PT97581A - Processo para a preparacao de derivados de 1h-substtuido-1,2,4-triazole, uteis para o tratamento de perturbacoes cardiovasculares - Google Patents

Processo para a preparacao de derivados de 1h-substtuido-1,2,4-triazole, uteis para o tratamento de perturbacoes cardiovasculares

Info

Publication number
PT97581A
PT97581A PT97581A PT9758191A PT97581A PT 97581 A PT97581 A PT 97581A PT 97581 A PT97581 A PT 97581A PT 9758191 A PT9758191 A PT 9758191A PT 97581 A PT97581 A PT 97581A
Authority
PT
Portugal
Prior art keywords
butyl
treatment
pentyl
compounds
triazole
Prior art date
Application number
PT97581A
Other languages
English (en)
Other versions
PT97581B (pt
Inventor
David B Reitz
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of PT97581A publication Critical patent/PT97581A/pt
Publication of PT97581B publication Critical patent/PT97581B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT97581A 1990-05-04 1991-05-06 Processo para a preparacao de derivados de 1h-substtuido-1,2,4-triazole, uteis para o tratamento de perturbacoes cardiovasculares PT97581B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/519,380 US5098920A (en) 1990-05-04 1990-05-04 1h-substituted-1,2,4-triazole compounds and methods of use thereof for treatment of cardiovascular disorders
PCT/US1991/002926 WO1991017148A1 (en) 1990-05-04 1991-05-06 1h-substituted-1,2,4-triazole compounds for treatment of cardiovascular disorders

Publications (2)

Publication Number Publication Date
PT97581A true PT97581A (pt) 1992-01-31
PT97581B PT97581B (pt) 1998-08-31

Family

ID=24068062

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97581A PT97581B (pt) 1990-05-04 1991-05-06 Processo para a preparacao de derivados de 1h-substtuido-1,2,4-triazole, uteis para o tratamento de perturbacoes cardiovasculares

Country Status (13)

Country Link
US (1) US5098920A (pt)
EP (1) EP0527851B1 (pt)
JP (1) JP3098772B2 (pt)
AT (1) ATE174910T1 (pt)
AU (1) AU7792491A (pt)
CA (1) CA2082074C (pt)
DE (1) DE69130671T2 (pt)
DK (1) DK0527851T3 (pt)
ES (1) ES2125868T3 (pt)
GR (1) GR3029772T3 (pt)
IE (1) IE62867B1 (pt)
PT (1) PT97581B (pt)
WO (1) WO1991017148A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0409332A3 (en) * 1989-07-19 1991-08-07 Merck & Co. Inc. Substituted triazoles as angiotensin ii antagonists
US5217985A (en) * 1990-08-28 1993-06-08 G. D. Searle & Co. Renal-selective biphenylalkyl 1h-substituted-1,2,4-triazole angiotensin ii antagonists for treatment of hypertension
US20040121989A1 (en) * 1990-08-28 2004-06-24 G.D. Searle & Co. Renal-selective biphenylalkyl 1H-substituted-1,2,4-triazole angiotensin II antagonists for treatment of hypertension
JP3890453B2 (ja) 1996-09-18 2007-03-07 リードケミカル株式会社 新規２，４−ジオキソピロリジンおよび２，４−ジオキソテトラヒドロフラン誘導体及び該化合物を有効成分とする医薬
US6495580B1 (en) 1998-01-29 2002-12-17 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
MXPA00007394A (es) * 1998-01-29 2003-08-01 Viropharma Inc Compuestos, composiciones y metodos para tratar o evitar infeccion de neumovirus y enfermedades asociadas.
WO2000003709A1 (en) * 1998-07-16 2000-01-27 Research Development Foundation Novel dna-cleaving antitumor agents
US6362342B1 (en) 1999-06-29 2002-03-26 Lion Bioscience Ag Triazole compounds and methods of making same
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
US8119672B2 (en) 2002-08-09 2012-02-21 Microdose Therapeutx, Inc. Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
US8202896B2 (en) * 2002-08-09 2012-06-19 Microdose Therapeutx, Inc. Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
ES2348356T3 (es) 2005-10-11 2010-12-03 F. Hoffmann-La Roche Ag Derivados de imidazo-benzodiazepina.
ES2393885T7 (es) 2007-06-04 2014-01-30 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
US10011637B2 (en) 2013-06-05 2018-07-03 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase C, method of making and using same
US11680076B2 (en) 2017-04-07 2023-06-20 Shikoku Chemicals Corporation Triazole silane compound, method for synthesizing said compound and use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2461406C2 (de) * 1974-12-24 1984-06-14 Bayer Ag, 5090 Leverkusen Azolyl-(1)-methane und deren Salze, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
DE2851086A1 (de) * 1978-11-25 1980-06-04 Bayer Ag Hydroxypropyl-triazole, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2912288A1 (de) * 1979-03-28 1980-10-09 Bayer Ag Verfahren zur herstellung von hydroxyethyl-azolen
US4816463A (en) * 1986-04-01 1989-03-28 Warner-Lambert Company Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive activity
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
CA1329614C (en) * 1987-05-02 1994-05-17 Rainer Buerstinghaus N-substituted azoles
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
EP0409332A3 (en) * 1989-07-19 1991-08-07 Merck & Co. Inc. Substituted triazoles as angiotensin ii antagonists

