PT90030A - Processo para a preparacao de liofilisado de ifosfamida e mesna - Google Patents

Processo para a preparacao de liofilisado de ifosfamida e mesna

Info

Publication number
PT90030A
PT90030A PT90030A PT9003089A PT90030A PT 90030 A PT90030 A PT 90030A PT 90030 A PT90030 A PT 90030A PT 9003089 A PT9003089 A PT 9003089A PT 90030 A PT90030 A PT 90030A
Authority
PT
Portugal
Prior art keywords
mesna
lyophylisate
ifosphamide
preparation
ifosfamide
Prior art date
Application number
PT90030A
Other languages
English (en)
Other versions
PT90030B (pt
Inventor
Dieter Sauerbier
Otto Isaac
Wolfgang Peter Brade
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of PT90030A publication Critical patent/PT90030A/pt
Publication of PT90030B publication Critical patent/PT90030B/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Control Of El Displays (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT90030A 1988-03-19 1989-03-17 Processo para a preparacao de liofilisado de ifosfamida e mesna PT90030B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3809337 1988-03-19

Publications (2)

Publication Number Publication Date
PT90030A true PT90030A (pt) 1989-11-10
PT90030B PT90030B (pt) 1994-05-31

Family

ID=6350216

Family Applications (1)

Application Number Title Priority Date Filing Date
PT90030A PT90030B (pt) 1988-03-19 1989-03-17 Processo para a preparacao de liofilisado de ifosfamida e mesna

Country Status (11)

Country Link
US (1) US4959215A (pt)
EP (1) EP0334083B1 (pt)
JP (1) JP2865698B2 (pt)
AT (1) ATE65402T1 (pt)
CA (1) CA1326452C (pt)
DE (1) DE58900183D1 (pt)
ES (1) ES2040394T3 (pt)
FI (1) FI89456C (pt)
GR (1) GR3002377T3 (pt)
IE (1) IE60721B1 (pt)
PT (1) PT90030B (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4122167A1 (de) * 1990-07-16 1992-01-23 Asta Pharma Ag Tablette und granulat enthaltend als wirkstoff mesna
US5252341A (en) * 1990-07-16 1993-10-12 Degussa Aktiengesellschaft Tablets and granulates containing mesna as active substance
US5227373A (en) * 1991-10-23 1993-07-13 Bristol-Myers Squibb Co. Lyophilized ifosfamide compositions
DE4233842A1 (de) * 1992-10-08 1994-04-14 Asta Medica Ag Mesna Injektionslösungen
WO1995007083A1 (en) * 1993-09-10 1995-03-16 F.H. Faulding & Co. Limited Ifosfamide lyophilisate composition
US5789000A (en) * 1994-11-14 1998-08-04 Bionumerik Pharmaceuticals, Inc. Sterile aqueous parenteral formulations of cis-diammine dichloro platinum
DE19529057B4 (de) * 1995-08-08 2007-12-13 Baxter Healthcare S.A. Ifosfamid-Lyophilisat-Zubereitungen
IT1284973B1 (it) * 1996-10-11 1998-05-28 A R D O Associazione Ricerca E Uso del sodio 2-mercaptoetansolfonato (mesna) in chirurgia
US6613927B1 (en) 2002-02-08 2003-09-02 American Pharmaceutical Partners, Inc. Sterile lyophilized ifosfamide and associated methods
CA2497898C (en) * 2002-09-05 2012-02-07 Bharat Serums & Vaccines Ltd. Liquid stable composition of oxazaphosphorine with mesna
MXPA05005919A (es) * 2002-12-02 2005-09-21 Bharat Serums & Vaccines Ltd Composiciones de ifosfamida para la administracion parenteral, y un proceso para su preparacion.
US20070192947A1 (en) * 2003-07-10 2007-08-23 Cylena Medical Technologies Inc. Protective apparel with improved doffing
DK1667655T3 (da) * 2003-10-01 2011-10-24 Baxter Int Ny anvendelse, farmaceutiske præparater og en fremgangsmåde til deres fremstilling
BRPI0515181A (pt) * 2004-09-13 2008-07-22 Bharat Serums & Vaccines Ltd composição de óleo-em-água estéril para administração intravenosa, uso de um monoglicerìdeo e processo de preparação de uma composição para administração intravenosa
US8436190B2 (en) 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
US8158152B2 (en) * 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
AR072777A1 (es) 2008-03-26 2010-09-22 Cephalon Inc Formas solidas de clorhidrato de bendamustina
WO2010010383A1 (en) * 2008-07-21 2010-01-28 Isis Innovation Limited Treatment of obesity
WO2010099213A1 (en) * 2009-02-24 2010-09-02 Dekk-Tec, Inc. Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents
EP3597128A1 (en) * 2013-05-07 2020-01-22 AuXin Surgery SA Device for chemically assisted dissection
WO2015101665A1 (en) 2014-01-06 2015-07-09 Auxin Surgery Sa Lyophilized mesna compositions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002495B1 (de) * 1977-12-14 1984-02-15 Asta-Werke Aktiengesellschaft Chemische Fabrik Erzeugnisse zur Anwendung in der cytostatischen Therapie
DE3111428A1 (de) * 1981-03-24 1982-10-07 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
ZA851062B (en) * 1984-03-01 1985-11-27 Asta Werke Ag Chem Fab Salts of oxazaphosphorine derivatives and process for their production
US4797388A (en) * 1984-05-21 1989-01-10 Cetus Corporation Pharmaceutical compositions with galactitol as carrier
US4859452A (en) * 1986-01-17 1989-08-22 Board Of Regents, The University Of Texas System Methods for the reduction of difluoromethylornithine associated toxicity
AU605512B2 (en) * 1986-10-07 1991-01-17 Boehringer Mannheim Italia S.P.A. Pharmaceutical compositions having antineoplastic activity
NO873860L (no) * 1986-10-31 1988-05-02 Asta Pharma Ag Ifosfamid-lyofilisat og fremgangsmaate til deres fremstilling.

Also Published As

Publication number Publication date
FI89456B (fi) 1993-06-30
GR3002377T3 (en) 1992-12-30
ATE65402T1 (de) 1991-08-15
IE60721B1 (en) 1994-08-10
JPH024796A (ja) 1990-01-09
DE58900183D1 (de) 1991-08-29
IE890854L (en) 1989-09-19
JP2865698B2 (ja) 1999-03-08
US4959215A (en) 1990-09-25
FI891283A0 (fi) 1989-03-17
CA1326452C (en) 1994-01-25
EP0334083A1 (de) 1989-09-27
PT90030B (pt) 1994-05-31
FI891283A (fi) 1989-09-20
FI89456C (fi) 1993-10-11
EP0334083B1 (de) 1991-07-24
ES2040394T3 (es) 1993-10-16

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19931110

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20090317