PT99135A - Processo para a preparacao de derivados de piperazina - Google Patents
Processo para a preparacao de derivados de piperazinaInfo
- Publication number
- PT99135A PT99135A PT99135A PT9913591A PT99135A PT 99135 A PT99135 A PT 99135A PT 99135 A PT99135 A PT 99135A PT 9913591 A PT9913591 A PT 9913591A PT 99135 A PT99135 A PT 99135A
- Authority
- PT
- Portugal
- Prior art keywords
- pct
- sec
- aryl
- hydrogen
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909021535A GB9021535D0 (en) | 1990-10-03 | 1990-10-03 | Piperazine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT99135A true PT99135A (pt) | 1992-08-31 |
| PT99135B PT99135B (pt) | 1999-03-31 |
Family
ID=10683193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99135A PT99135B (pt) | 1990-10-03 | 1991-10-01 | Processo para a preparacao de derivados de piperazina |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5346896A (pt) |
| EP (1) | EP0502169B1 (pt) |
| JP (1) | JP3085708B2 (pt) |
| KR (1) | KR100228608B1 (pt) |
| AT (1) | ATE132495T1 (pt) |
| AU (1) | AU645853B2 (pt) |
| CA (1) | CA2070173A1 (pt) |
| DE (1) | DE69116127T2 (pt) |
| DK (1) | DK0502169T3 (pt) |
| ES (1) | ES2081495T3 (pt) |
| GB (2) | GB9021535D0 (pt) |
| GR (1) | GR3018623T3 (pt) |
| IE (1) | IE65378B1 (pt) |
| NZ (1) | NZ240050A (pt) |
| PT (1) | PT99135B (pt) |
| WO (1) | WO1992006082A1 (pt) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2665160A1 (fr) * | 1990-07-26 | 1992-01-31 | Esteve Labor Dr | Nouveaux derives de 1-diphenylmethylpiperazine, leur preparation et leur application en tant que medicaments. |
| GB9022821D0 (en) * | 1990-10-19 | 1990-12-05 | Wyeth John & Brother Ltd | Piperazine derivatives |
| GB9305672D0 (en) * | 1993-03-19 | 1993-05-05 | Wyeth John & Brother Ltd | Amide derivatives |
| GB9306103D0 (en) * | 1993-03-24 | 1993-05-12 | Wyeth John & Brother Ltd | Piperazine derivatives |
| GB9312806D0 (en) * | 1993-06-22 | 1993-08-04 | Boots Co Plc | Therapeutic agents |
| US5741800A (en) * | 1993-06-22 | 1998-04-21 | Knoll Aktiengesellachaft | Azolyl-cyclic amine derivates with immunomodulatory activity |
| FR2707294B1 (fr) * | 1993-07-06 | 1995-09-29 | Pf Medicament | Nouveaux dérivés de la 3,5-dioxo-(2H,4H)-1,2,4-triazine, leur préparation et leur application en thérapeutique humaine. |
| US5609849A (en) * | 1994-03-11 | 1997-03-11 | The Trustees Of The University Of Pennsylvania | Serotonin (5-HT1A) receptor ligands and imaging agents |
| GB9408872D0 (en) * | 1994-05-03 | 1994-06-22 | Zeneca Ltd | Heterocyclic compounds |
| GB9411099D0 (en) * | 1994-06-03 | 1994-07-27 | Wyeth John & Brother Ltd | Piperazine derivatives |
| DE4425144A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Triazolverbindungen und deren Verwendung |
| US5998444A (en) * | 1995-10-24 | 1999-12-07 | Zeneca Ltd. | Piperidinyl compounds as NK1 or NK2 antagonists |
| DE69534213T2 (de) * | 1994-10-25 | 2006-01-12 | Astrazeneca Ab | Therapeutisch wirksame Heterocyclen |
| US6008223A (en) * | 1994-10-27 | 1999-12-28 | Zeneca Limited | Therapeutic compounds |
| GB9508786D0 (en) | 1995-04-29 | 1995-06-21 | Zeneca Ltd | Substituted heterocycles |
| DE19728996A1 (de) | 1997-07-07 | 1999-01-14 | Basf Ag | Triazolverbindungen und deren Verwendung |
| UA66370C2 (en) * | 1997-12-16 | 2004-05-17 | Lilly Co Eli | Arylpiperazines having activity to setotonin 1 receptors |
| PL345166A1 (en) * | 1998-06-30 | 2001-12-03 | Zeria Pharm Co Ltd | N-phenyl-n'-phenylpropylpiperazine derivatives and process for the preparation thereof |
| CN1867336B (zh) * | 2002-06-12 | 2010-05-12 | 凯莫森特里克斯股份有限公司 | 1-芳基-4-取代的哌嗪衍生物及其制药用途 |
| US7589199B2 (en) * | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
| US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
| US7842693B2 (en) * | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