Also Published As

Publication number Publication date
PT97581B (pt) 1998-08-31
AU7792491A (en) 1991-11-27
EP0527851A1 (en) 1993-02-24
JP3098772B2 (ja) 2000-10-16
IE911533A1 (en) 1991-11-06
CA2082074A1 (en) 1991-11-05
JPH05507079A (ja) 1993-10-14
IE62867B1 (en) 1995-03-08
ATE174910T1 (de) 1999-01-15
DE69130671T2 (de) 1999-05-27
WO1991017148A1 (en) 1991-11-14
DE69130671D1 (de) 1999-02-04
EP0527851B1 (en) 1998-12-23
GR3029772T3 (en) 1999-06-30
US5098920A (en) 1992-03-24
ES2125868T3 (es) 1999-03-16
DK0527851T3 (da) 1999-08-23
CA2082074C (en) 2002-02-05

Similar Documents

Publication Publication Date Title
PT97581A (pt) Processo para a preparacao de derivados de 1h-substtuido-1,2,4-triazole, uteis para o tratamento de perturbacoes cardiovasculares
AU1927892A (en) N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders
DE69119089D1 (de) N-substituierte imidazol-2-on-verbindungen zur behandlung von zirkulatorischen störungen
CA2288705A1 (en) Use of quinazoline compounds for the treatment of polycystic kidney disease
DK0619819T3 (da) 1-Arylheteroarylalkyl-substituerede 1H-1,2,4-triazolforbindelser til behandling af kredsløbsforstyrrelser
NO913923D0 (no) 17beta-substituerte-4-aza-5alfa-androstan-3-on-derivater ogfremgangsmaate ved fremstilling av disse
CA2196640A1 (en) Substituted quinazoline derivatives
CA2298033A1 (en) Certain 5-alkyl-2-arylaminophenylacetic acids and derivatives
CA2272463A1 (en) Treating or preventing the early stages of degeneration of articular cartilage or subchondral bone in mammals using carprofen and derivatives
ATE243689T1 (de) 5-amino-benzofuran-2-carbonsäurederivate
AU7927591A (en) Substituted aminoalkylbiphenyl derivatives
PT93213A (pt) Processo para a preparacao de derivados de n-fenilbenzamida com accao anti-ulcerosa e anti-alergica e de composicoes farmaceuticas que os contem
ATE177096T1 (de) 4-substituierte 1,2,4-triazolderivate
TR200001950T2 (tr) İkameli 2-benzilamino-2-fenil-asetamid bileşikler.
BR9509970A (pt) Composto
NO974749D0 (no) Fremgangsmåte for fremstilling av 2,2'-bipyrrolyl-pyrrometen (prodigiosiner) -derivater
SE8802412D0 (sv) Thiourea derivatives
KR960701041A (ko) 순환장애의 치료를 위한 1-페닐-이미다졸-2-온 비페닐 메틸 화합물(1-phenyl-imidazol-2-one biphenylmethyl compounds for treatmetnt of circulatory disorders)
NO975500D0 (no) Potensiering av mikrobiocid 2-(thiocyanometylthio)benzothiazole ved å anvende en n-alkylheterosyklisk forbindelse
ID18951A (id) Berbagai penggunaan sambungan tap untuk alat penghampar-angkat
DK0664802T3 (da) N-Arylheteroarylalkyl-1-phenyl-imidazol-2-on-forbindelser til behandling af kredsløbssygdomme
TR199802203A2 (xx) 4-Siyano-4-(ikame indazol) siklohegzan-karboksilik asitleri haz�rlama y�ntemi.
ES2101644A1 (es) Nuevo compuesto derivado del cromeno

Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19911008

FG3A Patent granted, date of granting

Effective date: 19980519

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20061120