PT97357A - Processo para a preparacao de adesivos de poli-isobutileno para dispositivos transdermicos - Google Patents
Processo para a preparacao de adesivos de poli-isobutileno para dispositivos transdermicosInfo
- Publication number
- PT97357A PT97357A PT97357A PT9735791A PT97357A PT 97357 A PT97357 A PT 97357A PT 97357 A PT97357 A PT 97357A PT 9735791 A PT9735791 A PT 9735791A PT 97357 A PT97357 A PT 97357A
- Authority
- PT
- Portugal
- Prior art keywords
- devices
- isobutilene
- transdermic
- adhesives
- poly
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/58—Adhesives
- A61L15/585—Mixtures of macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Materials Engineering (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/509,644 US5508038A (en) | 1990-04-16 | 1990-04-16 | Polyisobutylene adhesives for transdermal devices |
Publications (2)
Publication Number | Publication Date |
---|---|
PT97357A true PT97357A (pt) | 1992-01-31 |
PT97357B PT97357B (pt) | 1998-08-31 |
Family
ID=24027514
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT97357A PT97357B (pt) | 1990-04-16 | 1991-04-12 | Processo para a preparacao de adesivos de poli-isobutileno para dispositivos transdermicos |
Country Status (18)
Country | Link |
---|---|
US (1) | US5508038A (pt) |
EP (1) | EP0525105B1 (pt) |
JP (1) | JP3035346B2 (pt) |
KR (1) | KR0150228B1 (pt) |
AT (1) | ATE134512T1 (pt) |
AU (1) | AU630817B2 (pt) |
CA (1) | CA2040352A1 (pt) |
DE (1) | DE69117505T2 (pt) |
DK (1) | DK0525105T3 (pt) |
ES (1) | ES2084161T3 (pt) |
FI (1) | FI112171B (pt) |
GR (1) | GR3019157T3 (pt) |
IE (1) | IE74862B1 (pt) |
NO (1) | NO300086B1 (pt) |
NZ (1) | NZ237810A (pt) |
PT (1) | PT97357B (pt) |
WO (1) | WO1991016085A1 (pt) |
ZA (1) | ZA912753B (pt) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1251469B (it) * | 1991-07-15 | 1995-05-15 | Zambon Spa | Sistema terapeutico transdermale per la somministrazione di farmaci ad attivita' broncodilatante. |
EP0708627B1 (en) * | 1993-07-09 | 2000-02-02 | Cygnus, Inc. | Method and device for providing nicotine replacement therapy transdermally/transbuccally |
GB2281036A (en) * | 1993-08-02 | 1995-02-22 | Agri Tech | Topical compositions containing polybutenes |
EP0760238B1 (en) * | 1994-05-18 | 2002-04-17 | Hisamitsu Pharmaceutical Co., Inc. | Percutaneously administrable preparation for treating urination disorder |
WO1996022083A1 (en) * | 1995-01-19 | 1996-07-25 | Cygnus, Inc. | POLYISOBUTYLENE ADHESIVES CONTAINING HIGH Tg TACKIFIER FOR TRANSDERMAL DEVICES |
HU228434B1 (en) * | 1995-06-07 | 2013-03-28 | Ortho Mcneil Pharm Inc | Transdermal medicament for administering 17-deacetyl norgestimate alone or in combination with an estrogen |
US6011116A (en) * | 1996-05-08 | 2000-01-04 | Kaneka Corporation | Thermoplastic resin composition |
JP3545532B2 (ja) * | 1996-05-08 | 2004-07-21 | 鐘淵化学工業株式会社 | 複合ゴム粒子および複合ゴム系グラフト共重合体粒子 |
US6007837A (en) * | 1996-07-03 | 1999-12-28 | Alza Corporation | Drug delivery devices and process of manufacture |
US6174545B1 (en) | 1997-07-01 | 2001-01-16 | Alza Corporation | Drug delivery devices and process of manufacture |
US5948433A (en) * | 1997-08-21 | 1999-09-07 | Bertek, Inc. | Transdermal patch |
US6605751B1 (en) * | 1997-11-14 | 2003-08-12 | Acrymed | Silver-containing compositions, devices and methods for making |
