PT91411A - Processo para a producao melhorada de metabolitos secundarios usando genes biossinteticos agrupados - Google Patents
Processo para a producao melhorada de metabolitos secundarios usando genes biossinteticos agrupadosInfo
- Publication number
- PT91411A PT91411A PT91411A PT9141189A PT91411A PT 91411 A PT91411 A PT 91411A PT 91411 A PT91411 A PT 91411A PT 9141189 A PT9141189 A PT 9141189A PT 91411 A PT91411 A PT 91411A
- Authority
- PT
- Portugal
- Prior art keywords
- biosynthetic genes
- grouped
- secondary metabolites
- enhanced production
- antibiotic
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 5
- 230000001851 biosynthetic effect Effects 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 229930000044 secondary metabolite Natural products 0.000 title 1
- 230000003115 biocidal effect Effects 0.000 abstract 3
- 229930182555 Penicillin Natural products 0.000 abstract 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 2
- 238000002955 isolation Methods 0.000 abstract 2
- 229940049954 penicillin Drugs 0.000 abstract 2
- 241000228431 Acremonium chrysogenum Species 0.000 abstract 1
- 241000228143 Penicillium Species 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/375—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Basidiomycetes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP88201714 | 1988-08-11 | ||
| EP89201044 | 1989-04-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT91411A true PT91411A (pt) | 1990-03-08 |
| PT91411B PT91411B (pt) | 1995-05-31 |
Family
ID=26115259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT91411A PT91411B (pt) | 1988-08-11 | 1989-08-09 | Processo para a producao melhorada de metabolitos secundarios usando genes biossinteticos agrupados |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5462862A (pt) |
| EP (1) | EP0357119B1 (pt) |
| JP (2) | JP3095391B2 (pt) |
| KR (1) | KR900003364A (pt) |
| AT (1) | ATE130033T1 (pt) |
| AU (1) | AU631806B2 (pt) |
| CA (1) | CA1340916C (pt) |
| DE (1) | DE68924745T2 (pt) |
| DK (1) | DK393089A (pt) |
| ES (1) | ES2081831T3 (pt) |
| FI (1) | FI104264B (pt) |
| GR (1) | GR3018782T3 (pt) |
| HU (1) | HU214244B (pt) |
| IE (1) | IE72167B1 (pt) |
| PT (1) | PT91411B (pt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6258555B1 (en) | 1987-12-09 | 2001-07-10 | Beecham Group P.L.C. | DNA encoding ACV synthetase |
| ES2121764T3 (es) * | 1990-02-28 | 1998-12-16 | Gist Brocades Nv | Un metodo para aumentar la produccion de antibioticos beta-lactamicos y para aislar grandes cantidades de acv-sinteasa. |
| US5662898A (en) * | 1990-08-20 | 1997-09-02 | Ciba-Geigy Corporation | Genes for the synthesis of antipathogenic substances |
| US5639949A (en) * | 1990-08-20 | 1997-06-17 | Ciba-Geigy Corporation | Genes for the synthesis of antipathogenic substances |
| US6524812B1 (en) | 1993-10-07 | 2003-02-25 | Regents Of The University Of Minnesota | Genes encoding resistance to DNA alkylating agents |
| US6495348B1 (en) | 1993-10-07 | 2002-12-17 | Regents Of The University Of Minnesota | Mitomycin biosynthetic gene cluster |
| US6117670A (en) * | 1994-06-08 | 2000-09-12 | Novartis Finance Corporation | Pyrrolnitrin biosynthesis genes and uses thereof |
| EP0734452A1 (en) * | 1994-06-10 | 1996-10-02 | Gist-Brocades B.V. | Improved acylation method for penicillins and cephalosporins |
| US5882883A (en) * | 1994-09-28 | 1999-03-16 | Novo Nordisk A/S | Process for the production of secondary metabolites |
| AU4201897A (en) * | 1996-07-16 | 1998-02-09 | Gist-Brocades B.V. | Novel process for the preparation of cephalosporins using (acremonium chrysogenum) |
| US5976836A (en) * | 1997-05-07 | 1999-11-02 | Fermalogic, Inc. | Methods and compositions for enhancing erythromycin production |
| AU762910B2 (en) | 1997-11-19 | 2003-07-10 | Microbia, Inc. | Chimeric pre-activated transcription factors |
| EP1026248A3 (en) * | 1999-01-29 | 2002-09-18 | RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH & INDUSTRIAL DEVELOPMENT LTD. | Gene cluster |
