PT95184A - Processo para a preparacao de novos sais de metais bivalentes do acido n'n-di(carboximetil)-2-amino-3-ciano-4-carboximetil-5-carboxi-tiofeno - Google Patents
Processo para a preparacao de novos sais de metais bivalentes do acido n'n-di(carboximetil)-2-amino-3-ciano-4-carboximetil-5-carboxi-tiofenoInfo
- Publication number
- PT95184A PT95184A PT95184A PT9518490A PT95184A PT 95184 A PT95184 A PT 95184A PT 95184 A PT95184 A PT 95184A PT 9518490 A PT9518490 A PT 9518490A PT 95184 A PT95184 A PT 95184A
- Authority
- PT
- Portugal
- Prior art keywords
- carboxymethyl
- cyano
- amino
- carboxy
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyridine Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8911475A FR2651497B1 (fr) | 1989-09-01 | 1989-09-01 | Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
Publications (2)
Publication Number | Publication Date |
---|---|
PT95184A true PT95184A (pt) | 1991-05-22 |
PT95184B PT95184B (pt) | 1997-06-30 |
Family
ID=9385063
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT95184A PT95184B (pt) | 1989-09-01 | 1990-08-31 | Processo para a preparacao de novos sais de metais bivalentes do acido n'n-di(carboximetil)-2-amino-3-ciano-4-carboximetil-5-carboxi-tiofeno |
Country Status (18)
Country | Link |
---|---|
US (1) | US5128367A (pt) |
EP (1) | EP0415850B1 (pt) |
JP (1) | JPH0692386B2 (pt) |
AT (1) | ATE100093T1 (pt) |
AU (1) | AU624022B2 (pt) |
CA (1) | CA2024419C (pt) |
DE (2) | DE69005950T2 (pt) |
DK (1) | DK0415850T3 (pt) |
ES (1) | ES2062450T4 (pt) |
FR (1) | FR2651497B1 (pt) |
HK (1) | HK57097A (pt) |
IE (1) | IE65157B1 (pt) |
LU (1) | LU91125I2 (pt) |
NL (1) | NL300168I1 (pt) |
NZ (1) | NZ234770A (pt) |
OA (1) | OA09463A (pt) |
PT (1) | PT95184B (pt) |
ZA (1) | ZA906716B (pt) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7404967B2 (en) * | 1994-12-21 | 2008-07-29 | Cosmederm, Inc. | Topical product formulations containing strontium for reducing skin irritation |
FR2749759B1 (fr) * | 1996-06-17 | 1999-11-26 | Adir | Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose |
FR2844797B1 (fr) * | 2002-09-24 | 2004-10-22 | Servier Lab | Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
FR2844795B1 (fr) | 2002-09-24 | 2004-10-22 | Servier Lab | Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates |
FR2844796A1 (fr) * | 2002-09-24 | 2004-03-26 | Servier Lab | Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
FR2846558B1 (fr) * | 2002-11-05 | 2006-07-14 | Servier Lab | Utilisation du sel distrontique de l'acide 2-n,n-di(carboxymethyl)amino-3-cyano-4-carboxymethyl- thiophene-5-carboxylique pour l'obtention de medicaments destines au traitement des douleurs gastro-duodenales |
US20060216358A1 (en) * | 2003-05-07 | 2006-09-28 | Christian Hansen | Controlled release composition containing a strontium salt |
AU2004237438B2 (en) | 2003-05-07 | 2011-01-20 | Osteologix A/S | Strontium combinations for prophylaxis/treatment of cartilage and/or bone conditions |
CA2519189C (en) * | 2003-05-07 | 2012-07-17 | Osteologix A/S | Water-soluble strontium salts for use in treatment of cartilage and/or bone conditions |
US6905723B2 (en) * | 2003-05-30 | 2005-06-14 | Depuy Products, Inc. | Strontium-substituted apatite coating |
US20050085531A1 (en) * | 2003-10-03 | 2005-04-21 | Hodge Carl N. | Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