US6348210B1 (en) | 1998-11-13 | 2002-02-19 | Alza Corporation | Methods for transdermal drug administration |
CN1331586A (zh) | 1998-12-18 | 2002-01-16 | 阿尔扎有限公司 | 透明的透皮烟碱输送装置 |
US8679523B2 (en) * | 1999-12-30 | 2014-03-25 | Kimberly-Clark Worldwide, Inc. | Oxygen-delivery closed cell foam matrix for wound treatment |
DE10003767A1 (de) | 2000-01-28 | 2001-10-04 | Beiersdorf Ag | Hautfreundliches Wirkstoffpflaster zur transdermalen Verabreichung nichtsteroidaler Antirheumatika |
DE10056009A1 (de) * | 2000-11-11 | 2002-05-16 | Beiersdorf Ag | Hautfreundliches Wirkstoffpflaster zur transdermalen Verabreichung hyperämisierender Wirkstoffe |
CN1678277B (zh) | 2002-07-29 | 2010-05-05 | 艾克里麦德公司 | 治疗皮肤病的方法和组合物 |
TWI296531B (en) | 2002-10-18 | 2008-05-11 | Hisamitsu Pharmaceutical Co | Transdermal adhesive preparations for topical administration of fentanyl |
EP1778010B1 (en) * | 2004-07-30 | 2014-06-04 | Kimberly-Clark Worldwide, Inc. | Antimicrobial silver compositions |
US10251392B2 (en) * | 2004-07-30 | 2019-04-09 | Avent, Inc. | Antimicrobial devices and compositions |
US8361553B2 (en) | 2004-07-30 | 2013-01-29 | Kimberly-Clark Worldwide, Inc. | Methods and compositions for metal nanoparticle treated surfaces |
JP4745747B2 (ja) * | 2004-08-12 | 2011-08-10 | 日東電工株式会社 | フェンタニル含有貼付製剤 |
JP4824963B2 (ja) * | 2004-08-12 | 2011-11-30 | 日東電工株式会社 | 貼付材及び貼付製剤 |
WO2006034249A2 (en) * | 2004-09-20 | 2006-03-30 | Acrymed, Inc. | Antimicrobial amorphous compositions |
JP5058531B2 (ja) | 2005-09-09 | 2012-10-24 | 日東電工株式会社 | ビソプロロール含有貼付製剤 |
EP2308480B1 (en) | 2005-09-23 | 2014-08-13 | ALZA Corporation | High Enhancer-Loading Polyacrylate Formulation for Transdermal Applications |
US9056061B2 (en) * | 2005-09-23 | 2015-06-16 | Alza Corporation | Transdermal nicotine salt delivery system |
EP1774964B1 (en) | 2005-10-13 | 2014-08-06 | Nitto Denko Corporation | Nicotine transdermal preparation and production method thereof |
WO2007127236A2 (en) * | 2006-04-28 | 2007-11-08 | Acrymed, Inc. | Antimicrobial site dressings |
DK2117521T3 (da) | 2006-11-03 | 2012-09-03 | Durect Corp | Transdermale indgivelsessystemer omfattende bupivacain |
EP2101864A2 (en) * | 2006-12-20 | 2009-09-23 | ALZA Corporation | Anode for electrotransport of cationic drug |
US20100041704A1 (en) * | 2007-01-12 | 2010-02-18 | Aberg A K Gunnar | Dermal compositions of substituted amides and the use thereof as medication for pain and pruritus |
KR20090118957A (ko) * | 2007-03-08 | 2009-11-18 | 닛토덴코 가부시키가이샤 | 비소프롤롤 경피 투여 디바이스 |
US20100183519A1 (en) | 2007-06-08 | 2010-07-22 | University Of Virginia Patent Foundation | Topical Poloxamer Formulations for Enhancing Microvascular Flow: Compositions and Uses Thereof |
KR101583680B1 (ko) * | 2007-10-15 | 2016-01-08 | 알자 코퍼레이션 | 펜타닐의 1일-1회 교체 경피 투여 |
US20100190004A1 (en) * | 2008-11-24 | 2010-07-29 | Gibbins Bruce L | Antimicrobial laminate constructs |
WO2011011318A1 (en) * | 2009-07-21 | 2011-01-27 | Mylan, Inc. | Process for the continuous manufacture of a polyisobutylene based transdermal patch |
DE102009048973A1 (de) * | 2009-10-09 | 2011-04-14 | Beiersdorf Ag | Transdermale therapeutische Systeme enthaltend 4-n-Butylresorcin |
DE102011100619A1 (de) | 2010-05-05 | 2012-01-05 | Amw Gmbh | Transdermales therapeutisches System (TTS) mit einem Gehalt an einem Opiod-Analgetikum |