| US6284483B1 (en) * | 1999-10-06 | 2001-09-04 | Board Of Trustees Operating Michigan State University | Modified synthetases to produce penicillins and cephalosporins under the control of bicarbonate |
| US6949356B1 (en) * | 1999-10-20 | 2005-09-27 | Microbia, Inc. | Methods for improving secondary metabolite production in fungi |
| US20030194784A1 (en) * | 2001-04-17 | 2003-10-16 | Sherman David H. | DNA encoding methymycin and pikromycin |
| EP2123772A1 (en) * | 2008-04-29 | 2009-11-25 | DSM IP Assets B.V. | Beta-lactam antibiotic producing strains |
| CA3039625A1 (en) * | 2016-10-07 | 2018-04-12 | Idemitsu Kosan Co., Ltd. | Method for culturing spore-forming bacteria, and method for producing useful substance |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4892819A (en) * | 1985-11-25 | 1990-01-09 | Eli Lilly And Company | Recombinant DNA expression vectors and DNA compounds that encode isopenicillin N synthetase from penicillium chrysogenum |
| EP0260762B1 (en) * | 1986-09-16 | 1994-01-12 | Gist-Brocades N.V. | Penicillium transformants and methods for their production |
| US4950603A (en) * | 1987-11-02 | 1990-08-21 | Eli Lilly And Company | Recombinant DNA expression vectors and DNA compounds that encode isopenicillin N synthetase from Streptomyces lipmanii |
| GB8728811D0 (en) * | 1987-12-09 | 1988-01-27 | Beecham Group Plc | Novel substance |
| US5108918A (en) * | 1988-08-11 | 1992-04-28 | Gist-Brocades | Method for identifying and using biosynthetic genes for enhanced production of secondary metabolites |
-
1989
- 1989-08-07 FI FI893722A patent/FI104264B/fi not_active IP Right Cessation
- 1989-08-09 ES ES89202060T patent/ES2081831T3/es not_active Expired - Lifetime
- 1989-08-09 EP EP89202060A patent/EP0357119B1/en not_active Revoked
- 1989-08-09 AT AT89202060T patent/ATE130033T1/de not_active IP Right Cessation
- 1989-08-09 DE DE68924745T patent/DE68924745T2/de not_active Revoked
- 1989-08-09 PT PT91411A patent/PT91411B/pt not_active IP Right Cessation
- 1989-08-10 DK DK393089A patent/DK393089A/da not_active Application Discontinuation
- 1989-08-10 CA CA000608022A patent/CA1340916C/en not_active Expired - Fee Related
- 1989-08-10 IE IE257289A patent/IE72167B1/en not_active IP Right Cessation
- 1989-08-10 HU HU894104A patent/HU214244B/hu not_active IP Right Cessation
- 1989-08-11 KR KR1019890011451A patent/KR900003364A/ko not_active Application Discontinuation
- 1989-08-11 AU AU39569/89A patent/AU631806B2/en not_active Ceased
- 1989-08-11 JP JP01209493A patent/JP3095391B2/ja not_active Expired - Fee Related
-
1993
- 1993-01-25 US US08/008,688 patent/US5462862A/en not_active Expired - Fee Related
-
1996
- 1996-01-24 GR GR960400181T patent/GR3018782T3/el unknown
-
2000
- 2000-05-11 JP JP2000138900A patent/JP2000342289A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FI893722A0 (fi) | 1989-08-07 |
| FI893722A (fi) | 1990-02-12 |
| JP2000342289A (ja) | 2000-12-12 |
| DE68924745T2 (de) | 1996-04-11 |
| DK393089A (da) | 1990-02-12 |
| GR3018782T3 (en) | 1996-04-30 |
| FI104264B1 (fi) | 1999-12-15 |
| ATE130033T1 (de) | 1995-11-15 |
| JPH02150284A (ja) | 1990-06-08 |
| CA1340916C (en) | 2000-02-29 |
| US5462862A (en) | 1995-10-31 |
| PT91411B (pt) | 1995-05-31 |
| HUT51335A (en) | 1990-04-28 |
| JP3095391B2 (ja) | 2000-10-03 |
| AU3956989A (en) | 1990-02-15 |
| EP0357119A2 (en) | 1990-03-07 |
| AU631806B2 (en) | 1992-12-10 |
| EP0357119A3 (en) | 1990-04-04 |
| DE68924745D1 (de) | 1995-12-14 |
| KR900003364A (ko) | 1990-03-26 |
| EP0357119B1 (en) | 1995-11-08 |
| ES2081831T3 (es) | 1996-03-16 |
| IE72167B1 (en) | 1997-03-26 |
| IE892572L (en) | 1990-02-11 |
| HU214244B (hu) | 1998-03-02 |
| FI104264B (fi) | 1999-12-15 |
| DK393089D0 (da) | 1989-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19941125 |
|
| PC3A | Transfer or assignment |
Free format text: 19981117 DSM N.V. NL |
|
| MM3A | Annulment or lapse |
Effective date: 20050525 |