EP1732575B1 (en) * | 2004-02-26 | 2010-12-29 | Osteologix A/S | Strontium-containing compounds for use in the prevention or treatment of necrotic bone conditions |
JP4954867B2 (ja) * | 2004-05-06 | 2012-06-20 | オステオロジックス エイ/エス | 有機金属塩類を製造するための高収率で迅速な合成法 |
DK1768748T4 (da) | 2004-06-25 | 2019-06-11 | Mokwalo Spf S A | Sammensætninger omfattende strontium og vitamin D og anvendelser deraf |
FR2875807B1 (fr) * | 2004-09-30 | 2006-11-17 | Servier Lab | Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
CN100391955C (zh) * | 2005-04-30 | 2008-06-04 | 河北医科大学 | 一种雷尼酸锶中间体的合成方法 |
WO2007020527A2 (en) * | 2005-08-19 | 2007-02-22 | Glenmark Pharmaceuticals Limited | Process for the preparation of strontium ranelate |
FR2899895B1 (fr) | 2006-04-12 | 2010-09-17 | Servier Lab | Nouveaux sels de strontium d'acides sulfoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US20070292529A1 (en) * | 2006-06-19 | 2007-12-20 | Tabbiner Philip S | Strontium compositions and methods of treating osteoporotic conditions |
US20070292535A1 (en) * | 2006-06-19 | 2007-12-20 | Tabbiner Philip S | Strontium compositions and methods of treating arthritic and or osteoporitic conditions |
CN101229154B (zh) * | 2007-01-26 | 2010-05-12 | 鲁南制药集团股份有限公司 | 治疗骨质疏松的药物组合物 |
FR2921367B1 (fr) * | 2007-09-26 | 2009-10-30 | Servier Lab | Nouveau procede de synthese du ranelate de strontium et de ses hydrates |
US20120123131A1 (en) * | 2008-08-22 | 2012-05-17 | Koilpillai Joseph Prabahar | Process for the preparation of strontium ranelate |
EP2346846A1 (en) | 2008-09-29 | 2011-07-27 | Ratiopharm GmbH | Anhydrate and hydrate forms of strontium ranelate |
CN101747316B (zh) * | 2008-12-12 | 2013-09-25 | 重庆医药工业研究院有限责任公司 | 高纯度的雷奈酸锶及其制备方法 |
EP2416756A2 (en) | 2009-04-10 | 2012-02-15 | Mahmut Bilgic | Stable pharmaceutical compositions with high bioavailibility |
FR2953139B1 (fr) | 2009-11-27 | 2012-04-13 | Servier Lab | Composition pharmaceutique comprenant un sel de strontium, de la vitamine d et une cyclodextrine |
CN101775002B (zh) * | 2009-12-23 | 2015-07-15 | 浙江华海药业股份有限公司 | 一种制备雷尼酸锶的方法 |
HU228820B1 (en) | 2010-01-14 | 2013-05-28 | Richter Gedeon Nyrt | Process for the preparation of distrontium ranelate |
IT1398542B1 (it) | 2010-03-05 | 2013-03-01 | Chemelectiva S R L | Processo per la preparazione di un polimorfo |
WO2011110597A1 (de) | 2010-03-11 | 2011-09-15 | Azad Pharmaceutical Ingredients Ag | Verfahren zur herstellung von strontiumranelat |
WO2011124992A1 (en) | 2010-03-24 | 2011-10-13 | Actavis Group Ptc Ehf | Substantially pure strontium ranelate |
CN102241663B (zh) * | 2010-05-10 | 2013-02-13 | 山东方明药业集团股份有限公司 | 一种雷奈酸锶八水合物的制备方法 |
WO2012046251A2 (en) * | 2010-10-08 | 2012-04-12 | Glenmark Generics Limited | Novel form of ranelic acid |
CN102180864B (zh) * | 2011-03-28 | 2012-12-12 | 中国药科大学 | 一种雷尼酸锶的制备方法 |
CZ2011320A3 (cs) | 2011-05-30 | 2012-12-12 | Zentiva, K.S. | Stabilní krystalická forma X stroncium ranelátu |
EP2530068A1 (en) | 2011-05-31 | 2012-12-05 | Lacer, S.A. | New strontium salts, synthesis and use thereof in the treatment of osteoporosis |
US9301945B2 (en) | 2011-07-21 | 2016-04-05 | Emory University | Methods for treating inflammatory conditions and states, and cancers by antagonizing NF-κB activation |
CN102503931A (zh) * | 2011-09-20 | 2012-06-20 | 浙江华海药业股份有限公司 | 一种雷尼酸锶晶形h的制备方法 |