WO2012084969A1 (en) | 2010-12-22 | 2012-06-28 | Hexal Ag | Adhesive composition containing rotigotine and transdermal therapeutic system comprising the adhesive composition |
CA2826218C (en) * | 2011-02-02 | 2019-06-25 | Nitto Denko Corporation | A patch and patch preparation comprising a support and an adhesive layer |
JP5698018B2 (ja) * | 2011-02-02 | 2015-04-08 | 日東電工株式会社 | 貼付剤および貼付製剤 |
US9072682B2 (en) | 2012-12-31 | 2015-07-07 | Mylan Inc. | Transdermal dosage form for low-melting point active agent |
US20140271923A1 (en) | 2013-03-14 | 2014-09-18 | Christopher Brian Reid | Compositions & formulations for preventing and treating chronic diseases that cluster in patients such as cardiovascular disease, diabetes, obesity, polycystic ovary syndrome, hyperlipidemia and hypertension, as well as for preventing and treating other diseases and conditions |
AU2014281317A1 (en) * | 2013-06-20 | 2016-02-04 | Mylan Technologies, Inc. | Storage stable transdermal patch of rotigotine |
DE102017104026A1 (de) | 2017-02-27 | 2018-08-30 | Lts Lohmann Therapie-Systeme Ag | Nicotin enthaltendes transparentes transdermales therapeutisches System |
US10406114B2 (en) * | 2017-06-11 | 2019-09-10 | Masoumeh Nasrollahzadeh Abyazani | Antibiotic-loaded transdermal patch |
DE102017115701B4 (de) * | 2017-07-12 | 2022-03-03 | Lts Lohmann Therapie-Systeme Ag | Fampridin-TTS |
WO2021226470A1 (en) * | 2020-05-08 | 2021-11-11 | WeCool Toys Inc. | Modular and customizable toy systems comprising building blocks, removable non-adhesive graphics, and built-in instructions |
US20240149185A1 (en) * | 2022-11-04 | 2024-05-09 | Charlie-Kao Industry Co., Ltd. | Building block assembly |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
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US3252802A (en) * | 1964-06-11 | 1966-05-24 | Canadian Patents Dev | Method of supplementing the feed of growing swine with nicotine |
US3433775A (en) * | 1966-01-12 | 1969-03-18 | Exxon Research Engineering Co | Process of making butyl rubber whereby a broad molecular weight distribution is obtained under controlled conditions |
GB1163339A (en) * | 1966-01-25 | 1969-09-04 | Montedison Spa | Polyisobutene |
US3598123A (en) * | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US3734097A (en) * | 1969-04-01 | 1973-05-22 | Alza Corp | Therapeutic adhesive tape |
US3598122A (en) * | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US3877468A (en) * | 1970-07-22 | 1975-04-15 | Leo Ab | Chewable tobacco substitute composition |
US3731683A (en) * | 1971-06-04 | 1973-05-08 | Alza Corp | Bandage for the controlled metering of topical drugs to the skin |
US3845217A (en) * | 1972-11-16 | 1974-10-29 | Helsingborg L Ab | Buffered smoking substitute compositions |
US3870794A (en) * | 1974-02-20 | 1975-03-11 | Foundation For Behavioral Rese | Treatment of certain emotional disorders with nicotine compounds |
US4125623A (en) * | 1974-04-08 | 1978-11-14 | U.S. Philips Corporation | Spasmolytics |
NL178686C (nl) * | 1974-04-08 | 1986-05-01 | Duphar Int Res | Werkwijze ter bereiding of vervaardiging van spasmolytisch werkzame preparaten en werkwijze ter bereiding van n-alkyl-n-gesubstitueerd alkylbeta-fenylethylaminen met spasmolytische werking. |
