DK393089A - Dna omfattende samvirkende biosyntesegener og fremgangsmaade til oegning af produktion af sekundaere metabolitter under anvendelse af dette - Google Patents

Dna omfattende samvirkende biosyntesegener og fremgangsmaade til oegning af produktion af sekundaere metabolitter under anvendelse af dette Download PDF

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Publication number
DK393089A
DK393089A DK393089A DK393089A DK393089A DK 393089 A DK393089 A DK 393089A DK 393089 A DK393089 A DK 393089A DK 393089 A DK393089 A DK 393089A DK 393089 A DK393089 A DK 393089A
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Denmark
Prior art keywords
biosynth
dna
synthesis
procedure
secondary metabolites
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DK393089A
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English (en)
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DK393089D0 (da
Inventor
Martien Antonius Mathi Groenen
Annemarie Eveline Veenstra
Pieter Van Solingen
Bertus Pieter Koekman
Lucia Helena Maria Van D Voort
Juan Francisco Martin
Santiago Gutierrez
Bruno Diez
Emilio Alvarez
Jose Luis Barredo
Christina Esmahan
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Gist Brocades Nv
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26115259&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK393089(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv
Publication of DK393089D0 publication Critical patent/DK393089D0/da
Publication of DK393089A publication Critical patent/DK393089A/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/375—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Basidiomycetes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Enzymes And Modification Thereof (AREA)
DK393089A 1988-08-11 1989-08-10 Dna omfattende samvirkende biosyntesegener og fremgangsmaade til oegning af produktion af sekundaere metabolitter under anvendelse af dette DK393089A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP88201714 1988-08-11
EP89201044 1989-04-21

Publications (2)

Publication Number Publication Date
DK393089D0 DK393089D0 (da) 1989-08-10
DK393089A true DK393089A (da) 1990-02-12

Family

ID=26115259

Family Applications (1)

Application Number Title Priority Date Filing Date
DK393089A DK393089A (da) 1988-08-11 1989-08-10 Dna omfattende samvirkende biosyntesegener og fremgangsmaade til oegning af produktion af sekundaere metabolitter under anvendelse af dette

Country Status (15)

Country Link
US (1) US5462862A (da)
EP (1) EP0357119B1 (da)
JP (2) JP3095391B2 (da)
KR (1) KR900003364A (da)
AT (1) ATE130033T1 (da)
AU (1) AU631806B2 (da)
CA (1) CA1340916C (da)
DE (1) DE68924745T2 (da)
DK (1) DK393089A (da)
ES (1) ES2081831T3 (da)
FI (1) FI104264B1 (da)
GR (1) GR3018782T3 (da)
HU (1) HU214244B (da)
IE (1) IE72167B1 (da)
PT (1) PT91411B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6258555B1 (en) 1987-12-09 2001-07-10 Beecham Group P.L.C. DNA encoding ACV synthetase
EP0445868B1 (en) * 1990-02-28 1998-07-29 Gist-Brocades N.V. A method for influencing beta-lactam antibiotic production and for isolation of large quantities of ACV synthetase
US5662898A (en) * 1990-08-20 1997-09-02 Ciba-Geigy Corporation Genes for the synthesis of antipathogenic substances
US5639949A (en) * 1990-08-20 1997-06-17 Ciba-Geigy Corporation Genes for the synthesis of antipathogenic substances
US6495348B1 (en) * 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
US6524812B1 (en) 1993-10-07 2003-02-25 Regents Of The University Of Minnesota Genes encoding resistance to DNA alkylating agents
US6117670A (en) * 1994-06-08 2000-09-12 Novartis Finance Corporation Pyrrolnitrin biosynthesis genes and uses thereof
US5753458A (en) * 1994-06-10 1998-05-19 Gist-Brocades B.V. Acylation method for penicillins and cephalosporins
ATE334203T1 (de) * 1994-09-28 2006-08-15 Novozymes As Verfahren zur herstellung von sekundären metaboliten
AU4201897A (en) * 1996-07-16 1998-02-09 Gist-Brocades B.V. Novel process for the preparation of cephalosporins using (acremonium chrysogenum)
US5976836A (en) * 1997-05-07 1999-11-02 Fermalogic, Inc. Methods and compositions for enhancing erythromycin production
CA2310624A1 (en) * 1997-11-19 1999-05-27 Microbia, Inc. Chimeric pre-activated transcription factors
EP1026248A3 (en) * 1999-01-29 2002-09-18 RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH & INDUSTRIAL DEVELOPMENT LTD. Gene cluster
US6284483B1 (en) * 1999-10-06 2001-09-04 Board Of Trustees Operating Michigan State University Modified synthetases to produce penicillins and cephalosporins under the control of bicarbonate
US6949356B1 (en) * 1999-10-20 2005-09-27 Microbia, Inc. Methods for improving secondary metabolite production in fungi
US20030194784A1 (en) * 2001-04-17 2003-10-16 Sherman David H. DNA encoding methymycin and pikromycin
EP2123772A1 (en) * 2008-04-29 2009-11-25 DSM IP Assets B.V. Beta-lactam antibiotic producing strains
JP7019584B2 (ja) * 2016-10-07 2022-02-15 出光興産株式会社 芽胞形成細菌の培養方法および有用物質の製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4892819A (en) * 1985-11-25 1990-01-09 Eli Lilly And Company Recombinant DNA expression vectors and DNA compounds that encode isopenicillin N synthetase from penicillium chrysogenum
DE3788764T2 (de) * 1986-09-16 1994-06-23 Gist Brocades Nv Penicilliumtransformanten und Verfahren zu ihrer Herstellung.
US4950603A (en) * 1987-11-02 1990-08-21 Eli Lilly And Company Recombinant DNA expression vectors and DNA compounds that encode isopenicillin N synthetase from Streptomyces lipmanii
GB8728811D0 (en) * 1987-12-09 1988-01-27 Beecham Group Plc Novel substance
US5108918A (en) * 1988-08-11 1992-04-28 Gist-Brocades Method for identifying and using biosynthetic genes for enhanced production of secondary metabolites

Also Published As

Publication number Publication date
EP0357119A3 (en) 1990-04-04
AU3956989A (en) 1990-02-15
JP2000342289A (ja) 2000-12-12
EP0357119B1 (en) 1995-11-08
AU631806B2 (en) 1992-12-10
GR3018782T3 (en) 1996-04-30
JPH02150284A (ja) 1990-06-08
ES2081831T3 (es) 1996-03-16
FI104264B (fi) 1999-12-15
FI104264B1 (fi) 1999-12-15
FI893722A (fi) 1990-02-12
US5462862A (en) 1995-10-31
DE68924745D1 (de) 1995-12-14
HU214244B (hu) 1998-03-02
IE72167B1 (en) 1997-03-26
DE68924745T2 (de) 1996-04-11
HUT51335A (en) 1990-04-28
FI893722A0 (fi) 1989-08-07
EP0357119A2 (en) 1990-03-07
CA1340916C (en) 2000-02-29
IE892572L (en) 1990-02-11
PT91411A (pt) 1990-03-08
ATE130033T1 (de) 1995-11-15
KR900003364A (ko) 1990-03-26
JP3095391B2 (ja) 2000-10-03
PT91411B (pt) 1995-05-31
DK393089D0 (da) 1989-08-10

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