WO2013113319A1 (en) | 2012-01-31 | 2013-08-08 | Pharmathen S.A. | Process for the preparation of strontium ranelate, intermediate or hydrates thereof |
EP2641905A1 (en) | 2012-03-23 | 2013-09-25 | Urquima S.A. | Solid forms of strontium ranelate and processes for their preparation |
US8569514B1 (en) | 2012-05-17 | 2013-10-29 | Divi's Laboratories, Ltd. | Process for the preparation of strontium ranelate |
CN103804345B (zh) * | 2013-09-06 | 2017-03-15 | 精华制药集团股份有限公司 | 一种用hplc法中控制备高纯度雷尼酸锶的方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3905577A1 (de) * | 1989-02-23 | 1990-08-30 | Basf Ag | Diaminothiophene |
-
1989
- 1989-09-01 FR FR8911475A patent/FR2651497B1/fr not_active Expired - Lifetime
-
1990
- 1990-08-03 NZ NZ234770A patent/NZ234770A/xx unknown
- 1990-08-23 ZA ZA906716A patent/ZA906716B/xx unknown
- 1990-08-31 DE DE69005950T patent/DE69005950T2/de not_active Expired - Lifetime
- 1990-08-31 JP JP2232271A patent/JPH0692386B2/ja not_active Expired - Lifetime
- 1990-08-31 EP EP90402401A patent/EP0415850B1/fr not_active Expired - Lifetime
- 1990-08-31 AU AU62033/90A patent/AU624022B2/en not_active Expired
- 1990-08-31 IE IE316290A patent/IE65157B1/en not_active IP Right Cessation
- 1990-08-31 US US07/576,225 patent/US5128367A/en not_active Expired - Lifetime
- 1990-08-31 DE DE200512000001 patent/DE122005000001I2/de active Active
- 1990-08-31 AT AT90402401T patent/ATE100093T1/de active
- 1990-08-31 DK DK90402401.5T patent/DK0415850T3/da active
- 1990-08-31 ES ES90402401T patent/ES2062450T4/es not_active Expired - Lifetime
- 1990-08-31 PT PT95184A patent/PT95184B/pt not_active IP Right Cessation
- 1990-08-31 OA OA59850A patent/OA09463A/xx unknown
- 1990-08-31 CA CA002024419A patent/CA2024419C/fr not_active Expired - Lifetime
-
1997
- 1997-05-01 HK HK57097A patent/HK57097A/xx not_active IP Right Cessation
-
2004
- 2004-12-15 LU LU91125C patent/LU91125I2/fr unknown
- 2004-12-24 NL NL300168C patent/NL300168I1/nl unknown
Also Published As
Publication number | Publication date |
---|---|
EP0415850A1 (fr) | 1991-03-06 |
HK57097A (en) | 1997-05-09 |
NL300168I2 (nl) | 2005-03-01 |
NZ234770A (en) | 1991-11-26 |
NL300168I1 (nl) | 2005-03-01 |
FR2651497A1 (fr) | 1991-03-08 |
DE122005000001I2 (de) | 2006-02-09 |
ATE100093T1 (de) | 1994-01-15 |
CA2024419A1 (fr) | 1991-03-02 |
AU624022B2 (en) | 1992-05-28 |
US5128367A (en) | 1992-07-07 |
ZA906716B (en) | 1991-06-26 |
JPH03169876A (ja) | 1991-07-23 |
DE69005950D1 (de) | 1994-02-24 |
ES2062450T4 (es) | 2011-12-29 |
CA2024419C (fr) | 1999-07-20 |
DE122005000001I1 (de) | 2005-05-12 |
OA09463A (fr) | 1992-11-15 |
IE903162A1 (en) | 1991-03-13 |
LU91125I2 (fr) | 2005-02-15 |
FR2651497B1 (fr) | 1991-10-25 |
ES2062450T3 (es) | 1994-12-16 |
IE65157B1 (en) | 1995-10-04 |
JPH0692386B2 (ja) | 1994-11-16 |
EP0415850B1 (fr) | 1994-01-12 |
DK0415850T3 (da) | 1994-03-21 |
PT95184B (pt) | 1997-06-30 |
DE69005950T2 (de) | 1994-07-21 |
AU6203390A (en) | 1991-03-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
BB1A | Laying open of patent application |
Effective date: 19901214 |
|
FG3A | Patent granted, date of granting |
Effective date: 19970303 |
|
PC3A | Transfer or assignment |
Free format text: 20011105 LES LABORATOIRES SERVIER FR |
|
MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20120305 |