US3923939A (en) * | 1974-06-07 | 1975-12-02 | Alza Corp | Process for improving release kinetics of a monolithic drug delivery device |
US3926188A (en) * | 1974-11-14 | 1975-12-16 | Alza Corp | Laminated drug dispenser |
US4144317A (en) * | 1975-05-30 | 1979-03-13 | Alza Corporation | Device consisting of copolymer having acetoxy groups for delivering drugs |
US4562075A (en) * | 1982-05-20 | 1985-12-31 | Nelson Research & Development Co. | Penetration enhancers for transdermal drug delivery of systemic agents |
US4262003A (en) * | 1975-12-08 | 1981-04-14 | Alza Corporation | Method and therapeutic system for administering scopolamine transdermally |
US4031894A (en) * | 1975-12-08 | 1977-06-28 | Alza Corporation | Bandage for transdermally administering scopolamine to prevent nausea |
US4060084A (en) * | 1976-09-07 | 1977-11-29 | Alza Corporation | Method and therapeutic system for providing chemotherapy transdermally |
DE2702604C2 (de) * | 1977-01-22 | 1984-08-30 | Basf Ag, 6700 Ludwigshafen | Polyisobutene |
US4201211A (en) * | 1977-07-12 | 1980-05-06 | Alza Corporation | Therapeutic system for administering clonidine transdermally |
US4748181A (en) * | 1979-08-28 | 1988-05-31 | Foundation For Behavioral Research | Method for treating hypertension with nicotine |
US4286592A (en) * | 1980-02-04 | 1981-09-01 | Alza Corporation | Therapeutic system for administering drugs to the skin |
US4379454A (en) * | 1981-02-17 | 1983-04-12 | Alza Corporation | Dosage for coadministering drug and percutaneous absorption enhancer |
US4425337A (en) * | 1981-12-30 | 1984-01-10 | Merck & Co., Inc. | Adjuvants for rectal delivery of drug |
US4440740A (en) * | 1982-04-26 | 1984-04-03 | Merck & Co., Inc. | α-Keto aldehydes as enhancing agents of gastro-intestinal drug absorption |
IE54286B1 (en) * | 1983-01-18 | 1989-08-16 | Elan Corp Plc | Drug delivery device |
DE3344691A1 (de) * | 1983-12-10 | 1985-06-20 | Bayer Ag, 5090 Leverkusen | Wirkstoffabgasesysteme |
DE3347278A1 (de) * | 1983-12-28 | 1985-07-11 | Bayer Ag, 5090 Leverkusen | Wirkstoffabgabesysteme |
EP0177329B1 (en) * | 1984-10-05 | 1992-09-30 | Hercon Laboratories Corporation | Device for transdermal drug administration |
US4573995A (en) * | 1984-10-09 | 1986-03-04 | Alza Corporation | Transdermal therapeutic systems for the administration of naloxone, naltrexone and nalbuphine |
DE3438284A1 (de) * | 1984-10-16 | 1985-03-07 | Hans-Harald von 2400 Lübeck Tilly | Nikotinhaltiges depotpflaster |
US4752478A (en) * | 1984-12-17 | 1988-06-21 | Merck & Co., Inc. | Transdermal system for timolol |
EP0190814B1 (en) * | 1985-01-04 | 1992-05-13 | E.R. Squibb & Sons, Inc. | Wound dressing |
US4597961A (en) * | 1985-01-23 | 1986-07-01 | Etscorn Frank T | Transcutaneous application of nicotine |
US4680172A (en) * | 1985-03-05 | 1987-07-14 | Ciba-Geigy Corporation | Devices and methods for treating memory impairment |
US4665069A (en) * | 1985-04-02 | 1987-05-12 | Barnett Rosenberg | Analgesic composition and method of relieving pain |
EP0204968B1 (de) * | 1985-05-24 | 1989-09-27 | Beiersdorf Aktiengesellschaft | Nitro-Pflaster |
DE3518707A1 (de) * | 1985-05-24 | 1986-11-27 | Beiersdorf Ag, 2000 Hamburg | Nitro-pflaster |
US4647580A (en) * | 1985-07-18 | 1987-03-03 | Syntex (U.S.A.) Inc. | Treatment of Alzheimer's disease |
