ES8105034A1 - Procedimiento para la produccion de una istamicina - Google Patents

Procedimiento para la produccion de una istamicina

Info

Publication number
ES8105034A1
ES8105034A1 ES491077A ES491077A ES8105034A1 ES 8105034 A1 ES8105034 A1 ES 8105034A1 ES 491077 A ES491077 A ES 491077A ES 491077 A ES491077 A ES 491077A ES 8105034 A1 ES8105034 A1 ES 8105034A1
Authority
ES
Spain
Prior art keywords
istamycin
istamycins
production
new
denominated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES491077A
Other languages
English (en)
Other versions
ES491077A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP5251779A external-priority patent/JPS55145697A/ja
Priority claimed from JP11791279A external-priority patent/JPS5643295A/ja
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of ES8105034A1 publication Critical patent/ES8105034A1/es
Publication of ES491077A0 publication Critical patent/ES491077A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/46—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
    • C12P19/48—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin the cyclohexyl radical being substituted by two or more nitrogen atoms, e.g. destomycin, neamin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA LA PRODUCCION DE UNA ISTAMICINA. CONSISTE EN EL CULTIVO EN CONDICIONES AEROBIAS, DE DOS A SIETE DIAS, DE UNA CEPA STREPTOMYCES, A TEMPERATURA DE 25-30GC, EN UN MEDIO DE CULTIVO CONTENIENDO FUENTES DE CARBONO Y NITROGENO, HASTA PRODUCIR UNA CIERTA CANTIDAD DE ISTAMICINA. SE PASA EL PRODUCTO POR UNA COLUMNA DE UNA RESINA DE INTERCAMBIO CATIONICO Y SE RECUPERA LA ISTAMICINA EN FORMA CRUDA, EN SOLUCION O COMO SOLIDO. SE OBTIENE CUATRO CLASES DE ISTAMICINAS: A, B, A0 Y B0, SEGUN LA CEPA EMPLEADA, O BIEN UNA MEZCLA DE ELLAS. DE APLICACION EN INFECCIONES BACTERIANAS Y ESTERILIZACION DE MATERIAL QUIRURGICO.
ES491077A 1979-05-01 1980-04-30 Procedimiento para la produccion de una istamicina Granted ES491077A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP5251779A JPS55145697A (en) 1979-05-01 1979-05-01 Istamycins a or/and b, and their preparation
JP11791279A JPS5643295A (en) 1979-09-17 1979-09-17 Istamycin ao and/or istamycin bo, and their preparation

Publications (2)

Publication Number Publication Date
ES8105034A1 true ES8105034A1 (es) 1981-05-16
ES491077A0 ES491077A0 (es) 1981-05-16

Family

ID=26393116

Family Applications (1)

Application Number Title Priority Date Filing Date
ES491077A Granted ES491077A0 (es) 1979-05-01 1980-04-30 Procedimiento para la produccion de una istamicina

Country Status (9)

Country Link
US (1) US4296106A (es)
CA (1) CA1158999A (es)
CH (1) CH646712A5 (es)
DE (1) DE3012014C2 (es)
ES (1) ES491077A0 (es)
FR (1) FR2455596A1 (es)
GB (1) GB2048855B (es)
IT (1) IT1153794B (es)
NL (1) NL8001842A (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4382926A (en) * 1980-04-01 1983-05-10 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Formimidoyl A and B useful as semi-synthetic aminoglycosidic antibiotics
US4425430A (en) * 1980-07-15 1984-01-10 Kowa Company, Ltd. Process for production of antibiotics and novel antibiotics produced thereby
JPS5740496A (en) * 1980-08-22 1982-03-06 Microbial Chem Res Found Low toxic derivative of istamycin antibiotic
JPS5750996A (en) * 1980-09-11 1982-03-25 Microbial Chem Res Found 3-o-demthylistamycin b derivative
JPS58128395A (ja) * 1982-01-27 1983-07-30 Microbial Chem Res Found ３−０−デメチルイスタマイシンｂの低毒性誘導体
US4567165A (en) * 1984-05-08 1986-01-28 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai N-Methanesulfonic acid derivatives of 3-demethoxyistamycin B
JPH0631295B2 (ja) * 1986-03-11 1994-04-27 財団法人微生物化学研究会 低毒性の２′−デアミノ−２′−ヒドロキシイスタマイシンＢｏ誘導体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ185515A (en) * 1976-10-28 1980-08-26 Abbott Lab Fortimicin d and ke from culturing micromonospora olivoasterospora
US4205070A (en) * 1977-12-21 1980-05-27 Abbott Laboratories 6'N-Alkyl- and 6',6'-di-N-alkyl derivatives of fortimicins A and B

Also Published As

Publication number Publication date
DE3012014C2 (de) 1986-11-13
GB2048855B (en) 1983-06-15
GB2048855A (en) 1980-12-17
FR2455596B1 (es) 1983-05-20
IT1153794B (it) 1987-01-21
FR2455596A1 (fr) 1980-11-28
DE3012014A1 (de) 1980-11-13
CA1158999A (en) 1983-12-20
IT8009394A0 (it) 1980-03-28
CH646712A5 (de) 1984-12-14
ES491077A0 (es) 1981-05-16
NL8001842A (nl) 1980-11-04
US4296106A (en) 1981-10-20

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000301