackoverflow) 1974-03-12
IE37189L (en) 1973-06-09
NO137012B (no) 1977-09-05
NO137012C (no) 1977-12-14
DE2257547A1 (de) 1973-06-14
JPS4864097A (enrdf_load_stackoverflow) 1973-09-05
CH603652A5 (enrdf_load_stackoverflow) 1978-08-31
NL7216539A (enrdf_load_stackoverflow) 1973-06-13
LU66597A1 (enrdf_load_stackoverflow) 1973-03-15
IL40895A0 (en) 1973-01-30

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