US4715387A (en) * | 1985-08-23 | 1987-12-29 | The Regents Of The Univ. Of California | Aerosol for use in the reduction of tobacco smoking |
WO1987002870A1 (en) * | 1985-11-14 | 1987-05-21 | Rosen David I | Transdermal application of nicotine |
US4797284A (en) * | 1986-03-12 | 1989-01-10 | Merck & Co., Inc. | Transdermal drug delivery system |
EP0251425B1 (en) * | 1986-04-03 | 1993-06-16 | Hercon Laboratories Corporation | Article for administration of pharmacologically-active substances |
DE3629304A1 (de) * | 1986-08-28 | 1988-03-24 | Lohmann Gmbh & Co Kg | Transdermales therapeutisches system, seine verwendung und verfahren zu seiner herstellung |
DE3786998D1 (de) * | 1986-11-20 | 1993-09-16 | Ciba Geigy Ag | Benutzer-aktivierte therapeutische systeme. |
US4839174A (en) * | 1987-10-05 | 1989-06-13 | Pharmetrix Corporation | Novel transdermal nicotine patch |
JPH01251619A (ja) * | 1988-03-30 | 1989-10-06 | Nec Corp | 半導体装置の製造方法 |
JPH0725669B2 (ja) * | 1988-12-23 | 1995-03-22 | 日東電工株式会社 | 経皮投与用医薬製剤 |
-
1990
- 1990-04-16 US US07/509,644 patent/US5508038A/en not_active Expired - Lifetime
-
1991
- 1991-04-12 AU AU78521/91A patent/AU630817B2/en not_active Expired
- 1991-04-12 JP JP03508812A patent/JP3035346B2/ja not_active Expired - Lifetime
- 1991-04-12 CA CA002040352A patent/CA2040352A1/en not_active Abandoned
- 1991-04-12 KR KR1019920702548A patent/KR0150228B1/ko not_active IP Right Cessation
- 1991-04-12 DK DK91908912.8T patent/DK0525105T3/da active
- 1991-04-12 NZ NZ237810A patent/NZ237810A/en unknown
- 1991-04-12 IE IE124491A patent/IE74862B1/en not_active IP Right Cessation
- 1991-04-12 WO PCT/US1991/002516 patent/WO1991016085A1/en active IP Right Grant
- 1991-04-12 EP EP91908912A patent/EP0525105B1/en not_active Expired - Lifetime
- 1991-04-12 DE DE69117505T patent/DE69117505T2/de not_active Expired - Lifetime
- 1991-04-12 ES ES91908912T patent/ES2084161T3/es not_active Expired - Lifetime
- 1991-04-12 AT AT91908912T patent/ATE134512T1/de not_active IP Right Cessation
- 1991-04-12 PT PT97357A patent/PT97357B/pt not_active IP Right Cessation
- 1991-04-21 ZA ZA912753A patent/ZA912753B/xx unknown
-
1992
- 1992-10-12 NO NO923954A patent/NO300086B1/no not_active IP Right Cessation
- 1992-10-15 FI FI924676A patent/FI112171B/fi active
-
1996
- 1996-02-29 GR GR960400405T patent/GR3019157T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69117505T2 (de) | 1996-07-11 |
IE911244A1 (en) | 1991-10-23 |
FI924676A (fi) | 1992-10-15 |
ATE134512T1 (de) | 1996-03-15 |
JP3035346B2 (ja) | 2000-04-24 |
JPH05507682A (ja) | 1993-11-04 |
EP0525105B1 (en) | 1996-02-28 |
FI924676A0 (fi) | 1992-10-15 |
WO1991016085A1 (en) | 1991-10-31 |
NO300086B1 (no) | 1997-04-07 |
NO923954L (no) | 1992-12-16 |
DK0525105T3 (da) | 1996-06-24 |
ZA912753B (en) | 1992-01-29 |
IE74862B1 (en) | 1997-08-13 |
KR0150228B1 (ko) | 1998-10-01 |
ES2084161T3 (es) | 1996-05-01 |
FI112171B (fi) | 2003-11-14 |
NZ237810A (en) | 1992-03-26 |
GR3019157T3 (en) | 1996-05-31 |
CA2040352A1 (en) | 1991-10-17 |
US5508038A (en) | 1996-04-16 |
NO923954D0 (no) | 1992-10-12 |
EP0525105A1 (en) | 1993-02-03 |
PT97357B (pt) | 1998-08-31 |
DE69117505D1 (de) | 1996-04-04 |
AU630817B2 (en) | 1992-11-05 |
AU7852191A (en) | 1991-11-11 |
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