| US20040072839A1 (en) * | 2002-06-14 | 2004-04-15 | Amedeo Leonardi | 1-Phenylalkylpiperazines |
| US7071197B2 (en) * | 2002-06-14 | 2006-07-04 | Recordati S.A. | N,N-disubstituted diazocycloalkanes |
| ITMI20021327A1 (it) * | 2002-06-14 | 2003-12-15 | Recordati Chem Pharm | Nuove ossialchilpiperazine |
| US7419980B2 (en) * | 2003-10-14 | 2008-09-02 | Wyeth | Fused-aryl and heteroaryl derivatives and methods of their use |
| CN1950082B (zh) * | 2004-03-03 | 2013-02-06 | 凯莫森特里克斯股份有限公司 | 双环和桥连的含氮杂环化物 |
| US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4080453A (en) * | 1975-03-12 | 1978-03-21 | Dainippon Pharmaceutical Co., Ltd. | 1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives and compositions containing the same |
| CA1162540A (en) * | 1980-12-24 | 1984-02-21 | Ikutaro Saji | Imidazolylpropanol compounds and their acid addition salts, and production and use thereof |
| IT1214597B (it) * | 1985-04-15 | 1990-01-18 | Rorer Italiana Spa | Derivati dell'imidazolo adattivita' antimicotica, procedimento ed intermedi per laloro preparazione e composizioni che li contengono. |
| GB8729083D0 (en) * | 1987-12-12 | 1988-01-27 | Pfizer Ltd | Triazole antifungal agents |
| FR2642758B1 (fr) * | 1989-02-09 | 1991-05-17 | Esteve Labor Dr | Derives de pyrimidine,2-(4-((alpha)-heteroaryl-(alpha) aryl-((alpha)-alkyl)-methoxy)-butyl)-1-piperazinyl), avec activite serotoninergique |
| GB9021453D0 (en) * | 1990-10-03 | 1990-11-14 | Wyeth John & Brother Ltd | Piperazine derivatives |
-
1990
- 1990-10-03 GB GB909021535A patent/GB9021535D0/en active Pending
-
1991
- 1991-10-01 DE DE69116127T patent/DE69116127T2/de not_active Expired - Fee Related
- 1991-10-01 JP JP03516228A patent/JP3085708B2/ja not_active Expired - Fee Related
- 1991-10-01 CA CA002070173A patent/CA2070173A1/en not_active Abandoned
- 1991-10-01 AT AT91917542T patent/ATE132495T1/de not_active IP Right Cessation
- 1991-10-01 GB GB9120849A patent/GB2248449B/en not_active Expired - Fee Related
- 1991-10-01 KR KR1019920701293A patent/KR100228608B1/ko not_active IP Right Cessation
- 1991-10-01 EP EP91917542A patent/EP0502169B1/en not_active Expired - Lifetime
- 1991-10-01 US US07/867,221 patent/US5346896A/en not_active Expired - Lifetime
- 1991-10-01 WO PCT/GB1991/001693 patent/WO1992006082A1/en active IP Right Grant
- 1991-10-01 ES ES91917542T patent/ES2081495T3/es not_active Expired - Lifetime
- 1991-10-01 PT PT99135A patent/PT99135B/pt not_active IP Right Cessation
- 1991-10-01 DK DK91917542.2T patent/DK0502169T3/da active
- 1991-10-01 AU AU86544/91A patent/AU645853B2/en not_active Ceased
- 1991-10-01 NZ NZ240050A patent/NZ240050A/xx unknown
- 1991-10-02 IE IE347291A patent/IE65378B1/en not_active IP Right Cessation
-
1996
- 1996-01-09 GR GR960400043T patent/GR3018623T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH05502682A (ja) | 1993-05-13 |
| AU645853B2 (en) | 1994-01-27 |
| KR927003557A (ko) | 1992-12-18 |
| US5346896A (en) | 1994-09-13 |
| DE69116127D1 (de) | 1996-02-15 |
| EP0502169B1 (en) | 1996-01-03 |
| IE913472A1 (en) | 1992-04-08 |
| DE69116127T2 (de) | 1996-05-15 |
| ATE132495T1 (de) | 1996-01-15 |
| GR3018623T3 (en) | 1996-04-30 |
| IE65378B1 (en) | 1995-10-18 |
| PT99135B (pt) | 1999-03-31 |
| GB2248449B (en) | 1994-06-15 |
| EP0502169A1 (en) | 1992-09-09 |
| GB9021535D0 (en) | 1990-11-14 |
| KR100228608B1 (ko) | 1999-11-01 |
| JP3085708B2 (ja) | 2000-09-11 |
| AU8654491A (en) | 1992-04-28 |
| CA2070173A1 (en) | 1992-04-04 |
| GB2248449A (en) | 1992-04-08 |
| DK0502169T3 (da) | 1996-02-05 |
| GB9120849D0 (en) | 1991-11-13 |
| WO1992006082A1 (en) | 1992-04-16 |
| ES2081495T3 (es) | 1996-03-16 |
| NZ240050A (en) | 1993-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19920408 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19981202 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20020630 |